最新刊期
      卷 15 ， 期 7 ， 2009
      • KANG Chen1,LI Man-ling1,WANG Qian1,HUANG Lu-qi1,Franco Francesco Vincieri2,Anna Rita Bilia2
        Vol. 15, Issue 7, Pages: 1-3(2009) DOI: 10.13422/j.cnki.syfjx.2009.07.012
        摘要：Objective: To study and determine the Water-soluble substances of Salvia chinensis.Methods: The constituents of the n-Butanol-soluble portion of the water extractive were isolated and purified by means of Sephadex LH-20 column chromatographic methods.HPLC was used to determine the contents.Results: Two compounds were isolated and identified as danshensu and rosmarinic acid.The linear range of danshensu was 1.48～7.40 μg.The average recovery was 102.8% and RSD was 1.04%;The linear range of protocatechualdehyde was 0.05～0.26μg.The average recovery was 101.5% and RSD was 0.72%.Conclusion: The method can provide useful references to quality control of Herba Salvia chinensis.Danshensu was firstly isolated from Herba Salvia chinensis.  
        关键词：Herba Salvia chinensis;danshensu;rosmarinic acid;protocatechualdehyde;assaying   
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      • Vol. 15, Issue 7, Pages: 3-5(2009) DOI: 10.13422/j.cnki.syfjx.2009.07.013
        摘要：目的:探讨不同提取溶剂、不同比例配伍对黄芩柴胡"药对"中主要药效成分黄芩苷含量的影响;方法:选用水和70%的乙醇作为提取溶剂,参照临床常用给药方法对不同比例配比（0∶1,1∶1,1∶2,2∶1,1∶0）的黄芩柴胡"药对"进行提取并采用RP-HPLC法考察对"药对"中的主要药效成分黄芩苷含量的影响;结果:采用水和70%乙醇进行提取对黄芩-柴胡"药对"中的主要药效成分黄芩苷的提出无显著影响,"药对"不同比例配伍对提取液中黄芩苷的含量影响亦较小,但HPLC图中黄芩苷峰前的一个吸收峰明显增大,提示混合提取能提高其他组分的提出。结论:黄芩-柴胡"药对"不同提取溶剂、不同比例配伍对其主要药效成分黄芩苷的含量没有太多影响,但混提能明显提高其他药物成分的提出。  
        关键词：黄芩-柴胡药对;黄芩苷;物质基础;高效液相色谱法   
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      • XUE Xiao-ping,LU Yan-min,WANG Qian,LIU Hong-bin
        Vol. 15, Issue 7, Pages: 6-8(2009) DOI: 10.13422/j.cnki.syfjx.2009.07.014
        摘要：Objective:To develop an HPLC method for determination of aloe-emodin,rhein,emodin,chrysophanol and physcion in QING RE JIE DU entract.Methods: The analysis was carried out on a Kromasil C18（250 mm×4.6 mm,5 μm）column eluted with a mobile phase of methanal-water containing 0.2% phosphoric acid solution（V∶V=85∶15）.The flow rate was 1.0 mL·min-1 and column temperature was 35 ℃.The detection wavelength was set at 254 nm.Results: The calibration curve was linear within the range of 1.012 5～16.2,1.025～16.4,1.025～16.4,1.025～16.4 and 0.625～10 μg for aloe-emodin,rhein,emodin,chrysophanol and physcion,respectively.The average recoveries were 101.5%,99.2%,101.9%,101.5%,101.4% for the abore five conponents,respectively.Conclusion: This method is convenient,accurate and reproducible for determination of aloe-emodin,rhein,emodin,chrysophanol and phascion in QING RE JIE DU extraet.  
        关键词：HPLC;aloe-emodin;rhein;emodin;chrysophanol;physcion;QING RE JIE DU extraet   
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      • LI Yu-cui,CHEN Zhi-wei,BAO Mei-jia,HU Jia-min,PENG Shao-zhong,LI Ming,SU Zi-ren
        Vol. 15, Issue 7, Pages: 9-11(2009) DOI: 10.13422/j.cnki.syfjx.2009.07.015
