最新刊期
      卷 ， 期 4 ， 2005
      • LIU Jin,ZHANG Zhen-hai,LI Shi-fang,DONG Yun-fen
        Issue 4, Pages: 1-2(2005) DOI: 10.13422/j.cnki.syfjx.2005.04.001
        摘要：Objective:To investigate the effect of applying β-cyclodextrin to Danshenpian preparation on tanshinone ⅡA content. Methods:Taking the tanshinone ⅡA as the parameter,the tablets of applying β-cyclodextrin to Danshenpian preparation and the tablets prepared according to original Danshenpian process were compared.Results:The tanshinone ⅡA content in the tablets of applying β-cyclodextrin to Danshenpian preparation augmented.Conclusion:β-cyclodextrin is helpful to stabilization of tanshinone ⅡA.  
        关键词：β-cyclodextrin;Danshenpian;Tanshinone ⅡA   
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        发布时间：2024-09-23
      • Issue 4, Pages: 2-4(2005) DOI: 10.13422/j.cnki.syfjx.2005.04.002
        摘要：目的:研究黄连解毒栓的两种提取工艺流程。方法:采用水煎分提法和醇提加酸沉法制成栓剂,测定浸膏得率和黄芩苷含量,体外平皿抑菌法测定抑菌作用。结果:不同提取方法对浸膏得率和黄芩苷含量及对大肠杆菌,金黄色葡萄球菌,乙型溶血型链球菌,绿脓杆菌抑制作用均有一些影响。结论:为黄连解毒栓生产提供理论依据。  
        关键词：黄连解毒栓;提取工艺;抑菌;得率和含量   
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        发布时间：2024-09-23
      • LEI hong1,FENG Wei-hong2
        Issue 4, Pages: 5-6(2005) DOI: 10.13422/j.cnki.syfjx.2005.04.003
        摘要：Objective:To establish a determining method for hesperidin in Zhizhu Pill by High-Perfomance Liquid Chromatograpgy. Methods:hesperidin was extracted from Zhizhu Pill by methanol. Kromasil C 18 column （4.6mm×250mm,5μm） was used as mobile phase, The flow rate was 1.0mL·min -1 and the wavelength of detection was as 288nm. Results: The calibration curve was showed good linearity within the concentration range of 0.1168μg～1.168μg,r=0.9998,the average recovery was 96.911%, RSD=1.574%. Conclusion:This method is simple and reproducible, and it can be used for the quantitative analysis of hesperidin in Zhizhu Pill.  
        关键词：hesperidin;Capsule;Zhishi;HPLC   
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        发布时间：2024-09-23
      • Issue 4, Pages: 7-9(2005) DOI: 10.13422/j.cnki.syfjx.2005.04.004
        摘要：目的:建立利肝隆片的质量标准。方法:采用TLC法对茵陈、五味子、甘草、当归、黄芪、刺五加进行了鉴别试验,用HPLC法测定药品中五味子醇甲的含量。结果:用TLC法检出了茵陈、五味子、甘草、当归、黄芪、刺五加。五味子醇甲在0.12～1.80μg范围内呈良好的线性关系;R=0.9992,平均回收率99.4%,RSD为0.9%。结论:所建立的方法简便可行,本法灵敏,准确,专属性强,重复性好,可作为该制剂的质量控制方法。  
        关键词：利肝隆片;薄层色谱;质量标准;高效液相色谱;五味子醇甲   
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        发布时间：2024-09-23
      • Issue 4, Pages: 10-11(2005) DOI: 10.13422/j.cnki.syfjx.2005.04.005
        摘要：目的:建立清热消炎冲剂中黄芩苷含量的测定方法。方法:采用反相高效液相色谱法测定清热消炎冲剂中黄芩苷的含量,色谱柱为LichrospherC18（4.6×200mm5μm）柱,流动相为甲醇:0.05%三氟乙酸（47∶53）流速为1.0mLmin,检测波长280nm。结果:平均加样回收率为97.98%。其线性回归方程Y=16821937X-49281.4。相关系数r=0.99991（n=5）。结论:该方法简便,快速,准确,可用于生产监控的质量控制。  
