最新刊期
      卷 13 ， 期 8 ， 2007
      • HUANG Shui-qing~1,WEI Gang~2,HUANG Yue-chun~
        Issue 8, Pages: 1-3(2007) DOI: 10.13422/j.cnki.syfjx.2007.08.004
        摘要：Objective:To study the main components of volatile oil from Danggui Buxue decoction,and establish the GC-MS fingerprint of its volatile oil.Methods:The main components of volatile oil were analyzed by GC-MS.The injector temperature was 250 ℃.The interface temperature was 230 ℃.The flow rate of the carrier gas was 1.3 mL·min-1.The programmed temperature rate was 3 ℃·min-1.Results:11 peaks were separated on GC-MS fingerprint.The main components were tested as trans-ligustilide,butylidene phthalide,n-butylphthalide,and cis-ligustilide.Conclusions:The fingerprint can be used as a referrence for monitoring the stability of volatile oil of Danggui Buxue decoction.  
        关键词：Danggui Buxue decoction;volatile oil;fingerprint;GC-MS   
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        发布时间：2024-09-23
      • HUANG Shui-qing1,WEI Gang2,HUANG Yue-chun2,LIU Dong-hui1
        Vol. 13, Issue 8, Pages: 1-3(2007)
        摘要：Objective:To study the main components of volatile oil from Danggui Buxue decoction,and establish the GC-MS fingerprint of its volatile oil.Methods:The main components of volatile oil were analyzed by GC-MS.The injector temperature was 250 ℃.The interface temperature was 230 ℃.The flow rate of the carrier gas was 1.3 mL·min-1.The programmed temperature rate was 3 ℃·min-1.Results:11 peaks were separated on GC-MS fingerprint.The main components were tested as trans-ligustilide,butylidene phthalide,n-butylphthalide,and cis-ligustilide.Conclusions:The fingerprint can be used as a referrence for monitoring the stability of volatile oil of Danggui Buxue decoction.  
        关键词：Danggui Buxue decoction;volatile oil;fingerprint;GC-MS   
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      • Issue 8, Pages: 4-5(2007) DOI: 10.13422/j.cnki.syfjx.2007.08.005
        摘要：目的:采用高效液相色谱法-蒸发激光散射检测器测定银杏酮酯胶囊中萜类内酯的含量,以控制该制剂的质量。方法:采用高效液相色谱法-蒸发激光散射检测器测定4种萜类内酯的含量。色谱条件为:DiamonsilTMC18色谱柱（150 mm×4.6mm,5μm）:流动相:甲醇∶水（30∶70）;柱温:30℃;流速为1.0 mL/min;检测器条件:漂移管温度为110℃,载气流速为2.8 L/min。结果:4种萜类内酯之间分离度均达1.5以上;理论塔板数以白果内酯峰计算为7 287,平均加样回收率为97.8%（RSD为0.55%）;白果内酯、银杏内酯C、银杏内酯A、银杏内酯B分别在4.8224.1,3.8119.0,2.8414.2,1.909.50μg范围内,进样量对数值与峰面积对数值呈良好的线性关系。结论:该方法分离度高,重现性好,简便,准确,可用于银杏酮酯胶囊的质量控制。  
        关键词：高效液相色谱法;蒸发激光散射检测器;萜类内酯   
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        发布时间：2024-09-23
      • Issue 8, Pages: 6-7(2007) DOI: 10.13422/j.cnki.syfjx.2007.08.006
        摘要：目的:建立用高效液相色谱法同时测定参杞杜仲丸中人参皂苷Rg1和人参皂苷Re的含量。方法:Lichrospher C18色谱柱（4.6 mm×200 mm,5μm）;流动相:乙腈-0.05%磷酸溶液（199:801）;流速:1.0 mL·min-1;检测波长:203 nm;柱温:30℃。结果:该方法回收率人参皂苷Rg1为99.39%（RSD为2.88%）,人参皂苷Re为99.83%（RSD为2.57%）。结论:该方法简便、准确,所测结果稳定,重复性好,可用于该品种的质量控制。  
        关键词：参杞杜仲丸;人参皂苷Rg1;人参皂苷Re;高效液相色谱法;含量测定   
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        发布时间：2024-09-23
      • QIAO Ming,HAN Jian-wei,LI Hua
        Vol. 13, Issue 8, Pages: 8-9(2007)
        摘要：Objective:To investigate the optimal extraction technique patch of Kechuan Plaster.Method:The extraction technique was optimized by orthogonal experimental design and the content of ephedrine chloride was used as the inspecting mark.Results:The optimal extraction technique was that the raw material was refluxed with 65% ethanol whose volume was 6 times than that of the raw material for 3 times lasting 1.5h for each time.Conclusion:The extraction technique is stable and feasible.  
        关键词：Kechuan Plaster;orthogonal design;ephedrine chloride   
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      • QIAO Ming~,HAN Jian-wei,LI Hua
        Issue 8, Pages: 8-9(2007) DOI: 10.13422/j.cnki.syfjx.2007.08.001
        摘要：Objective:To investigate the optimal extraction technique patch of Kechuan Plaster.Method:The extraction technique was optimized by orthogonal experimental design and the content of ephedrine chloride was used as the inspecting mark.Results:The optimal extraction technique was that the raw material was refluxed with 65% ethanol whose volume was 6 times than that of the raw material for 3 times lasting 1.5h for each time.Conclusion:The extraction technique is stable and feasible.  
