最新刊期
      卷 13 ， 期 9 ， 2007
      • Vol. 0, Issue 9, Pages: 1-3(2007) DOI: 10.13422/j.cnki.syfjx.2007.09.004
          
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      • Issue 9, Pages: 4-5(2007) DOI: 10.13422/j.cnki.syfjx.2007.09.009
        摘要：目的:建立人工麝香中麝香酮的含量测定方法。方法:色谱柱为HP-5柱（30 mm×0.32 mm×0.25μm）,以交联5%苯基甲基聚硅氧烷为固定相;柱温采用程序升温:起始120℃,10℃.min-1升至180℃,保持16 min;气化温度:250℃;检测器温度:280℃:进样量1μL,分流比为2∶1;流速为1.3 mL。结果:麝香酮浓度在（0.040.64）mg/mL范围内线性关系良好,相关系数r=0.999 4,加样回收率为97.96%,RSD为2.13%。结论:麝香酮含量可作为人工麝香质量的控制指标之一。  
        关键词：麝香酮;含量测定;气相色谱法   
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      • Issue 9, Pages: 6-7(2007) DOI: 10.13422/j.cnki.syfjx.2007.09.010
        摘要：目的:建立麝香接骨胶囊的质量标准。方法:采用气相色谱法鉴别麝香接骨胶囊中的麝香;采用薄层色谱法鉴别该药中的三七、当归、川芎;并采用HPLC法测定该药中芍药苷的含量。结果:在气相色谱中能检出麝香,阴性空白无干扰;在TLC色谱中能检出三七,当归,川芎,阴性空白无干扰。HPLC法测定芍药苷的量在（0.14161.416）μg范围内线性关系良好（r=0.99998）,平均回收率为97.8%,RSD=0.3%（n=5）。结论:定性、定量方法简便,准确,重复性好,能有效控制该制剂的质量。  
        关键词：麝香接骨胶囊;气相色谱法;薄层色谱法;高效液相色谱法;质量控制   
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      • LI Man-ling~,FENG Wei-hong
        Issue 9, Pages: 8-10(2007) DOI: 10.13422/j.cnki.syfjx.2007.09.011
        摘要：Objective:To establish a quqlity standard of Zhifukang Capsule.Methods:Zhifukang Capsule was identifyied by TLC;the rhrin in Zhifukang Capsule waws determined by HPLC.Results:The relevant spots in Rheum palmatem L.,Lycium barbarum L.and Cistanche deserticola T.C.Ma were identifyied by TLC;The content of rhein could be determined by HPLC.Conclusion:The quality standard is simple,feasible and repeatble,it can be used as quality superviseory control inhifukang Capsule.  
        关键词：Zhifukang Capsule;TLC;HPLC   
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        发布时间：2024-09-23
      • LI Man-ling,FENG Wei-hong
        Vol. 13, Issue 9, Pages: 8-9(2007)
        摘要：Objective:To establish a quqlity standard of Zhifukang Capsule.Methods:Zhifukang Capsule was identifyied by TLC;the rhrin in Zhifukang Capsule waws determined by HPLC.Results:The relevant spots in Rheum palmatem L.,Lycium barbarum L.and Cistanche deserticola T.C.Ma were identifyied by TLC;The content of rhein could be determined by HPLC.Conclusion:The quality standard is simple,feasible and repeatble,it can be used as quality superviseory control inhifukang Capsule.  
        关键词：Zhifukang Capsule;TLC;HPLC   
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      • LIU Zhen~,CHEN Ping,YANG Lian-fang
        Issue 9, Pages: 10-11(2007) DOI: 10.13422/j.cnki.syfjx.2007.09.012
        摘要：Objective:To set up a method for determining 2,3,5,4-Tetrahydroxystilbene-2-O-β-D-glucoside Anmian Bunao Tangjiang.Methods:HPLC,mobile phase:acetonitrile-water（21∶79）,detection wavelenpth:320 nm.Results:Linearity of 2,3,5,4-Tetrahydroxystilbene-2-O-β-D-glucoside was ottainedin in the range of（25.70～179.90） μg.The average recovery and RSD were 97.5% and 1.8%.Conclusin:The method was available for quality control of Anmian Bunao Tangjiang.  
        关键词：Anmian Bunao Tangjiang;2,3,5,4-Tetrahydroxystilbene-2-O-β-D-glucoside;HPLC   
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      • LIU Zhen,CHEN Ping,YANG Lian-fang
        Vol. 13, Issue 9, Pages: 10-11(2007)
        摘要：Objective:To set up a method for determining 2,3,5,4-Tetrahydroxystilbene-2-O-β-D-glucoside Anmian Bunao Tangjiang.Methods:HPLC,mobile phase:acetonitrile-water(21∶79),detection wavelenpth:320 nm.Results:Linearity of 2,3,5,4-Tetrahydroxystilbene-2-O-β-D-glucoside was ottainedin in the range of(25.70～179.90) μg.The average recovery and RSD were 97.5% and 1.8%.Conclusin:The method was available for quality control of Anmian Bunao Tangjiang.  