        关键词：清热消炎冲剂;黄芩苷;反相高效液相色谱法;含量测定   
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        发布时间：2024-09-23
      • Issue 4, Pages: 12-13(2005) DOI: 10.13422/j.cnki.syfjx.2005.04.006
        摘要：目的:测定不同煎法下葛根汤中葛根素的溶出量及变化规律。方法:采用RPHPLC法,μBondapakC18柱（250mm×4.6mm,10μm）,以甲醇水（28∶72）为流动相,流速为1mL·min-1,波长为265nm,柱温:30℃。结果:葛根素在0.05～1μg范围内线性关系良好,r=0.9997。结论:本方在煎煮过程中,除君药葛根外,同煎的其他药物对葛根素的溶出影响不大,文火煎煮81min后,药汤中葛根素含量达到高峰。  
        关键词：葛根汤;葛根素;反相高效液相色谱法   
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        发布时间：2024-09-23
      • Issue 4, Pages: 13-14(2005) DOI: 10.13422/j.cnki.syfjx.2005.04.007
        摘要：目的:建立妇乐颗粒中延胡索乙素的含量测定方法。方法:采用高效液相色谱法,色谱柱为SinoChromODSBP5μm（4.6×250mm）,流动相为甲醇0.1%磷酸（60∶40）用三乙胺调节pH值为7.0,流速为1.0mL·min-1,检测波长为280nm。结果:延胡索乙素浓度在7.56～43.36μg·mL-1的范围内与峰面积呈良好的线性关系,r=0.9996,平均回收率为98.7%。结论:方法简便快速,分离度好,结果准确可靠。  
        关键词：妇乐颗粒;延胡索乙素;高效液相色谱法   
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        发布时间：2024-09-23
      • Issue 4, Pages: 15-16(2005) DOI: 10.13422/j.cnki.syfjx.2005.04.008
        摘要：目的:建立降糖宁胶囊中人参皂苷Rg1、Re含量测定方法。方法:采用HPLC法测定降糖宁胶囊中人参皂苷Rg1、Re含量,并考察溶剂的选择及用量、提取时间和流动相对含量测定的影响。结论:本法简便、准确,可作为降糖宁胶囊中人参皂苷Rg1、Re的含量测定方法。  
        关键词：HPLC法;降糖宁胶囊;人参皂苷Rg1、Re   
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        发布时间：2024-09-23
      • Issue 4, Pages: 16-17(2005) DOI: 10.13422/j.cnki.syfjx.2005.04.009
        摘要：目的:建立骨泰胶囊中血竭素的含量测定方法。方法:HPLC法,流动相:乙腈0.05mol/L磷酸二氢钠溶液（55∶45）;检测波长为440nm;柱温40℃。结果:血竭素线性范围为0.12μg～0.72μg,平均回收率101.6%,RSD为2.53%。结论:方法可靠,简单可行,为控制骨泰胶囊的内在质量提供了科学依据。  
        关键词：骨泰胶囊;血竭素;高效液相色谱法   
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        发布时间：2024-09-23
      • Issue 4, Pages: 18-19(2005) DOI: 10.13422/j.cnki.syfjx.2005.04.010
        摘要：目的:建立神农消颗粒的质量标准。方法:采用薄层色谱法对处方中虎杖、半枝莲、重楼进行鉴别;应用薄层扫描法测定虎杖中大黄素的含量。结果:定性鉴别分离度好、专属性强;大黄素的含量测定线性范围为0.033～1.056μg（r=0.9998）,平均回收率为96.37%,RSD为3.74%。结论:该法简便、准确,可用于神农消颗粒的质量控制。  
        关键词：神农消;大黄素;薄层扫描法   
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        发布时间：2024-09-23
      • GU Wei,ZHU Dan-ni,ZHANG Zhi-yu,YAN Yong-qing,YU Bo-yang
        Issue 4, Pages: 20-23(2005) DOI: 10.13422/j.cnki.syfjx.2005.04.011
        摘要：Object:To study chemical constituents of polyhexoses fraction from FBD.Methods:FBD polyhexoses were segregated and purified with Sephadex G-75、G-150.Their molecular weights were measured with HPLC-ELSD;The components and proportions of monosaccharides were hydrolyzed and analyzed with GC.Results:We obtained polyhexoses PsA、PsB、PsC from FBD and measured their molecular weights as 1777577,400172,4369.PsA consisted of Rhamnose and fructose,PsB consisted of Rhamnose、glucose and fructose,PsC consisted of Rhamnose、mannose and fructose.Conclusion:We determined the chemical constituents of polyhexoses fraction from FBD.  