        关键词：Kechuan Plaster;orthogonal design;ephedrine chloride   
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        发布时间：2024-09-23
      • ZHANG Qi-chun1,KOU Jun-ping2,ZHU Dan-ni2,WANG Qiu-juan1,YAN Yong-qing2
        Vol. 13, Issue 8, Pages: 10-13(2007)
        摘要：Objective:To explore the standard conditions of the cerebrospinal fluid pharmacological method,by investigating the neural protective effect of cerebrospinal fluid(CSF) containing FBD.Methods:The effect of rat CSF with FBD on injured PC12 cell induced by hydrogen peroxide was observed by MTT assay under various experimental conditions(dosage regiment,addition level,treatment process).Results:The viability of PC12 cell injured by hydrogen peroxide increased with the addition level of CSF with FBD,and at the same addition level(5%,10%,20%),CSF of rat after administrating FBD repetitiously (2 times/d)×3.5 d) exerted higher protective efficacy on PC12 cell than that of after administrating FBD once.The raw CSF with FBD and the CSF with FBD treated by heat(56 ℃),ethanol,acetone all had notable protective effects on PC12 cell(P<0.01),and there was no significant statistical difference among them.Meanwhile,CSF with FBD of different batch of rats and with different preserved time also showed distinct activities,however,protective rate declined with prolonging of the preserved time.Conclusion:It is proposed that the CSF containing drugs may be prepared with 10% rat CSF without treating after administrating drugs repetitiously and preserved at -20 ℃ no more than 30 days.  
        关键词：cerebrospinal fluid pharmacology;optimized Danggui Shaoyao San (FBD);method standardization   
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        发布时间：2024-09-23
      • ZHANG Qi-chun~1,KOU Jun-ping~2,ZHU Dan-ni~2,WANG Qiu-juan~1,YAN Yong-qing~
        Issue 8, Pages: 10-13(2007) DOI: 10.13422/j.cnki.syfjx.2007.08.007
        摘要：Objective:To explore the standard conditions of the cerebrospinal fluid pharmacological method,by investigating the neural protective effect of cerebrospinal fluid（CSF） containing FBD.Methods:The effect of rat CSF with FBD on injured PC12 cell induced by hydrogen peroxide was observed by MTT assay under various experimental conditions（dosage regiment,addition level,treatment process）.Results:The viability of PC12 cell injured by hydrogen peroxide increased with the addition level of CSF with FBD,and at the same addition level（5%,10%,20%）,CSF of rat after administrating FBD repetitiously （2 times/d）×3.5 d) exerted higher protective efficacy on PC12 cell than that of after administrating FBD once.The raw CSF with FBD and the CSF with FBD treated by heat（56 ℃）,ethanol,acetone all had notable protective effects on PC12 cell（P<0.01）,and there was no significant statistical difference among them.Meanwhile,CSF with FBD of different batch of rats and with different preserved time also showed distinct activities,however,protective rate declined with prolonging of the preserved time.Conclusion:It is proposed that the CSF containing drugs may be prepared with 10% rat CSF without treating after administrating drugs repetitiously and preserved at20 ℃ no more than 30 days.  
        关键词：cerebrospinal fluid pharmacology;optimized Danggui Shaoyao San （FBD）;method standardization   
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        发布时间：2024-09-23
      • LIU Jie,LIN Zhi-hong,ZHU Dan-ni,YAN Yong-qing,YU Bo-yang~
        Issue 8, Pages: 14-17(2007) DOI: 10.13422/j.cnki.syfjx.2007.08.008
        摘要：Objective:To observe the protective effect of FBD,the simplified formula from Danggui Shaoyao San（DSS）,and CO2 supercritical fluid extract（P\2） on the hypoxic astrocyte anoxic injury.Methods:Sampling cerebrospinal fluid containing FBD/P2（CSF-FBD/P2） after administration with FBD 125 mg/kg or P2 16.3 mg/kg;MTT assay was used to measure the viability in the damaged astrocyte induced by Na2S2O4.Results:1 h hypoxia and 4 h reoxygen significantly decreased the viability in astrocyte（P<0.01）;（0.1～1）mg/L ACSF-FBD and 5%～15% CSF-FBD can substantially increase the viability of astrocyte induced by Na2S2O4（P<0.01）;（0.01～1） mg/L ACSF-P2 and 15% CSF-P2 can substantially increase the viability of astrocyte（P<0.01～0.05）.Conclusion:FBD and P2 could prevent astrocyte from Na2S2O4-induced hypoxic damage,which was beneficial to the treatment of cerebral ischemia.  
        关键词：FBD;hypoxia;CO2 supercritical fluid;Cerebrospinal fluid;astrocyte   
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        发布时间：2024-09-23
      • Liu Jie,LIN Zhi-hong,ZHU Dan-ni,YAN Yong-qing,YU Bo-yang
        Vol. 13, Issue 8, Pages: 14-17(2007)
        摘要：Objective:To observe the protective effect of FBD,the simplified formula from Danggui Shaoyao San(DSS),and CO2 supercritical fluid extract(P2) on the hypoxic astrocyte anoxic injury.Methods:Sampling cerebrospinal fluid containing FBD/P2(CSF-FBD/P2) after administration with FBD 125 mg/kg or P2 16.3 mg/kg;MTT assay was used to measure the viability in the damaged astrocyte induced by Na2S2O4.Results:1 h hypoxia and 4 h reoxygen significantly decreased the viability in astrocyte(P<0.01);(0.1～1)mg/L ACSF-FBD and 5%～15% CSF-FBD can substantially increase the viability of astrocyte induced by Na2S2O4(P<0.01);(0.01～1) mg/L ACSF-P2 and 15% CSF-P2 can substantially increase the viability of astrocyte(P<0.01～0.05).Conclusion:FBD and P2 could prevent astrocyte from Na2S2O4-induced hypoxic damage,which was beneficial to the treatment of cerebral ischemia.  