        关键词：Anmian Bunao Tangjiang;2,3,5,4-Tetrahydroxystilbene-2-O-β-D-glucoside;HPLC   
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      • Issue 9, Pages: 12-13(2007) DOI: 10.13422/j.cnki.syfjx.2007.09.013
        摘要：目的:用高效液相色谱法测定怡神胶囊中五味子乙素的含量。方法:色谱柱为Kromasil C18柱:流动相:甲醇-水（75∶25）;检测波长:224 nm;流速:1.0 mL.min-1。结果:线性范围为0.1680.84μg,r=0.9996;平均回收率为99.19%,RSD为0.65%。结论:该法简便、灵敏、准确。  
        关键词：高效液相色谱法;怡神胶囊;五味子乙素;含量测定   
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      • Vol. 0, Issue 9, Pages: 5-13(2007) DOI: 10.13422/j.cnki.syfjx.2007.09.005
          
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      • YU Yang,ZHOU Li-ling,WEI Min,LI Xiu-mei
        Vol. 13, Issue 9, Pages: 14-16(2007)
        摘要：Objective:To optimize the preparation of drug in adhesive transdermal patch.Methods:Taking SD mouse skin as protective screen of the experiment and tackness and transdermal speed constant of vitro as evaluation index to optimize the best matching of plasticizer,cross-linking agent and penetration enhancer in transdermal patch.Results:Second-order quadratic models of index are superior to the plural linear regress equation,plasticizer:cross-linking agent:penetration enhancer is 45%∶2.8%∶7.4%.Conclusions:In this experiment,the established model can describe the relation between factor and index and the outcome of prediction is good.  
        关键词：transdermal patch;central composite design;response surface methodology   
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      • Vol. 0, Issue 9, Pages: 73(2007) DOI: 10.13422/j.cnki.syfjx.2007.09.029
          
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      • YU Yang,ZHOU Li-ling~,WEI Min,LI Xiu-mei
        Issue 9, Pages: 14-17(2007) DOI: 10.13422/j.cnki.syfjx.2007.09.001
        摘要：Objective:To optimize the preparation of drug in adhesive transdermal patch.Methods:Taking SD mouse skin as protective screen of the experiment and tackness and transdermal speed constant of vitro as evaluation index to optimize the best matching of plasticizer,cross-linking agent and penetration enhancer in transdermal patch.Results:Second-order quadratic models of index are superior to the plural linear regress equation,plasticizer:cross-linking agent:penetration enhancer is 45%∶2.8%∶7.4%.Conclusions:In this experiment,the established model can describe the relation between factor and index and the outcome of prediction is good.  
        关键词：transdermal patch;central composite design;response surface methodology   
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      • Issue 9, Pages: 17-19(2007) DOI: 10.13422/j.cnki.syfjx.2007.09.002
        摘要：目的:优选β-环糊精（β-CD）包合当归超临界CO2提取精油的工艺。方法:采用正交实验,以挥发油包合率、包合物产率为主要筛选指标选出制备超临界CO2萃取当归精油-β-环糊精包合物的最佳包合条件;并考察了包合物的热稳定性。结果:超临界CO2萃取当归精油-β-环糊精包合物的最佳包合条件为:β-CD:当归油（8∶1）,温度为50℃,搅拌时间为2 h。结论:用正交实验得出的包合工艺合理,包合率高,热稳定性好。  
        关键词：当归精油;β-环糊精;包合物   
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      • Issue 9, Pages: 20-21(2007) DOI: 10.13422/j.cnki.syfjx.2007.09.003
        摘要：目的:研究六味清咽滴丸的最佳成型工艺。方法:采用正交试验法对滴制过程所需冷却剂和滴丸成型工艺进行优选。结果:冷却剂用二甲基硅油;最佳滴制条件为:药材提取物与基质的配比为1∶1.5,滴制温度为80℃,滴头口径为1/2 mm（内/外径mm）。结论:用最佳工艺条件制得滴丸,其外观呈微黄,味微苦,表面光滑,大小一致,符合《中国药典》规定。  
        关键词：六味清咽滴丸;制备工艺;正交试验法   
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        发布时间：2024-09-23
      • Wang Ping,CHENG Jing,TIAN Dai-zhi,ZOU Xiao-juan,LIU Song-lin,CHENG Fang-ping
        Vol. 13, Issue 9, Pages: 22-25(2007)
        摘要：Objective:To investigate the effect of Guben Huatan Tongmai Recipe(GHTR) on the proliferation,cell cycle and eyclin D1 activity of vascular smooth muscle cells(VSMCs) in rat in order to find out the mechanism of its action.Methods:In this study,cell culture technique was used in vitro.VSMCs stimulated by platelet derived growth factor BB(PDGF-BB) were treated by GHTR in different concentration for a certain period,then the inhibitory ratio of cell proliferation was measured by MTT,cell cycle distribution and cyclin D1 activity of the cells were observed by Flow-Cytometry respectively.Results:GHTR could obviously inhibit the proliferation of VSMCs stimulated by PDGF-BB,and it could also decrease S phase cells,increase G0/G1 phase cells and down-regulate cyclin D1 activity of VSMCs in concentration-dependent fashion,and the results were significant compared with the normal serum plus PDGF-BB-treated.Conclusion:GHTR could obviously inhibit the proliferation of VSMCs and may prevent atherosclerosis,which mechanism may be realized by regulating cyclin D1 activity of VSMC.  