        摘要：Objective:To establish a method for the determination of effective components in Lingzhi Jiangtang Capsule.Methods: The contents of ginsenoside Rg1、Re、Rb1 and notoginsenoside R1 in Lingzhi Jiangtang Capsule were determined by HPLC.Results: The resolutions of the determined peaks were fine.The linearity ranges for ginsenoside Rg1,ginsenoside Re,ginsenoside Rb1 and notoginsenoside R1 were 3.86～23.16 μg（r=0.999 9）,0.628～3.768 μg（r=0.999 9）,3.74～22.44 μg（r=0.999 9） and 0.764～4.584 μg（r=0.999 9） respectively.The average recoveries were 100.18% with RSD 1.52%,100.22% with RSD 0.41%,100.51% with RSD 0.74%,and 99.05% with RSD 1.10% for ginsenoside Rg1,ginsenoside Re,ginsenoside Rb1,notoginsenoside R1 respectively.Conclusion: The quantitative method for determining the ingredient of Lingzhi Jiangtang Capsule is simple,feasible and repeatable,and is beneficial to quality control of Lingzhi Jiangtang Capsule.  
        关键词：Lingzhi Jiangtang Capsule;HPLC;Ginsenoside Rg1;Ginsenoside Re;ginsenoside Rb1;notoginsenoside R1   
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        发布时间：2024-09-23
      • HUANG Sen1,LIU Bo2
        Vol. 15, Issue 7, Pages: 12-13(2009) DOI: 10.13422/j.cnki.syfjx.2009.07.016
        摘要：Objective:To develop an HPLC method for determination of Isocorydine in Jinshining Eye gelatin.Method: AgiLentTC-C18 chromatographi coLumn（4.6 mm×150 mm,5 μm） was used,methanoL-0.2% phosphoric acid soLution（adjust the pH 7.0 take methyL aLcohoL）（54∶46）as the mobiLe phase,the detection waveLength was 267 nm,fLow rate at 1.0 mL·min-1.Result:The calibration curve of Isocorydine as linear between 0.123 0～1.107 0 μg,The average recovery and the relative standard deviation were 97.11% and 1.65%.Conclusions:The method is simple,accurate,repeatable.It can be used for quality control of JinshiLe Eye gelatin.  
        关键词：HPLC;Jinshining Eye gelatin;Isocorydine   
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      • ZHANG Yan,JIN Xiang-qun,WANG Guang-shu
        Vol. 15, Issue 7, Pages: 14-16(2009) DOI: 10.13422/j.cnki.syfjx.2009.07.017
        摘要：Objective:To establish the qualitative and quantitative methods for Gubaoxinshen Tablets.Method: Soy bean,and epimedium herb were identified by TLC,and the content of genistein and icarrin were determined by HPLC.Result: The developed TLC sports were was fairly clear,the HPLC method showed good repeatability.The average recovery of genistein was 98.9% with RSD 0.9%,and the average recovery of icarrin the was 98.0% with RSD 1.0%.Conclusion: The method is simple,accurate and can becauseofon control quality of Gubaoxinshen Tablets.  
        关键词：HPLC;TLC;genistein;icarrin;Gubaoxinshen Tablets   
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      • Vol. 15, Issue 7, Pages: 17-19(2009) DOI: 10.13422/j.cnki.syfjx.2009.07.018
        摘要：目的:建立高效液相色谱法测定功劳去火片中盐酸巴马汀和盐酸小檗碱的含量。方法:采用Shimadzu-C18柱,乙腈-0.05 mo.lL-1磷酸二氢钠溶液（用磷酸调节pH至3）（35∶65）为流动相;检测波长为345 nm。结果:测得盐酸巴马汀线性范围0.056 1～0.561μg（r=0.999 9）,盐酸小檗碱线性范围0.052 2～0.522μg（r=0.999 9）,加样回收试验测得盐酸巴马汀平均回收率为99.32%,RSD为1.09%（n=5）;盐酸小檗碱平均回收率为99.96%,RSD为1.98%（n=5）。结论:该法准确,专属性强。  
        关键词：高效液相色谱法;功劳去火片;盐酸巴马汀;盐酸小檗碱   
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      • DU Xiao-wei1,ZHANG Wen-wei1,YU Dan1,CAO Hong-xin2,LIU Yan1,WU Pei-can1
        Vol. 15, Issue 7, Pages: 19-22(2009) DOI: 10.13422/j.cnki.syfjx.2009.07.019