        关键词：FBD;hypoxia;CO2 supercritical fluid;Cerebrospinal fluid;astrocyte   
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        发布时间：2024-09-23
      • WANG Xi-jun1,CHEN Xi1,CAO Hong-xin2,SUN Hui1,YANG Ge1
        Vol. 13, Issue 8, Pages: 18-20(2007)
        摘要：Objective:Elucidating the pharmacokinetic properties of Zhizhu Wan.Method:By using β-Glucuronidase,free hesperintin and naringenin were obtained from the hesperetin-glucronide naringenin-glucronaide in plasma,the contents of the two compounds in plasma was determined by HPLC.Results:T1/2(ka)/T1/2(ke)(h) for naringenin and hesperetin are 2.142±0.999/5.491±3.926 and 2.106±0.728/5.824±3.067 respectively,and the AUC(mg/L·h) value are 34.886±22.199 and 39.407±19.535 for naringenin and hesperetin respectively.Conclusion:The method for determinning naringenin and hesperetin in plasma has been established,and the pharmacokinetic parameters can be instructive for clinic apllication.  
        关键词：Zhizhu Wan;naringenin;hesperetin;pharmacokinetics   
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        发布时间：2024-09-23
      • WANG Xi-jun~
        Issue 8, Pages: 18-20(2007) DOI: 10.13422/j.cnki.syfjx.2007.08.009
        摘要：Objective:Elucidating the pharmacokinetic properties of Zhizhu Wan.Method:By using β-Glucuronidase,free hesperintin and naringenin were obtained from the hesperetin-glucronide naringenin-glucronaide in plasma,the contents of the two compounds in plasma was determined by HPLC.Results:T1/2（ka）/T1/2（ke）（h） for naringenin and hesperetin are 2.142±0.999/5.491±3.926 and 2.106±0.728/5.824±3.067 respectively,and the AUC（mg/L·h） value are 34.886±22.199 and 39.407±19.535 for naringenin and hesperetin respectively.Conclusion:The method for determinning naringenin and hesperetin in plasma has been established,and the pharmacokinetic parameters can be instructive for clinic apllication.  
        关键词：Zhizhu Wan;naringenin;hesperetin;pharmacokinetics   
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        发布时间：2024-09-23
      • LIU Zhi-bao,LAN Yan-yu,WANG Yong-lin,WANG Ai-min,LI Yong-jun,HE Xun
        Vol. 13, Issue 8, Pages: 21-23(2007)
        摘要：Objective:To compare Pharmacodynamics properties between the extracts of Hongcao,and determine an optimum technique to refine and purify.Methods:The acute myocardial infarction of rat was induced by ligating anterior branch of the left coronary artery.The change of ECG,and the level of CK,LDH were determined,the infarction area of myocardium was also observed.Results:N-butanol extracts of Hongcao could obviously decrease the elevated J of ECG,decrease the infarction area of myocardium,reduce the level of CK,LDH.Conclusion:Adopt n-butanol extraction can concentrate effective composition of Hongcao.  
        关键词：Hongcao;Myocardial ischemia;macroporous absorbing resin;n-butanol   
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        发布时间：2024-09-23
      • LIU Zhi-bao,LAN Yan-yu~,WANG Yong-lin,WANG Ai-min,LI Yong-jun,HE Xun
        Issue 8, Pages: 21-24(2007) DOI: 10.13422/j.cnki.syfjx.2007.08.010
        摘要：Objective:To compare Pharmacodynamics properties between the extracts of Hongcao,and determine an optimum technique to refine and purify.Methods:The acute myocardial infarction of rat was induced by ligating anterior branch of the left coronary artery.The change of ECG,and the level of CK,LDH were determined,the infarction area of myocardium was also observed.Results:N-butanol extracts of Hongcao could obviously decrease the elevated J of ECG,decrease the infarction area of myocardium,reduce the level of CK,LDH.Conclusion:Adopt n-butanol extraction can concentrate effective composition of Hongcao.  
        关键词：Hongcao;Myocardial ischemia;macroporous absorbing resin;n-butanol   
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        发布时间：2024-09-23
      • WEN Xiao-Ping1,ZHENG Xiao-jie1,Hiroya Kawasaki2,Takehito Tanbo2,Masahiko Nonaka2,CHEN De-xing1
        Vol. 13, Issue 8, Pages: 24-28(2007)
        摘要：Objective:To investigate the effects and mechanisms of Panax notoginseng(SQ) and Gynostemma pentaphyllum(JGL) on vascular remodeling.Methods:A total of sixity-four male New Zealand rabbits was randomly divided into six groups:Normal,Model,SQ,JGL,FF(SQ+JGL) and Captopril.The rabbits in control group were fed with regular diet,others were injected with bovine serum albumin 250 mg/kg and fed with high cholesterol diet,meanwhile,durgs were administrated orally.Rabbits were sacrificed at the end of 12 week,aortas serial crosssections were stained with hematoxylin-eosin and elastic fibers.Immunohistochemistry were performed to label PCNA and TGF-β1.Results:(1)The pathological changes of all drug treated groups were alleviated.(2)Compound prescription decreased the quantity of aorta VSMC nucleus compared with model group(P<0.05).(3)The aorta PCNA immunostaining number and TGF-β1 immunostaining area of model group were significantly higher than normal group(P<0.01),all drug treated groups decreased.Conclusion:Reduced expression of TGFβ1,and cellular proliferation may be related with inhibition of VR.  
