1.河南中医药大学 第一附属医院,郑州 450000
2.河南中医药大学 第一临床医学院,郑州 450046
3.黑龙江中医药大学 研究生院,哈尔滨 150040
代婷,在读博士,从事常见功能障碍中医康复的临床与基础研究,E-mail:1065242806@qq.com
冯晓东,博士生导师,主任医师,从事常见功能障碍中医康复的临床与基础研究,E-mail:fxd0502@163.com
收稿:2024-08-04,
录用:2024-09-20,
网络出版:2024-09-23,
纸质出版:2025-04-20
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代婷,陈言,郭长胜等.线粒体质量控制调控肌少症发病机制及其中医药干预的研究进展[J].中国实验方剂学杂志,2025,31(08):279-286.
DAI Ting,CHEN Yan,GUO Changsheng,et al.Mitochondrial Quality Control Regulating Pathogenesis of Sarcopenia and Its Intervention by Traditional Chinese Medicine: A Review[J].Chinese Journal of Experimental Traditional Medical Formulae,2025,31(08):279-286.
代婷,陈言,郭长胜等.线粒体质量控制调控肌少症发病机制及其中医药干预的研究进展[J].中国实验方剂学杂志,2025,31(08):279-286. DOI: 10.13422/j.cnki.syfjx.20250569.
DAI Ting,CHEN Yan,GUO Changsheng,et al.Mitochondrial Quality Control Regulating Pathogenesis of Sarcopenia and Its Intervention by Traditional Chinese Medicine: A Review[J].Chinese Journal of Experimental Traditional Medical Formulae,2025,31(08):279-286. DOI: 10.13422/j.cnki.syfjx.20250569.
肌少症是一种以骨骼肌力量、质量下降为主要表现的临床综合征,常伴有跌倒、功能丧失和虚弱等不良结局。肌少症的发病机制复杂,有研究表明线粒体质量控制受损引起的功能障碍是导致肌少症发生发展的一个重要病理因素。中医药凭借其多靶点、多途径的优势在调控线粒体内环境稳态和防治肌少症方面受到广泛青睐。中医药能够通过调控线粒体质量控制系统抑制线粒体氧化应激的发生、调节线粒体动力学平衡、抑制线粒体自噬、促进线粒体生物合成、抗线粒体凋亡的发生、维持线粒体钙稳态和蛋白稳态,从而发挥防治肌少症的作用。基于此,该文综述了线粒体质量控制与肌少症的关系,以及中医药干预线粒体质量控制系统治疗肌少症的作用机制,以期为中医药防治肌少症提供新思路,为中医药干预肌少症的临床研究提供理论依据。
Sarcopenia is a clinical syndrome characterized by a decrease in skeletal muscle strength and quality, often accompanied by adverse outcomes such as falls, loss of function and weakness. The pathogenesis of sarcopenia is complex, and studies have shown that dysfunction due to impaired mitochondrial quality control is an important pathological factor in the occurrence and development. Traditional Chinese medicine(TCM) has been widely favoured for regulating mitochondrial homeostasis and preventing sarcopenia by virtue of its multi-target and multi-pathway advantages. They can play a role in the prevention and treatment of sarcopenia by regulating the mitochondrial quality control system to inhibit the occurrence of mitochondrial oxidative stress, regulate the balance of mitochondrial dynamics, inhibit mitochondrial autophagy, promote mitochondrial biosynthesis, resist the occurrence of mitochondrial apoptosis, and maintain the mitochondrial calcium and protein homeostasis. Based on this, the paper reviewed the relationship between mitochondrial quality control and sarcopenia, as well as the mechanism of TCM in intervening the mitochondrial quality control system to treat sarcopenia, in order to provide a new idea for the prevention and treatment of sarcopenia by TCM and to a theoretical basis for the clinical research on TCM intervention in sarcopenia.
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