        关键词：FBD;Dang-gui;Bai-shu;Fu-ling;polyhexose;HPLC;GC   
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        发布时间：2024-09-23
      • Issue 4, Pages: 23-24(2005) DOI: 10.13422/j.cnki.syfjx.2005.04.012
        摘要：目的:确定降香挥发油的最佳提取工艺。方法:用正交试验法对降香挥发油的提取工艺条件进行优选,以挥发油得率为指标,选用L9（34）正交试验表;考察影响挥发油收率的提取时间（A）、浸泡时间（B）、药材细度（C）、加水量（D）4个因素,每个因素取3个水平。结果:降香挥发油的最佳提取工艺为药材粗粉加入8倍量的水、浸泡5h、提取16h。结论:此方法适合于降香挥发油提取工艺。  
        关键词：降香;提取工艺;挥发油;正交试验   
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        发布时间：2024-09-23
      • YANG Qing,NIE Shu-qin,WENG Xiao-gang,LI Lan-fang,HUANG Lu-qi
        Issue 4, Pages: 25-28(2005) DOI: 10.13422/j.cnki.syfjx.2005.04.013
        摘要：We selected Aconitum carmichaelii Debx. and Fritillaria thunbergii MiO.,a couple of counteracted drugs,as study objects to verify the mechanism of counteracted drugs by the anti-tumor experiments,which include studies of Anti-tumor effect on Lewis carcinoma of Mouse by application of Aconitum carmichaelii Debx. and Fritillaria thunbergii MiQ.singly or matched and Affection on appoptosis of LM-2 carcinoma cells.Both the drugs used singly can inhibit tumor growth and tumor metastasis,but two drugs matched can’t reinforce this effect;there were statistic differences with two drugs used singly on affection of thymus gland,but the matched drugs were not effective.Aconite decoction can reinforce the apoptosis of LM-2 cells dosage dependently within 5mg/mL～75mg/mL,moreover,the longer the cell were stimulated,the higher the apoptosis rate;while LM-2 cells stimulated by fritillaryia decoction with 75mg/mL for 48h,the rate of apoptosis rose;compare with aconite decoction used singly,aconite matched with fritillaria（1∶1） under same concentration as used singly can depress cells apoptosis significantly,which show that the matched drugs can suppress LM-2 cells apoptosis.As showed by the results,the statement of “aconite counteracts fritillaria” was supported by our experiment.  