        关键词：atherosclerosis;vascular remodeling;Panax notoginseng;Gynostemma pentaphyllum   
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        发布时间：2024-09-23
      • WEN Xiao-Ping~1,ZHENG Xiao-jie~1,Hiroya Kawasaki~2,Takehito Tanbo~2,Masahiko Nonaka~2,CHEN De-xing~
        Issue 8, Pages: 24-28(2007) DOI: 10.13422/j.cnki.syfjx.2007.08.011
        摘要：Objective:To investigate the effects and mechanisms of Panax notoginseng（SQ） and Gynostemma pentaphyllum（JGL） on vascular remodeling.Methods:A total of sixity-four male New Zealand rabbits was randomly divided into six groups:Normal,Model,SQ,JGL,FF（SQ+JGL） and Captopril.The rabbits in control group were fed with regular diet,others were injected with bovine serum albumin 250 mg/kg and fed with high cholesterol diet,meanwhile,durgs were administrated orally.Rabbits were sacrificed at the end of 12 week,aortas serial crosssections were stained with hematoxylin-eosin and elastic fibers.Immunohistochemistry were performed to label PCNA and TGF-β1.Results:（1）The pathological changes of all drug treated groups were alleviated.（2）Compound prescription decreased the quantity of aorta VSMC nucleus compared with model group（P<0.05）.（3）The aorta PCNA immunostaining number and TGF-β1 immunostaining area of model group were significantly higher than normal group（P<0.01）,all drug treated groups decreased.Conclusion:Reduced expression of TGFβ1,and cellular proliferation may be related with inhibition of VR.  
        关键词：atherosclerosis;vascular remodeling;Panax notoginseng;Gynostemma pentaphyllum   
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        发布时间：2024-09-23
      • GE Hong-yan~1,YANG Jin-gang~2,FANG Xue-xun~2,ZHAO Shu-hua~
        Issue 8, Pages: 29-31(2007) DOI: 10.13422/j.cnki.syfjx.2007.08.012
        摘要：Objective:To observe the inhibition of matrix metalloproteinase（MMP） by Caulis Polygoni Multiflori.Methods:Decreased the degrade rate of substrate is associated with the inhibition of MMP.We studied the inhibitory activity of Caulis Polygoni Multiflori on MMP by observing the degrade rate of substrate.Results:Caulis Polygoni Multiflori inhibited the MMP-16 activity,and the IC50 was 21 μg/mL.Conclusion: The Caulis Polygoni Multiflori has the inhibitory activity of MMP-16.  
        关键词：Caulis Polygoni Multiflori;matrix metalloproteinase;the methods for the analysis of enzymatic activity.   
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      • GE Hong-yan1,YANG Jin-gang2,FANG Xue-xun2,ZHAO Shu-hua1
        Vol. 13, Issue 8, Pages: 29-31(2007)
        摘要：Objective:To observe the inhibition of matrix metalloproteinase(MMP) by Caulis Polygoni Multiflori.Methods:Decreased the degrade rate of substrate is associated with the inhibition of MMP.We studied the inhibitory activity of Caulis Polygoni Multiflori on MMP by observing the degrade rate of substrate.Results:Caulis Polygoni Multiflori inhibited the MMP-16 activity,and the IC50 was 21 μg/mL.Conclusion: The Caulis Polygoni Multiflori has the inhibitory activity of MMP-16.  
        关键词：Caulis Polygoni Multiflori;matrix metalloproteinase;the methods for the analysis of enzymatic activity.   
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        发布时间：2024-09-23
      • Issue 8, Pages: 32-35(2007) DOI: 10.13422/j.cnki.syfjx.2007.08.013
        摘要：目的:观察新加良附颗粒对人胃癌细胞（BGC-823）诱导凋亡效应。方法采用MTT法测定新加良附颗粒含药血清体外对BGC-823生长抑制率,用流式细胞仪检测其对细胞凋亡影响的同时,以倒置显微镜和透射电镜观察细胞形态学变化。结果:新加良附颗粒对BGC-823有生长抑制效应和促进凋亡作用,并与用药剂量呈正相关;倒置显微镜下及透射电镜下对照组无明显变化,给药各组出现细胞形态学改变并可见凋亡特征出现。结论:新加良附颗粒体外具有抑制人胃癌细胞（BGC-823）,诱导其凋亡作用。  
        关键词：新加良附颗粒;人胃癌细胞;细胞株;凋亡   
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      • SUN Jie~,WNAG Jun-xia,ZHAO Hong-liang,WU Li-wen
        Issue 8, Pages: 36-38(2007) DOI: 10.13422/j.cnki.syfjx.2007.08.014
        摘要：Objective:To research the functionary mechanism and treating effect of Feixintong（FXT） on chronic pulmonary heart disease（CPHD）.Methods:50 Wister rats were randomly separated into five groups:blank control group,model group,FXT groups of high,middle and low dosage,The rat model of corpulmonale was established by injecting 2% monocrotaline（60 mg/kg）i.p.At the same time,model group,FXT groups of high,middle and low dosage were separately administrated with physical saline or FXT for 21 days.NO,ET-1 and expression of VEGF in bronchi arterioles was measured.Lung tissue sections were examined to study the morphological alternations.Results:FXT could evidently improve the NO content of rat model of CPHD;reduce the ET-1 content;reduce the expression of VEGF in bronchi arterioles.Conclusions:FXT treatment is effective on rat model of CPHD.  