        关键词：vascular smooth muscle cell;cell cycle;cyclin D1   
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      • WANG Ping~,CHENG Jing,TIAN Dai-zhi,ZOU Xiao-juan,LIU Song-lin,CHENG Fang-ping
        Issue 9, Pages: 22-25(2007) DOI: 10.13422/j.cnki.syfjx.2007.09.014
        摘要：Objective:To investigate the effect of Guben Huatan Tongmai Recipe（GHTR） on the proliferation,cell cycle and eyclin D1 activity of vascular smooth muscle cells（VSMCs） in rat in order to find out the mechanism of its action.Methods:In this study,cell culture technique was used in vitro.VSMCs stimulated by platelet derived growth factor BB（PDGF-BB） were treated by GHTR in different concentration for a certain period,then the inhibitory ratio of cell proliferation was measured by MTT,cell cycle distribution and cyclin D1 activity of the cells were observed by Flow-Cytometry respectively.Results:GHTR could obviously inhibit the proliferation of VSMCs stimulated by PDGF-BB,and it could also decrease S phase cells,increase G0/G1 phase cells and down-regulate cyclin D1 activity of VSMCs in concentration-dependent fashion,and the results were significant compared with the normal serum plus PDGF-BB-treated.Conclusion:GHTR could obviously inhibit the proliferation of VSMCs and may prevent atherosclerosis,which mechanism may be realized by regulating cyclin D1 activity of VSMC.  
        关键词：vascular smooth muscle cell;cell cycle;cyclin D1   
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      • Issue 9, Pages: 26-28(2007) DOI: 10.13422/j.cnki.syfjx.2007.09.015
        摘要：目的:探讨紫芪方对IEC-6肠上皮细胞缺氧复氧损伤的保护效应。方法:建立IEC-6细胞缺氧复氧损伤模型;采用血清药理学方法,在细胞培养液中加入不同给药剂量制备的紫芪方药物血清（给药1次和间隔1 h两次给药10 g.kg-1DJ-1,SJ-1;给药1次和间隔1 h两次给药20 g.kg-1;DJ-2,SJ-2）,和参附药物血清（间隔1 h两次给药20 g.kg-1SF）及对照血清（C）。测定LDH漏出量和其细胞生长曲线。结果:与对照组比较,SJ-1,SJ-2两组制备的药物血清能明显减少IEC-6细胞LDH的漏出量,其中SJ-1（P<0.05）,SJ-2（P<0.01）;SJ-2组24 h细胞活力明显高于缺氧复氧细胞损伤组及参附血清组（P<0.05）,并随时间而逐渐增强。结论:紫芪方对IEC-6肠上皮细胞缺氧复氧损伤具有显著保护效应。  
        关键词：缺氧复氧;肠上皮细胞;紫芪方;乳酸脱氢酶;细胞生长曲线   
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      • Issue 9, Pages: 29-30(2007) DOI: 10.13422/j.cnki.syfjx.2007.09.016
        摘要：目的:对康心复脉颗粒进行与功能主治相关的药理研究,为临床治疗提供佐证。方法:应用密闭容器造常压缺氧环境,观察康心复脉颗粒对小鼠耐缺氧能力的影响。皮下注射肾上腺素2次外加冷刺激造大鼠急性"血瘀"模型,观察对血瘀大鼠血液流变学指标的影响。结果:康心复脉颗粒对常压缺氧条件下的小鼠存活有明显的保护作用,可推迟死亡时间。能降低血瘀大鼠全血黏度、红细胞压积以及聚集指数,改善机体血液流变性,与模型对照比较有明显的差异。结论:康心复脉颗粒能提高小鼠耐缺氧能力。明显降低血液"浓、黏、聚、凝"状态,具有良好的活血化瘀作用。  
        关键词：康心复脉颗粒;缺氧;活血化瘀;实验研究   
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      • LU Zhen-xiang,ZHU Yu,NING Kang-jian,L Jin-fang
        Vol. 13, Issue 9, Pages: 31-32(2007)
        摘要：Objective:AA broilers were fed on Cortex Encomia compound and studied its effect on immune function through detecting HI level of antibody of Newcastle disease(ND).Methods:Two hundreds and twenty-four AA broilers were randomly divided into four groups,including a control group and three groups given Cortex Encomia compound.All groups had been investigated for 42 days.Every group took the same immunity approaches and blood was taken from AA broiler' heart.Results:After injection two or three weeks,in the Cortex Encomia compound groups the level of HI antibody were higher than the control group.The high dosage group was very remarkable compared to that of the controls(P<0.01);The low dosage group and the middle dosage group were remarkable compared to that of the controls(P<0.05).Conclusion:Results showed that the Cortex Encomia compound was effective in enhancing immunity for Newcastle disease(ND).  