        摘要：Objective:To study the qualitative and quantitative methods of Shenbai concentrated pills.Methods: Danshen root and lightyellow sophora root in Shenbai concentrated pills were identified with the method of TLC.The contents of astragaloside Ⅳ and paeoniflorin were determined with the method of HPLC.Results: For TLC,the spots of the two herbal drugs were well separated and without interference.Quantitative analysis of HPLC showed that the average recovery of astragaloside Ⅳ was 100.82%（RSD1.73%） with the RSD values of precision,repeatability and stability tests were 2.79%,1.48% and 1.44%,respectively;and the average recovery of paeoniflorin was 99.83%（RSD2.34%） with the RSD values of precision,repeataibility and stability tests were 2.25%,2.16% and 1.60%,respectively.Conclusions: The methods set up by this study are accurate and easy to perform with the merits of good resolution,specificity and reproducibility.It could effectively control the quality of Shenbai concentrated pills.  
        关键词：Shenbai concentrated pills;quality standards;TLC;HPLC   
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      • Vol. 15, Issue 7, Pages: 23-24(2009) DOI: 10.13422/j.cnki.syfjx.2009.07.020
        摘要：目的:建立复方补骨脂颗粒的质量标准。方法:采用HPLC法对复方补骨脂颗粒的赤芍进行含量测定。结果:芍药苷在0.0825～3.30μg之间呈良好的线性关系,r=0.999,平均回收率为99.3%。RSD为0.93%。结论:所建立的方法简便,重复性好,可作为复方补骨脂颗粒的质量控制方法。  
        关键词：复方补骨脂颗粒;赤芍;芍药苷;高效液相色谱法   
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      • ZHANG Rong1,Deng Xiu-xia2,WEI Gang1,LI Run-mei1,LI Wen-zhou1,CHEN Jun1
        Vol. 15, Issue 7, Pages: 25-27(2009) DOI: 10.13422/j.cnki.syfjx.2009.07.021
        摘要：Objective: To denvolop HPLC an method for the determination of the content of three saponins in Zhixiao suppositories.Methods: Analysis carriedout was performed on a Kromasil C18 column（4.6 mm×250 mm.,5 μm）at 23 ℃.The mobile phases were methanol and 0.2% phosphoricacid solution in a gradient elution.The flow rate was set at 1.0 mL·min-1 and the ultraviolet detector was operated at 203 nm.Results: The linear ranges of notoginsenoside R1,ginsenoside Rg1 and ginsenoside Rb1 were 0.368～2.76 μg,0.676～5.07 μg and 0.812～6.09 μg,respectively.The average recoveries of the three saponins were 98.53%,99.20% and 99.35%,respectively.The RSD（n=5）were 2.11%,1.88% and 2.38%,respectively.Conclusion: The separation is a good and the results are accurate and reproducible.It can be used for the quality control of Zhixiao suppositories.  
        关键词：Zhixiao suppositories;notoginsenoside R1;Ginsenoside Rg1;ginsenoside Rb1;HPLC   
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      • Vol. 15, Issue 7, Pages: 28-30(2009) DOI: 10.13422/j.cnki.syfjx.2009.07.022
        摘要：目的:建立糖脂欣口服液中多糖及腺苷含量测定方法。方法:采用苯酚-硫酸法测定了糖脂欣口服液中多糖的含量;采用HPLC法测定糖脂欣口服液中腺苷的含量。结果:测定多糖含量时,回归方程Y=0.007 2X+0.010 3,r=0.999 6,线性范围为12.5～100μg.mL-1,平均加样回收率为99.7%;HPLC测定腺苷含量时,以磷酸盐缓冲液（pH6.5）-甲醇（17∶3）为流动相;流速为1 mL.min-1,检测波长为260 nm,回归方程Y=110.47X-4.11,r=0.999 9,线性范围为3.04×10-2～15.20×10-2μg,平均加样回收率为99.0%。结论:建立的测定方法灵敏度高、重现性好,可用于糖脂欣口服液的质量控制。  
        关键词：糖脂欣口服液;人工蛹虫草;多糖;腺苷;高效液相   
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      • Vol. 15, Issue 7, Pages: 31-33(2009) DOI: 10.13422/j.cnki.syfjx.2009.07.046
        摘要：目的:研究克林霉素磷酸酯注射液在不同条件下贮存的稳定性。方法:通过影响因素试验及加速试验,考察克林霉素磷酸酯注射液的外观、pH值、含量和有关物质。结果:该注射液在强光下较稳定,对热则很敏感。在（30±2）℃,相对湿度60%±5%条件下放置6个月,各项指标基本符合规定。结论:该品对热较敏感,在（30±2）℃,相对湿度60%±5%条件下较稳定,故应存放于阴凉处。  
        关键词：克林霉素磷酸酯注射液;稳定性;含量   
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      • Vol. 15, Issue 7, Pages: 34-37(2009) DOI: 10.13422/j.cnki.syfjx.2009.07.028
        摘要：目的:建立金力胶囊中多糖含量测定的方法。方法:采用硫酸-蒽酮法测定金力胶囊中多糖含量。结果:多糖在0.017 2～0.086 mg.mL-1范围内呈良好的线形关系（r=0.998 1）,平均回收率99.42%（n=6）,RSD为3.22%。结论:该法测定金力胶囊中多糖,方法准确可靠,重复性好。  
        关键词：金力胶囊;多糖;含量测定   
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      • Vol. 15, Issue 7, Pages: 30(2009) DOI: 10.13422/j.cnki.syfjx.2009.07.039
          