          
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        发布时间：2024-09-23
      • SUN Jie,WNAG Jun-xia,ZHAO Hong-liang,WU Li-wen
        Vol. 13, Issue 8, Pages: 36-38(2007)
        摘要：Objective:To research the functionary mechanism and treating effect of Feixintong(FXT) on chronic pulmonary heart disease(CPHD).Methods:50 Wister rats were randomly separated into five groups:blank control group,model group,FXT groups of high,middle and low dosage,The rat model of corpulmonale was established by injecting 2% monocrotaline(60 mg/kg)i.p.At the same time,model group,FXT groups of high,middle and low dosage were separately administrated with physical saline or FXT for 21 days.NO,ET-1 and expression of VEGF in bronchi arterioles was measured.Lung tissue sections were examined to study the morphological alternations.Results:FXT could evidently improve the NO content of rat model of CPHD;reduce the ET-1 content;reduce the expression of VEGF in bronchi arterioles.Conclusions:FXT treatment is effective on rat model of CPHD.  
          
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        发布时间：2024-09-23
      • LENG Ping1,YANG Shu-ping2,SHI Ping1,ZHANG Jie2,CAO Zhi-hong1
        Vol. 13, Issue 8, Pages: 39-41(2007)
        摘要：Objective:To observe the effects of Fuzheng Huatan Huoxue Formula on lowering blood sugar and improving related index of insulin resistance(IR) of type 2 diabetic rats.Methods:To establish type 2 diabetic rats with IR by injecting STZ and giving fat foods.The effects of Fuzheng Huatan Huoxue Formula on blood sugar,FLNS,HBA1C,IGF-1,insulin resistant index(IRI)and index of insulin sensitivity(ISI)were observed.Results:The treatment group has better effects than the control group in lowering blood sugar,HBA1C,insulin and improving IGF-1 and the sensitive index of insulin(P<0.05).Conclusion:It is verified that Fuzheng Huatan Huoxue Formula has obvious effects on lowering blood sugar,improving index of insulin resistance(IR),preventing and curing the complications of diabetes.  
        关键词：Fuzheng Huatan Huoxue Formula;type 2 diabetes;insulin resistance   
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      • LENG Ping~
        Issue 8, Pages: 39-41(2007) DOI: 10.13422/j.cnki.syfjx.2007.08.015
        摘要：Objective:To observe the effects of Fuzheng Huatan Huoxue Formula on lowering blood sugar and improving related index of insulin resistance（IR） of type 2 diabetic rats.Methods:To establish type 2 diabetic rats with IR by injecting STZ and giving fat foods.The effects of Fuzheng Huatan Huoxue Formula on blood sugar,FLNS,HBA1C,IGF-1,insulin resistant index（IRI）and index of insulin sensitivity（ISI）were observed.Results:The treatment group has better effects than the control group in lowering blood sugar,HBA1C,insulin and improving IGF-1 and the sensitive index of insulin（P<0.05）.Conclusion:It is verified that Fuzheng Huatan Huoxue Formula has obvious effects on lowering blood sugar,improving index of insulin resistance（IR）,preventing and curing the complications of diabetes.  
        关键词：Fuzheng Huatan Huoxue Formula;type 2 diabetes;insulin resistance   
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      • ZENG Ming~
        Issue 8, Pages: 42-44(2007) DOI: 10.13422/j.cnki.syfjx.2007.08.016
        摘要：Objective:To observe the effects of Kudzu extract on kidney function in rats with diabetic nephropathy（DN）,and to probe its mechanism.Methods:The rat model of diabetic nephropathy was induced by streptozotocin.The effects of TFP on diabetic rats were detected by blood sugar before meal,the concentration of fructosamine,urea nitrogen,creatinine in blood serum,and levels of ET,6-keto-PGF1 in plasma,compared with aminoguanidin treatment.Results:The Kudzu extract could decrease the level of blood sugar,the concentrations of fructosamine,urea nitrogen,creatinine in blood serum,and levels of ET,6-keto-PGF1 in plasma,comparing to that of the diabetic model group（P<0.01,or P<0.05）remarkably.Conclusion:The Kudzu extract has preventive and therapeutic effects on DN.  
        关键词：kudzu extract;DM rats;kidney function   
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      • ZENG Ming1,ZHENG Shui-qing2,TAO Kai-zhong3,WANG Jin-ping1,BIAN Jia-ming1,XU Hong-fa4
        Vol. 13, Issue 8, Pages: 42-44(2007)
        摘要：Objective:To observe the effects of Kudzu extract on kidney function in rats with diabetic nephropathy(DN),and to probe its mechanism.Methods:The rat model of diabetic nephropathy was induced by streptozotocin.The effects of TFP on diabetic rats were detected by blood sugar before meal,the concentration of fructosamine,urea nitrogen,creatinine in blood serum,and levels of ET,6-keto-PGF1 in plasma,compared with aminoguanidin treatment.Results:The Kudzu extract could decrease the level of blood sugar,the concentrations of fructosamine,urea nitrogen,creatinine in blood serum,and levels of ET,6-keto-PGF1 in plasma,comparing to that of the diabetic model group(P<0.01,or P<0.05)remarkably.Conclusion:The Kudzu extract has preventive and therapeutic effects on DN.  
