Objective:To study function of Weiweikang on treating chronic atrophic gastritis (CAG) model rats. Method: Twelve rats were randomly selected from 70 Wistar rats as normal control group (normal group).The remaining 58 rats were made CAG model with the multiple stimulations for 6 weeks. The remaining 50 rats which were modelede successfully were randomly divided into five groups such as model group

Weiweikang whole formula group (the whole formula group)

split part Ⅰ group (buyi group)

split part Ⅱ group (quxie group)and western medicine control group (western medicine group). The rats in every groups were ig 0.9% saline (0.09 g · kg-1)

Weiweikang decoction (8 g · kg-1)

split part I decoction (5.5 g · kg-1)

split part Ⅱ decoction (2.5 g · kg-1) and the neomycin-dimensional suspension (0.3 g · kg-1)

once a day

respectively.After 90 days of treatment

the gastric mucosa pathological changes were observed

the changes of superoxide dismutas(SOD)and malonyl dialdehyd(MDA)content in blood serum were detect. Result: There was no marked difference in the different-iation of gastric mucosa pathematology and microanatomy between the whole formula group and the normal group. Compared with normal control group whose SOD is (239.88±6.32) U ·mL-1and MDA is (3.17±0.02) μmol ·L-1

SOD of model group with (174.59±12.81) U ·mL-1decrease significantly(P<0.01) and MDA of model group with (5.14±0.15) μmol ·L-1 increase significantly(P<0.01). Compared with model group

the other medication groups made a significant increase of SOD and made the level of MDA decrease significantly(P<0.01 or P<0.05);Compared with model group with SOD (174.59±12.81) U ·mL-1

MDA (5.14±0.15) μmol · L-1

the other medication groups made a significant increase of SOD and the level of MDA decrease significantly(P<0.01 or P<0.05);Compared with the whole formula group with SOD (233.91±9.03) U ·mL-1

MDA: (3.11±0.19) μmol ·L-1

the buyi group and quxie group made a significant decrease of SOD and made the level of MDA increase significantly (P<0.01 or P<0.05);Compared with the buyi group with SOD (221.58±5.71) U ·mL-1

the activity of SOD with (209.89±5.27) U ·mL-1 in serum was significantly lower in quxie group rats (P<0.05). Conclusion: Weiweikang can improve and reverse the gastric atrophy of experimental atrophic gastritis of rats

among which ingredinets with benefiting QI and nourishing YIN founctios play a major role and ingredients with expelling pathogen plays synergy action.Its mechanism may be related to scavenging resisting the free radicals.