        关键词：aconite;fritillaria;matching;anti-tumor;apoptosis rate   
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        发布时间：2024-09-23
      • HE Wen-bin1,ZHANG Jun-long1,CHEN Nai-hong2,ZHANG Ling2,ZHU Hai-bo2
        Issue 4, Pages: 28-32(2005) DOI: 10.13422/j.cnki.syfjx.2005.04.014
        摘要：Objectives:The antagonistic effects of serum with Bu Shen Decoction （BS） on apoptosis of PC12 cells induced by glutamate （Glu） were investigated in vitro. So were the effects of serum with BS on the calcium signal transduction system.Methods:The antagonistic action of the BS on neurotoxicity induced by Glu was observed with MTT method.The fluorescence microscope technique was employed to observe the effect of BS on apoptosis of PC12 cells induced by Glu. Its intracellular free calcium concentration was determined by flow cytometry.The Western-blotting technique was applied for observing the effect of BS on phosphorylation of CaMK Ⅱ in apoptotic PC12 cells.Results:The serum with BS in 20% concentration was discovered to be able to exert antagonistic effect on Glu-induced excitatory neurotoxicity and to inhibit the apoptosis of PC12 cells induced by Glu. Moreover,it was discovered that the increase in intracellular free calcium concentration and the excessive phosphorylation of CaMK Ⅱ during apoptosis of PC12 cells induced by Glu could be inhibited by serum with BS in 20% concentration.Conclusion:BS exert an antagonistic action on excitatory neurotoxicity induced by Glu.The mechanism of neuroprotective effect afforded by serum with BS might be related with relieving calcium overload and adjusting phosphorylation of the key signal molecules in the downstream of calcium ion signal transduction system.  
        关键词：Bu Shen Decoction;apoptosis;intracellular free calcium;CaMK Ⅱ;serum pharmacology method of the traditional Chinese medicine   
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        发布时间：2024-09-23
      • XU Guo-liang1,XIAO Bing-hua2,CHEN Qi2,XU You-mei3,Bi Ming2
        Issue 4, Pages: 33-36(2005) DOI: 10.13422/j.cnki.syfjx.2005.04.015
        摘要：Aim:To observe the effect of Sarcand glabra and its separated parts on Immunologic Thrombocytopenic Purpura（ITP） in mice,and to find the effective separated part of Sarcand glabra.Methods:ITP BALB/C mice were induced by injecting extrinsic antibody,Then we investigated the change of peripheral blood picture and the weight of spleen,adrenal gland,thymus gland of mice after administering Sarcand glabra and its separated parts.Results:Sarcand glabra and separated parts Ⅰ had effect on increasing the number of blood platelet.No obvious change of the weight of spleen,adrenal gland,thymus gland was found in Sarcand glabra group.The weight of thymus gland in separated part Ⅰ group has obvious increased.Conclusion:Sarcand glabra has effect on treating Immunologic Thrombocytopenic Purpura and separated part Ⅰ is the effective part of Sarcand glabrain.  