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      • Vol. 15, Issue 7, Pages: 49-99(2009) DOI: 10.13422/j.cnki.syfjx.2009.07.006
          
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      • Vol. 15, Issue 7, Pages: 64(2009) DOI: 10.13422/j.cnki.syfjx.2009.07.004
          
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      • Vol. 15, Issue 7, Pages: 100(2009) DOI: 10.13422/j.cnki.syfjx.2009.07.043
          
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      • Vol. 15, Issue 7, Pages: 100-101(2009) DOI: 10.13422/j.cnki.syfjx.2009.07.040
          
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      • Vol. 15, Issue 7, Pages: 101-102(2009) DOI: 10.13422/j.cnki.syfjx.2009.07.008
          
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      • Vol. 15, Issue 7, Pages: 102-103(2009) DOI: 10.13422/j.cnki.syfjx.2009.07.007
          
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      • Vol. 15, Issue 7, Pages: 103-104(2009) DOI: 10.13422/j.cnki.syfjx.2009.07.042
          
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      • Vol. 15, Issue 7, Pages: 104(2009) DOI: 10.13422/j.cnki.syfjx.2009.07.044
          
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      • Vol. 15, Issue 7, Pages: 35-37(2009) DOI: 10.13422/j.cnki.syfjx.2009.07.029
        摘要：目的:研究决明子Cassia obtusifolia中的苷类化学成分。方法:采用各种现代色谱方法对决明子进行提取分离,并运用波谱方法鉴定其结构。结果:分离鉴定了7个苷类化合物,分别为Obtusifolin-2-O-β-D-glucoside（1）、决明子苷（2）、决明子苷B（3）、rubrofusarin gentiobioside（4）、Alaternin-2-O-β-D-glucopyranoside（5）、大黄素-8-O-β-D-glucopyranoside（6）、aurantio-obtusin-6-O-β-D-glucopyranoside（7）。结论:化合物1,4,5为首次从豆科植物决明Cassia obtusifolia中分离得到,并首次对化合物7的13C-NMR信号作了全归属。  
        关键词：决明子;化学成分;蒽醌苷;萘并吡喃酮苷   
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      • Vol. 15, Issue 7, Pages: 38-40(2009) DOI: 10.13422/j.cnki.syfjx.2009.07.001