        关键词：Cortex Encomia compound;Newcastle disease(ND);HI antibody valence   
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      • LU Zhen-xiang~,ZHU Yu,NING Kang-jian,L Jin-fang
        Issue 9, Pages: 31-33(2007) DOI: 10.13422/j.cnki.syfjx.2007.09.017
        摘要：Objective:AA broilers were fed on Cortex Encomia compound and studied its effect on immune function through detecting HI level of antibody of Newcastle disease（ND）.Methods:Two hundreds and twenty-four AA broilers were randomly divided into four groups,including a control group and three groups given Cortex Encomia compound.All groups had been investigated for 42 days.Every group took the same immunity approaches and blood was taken from AA broiler’ heart.Results:After injection two or three weeks,in the Cortex Encomia compound groups the level of HI antibody were higher than the control group.The high dosage group was very remarkable compared to that of the controls（P<0.01）;The low dosage group and the middle dosage group were remarkable compared to that of the controls（P<0.05）.Conclusion:Results showed that the Cortex Encomia compound was effective in enhancing immunity for Newcastle disease（ND）.  
        关键词：Cortex Encomia compound;Newcastle disease（ND）;HI antibody valence   
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      • Issue 9, Pages: 33-34(2007) DOI: 10.13422/j.cnki.syfjx.2007.09.018
        摘要：目的:探讨调肝导浊中药对实验性动脉粥样硬化（AS）家兔模型肝脏脂质代谢及抗氧化损伤的影响,以阐明其抗动脉粥样硬化的作用机制。方法:采用高胆固醇饮食饲喂家兔,并在饲喂过程中依分组进行不同处理。实验结束后,处死动物取肝脏,检测肝脏胆固醇（TC）、甘油三酯（TG）、丙二醛（MDA）含量以及超氧化物歧化酶（SOD）活性的变化。结果:AS模型组家兔肝脏TC,TG,MDA含量明显升高,SOD活性则显著降低;而调肝导浊中药可有效抑制此作用。结论:调肝导浊中药可有效抑制高胆固醇饮食诱导的脂质含量升高及氧化损伤,从而阻止AS的发生发展。  
        关键词：调肝导浊;动脉粥样硬化;脂质;丙二醛;超氧化物歧化酶   
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      • LIU Ting,QIN Cai-ling,Zhang Yi,WU Gui-lan,LI Dong-cheng,LI Chun-ying
        Vol. 13, Issue 9, Pages: 35-36(2007)
        摘要：Objective:To compare the antitussive action of pinellia temata(Thunb.)Breit.growing in different environment.Methods:By using nehulixation of NH3 aq.in mice,observe the antitussive effect of pinellia temata(Thunb.)Breit.growing in different environemnt,and calculate the ED50 of the inhibitory rate for cough times induced by NH3 aq.in mice.Results:Pinellia temata(Thunb.)Breit.in Gansu-XiHe,Sichuan-MianYang,Yunnan-Zhao Tong,Hubei-TianMen,and Anhui-NanLing demonstrated different antitussive effect,the ED50 of the inhibitory rate of cough times were 2.76,3.01,14.34,0.47,and 0.70 g·kg-1.Conclusion:Pinellia temata(Thunb.)Breit.growing in different environment demonstrated obvious antitussive action,but the ED50 of the inhibitory rate of cough times had big difference.  
        关键词：Pinellia temata(Thunb.)Breit.;antitussive action;ED50   
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      • LIU Ting~,QIN Cai-ling,ZHANG Yi,WU Gui-lan,LI Dong-cheng,LI Chun-ying
        Issue 9, Pages: 35-37(2007) DOI: 10.13422/j.cnki.syfjx.2007.09.019
        摘要：Objective:To compare the antitussive action of pinellia temata（Thunb.）Breit.growing in different environment.Methods:By using nehulixation of NH3 aq.in mice,observe the antitussive effect of pinellia temata（Thunb.）Breit.growing in different environemnt,and calculate the ED50 of the inhibitory rate for cough times induced by NH3 aq.in mice.Results:Pinellia temata（Thunb.）Breit.in Gansu-XiHe,Sichuan-MianYang,Yunnan-Zhao Tong,Hubei-TianMen,and Anhui-NanLing demonstrated different antitussive effect,the ED50 of the inhibitory rate of cough times were 2.76,3.01,14.34,0.47,and 0.70 g·kg-1.Conclusion:Pinellia temata（Thunb.）Breit.growing in different environment demonstrated obvious antitussive action,but the ED50 of the inhibitory rate of cough times had big difference.  