        关键词：kudzu extract;DM rats;kidney function   
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      • Issue 8, Pages: 45-46(2007) DOI: 10.13422/j.cnki.syfjx.2007.08.017
        摘要：目的:研究不同剂量的复方杜仲水煎液对AA肉鸡生长激素（GH）、三碘甲腺原氨酸（T3）、甲状腺素（T4）分泌的影响。方法:选择1日龄AA肉鸡224只随机均分4组。分别以0,1.25,2.5,5.0 g/L浓度的复方杜仲水煎液饮用。常规饲养6周,于14,28,42 d清晨每组随机抽样6只空腹采血,测量血清GH,T3,T4水平。结果:各给药浓度均对4周龄肉鸡血清中GH,T3,T4的含量有较大影响,GH,T3水平提高（P<0.01）,T4水平下降（P<0.01）。结论:复方杜仲对肉鸡不同生长阶段的GH,T3,T4分泌有不同的影响。  
        关键词：肉鸡;复方杜仲;生长激素;甲状腺激素   
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      • Issue 8, Pages: 47-49(2007) DOI: 10.13422/j.cnki.syfjx.2007.08.018
        摘要：目的:探讨壮阳填精口服液对肾阳虚小鼠免疫功能的影响。方法:用氢化可的松制备肾阳虚小鼠模型;灌胃给予壮阳填精口服液10日后测定小鼠胸腺指数、脾指数;MTT法测定脾淋巴细胞增殖反应;流式细胞术测定T淋巴细胞亚型。结果:壮阳填精口服液显著提高肾阳虚小鼠胸腺指数,降低其脾指数;促进肾阳虚小鼠ConA、LPS诱导的淋巴细胞增殖反应;显著提高肾阳虚小鼠CD4+亚型细胞百分比及CD4+/CD8+的比值,降低CD8+细胞百分比。结论:壮阳填精口服液明显增强肾阳虚小鼠的免疫功能。  
        关键词：壮阳填精口服液;免疫;阳虚:脾细胞增殖;T淋巴细胞   
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      • Issue 8, Pages: 49-51(2007) DOI: 10.13422/j.cnki.syfjx.2007.08.019
        摘要：目的:研究精制藿胆方抗菌作用。方法:体外抗菌试验采用液体试管法,观察精制藿胆方的最低抑菌浓度;体内抗菌试验采用治疗感染肺炎双球菌、乙型溶血性链球菌、金黄色葡萄球菌的小鼠模型的方法。结果:体外抗菌试验对所试菌种（金黄色葡萄球菌、甲型溶血性链球菌、乙型溶血性链球菌、肺炎链球菌、卡他球菌、白喉棒状杆菌、大肠埃希菌、绿脓假单胞菌及白色念珠菌）均有不同程度的抗菌作用;体内抗菌试验对肺炎双球菌、乙型溶血性链球菌、金黄色葡萄球菌有较强的抑制作用。结论:精制藿胆方体内外对多个菌株有抗菌作用。  
        关键词：精制藿胆方;体外抗菌作用;体内抗菌作用   
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      • Issue 8, Pages: 52-53(2007) DOI: 10.13422/j.cnki.syfjx.2007.08.020
        摘要：目的:观察芩连抗病毒胶囊的抗炎镇痛作用。方法:用棉球包埋法引起大鼠肉芽肿和二甲苯致小鼠耳廓肿胀的方法观察抗炎作用;采用热板致痛法和醋酸扭体法观察镇痛作用。结果:芩连抗病毒胶囊能抑制肉芽肿组织的增殖;能降低小鼠耳廓肿胀度和肿胀百分率;能提高小鼠热板痛阈值和醋酸致小鼠扭体反应出现的潜伏期,减少15 min内的扭体反应次数。结论:芩连抗病毒胶囊具有抗炎镇痛作用。  
        关键词：芩连抗病毒胶囊;抗炎;镇痛   
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      • ZHANG Shi-long,ZHAI Ren-you,DAI Ding-ke,LI Jian-jun,WEI Bao-jie,LIU Jin-mei
        Vol. 13, Issue 8, Pages: 54-57(2007)
        摘要：Objective:To evaluate the technique of improving the image quality of DSA(Digital substraction angiography) in animal experiment and enhance the veracity of the experiment and its persuasion.Methods:In the experiment of pulmonary embolism with 85 canines,the parameter was selected with six frames per second to increase the chance of acquiring the best image.The contrast media of 75% high concentration was used to increase the contrast and definition.Before the angiography,the pressure on abdomen of canine was enhanced and 1～3 mL Diprivan was used to weaken the respiration of canine and make preparation for the angiograph.The techniques of brim enhancing and pixel shift were used to improve the image quality after exam.Results: The artifact of the DSA image was reduced when the above methods were used.The experiments were accomplished successfully and the image quality was improved.Conclusions: In the angiograph of the animal experimental,the DSA image quality can be improved and satisfactory effect can be acquired through selecting the parameter of the DSA and controlling the move and respiration of the animal using the methods of medication and physics.  