        关键词：Sarcand glabra;effective part;Immunologic Thrombocytopenic Purpura   
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        发布时间：2024-09-23
      • Issue 4, Pages: 36-38(2005) DOI: 10.13422/j.cnki.syfjx.2005.04.016
        摘要：目的:探讨关节通片对炎症关节模型的预防治疗作用、作用机制、及其急性毒性。方法:①采用角叉菜胶及甲醛大鼠踝关节炎症模型探讨关节通片对关节炎的防治作用;②采用佐剂性关节炎大鼠模型观察关节通片对关节液IL1β、TNFα及PGE2的影响;③最大耐受量法观察关节通片对小鼠的急性毒性。结果:关节通片能显著减轻角叉菜胶及甲醛致大鼠踝关节炎症的肿胀度（P<0.05～0.01）;病理组织形态观察显示关节通片能减轻大鼠踝关节炎症时关节滑膜的充血、水肿,减少炎症细胞的浸润及关节囊内炎性渗出物;关节通片还能明显地降低模型大鼠关节液ILβ、TNFα及PGE2含量;小鼠一次灌服191.6%的关节通提取液的最大耐受量为40mL（76.64g）kg,为临床日用量的223倍。结论:关节通提取液对关节炎具有一定的预防及治疗作用,其作用与降低关节液中IL1β、TNFα及PGE2含量有关。  
        关键词：关节通片;药效学;实验性关节炎;急性毒性试验   
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        发布时间：2024-09-23
      • Issue 4, Pages: 39-41(2005) DOI: 10.13422/j.cnki.syfjx.2005.04.017
        摘要：目的:通过观察ITP模型小鼠外周血小板计数与T淋巴细胞亚群和细胞因子IL2、IL6、IL8的变化及其相关性,探讨血小板、T淋巴细胞亚群以及其相关细胞因子在原发性血小板减少性紫癜（ITP）中的作用。方法:全自动血细胞分析仪计数外周血细胞数;FCM法测定T淋巴细胞亚群CD3+、CD4+、CD8+;放免法测定IL2、IL6、IL8。结果:ITP时血小板数降低、CD4+、CD8+百分率下降,与对照组比较有明显差异（P<0.05）;IL2、IL6、IL8均上升,与对照组比较有明显差异（P<0.05）;相关性分析发现血小板计数与T亚群有一定的相关性（P<0.05）,而与IL2、IL6、IL8无明显相关性（P>0.05）。结论:ITP细胞免疫异常在发病机制中起着重要的作用,细胞因子IL2、IL6、IL8与ITP的发病及预后有关;血小板含量变化与T淋巴细胞亚群有一定相关性,而与细胞因子无明显相关性。  
        关键词：紫癜颗粒;ITP模型;血小板;T细胞亚群;细胞因子   
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        发布时间：2024-09-23
      • Issue 4, Pages: 42-45(2005) DOI: 10.13422/j.cnki.syfjx.2005.04.018
        摘要：目的:探讨生血宝颗粒对大鼠肾功能衰竭贫血模型的影响。方法:大鼠长期口服腺嘌岭致慢性肾功能衰竭制备贫血模型,造模同时给予药物治疗。观察各组动物体重、食量、血红蛋白含量（Hb）、血肌酐（Cr）、尿素氮（BUN）及尿酸（UA）、血清铁与促红细胞生成素（EPO）含量。结果:生血宝可以使腺嘌呤造模后动物的体重与进食量增加,一定剂量的生血宝对慢性肾衰过程中的Hb下降有改善作用,并使血Cr与UA有一定程度的降低,血清铁含量增加。但对EPO含量的影响不明显。结论生血宝对腺嘌呤所致慢性肾衰贫血有一定治疗作用。但其作用机理有可能并不是通过提高血清EPO水平,而是与增加模型动物进食量、提高血清蛋白含量和一定程度降低血Cr与UA有关。  
        关键词：生血宝颗粒;阿胶补血;硫酸亚铁;腺嘌呤;肾衰贫血   
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        发布时间：2024-09-23
      • WU Qing-guang,LIU Ming-ping,ZHAO Zhen-dong
        Issue 4, Pages: 45-47(2005) DOI: 10.13422/j.cnki.syfjx.2005.04.019
        摘要：Objective:To observe the effect of Hujin Pill on fibrous hyperplasia and express of collagen Ⅳ in liver fibrosis rats.Methods:Model of liver fibrosis were induced by subcutaneous injection of CCl4 and treated with Hujin Pill.The changes of fibrous hyperplasia and express of collagen Ⅳ of the rats’ liver were observed with Van Gieson stain and immunohistochemistry.Results:The fibrous hyperplasia of liver and the express of collagen Ⅳ in liver fibrosis rats’ model had been markedly increased than that of control group.However,Hujin Pill could restrain fibrous hyperplasia and express of collagen Ⅳ in liver fibrosis rats.Conclusion:Hujin Pill was effective in treatment of CCl4-induced liver fibrosis.  
