基于Nrf2/HO-1信号通路的中药及其有效成分抗心血管疾病作用研究进展

王翔; 莫佳佳; 周鹏; 施慧; 黄金玲

doi:10.13422/j.cnki.syfjx.20200405

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基于Nrf2/HO-1信号通路的中药及其有效成分抗心血管疾病作用研究进展

综述 | 更新时间：2021-02-09

- 基于Nrf2/HO-1信号通路的中药及其有效成分抗心血管疾病作用研究进展
- Effect of Traditional Chinese Medicine and Its Active Ingredients on Cardiovascular Disease Based on Nrf2/HO-1 Signaling Pathway
- 中国实验方剂学杂志 2020年26卷第10期页码：227-234
- 作者机构：
  
  1.安徽中医药大学，合肥　 230038
  2.合肥医工医药股份有限公司，合肥　 230601
- 作者简介：
  
  [第一作者]　王翔，在读博士，讲师，从事中药及复方效应机制与物质基础研究，E-mail：stamperwang@163.com
  *黄金玲，博士，教授，博士生导师，从事中药及复方效应机制与物质基础研究，E-mail：jinling6181@126.com
- 基金信息：
  
  国家自然科学基金项目(81373533;81973844)
- DOI：10.13422/j.cnki.syfjx.20200405
  中图分类号： R2-0; R22; R285.5; R284
- 收稿日期：2019-09-02，
  
  网络出版日期：2019-11-05，
  
  纸质出版日期：2020-05-20
- 稿件说明：
移动端阅览
王翔, 莫佳佳, 周鹏, 等. 基于Nrf2/HO-1信号通路的中药及其有效成分抗心血管疾病作用研究进展[J]. 中国实验方剂学杂志, 2020,26(10):227-234.

Xiang WANG, Jia-jia MO, Peng ZHOU, et al. Effect of Traditional Chinese Medicine and Its Active Ingredients on Cardiovascular Disease Based on Nrf2/HO-1 Signaling Pathway[J]. Chinese journal of experimental traditional medical formulae, 2020, 26(10): 227-234.
王翔, 莫佳佳, 周鹏, 等. 基于Nrf2/HO-1信号通路的中药及其有效成分抗心血管疾病作用研究进展[J]. 中国实验方剂学杂志, 2020,26(10):227-234. DOI： 10.13422/j.cnki.syfjx.20200405.

Xiang WANG, Jia-jia MO, Peng ZHOU, et al. Effect of Traditional Chinese Medicine and Its Active Ingredients on Cardiovascular Disease Based on Nrf2/HO-1 Signaling Pathway[J]. Chinese journal of experimental traditional medical formulae, 2020, 26(10): 227-234. DOI： 10.13422/j.cnki.syfjx.20200405.

摘要

心血管疾病是我国居民死亡的首要原因，因其在遗传背景、发病原因、疾病发展走向等方面存在非常大的个体差异性，目前指南指导下的西医规范化治疗的残存死亡风险率仍然很高。中药具有多靶点、多途径、多层次的独特优势，可有效弥补西药的不足，在心血管疾病的治疗中被广泛应用。氧化应激是导致心血管疾病发生的重要原因之一，核因子E2相关因子2(Nrf2)是该反应的中枢调节者，当其被激活后可向核内转移并启动下游通路信号传导，发挥抗氧化应激作用。作为机体最重要的内源性保护体系之一，Nrf2/血红素加氧酶-1(Nrf2/HO-1)信号通路是Nrf2发挥作用的最经典途径。近年来运用现代分子生物学等方法研究并阐明中药通过调控该通路治疗心血管疾病已取得一定的成果。基于此，本文总结了Nrf2/HO-1信号通路与心血管疾病的关系，并归纳分析了中药有效成分、中药药对有效成分、中药提取物及中药复方调节该信号通路干预心血管疾病的的作用方式及可能机制，以期为抗心血管疾病药物的研发与利用提供理论参考。

Abstract

Cardiovascular disease is the leading cause of death in China. Due to its great individual differences in genetic background

pathogenesis and disease development trend

the survival risk rate after standardized western medicine treatment under the guidance of the current guidelines remains high. Traditional Chinese medicine(TCM) has unique multiple-target

multiple-pathway and multiple-layer advantages

which can effectively make up for shortcomings of western medicine. Therefore

it has been widely used in the treatment of cardiovascular diseases. Oxidative stress is one of the important causes of cardiovascular diseases. Nuclear factor erythroid-2-related factor 2(Nrf2) is the central regulator of this reaction. When being activated

it can transfer to the nucleus and initiate signaling in the downstream pathway

thus playing an anti-oxidative stress role. As one of the most important endogenous protection systems in the body

the Nrf2/heme oxygenase-1 (Nrf2/HO-1) signaling pathway is the most classical approach for Nrf2 in playing roles. There have been certain achievements in studying and clarifying TCM by regulating this pathway to treat cardiovascular diseases using modern molecular biology and other methods. Based on this

this paper summarized the relationship between Nrf2/HO-1 signaling pathway and cardiovascular diseases

then concluded and analyzed the mechanism and pharmacological effects of TCM and its active ingredients in Nrf2/HO-1 signaling pathway on different cardiovascular diseases

involving active ingredients of TCM

TCM pairs active ingredients

TCM extracts and TCM formula. This paper provides a theoretical reference for the development and utilization of anti-cardiovascular drugs.

关键词

Keywords

references

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