        关键词：animal experiment;image quality;digital substraction angiography   
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      • ZHANG Shi-long~,ZHAI Ren-you,DAI Ding-ke,LI Jian-jun,WEI Bao-jie,LIU Jin-mei
        Issue 8, Pages: 54-57(2007) DOI: 10.13422/j.cnki.syfjx.2007.08.025
        摘要：Objective:To evaluate the technique of improving the image quality of DSA（Digital substraction angiography） in animal experiment and enhance the veracity of the experiment and its persuasion.Methods:In the experiment of pulmonary embolism with 85 canines,the parameter was selected with six frames per second to increase the chance of acquiring the best image.The contrast media of 75% high concentration was used to increase the contrast and definition.Before the angiography,the pressure on abdomen of canine was enhanced and 1～3 mL Diprivan was used to weaken the respiration of canine and make preparation for the angiograph.The techniques of brim enhancing and pixel shift were used to improve the image quality after exam.Results: The artifact of the DSA image was reduced when the above methods were used.The experiments were accomplished successfully and the image quality was improved.Conclusions: In the angiograph of the animal experimental,the DSA image quality can be improved and satisfactory effect can be acquired through selecting the parameter of the DSA and controlling the move and respiration of the animal using the methods of medication and physics.  
        关键词：animal experiment;image quality;digital substraction angiography   
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      • Issue 8, Pages: 58-59(2007) DOI: 10.13422/j.cnki.syfjx.2007.08.022
        摘要：目的:探讨加味小柴胡汤对顺铂诱导的大鼠肝癌CBRH7919细胞凋亡相关基因表达的影响。方法:采用TUNEL,Ladder,免疫组化及完整细胞蛋白质斑点印迹技术等方法,检测各组细胞凋亡率及细胞凋亡蛋白的变化。结果:空白组细胞凋亡率为6%;顺铂组52%;实验1组（加味小柴胡汤大剂量）58%;实验2组（小剂量）53%。与空白组比,顺铂组及加味小柴胡汤2个剂量组Rb,Caspase-3,Bax,wp53均升高,Bcl-2,mp53降低。实验1,2组Rb,Bax,wp53明显较顺铂组升高,Bcl-2,mp53较顺铂组降低。结论:加味小柴胡汤是通过调控细胞凋亡相关基因,而增强顺铂的抑癌作用。  
        关键词：肝癌CBRH7919细胞;顺铂;加味小柴胡汤;凋亡率;细胞凋亡蛋白   
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      • Vol. 0, Issue 8, Pages: 57-63(2007) DOI: 10.13422/j.cnki.syfjx.2007.08.021
          
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      • MA Bo-yan~1,FU Lin-chun~
        Issue 8, Pages: 60-63(2007) DOI: 10.13422/j.cnki.syfjx.2007.08.023
        摘要：Objective:To study the effectiveness of Aikeqing Capsule to attenuate adverse effect and enhance curative effect of HAART by the clinical observation of 7 HIV/AIDS patients who have been taken HAART.Methods:7 HIV/AIDS patients on HAART treatment took Aikeqing Capsules orally.These patients were given plasma HIV viral load test,CD4,CD8 cell count,blood test and liver function test and their symptoms and signs were evaluated by the established evaluation criteria including scores of symptoms and signs（Score 1）,scores of symptoms and tongue and pulse examination（Score 2）.Body weight and the quality of life were valuated by Karnovsky Score before and after the treatment of three months and six months.Results:After the treatment of 6 months,the copy of HIV of the patients were controlled effectively.CD4 and CD8 counts and CD4/CD8 increased after the treatment of three months or six months,and CD4 counts and CD4/CD8 were signficantly higher than before treatment（P<0.01,P<0.05）.Score 1 and Score 2 significantly decreased,The abnormal indexes of the blood test and live function were also improved after the treatment.Conclusion:Aikeqing Capsule can attenuate adverse effects and enhance curative effects of HAART.It agrees with the results achieved from the animal experiments.  
          
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      • MA Bo-yan1,FU Lin-chun1,CAI Wei-ping2,CHEN Xie-jie2,HU Ying-jie1,TAN Xing-hua2
        Vol. 13, Issue 8, Pages: 60-63(2007)
        摘要：Objective:To study the effectiveness of Aikeqing Capsule to attenuate adverse effect and enhance curative effect of HAART by the clinical observation of 7 HIV/AIDS patients who have been taken HAART.Methods:7 HIV/AIDS patients on HAART treatment took Aikeqing Capsules orally.These patients were given plasma HIV viral load test,CD4,CD8 cell count,blood test and liver function test and their symptoms and signs were evaluated by the established evaluation criteria including scores of symptoms and signs(Score 1),scores of symptoms and tongue and pulse examination(Score 2).Body weight and the quality of life were valuated by Karnovsky Score before and after the treatment of three months and six months.Results:After the treatment of 6 months,the copy of HIV of the patients were controlled effectively.CD4 and CD8 counts and CD4/CD8 increased after the treatment of three months or six months,and CD4 counts and CD4/CD8 were signficantly higher than before treatment(P<0.01,P<0.05).Score 1 and Score 2 significantly decreased,The abnormal indexes of the blood test and live function were also improved after the treatment.Conclusion:Aikeqing Capsule can attenuate adverse effects and enhance curative effects of HAART.It agrees with the results achieved from the animal experiments.  