        关键词：Hujin Pill;liver fibrosis;Collagen Ⅳ   
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        发布时间：2024-09-23
      • MA Tian-shu+1,GE Ying-chun+1,LIU Ping+1,JIA Yu-hong+2,REN Hui-jun+1,XU Ya-juan+3,XU Dong-ming+3
        Issue 4, Pages: 48-51(2005) DOI: 10.13422/j.cnki.syfjx.2005.04.020
        摘要：Objective:To study the protective effect of the extracts from Sini Tang Serial Decoctions （ESTSD）against hypoxia/reoxygenation（H/R） injury on neonatal rat cardiomyocytes.Methods:Cultured neonatal rat cardiomyocytes were preconditioned with ESTSD in different concentrations（1,5,25 μg/mL）respectively.Then after H/R treatment the enzymatic activity of intracellular mitochondria dehydrogenase and the contents of intracellular maleic dialdehyde（MDA）as well as the activity of extracellular lactate dehydrogenase（LDH）were measured using colorimetric method.Results:Compared with the control group,the ESTSD including extracts from Aconite root,Dried ginger and Fistular onion stalk（EAGO）,extracts from Aconite root,Dried ginger and Prepared licorice root（EAGL）,extracts from Aconite root,Dried ginger and pig’s Bile（EAGB）and extracts from Aconite root,Dried ginger and Ginseng（EAGG）could increase significantly the activities of intracellular mitochondria dehydrogenase and had no significant difference compared with extracts from Aconite root and Dried ginger （EAG）.EAGO,EAGL,EAGB,EAGG all could significantly decrease the activities of extracellular LDH compared with the group and EAG.EAGL and EAGG decreased significantly the contents of intracellular MDA compared with the control group and EAG.Conclusion:The results showed ESTSD increased significantly the activities of intracellular mitochondria dehydrogenase,but decreased significantly the activities of extracellular LDH.EAGL and EAGG decreased significantly the contents of intracellular MDA.ESTSD has a protective effect against H/R injury on cultured neonaltal rat cardiomyocytes.  
        关键词：Sini Tang Serial Decoctions;cardiomyocytes;hypoxia/reoxygenation   
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        发布时间：2024-09-23
      • HUO Hai-ru,TAN Yu-qing,ZHOU Ai-xiang,LI Xiao-qin,GUO Shu-ying,JIANG Ting-liang
        Issue 4, Pages: 51-54(2005) DOI: 10.13422/j.cnki.syfjx.2005.04.021
        摘要：Objective:To investigate the effective mechanism of dual-direction regulation of Fr.B,an active fraction extracted from Guizhi Tang（GZT）.on gastrointestinal motility.Methods:The cAMP content,protein kinase A（PKA）and C（PKC）activity of hypothalamus and gastrointestinal tissues in rats with excited or inhibited gastrointestinal motility induced respectively by neostigmine or atropine were measured via radioimmunoassay.Results:Fr.B increased the cAMP content and PKA and PKC activity of hypothalamus and jejunum in rats with inhibited gastrointestinal motility significantly,and antagonized the decrease of PKA activity of gastric antrum.In rats with excited gastrointestinal motility,Fr.B increased PKA activity of gastric antrum,PKC activity of hypothalamus and jejunum,and did not affect the cAMP content.Conclusion:Fr.B could affect the cAMP content,PKA and C activity in hypothalamus and gastrointestinal tissues to regulate gastrointestinal motility in a dual-direction manner.  
        关键词：guizhi tang;Active fraction;cAMP;protein kinase A（PKA）;protein kinase C（PKC）   
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        发布时间：2024-09-23
      • ZHANG Ting-ting,NIE Liu-wang,LIU Ai-min,ZHU Sheng-xue,YANG Yang,ZHAO Shan-shan
        Issue 4, Pages: 55-58(2005) DOI: 10.13422/j.cnki.syfjx.2005.04.022
        摘要：Objective:To research the immune activities of Rosa laevigata michx polysaccharide（RP）.Methods:After feeding mouse with RP for several days to determine:1.Mouse MΦ’S ability of removing Congo Red from the blood.2.RP’s effect on haemolysin content in mouse body induced by chicken erythrocytes.3.RP’s effect on the delayed-type hypersensitivity（DTH）induced by 2,4-dinitrofluorobenzene.4.RP’s immune modulation effect on mouse liver immune injure induced by BCG and LPS.Results:1.RP（125mg-250mg/kg）has strong ability to enhance mouse M  to swallow Congo Red.Compared with normal control group,it could significantly reduce the content of Congo Red in mouse blood （p<0.001）.2.RP can significantly enhance the content of haemolysin in mouse body.3.RP can significantly enhance response of the DTH in normal mouse and recover response to DTH in cyclophosphamide（Cy）intoxicated mouse.4.RP has obvious immune modulation effect on mouse liver immune injure induced by BCG and LPS.,and reduce the content of ALT and AST in serum（p<0.01 and 0.001）.Besides,they all can reduce the liver and spleen index.Conclusion:RP can enhance the immune reaction in mouse and has immune modulation function.  