        关键词：Pinellia temata（Thunb.）Breit.;antitussive action;ED50   
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      • SUN Jie,ZHAO Hong-liang,WANG Jun-xia,WU Li-wen
        Vol. 13, Issue 9, Pages: 37-40(2007)
        摘要：Objective:To research the effect and the mechanism of Feixintong on rat model of chronic pulmonary heart disease(CPHD).Methods:50 Wistar rats were randomly divided into five groups.Rats were given a single injection of monocrotaline(MCT,60 μg/g)to induce the model of CPHD.The Feixintong groups were treated by suspension in 21 days,then total white cell counts and differential counts and interleukin-8(IL-8)and tumor necrosis factor-α(TNF-α)were examined.Lung organism slices were observed with microscope.Results:The examined items of the Feixintong groups were lower than the model groups(P<0.01 or P<0.05),endotheliocytes were repaired by Feixintong.Conclusions:Feixintong has good efficacy for treatment of rat model of CPHD.  
        关键词：chronic pulmonary heart disease;Feixintong;monocrotaline;bronchoalveolar lavage fluid;interleukin-8;tumor necrosis factor-α   
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      • SUN Jie~,ZHAO Hong-liang,WANG Jun-xia,WU Li-wen
        Issue 9, Pages: 37-40(2007) DOI: 10.13422/j.cnki.syfjx.2007.09.020
        摘要：Objective:To research the effect and the mechanism of Feixintong on rat model of chronic pulmonary heart disease（CPHD）.Methods:50 Wistar rats were randomly divided into five groups.Rats were given a single injection of monocrotaline（MCT,60 μg/g）to induce the model of CPHD.The Feixintong groups were treated by suspension in 21 days,then total white cell counts and differential counts and interleukin-8（IL-8）and tumor necrosis factor-α（TNF-α）were examined.Lung organism slices were observed with microscope.Results:The examined items of the Feixintong groups were lower than the model groups（P<0.01 or P<0.05）,endotheliocytes were repaired by Feixintong.Conclusions:Feixintong has good efficacy for treatment of rat model of CPHD.  
        关键词：chronic pulmonary heart disease;Feixintong;monocrotaline;bronchoalveolar lavage fluid;interleukin-8;tumor necrosis factor-α   
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      • LI Bao-chun
        Vol. 13, Issue 9, Pages: 41-43(2007)
        摘要：Objective:To observe the effects of SQE on craniocerebral injury.Methods:The mice were randomly divided into model group,NAOFUKANG(NFK)group(0.24 g·kg-1),three SQE groups(0.282,0.141,0.071 g·kg-1)and control group.The model was produced by the freely falling object.Endure time of anoxia,the content of brain water,brain index,and penetrability of blood-brain-barrier(BBB)were measured.Results:SQE can obviously decrease the content of brain water,brain index,and penetrability of BBB and improve the endure time of anoxia.Conclusion:SQE has the protective effects on craniocrebraly injury.  
        关键词：SQE;craniocerebral injury;endure time of anoxia;evans blue;blood-brain-barrier   
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      • LI Bao-chun~
        Issue 9, Pages: 41-43(2007) DOI: 10.13422/j.cnki.syfjx.2007.09.021
        摘要：Objective:To observe the effects of SQE on craniocerebral injury.Methods:The mice were randomly divided into model group,NAOFUKANG（NFK）group(0.24 g·kg-1),three SQE groups(0.282,0.141,0.071 g·kg-1)and control group.The model was produced by the freely falling object.Endure time of anoxia,the content of brain water,brain index,and penetrability of blood-brain-barrier（BBB）were measured.Results:SQE can obviously decrease the content of brain water,brain index,and penetrability of BBB and improve the endure time of anoxia.Conclusion:SQE has the protective effects on craniocrebraly injury.  
        关键词：SQE;craniocerebral injury;endure time of anoxia;evans blue;blood-brain-barrier   
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      • ZHAO Fu-dong,DONG Jing-cheng,CUI Yan,Xie Jin-yu,WU Jin-feng,Gong Zhao-hua,WU Shan-mei
        Vol. 13, Issue 9, Pages: 44-46(2007)
        摘要：Objective:To study changes of several related subjects of neuro-endocrino-immune network(NEI) in asthma models,to study the effects of Epimedium Herb on NEI.Methods:54 BN rats were randomly divided into 5 groups,Group A,B,C,D and E.Group A was the normal group.Group B was the allergic asthma model.Group C,D and E were administered respectively with low,moderate and high dose Epimedium Herb.CRHmRNA,ACTH,CORT,IL-6,IL-4,IFN-γ were measured in all groups.Results:The expression of CRHmRNA in hypothalamic tissue and concentration of interferon gamma in blood both increased in controlled groups in comparison with group B.There were higher expression of CRHmRNA in group C or D than that in group B.There were higher concentration of IFN-γ in group D than that in group B.Conclusion:The rats troubled with repeated asthmatic attack for three weeks had disorders of NEI(mainly including HPA axis and several cytokines).Epimedium Herb could improve HPA axis and Th1/Th2 cytokines so as to alleviate the inflammation of asthma.  
