Objective: To observe the effect of Shenqi Jiuyuan Decoction on blood glucose and blood lipids in rats with type 2 diabetes. Method: With feeding high fat diet for a certain duration

the diabetic rat model was established through intraperitoneal injection of STZ of 25 mg ·kg-1 . And then the diabetic rats were randomly divided into 4 groups: model control group

merformin hydrochloride group (0.25 g ·kg-1)

high dosage of Shenqi Jiuyuan Decoction (10 g ·kg-1)

and low dosage of Shenqi Jiuyuan Decoction (5 g ·kg-1 ). After 2 weeks’ medical ig administration

the influence of Shenqi Jiuyuan Decoction on type 2 diabetic rats regarding fast blood glucose

blood lipids

and insulin content was evaluated. Result: Compared with the model control group

Shenqi Jiuyuan Decoction could significantly reduce blood glucose in type 2 diabetic rats

with significant hypoglycemic effect after administration for 7 days and 14 days (P<0.05). Compared with the model control group

Shenqi Jiuyuan Decoction could decrease the serum total cholesterol and triglyceride concentration

as well as increase the serum high density lipoprotein cholesterol and the insulin content (P<0.05). Conclusion: Shenqi Jiuyuan Decoction has hypoglycemic and hypolipidemic effects

which may be related to promotion of insulin secretion and regulation of lipids metabolism.