        关键词：Polysaccharide from Rosa laevigata michx（RP）;Unspecific immunoresponse;Cellular immunoresponse;Humoral immunoresponse;Immune modulation function.   
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        发布时间：2024-09-23
      • ZHANG Le-zhi1,MEN De-sheng2,WEN Bao-shu1,LU Jin-sheng2,WEI Bin1
        Issue 4, Pages: 58-61(2005) DOI: 10.13422/j.cnki.syfjx.2005.04.023
        摘要：Objective:To investigate the effects of Quyuningtong Paster（QYNTP） on hemorheological parameters, platelet aggregation and thrombus formation in vitro in acute blood stasis rats. Methods:The acute blood stasis model in rats were established with subcutaneous injection of high-dose adrenaline hydrochloride and being socked in ice-water. The effects of QUNTP on the indexes of hemorheology, platelet aggregation and thrombus formation in vitro in acute blood stasis model rats were observed. Results: The QYNTP（0.3g/kg、0.9g/kg、1.8g/kg） could not only significantly reduce the viscosity of whole blood, viscosity of plasma, content of fibrinogen, packed volume of erythrocyte, slow down the erythrocyte sedimentation rate and shorten the erythrocyte electrophoresis time, it also remarkably inhibit the platelet aggregation and thrombus formation in vitro （respectively P<0.05 or 0.01）. Conclusion:QYNTP could obviously ameliorate the hemorheological parameters, inhibit platelet aggregation and thrombus formation in acute blood stasis rats.  
        关键词：Quyuningtong paster;acute blood stasis model;hemorheology;platelet aggregation;thrombus formation   
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        发布时间：2024-09-23
      • WANG Xue-mei1,FU Hong1,LIU Geng-xin1,LI Shu-ping2
        Issue 4, Pages: 62-64(2005) DOI: 10.13422/j.cnki.syfjx.2005.04.024
        摘要：Objective:To investigate the effect of Tongfeng Pill gout. Methods:Gout-relieving effect of Tongfeng Pill was observed in rats with adjuvant arthritis induced by sodium urate and in mice with hyperuricemia induced by yeast. analgesic effect was investigated in mice with writhing reaction. Results:The Tongfeng Pill could not only reduce the blood level of uric acid and time of writhing reaction, but also decrease the swollen degree of ankle in model animals. Conclusion:Tongfeng Pill had significant effect on treating acute attack of gout.  