        关键词：bronchial asthma;inflammation;neuro-endocrino-immune network;epimedium herb   
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      • ZHAO Fu-dong,DONG Jing-cheng~,CUI Yan,XIE Jin-yu,WU Jin-feng,Gong Zhao-hua,WU Shan-mei
        Issue 9, Pages: 44-46(2007) DOI: 10.13422/j.cnki.syfjx.2007.09.022
        摘要：Objective:To study changes of several related subjects of neuro-endocrino-immune network（NEI） in asthma models,to study the effects of Epimedium Herb on NEI.Methods:54 BN rats were randomly divided into 5 groups,Group A,B,C,D and E.Group A was the normal group.Group B was the allergic asthma model.Group C,D and E were administered respectively with low,moderate and high dose Epimedium Herb.CRHmRNA,ACTH,CORT,IL-6,IL-4,IFN-γ were measured in all groups.Results:The expression of CRHmRNA in hypothalamic tissue and concentration of interferon gamma in blood both increased in controlled groups in comparison with group B.There were higher expression of CRHmRNA in group C or D than that in group B.There were higher concentration of IFN-γ in group D than that in group B.Conclusion:The rats troubled with repeated asthmatic attack for three weeks had disorders of NEI（mainly including HPA axis and several cytokines）.Epimedium Herb could improve HPA axis and Th1/Th2 cytokines so as to alleviate the inflammation of asthma.  
        关键词：bronchial asthma;inflammation;neuro-endocrino-immune network;epimedium herb   
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      • SUO Juan1,XIAN Yan-fang1,HUANG Xiao-dan2,HOU Shao-zhen1,CHEN Jian-nan1,YE Mu-rong1,SU Zi-ren1
        Vol. 13, Issue 9, Pages: 47-49(2007)
        摘要：Objective:To study anti-allergy effects of Refined Huodan Recipe and its disassembled prescriptions.Methods:Extracorporeal ileum muscles' hypersensitive contractility reaction of Guinea pig sensitized by albumin,homogeneous passive cutaneous anaphylaxis in rat,auricle cutaneous forme tardive supersensitivity action by 2,4-dinitrochlorobenzene in mouse were used to determine the anti-allergy effect of Refined Huodan Recipe and its disassembled prescriptions.Results:Refined Huodan Recipe and its disassembled prescriptions had obvious inhibitory action on extracorporeal ileum muscles' hypersensitive contractility reaction of Guinea pig sensitized by albumin,homogeneous passive cutaneous anaphylaxis in rat,auricle cutaneous forme tardive supersensitivity action by 2,4-dinitrochlorobenzene in mouse.Oleum pogostemonis and Pulvis fellis suis showed remarkable interaciton.Conclusions:Refined Huodan Recipe and its disassembled prescriptions have remarkable anti-allergy effects.  
        关键词：Refined Huodan Recipe;anti-allergy effects;drug synergy   
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      • SUO Juan~1,XIAN Yan-fang~1,HUANG Xiao-dan~2,HOU Shao-zhen~1,CHEN Jian-nan~1,YE Mu-rong~1,SU Zi-ren~
        Issue 9, Pages: 47-49(2007) DOI: 10.13422/j.cnki.syfjx.2007.09.023
        摘要：Objective:To study anti-allergy effects of Refined Huodan Recipe and its disassembled prescriptions.Methods:Extracorporeal ileum muscles’ hypersensitive contractility reaction of Guinea pig sensitized by albumin,homogeneous passive cutaneous anaphylaxis in rat,auricle cutaneous forme tardive supersensitivity action by 2,4-dinitrochlorobenzene in mouse were used to determine the anti-allergy effect of Refined Huodan Recipe and its disassembled prescriptions.Results:Refined Huodan Recipe and its disassembled prescriptions had obvious inhibitory action on extracorporeal ileum muscles’ hypersensitive contractility reaction of Guinea pig sensitized by albumin,homogeneous passive cutaneous anaphylaxis in rat,auricle cutaneous forme tardive supersensitivity action by 2,4-dinitrochlorobenzene in mouse.Oleum pogostemonis and Pulvis fellis suis showed remarkable interaciton.Conclusions:Refined Huodan Recipe and its disassembled prescriptions have remarkable anti-allergy effects.  
        关键词：Refined Huodan Recipe;anti-allergy effects;drug synergy   
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      • TANG Li-ming,ZHANG Su-hui,NING Lian
        Vol. 13, Issue 9, Pages: 50-52(2007)
        摘要：Objective:To investigate the effect of Qingfengteng Compound capsules(QFC)on rheumatoid arthritis.Method:Several pathologic models were used to observe the effect of QFC,including effects on the paw edema in the AA rats model adjuvant-induced arthritis and effects on contorition in the acetic acid-induced pain model in mice.Result:QFC can reduce the value of TNF-α1,the joint swelling in rats model.QFC can reduce the response of contortion and osmosis of capillary vessel,and enhance the threshold value of pain in mice model.Conclusion:QFC has the effects of immunity suppresion,anti-inflammation and analgesia.So it could be used to treat rheumatoid arthritis.  