          
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      • Issue 8, Pages: 64-65(2007) DOI: 10.13422/j.cnki.syfjx.2007.08.002
        摘要：目的:观察双参促智颗粒对血管性痴呆（VD）患者的临床疗效,并探讨其部分作用机制。方法:选取符合标准的血管性痴呆患者72例,随机分为治疗组（双参促智颗粒组）和对照组（都可喜组）,治疗前和治疗3个月后分别评定其认知能力和日常生活活动能力,及检测同型半胱氨酸（HCY）,Vit-B12和叶酸（THF）,且与健康老年人对照。结果:治疗后两组认知能力和日常生活活动能力都有显著提高（P<0.05）。在认知能力方面,治疗组比对照组的简易精神状态检查（MMSE）积分改善明显（P<0.05）;与健康组比较,治疗前治疗组血浆HCY水平显著升高、血清THF和Vit-B12水平显著降低（P<0.01）;两组患者治疗后较治疗前血浆HCY水平显著降低、血清THF和Vit-B12水平均显著升高（P<0.01）;两组比较,治疗组改善明显（P<0.05）。结论:双参促智颗粒对VD患者的认知能力有明显改善作用,其部分作用机制可能与显著升高血中THF和Vit-B12水平,从而降低VD患者的血浆HCY水平有关。  
        关键词：双参促智颗粒;血管性痴呆;临床研究   
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      • SHI Dao-hua,CHEN Lu-ying,ZHENG Wei
        Vol. 13, Issue 8, Pages: 66-68(2007)
        摘要：Objective:To study the effects of traditional Chinese drugs using mathematical model and computer virtual technique.Methods:The effects of traditional Chinese drugs were investigated by traditional Chinese medicine physician together with mathematician,computer scientist,and pharmacologists using fuzzy mathematics,grey theory,and computer virtual technique,etc.Results:Equations about the complex effects of traditional Chinese drugs are solved clearly with little source of traditional Chinese drugs,money,and manpower.Conclusion:This method is simple and feasible.It is useful for the modernization of traditional Chinese drugs.  
        关键词：traditional chinese drugs pharmacodynamics;mathematics;computer;virtual technique   
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      • SHI Dao-hua~,CHEN Lu-ying,ZHENG Wei
        Issue 8, Pages: 66-68(2007) DOI: 10.13422/j.cnki.syfjx.2007.08.026
        摘要：Objective:To study the effects of traditional Chinese drugs using mathematical model and computer virtual technique.Methods:The effects of traditional Chinese drugs were investigated by traditional Chinese medicine physician together with mathematician,computer scientist,and pharmacologists using fuzzy mathematics,grey theory,and computer virtual technique,etc.Results:Equations about the complex effects of traditional Chinese drugs are solved clearly with little source of traditional Chinese drugs,money,and manpower.Conclusion:This method is simple and feasible.It is useful for the modernization of traditional Chinese drugs.  
        关键词：traditional chinese drugs pharmacodynamics;mathematics;computer;virtual technique   
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      • Issue 8, Pages: 69-70(2007) DOI: 10.13422/j.cnki.syfjx.2007.08.003
        摘要：目的:介绍著名中西医结合肿瘤专家郁仁存老师运用中医以及中西医结合治疗胃癌的学术思想和临床用药经验。方法:作为第三批国家级名老中医经验继承人,采用跟师临症学习的方式,将郁仁存老师运用中医以及中西医结合疗法治疗胃癌的学术思想和临床用药经验进行归纳和总结。结果结论:中医治疗可应用于各期胃癌患者以及胃癌治疗的各个阶段,尤其对于无法手术及放化疗的晚期患者,中医治疗作为主要的治疗手段,在胃癌的治疗中发挥着重要的作用。作为综合治疗的一部分,有计划地与手术、放化疗等结合使用,可促进手术后体力恢复,减轻放化疗的毒副反应,提高放化疗疗效,预防胃癌转移及复发,提高近期及远期疗效。  
        关键词：郁仁存;治疗;胃癌;经验   
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      • YIN Lian~
        Issue 8, Pages: 71-73(2007) DOI: 10.13422/j.cnki.syfjx.2007.08.024
        摘要：Objective:To study principles of diagnosis of categorized formulas,and provide how to study principles of diagnosis of categorized formulas.Methods:Taking for demonstration the categorized formulas of Ermiao Wan,Sanmiao Wan,Simiao Wan,and Jiawei Simiao Wan,its structure of formulation,pathogenesis for treatment disease and the effect were discussed.Results:Ermiao Wan Categorized Formula are relativity on structure of formulation and the effect of anti-inflammatory,analgesia,reduction of uric acid levels and immuno-potentiating actions.  
        关键词：Ermiao wan categorized formula;principles of diagnosis;relativity   
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      • YIN Lian
        Vol. 13, Issue 8, Pages: 71-73(2007)
        摘要：Objective:To study principles of diagnosis of categorized formulas,and provide how to study principles of diagnosis of categorized formulas.Methods:Taking for demonstration the categorized formulas of Ermiao Wan,Sanmiao Wan,Simiao Wan,and Jiawei Simiao Wan,its structure of formulation,pathogenesis for treatment disease and the effect were discussed.Results:Ermiao Wan Categorized Formula are relativity on structure of formulation and the effect of anti-inflammatory,analgesia,reduction of uric acid levels and immuno-potentiating actions.  
        关键词：Ermiao wan categorized formula;principles of diagnosis;relativity   
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