        关键词：Tongfeng Pill;gouty arthritis;hyperuricemia;analgesia   
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        发布时间：2024-09-23
      • Vol. 0, Issue 4, Pages: 64(2005) DOI: 10.13422/j.cnki.syfjx.2005.04.025
          
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        发布时间：2024-09-23
      • YANG Hong-zhi1,DAI Min1,ZHAO Ai-qiang2,WANG Yong-zhe1,GUAN Wei-bing1,YANG Yao-wu1,XIE He-ping1
        Issue 4, Pages: 65-67(2005) DOI: 10.13422/j.cnki.syfjx.2005.04.026
        摘要：AIM:Through the analysis of hepatic fibrosis indices and CHB patients’ HBV precore mutant in 1896 site, also by means of Traditional Chinese Medicine（TCM） Syndrome differentiation and western medicine diagnosis, and hepatic fibrosis indicator analysis, the distributive characteristics of TCM syndromes in patients and the pathogenesis were investigated so as to provide objective data with clinical Syndrome differentiation of TCM.METHODS: 140 CHB patients were divided into two groups, HBV precore mutant positive group（70 cases） and HBV precore mutant negative group（70 cases）, Besides, 30 healthy donors were taken as the control group. The serial indices of liver fibrosis（including HA, PCⅢ, Ⅳ.C and LN）, and the HBV precore variant strains were tested. Patients in the study groups were categorized as six Syndromes according to TCM diagnostic theory. RESULTS: There existed significant distributive differences between the two study groups. The level of hepatic fibrosis indices was found higher in mutation positive group than in the negative and control group, and the level in the mutation negative group was higher than in the control group. In the mutation negative group, the severe hepatitis B patients had considerably higher level of HA, PCⅢ and Ⅳ.C than the medium patients had, and the level in the medium patients was markedly higher than in the mild patients. Similar results were seen with HA, PCⅢ, Ⅳ.C and LN level in mutation positive group concerning the severe, medium and mild patients. Conclusion:Blood Stasis Syndrome exists in different stages as one of the basic syndrome of CHB patients with precore mutation. The level of HA, PCⅢ, Ⅳ.C and LN level may be taken as one of the objective data in confirming Blood Stasis Syndrome.  
        关键词：HA;PCⅢ;Ⅳ.C;LN   
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        发布时间：2024-09-23
      • Issue 4, Pages: 67-68(2005) DOI: 10.13422/j.cnki.syfjx.2005.04.027
        摘要：目的:研究苏子油软胶囊治疗高脂血症（痰涎阻遏证）的有效性及安全性。方法:以血脂康胶囊为阳性对照,双盲双模拟、分层区组随机、平行对照、多中心临床试验。结果:降血脂疗效,苏子油软胶囊组总有效率为76.90%,愈显率为53.00%,血脂康胶囊组总有效率为67.50%,愈显率为36.30%。中医证候疗效,苏子油软胶囊组总有效率为94.00%,愈显率为37.60%,血脂康胶囊组总有效率为78.00%,愈显率为27.50%。结论:苏子油软胶囊治疗高脂血症疗效显著。  
        关键词：苏子油软胶囊;诊断标准;高脂血症;临床研究   
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        发布时间：2024-09-23
      • Issue 4, Pages: 69-70(2005) DOI: 10.13422/j.cnki.syfjx.2005.04.028
        摘要：目的:观察温胆汤加味治疗糖尿病胃轻瘫的效果。方法:将113例糖尿病胃轻瘫患者随机分为治疗组59例,对照组54例。两组均保持原饮食控制及降糖药或注射胰岛素控制血糖。治疗组予温胆汤加味,对照组予吗丁啉,疗程均为4周。结果:治疗组对消化不良症状总有效率为94.6%,对照组总有效率为75.1%,在治疗上腹部不适、食欲减退、恶心呕吐、便秘方面,两组有显著性差异。治疗后治疗组3h和5h钡条总排出率为57.67%和91.87%,对照组为50.38%和88.92%,3h两组有显著性差异。结论:温胆汤加味对改善糖尿病胃轻瘫患者的消化不良症状、促进胃排空有明显的效果。  
        关键词：糖尿病;胃轻瘫;温胆汤加味;胃排空   
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        发布时间：2024-09-23
      • LI Geng,YANG Hong-jun,BIAN Bao-lin
        Issue 4, Pages: 71-73(2005) DOI: 10.13422/j.cnki.syfjx.2005.04.029
        摘要：Concisely summarized the general situation of the formulation of standards on pesticide residue limit established by the international organization and the current situation of the domestic studies on the pesticide residue in Chinese herbal medicines, through comparing the difference between the researches home and abroad, we discussed the problems facing us, the trend of development and the measure of solution of pesticide residue in Chinese herbal medicines.  
        关键词：Chinese herbal medicines;pesticide residue;Maximum Residue Limit   
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        发布时间：2024-09-23
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