        关键词：Qingfengteng Compound Capsules;rheumatioid arthritis;immunity;anti-inflammation;analgesia   
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      • TANG Li-ming~,ZHANG Su-hui,NING Lian
        Issue 9, Pages: 50-53(2007) DOI: 10.13422/j.cnki.syfjx.2007.09.024
        摘要：Objective:To investigate the effect of Qingfengteng Compound capsules（QFC）on rheumatoid arthritis.Method:Several pathologic models were used to observe the effect of QFC,including effects on the paw edema in the AA rats model adjuvant-induced arthritis and effects on contorition in the acetic acid-induced pain model in mice.Result:QFC can reduce the value of TNF-α1,the joint swelling in rats model.QFC can reduce the response of contortion and osmosis of capillary vessel,and enhance the threshold value of pain in mice model.Conclusion:QFC has the effects of immunity suppresion,anti-inflammation and analgesia.So it could be used to treat rheumatoid arthritis.  
        关键词：Qingfengteng Compound Capsules;rheumatioid arthritis;immunity;anti-inflammation;analgesia   
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      • Issue 9, Pages: 53-56(2007) DOI: 10.13422/j.cnki.syfjx.2007.09.025
        摘要：目的:比较茜草、茜草炭饮片在抗炎、镇痛、活血化瘀、止血等方面药理作用的强弱,为临床两者分用提供药理学依据,探讨茜草炮制的目的。方法:小鼠耳廓肿胀法比较两者抗炎作用;热板法、扭体法比较两者镇痛作用;地塞米松0.8 mg/kg肌肉注射两周造成血瘀模型,比较两者对血瘀模型的影响来比较活血化瘀作用;剪尾法、毛细血管法测定出血时间及凝血时间比较两者止血作用的区别。结果:茜草、茜草炭均有明显的抗炎、镇痛和活血化瘀作用,茜草作用强于茜草炭（P<0.05）;茜草、茜草炭具有明显的止血作用,茜草作用弱于茜草炭（P<0.05）。结论:茜草炮制后,抗炎、镇痛、活血化瘀等药理作用减弱,但止血作用增强,说明茜草炮制的目的是增强止血作用,为临床分用提供了药理学依据。  
        关键词：茜草;茜草炭;抗炎;镇痛;活血化瘀;止血   
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      • Issue 9, Pages: 57-58(2007) DOI: 10.13422/j.cnki.syfjx.2007.09.006
        摘要：目的:探讨益气滋肾安胎方治疗早期妊娠流产的临床疗效。方法:治疗组采用口服益气滋肾安胎方,与黄体酮治疗组、孕康口服液组相对照,均连续治疗2周。治疗前后观察阴道出血、腰酸、腰痛、B超检查等,并随访2个月。结果:3组有效率差异无显著性（P>0.05）,中药治疗组2个月内继续妊娠率明显优于黄体酮治疗组及孕康口服液组（P<0.05）。停药后孕1112周血孕酮维持中药治疗组明显优于黄体酮对照组及孕康口服液组。结论:益气滋肾安胎方治疗早期妊娠流产的远期疗效可靠,中药在治疗早期妊娠流产有其自身特有价值。  
        关键词：早期妊娠;流产;中药;孕酮   
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      • Issue 9, Pages: 59-60(2007) DOI: 10.13422/j.cnki.syfjx.2007.09.007
        摘要：目的:观察补元润通汤治疗老年性便秘的临床效果。方法:随机分为治疗组和对照组各40例,分别给予补元润通汤和一般常用通便药,以7 d为1疗程,治疗13个疗程,随访观察30 d,以排便间隔天数和主要症状积分为疗效评价指标,并比较两组治愈率及有效率。结果:治疗组的总有效率为92.5%,对照组为65.0%,差异有非常显著性意义,P=0.0026);大便间隔时间缩短治疗组亦优于对照组,差异有极显著性意义,P<0.001;治疗前后两组症状积分（-x±s）,治疗组好转明显优于对照组,差异有极显著性意义,P<0.001。结论:补元润通汤疗效明显,宜推广使用。  
        关键词：老年便秘;中医药疗法;补元润通汤   
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      • Issue 9, Pages: 61-62(2007) DOI: 10.13422/j.cnki.syfjx.2007.09.008
        摘要：目的:探讨银丹心脑通在常规治疗冠心病心绞痛基础上的临床疗效。方法:冠心病心绞痛患者在常规抗心绞痛治疗基础上加用银丹心脑通治疗,每次3粒,每日3次,同时选用冠心病心绞痛患者常规抗心绞痛治疗作为对照组,二组疗程为8周。结果:治疗组心绞痛症状的总有效率为87.5%,治疗组的全血粘的低切、高切和红细胞聚集指数的降低较对照组有显著性差异。治疗组的内皮功能下降,而一氧化氮上升,治疗组的症状、血黏度及NO、ET等方面均优于对照组（P<0.05,P<0.01）。结论:银丹心脑通是治疗冠心病心绞痛的有效药物。  
        关键词：冠心病心绞痛;银丹心脑通;血脂;内皮功能;一氧化氮   
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      • YU Jing-jing1,CHEN Su-hong2,LU Gui-yuan1
        Vol. 13, Issue 9, Pages: 63-65(2007)
        摘要：Objective:To illuminate the theory of traditional chinese drug effects(TCDE)of Radix Scrophulariae's function on cooling blood and nourishing yin from pharmacology.Method:Summarized the pharmacodynamics in cooling blood and nourishing yin of Scrophulariae through analyzing the related literatures in CNKI from 1994 to 2006.Result:The related pharmacodynamics of Scrophulariae's function on cooling blood are mainly anti-tumor,anti-inflammation,relieving fever and so on,and that of nourishing yin are enhancing the immunity,lowering glycaemia,protecting the liver and so on.Conclusion:Scrophulariae's function on cooling blood and nourishing yin has various pharmacological effects.It provides scientific basis for perfecting TCDE of scrophulariae.  
        关键词：Radix Scrophulariae;cool blood and nourish yin;pharmacodynamics;review   
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      • YU Jing-jing~1,CHEN Su-hong~2,LU Gui-yuan~
        Issue 9, Pages: 63-66(2007) DOI: 10.13422/j.cnki.syfjx.2007.09.026
        摘要：Objective:To illuminate the theory of traditional chinese drug effects（TCDE）of Radix Scrophulariae’s function on cooling blood and nourishing yin from pharmacology.Method:Summarized the pharmacodynamics in cooling blood and nourishing yin of Scrophulariae through analyzing the related literatures in CNKI from 1994 to 2006.Result:The related pharmacodynamics of Scrophulariae’s function on cooling blood are mainly anti-tumor,anti-inflammation,relieving fever and so on,and that of nourishing yin are enhancing the immunity,lowering glycaemia,protecting the liver and so on.Conclusion:Scrophulariae’s function on cooling blood and nourishing yin has various pharmacological effects.It provides scientific basis for perfecting TCDE of scrophulariae.  
        关键词：Radix Scrophulariae;cool blood and nourish yin;pharmacodynamics;review   
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      • Issue 9, Pages: 66-68(2007) DOI: 10.13422/j.cnki.syfjx.2007.09.027
        摘要：目的:探讨半夏、生姜、甘草三泻心汤的君药问题。方法:从意旨源流考证、实验及临床研究方面探讨半夏、生姜、甘草三泻心汤君药问题。结果:半夏泻心汤有半夏为君,黄连为君,黄连、干姜共为君,半夏、黄连共为君,半夏、黄连、干姜共为君等观点;生姜泻心汤有生姜为君,半夏为君的观点;甘草泻心汤有甘草为君,半夏为君,生姜、半夏、甘草共为君的观点。结论:意旨源流考证、实验及临床研究相结合的多层面的系统研究可以为揭示君药问题提供一定依据。  
        关键词：半夏泻心汤;生姜泻心汤;甘草泻心汤;君药   
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      • XU Jin-ning,ZHAO Xiu-hua
        Vol. 13, Issue 9, Pages: 69-72(2007)
        摘要：Objective:Advance of studies on method of quantitative analysis and pharmacokinetics for effective constituents of Sophora flavescens Ait was reviewed.Methods:Methods of quantitative analysis for effective constituent of Sophora flavescens Ait and technology of the pharmacokinetical are introduced and commented.Results:Methods of titration,TLC-scanning and acid dye colorimetry used to analyse of effective constituents has definite limitation.HPLC and HPCE have characteristics of sensitivity,accuracy,reproduction and applicability.Conclusions:The research for Sophora flavescens Ait has a certain foundation.LC-MS has been widely used in the study of effective constituent analysis.  
        关键词：Sophora flavescens Ait.;matrine;flavonids;pharmacokinetics   
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      • XU Jin-ning~,ZHAO Xiu-hua
        Issue 9, Pages: 69-72(2007) DOI: 10.13422/j.cnki.syfjx.2007.09.028
        摘要：Objective:Advance of studies on method of quantitative analysis and pharmacokinetics for effective constituents of Sophora flavescens Ait was reviewed.Methods:Methods of quantitative analysis for effective constituent of Sophora flavescens Ait and technology of the pharmacokinetical are introduced and commented.Results:Methods of titration,TLC-scanning and acid dye colorimetry used to analyse of effective constituents has definite limitation.HPLC and HPCE have characteristics of sensitivity,accuracy,reproduction and applicability.Conclusions:The research for Sophora flavescens Ait has a certain foundation.LC-MS has been widely used in the study of effective constituent analysis.  
        关键词：Sophora flavescens Ait.;matrine;flavonids;pharmacokinetics   
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      • Vol. 0, Issue 9, Pages: 40(2007)
          
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