        摘要：目的:研究一种妇科腔道用药中药新制剂"参柏克霉泡沫气雾剂"。方法:采用L9（34）正交试验法,以泡沫稳定时间、苦参碱含量为量效考察指标,对影响制剂成型工艺的关键环节如抛射剂密度、用量、共溶剂和助剂用量4因素进行了优选考察;对雾化效果及其影响因素进行了初步考察。结果:对综合评分影响程度最大的因素为抛射剂密度,最佳成型工艺为:A2B2C3D2,即以密度为0.6 mg.mL-1的丙/丁烷混合气为抛射剂,抛射剂:药液比为5∶5,以吐温-80为助溶剂,以3%两性甜菜碱为发泡剂。结论:该工艺合理、稳定,为中药泡沫气雾剂的研究提供了依据。  
        关键词：参柏克霉泡沫气雾剂;苦参碱;正交试验   
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      • Vol. 15, Issue 7, Pages: 41-42(2009) DOI: 10.13422/j.cnki.syfjx.2009.07.030
        摘要：目的:通过正交实验优选牡丹皮的最佳提取工艺。方法:以牡丹皮的提取量为指标,通过正交实验法对提取过程中加水量、蒸馏时间、蒸馏液流速3个因素进行筛选。结果:加水量和蒸馏液流速均对丹皮酚提取量有显著影响,蒸馏时间有极显著性影响。结论:牡丹皮中丹皮酚的提取工艺为加14倍水量,控制蒸馏液流速按每100 g药材为3 mL.min-1,蒸馏5 h。  
        关键词：牡丹皮;丹皮酚;提取工艺;正交实验   
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      • Vol. 15, Issue 7, Pages: 42-44(2009) DOI: 10.13422/j.cnki.syfjx.2009.07.002
        摘要：目的:优选β-环糊精包合荜澄茄超临界提取精油的工艺。方法:采用L9（3）4正交实验方法,以油利用率及包合物得率两个指标,考察β-CD与精油的比例、包合温度、包合时间3因素对β-环糊精包合荜澄茄超临界提取精油工艺的影响。结果:优选出工艺为A2B2C2,即β-环糊精:精油为7∶1,包合温度为60℃,包合时间为2 h。结论:包合方法工艺简单,方便实用,有效地提高了荜澄茄超临界提取精油的稳定性。  
        关键词：荜澄茄;挥发油;β-环糊精;包合工艺   
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      • Vol. 15, Issue 7, Pages: 45-47(2009) DOI: 10.13422/j.cnki.syfjx.2009.07.003
        摘要：目的:优选板蓝根滴丸最佳制备工艺。方法:以浸膏得率、总含氮量、丸重差异、溶散时限、滴丸成型率等为评价指标,进行工艺优选;并进行中试放大研究。结果:加水煎煮两次,第一次加水8倍量,煎煮1 h,第二次加水6倍量,煎煮45min;板蓝根浸膏的含水量控制在30%以内;冷却温度为5～10℃;滴丸基质为聚乙二醇6 000,中药浸膏与基质的比例为1∶2,药液滴制温度为80℃;滴速为50～60滴/min。结论:该工艺合理可行,适用于板蓝根滴丸的制备与生产。  
        关键词：板蓝根滴丸;制备工艺;正交试验   
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      • Vol. 15, Issue 7, Pages: 47-49(2009) DOI: 10.13422/j.cnki.syfjx.2009.07.031
        摘要：目的:对复方六味地黄汤的煮散和传统汤剂的煎出率进行比较研究。方法:比较两种剂型总浸出物的煎出率以及用高效液相测定两种剂型中的马钱苷煎出率。结果:六味地黄汤煮散的总浸出物量及马钱苷的煎出率都高于传统汤剂。结论:应用中药煮散可达到节约药材,提高中药使用率的目的。  
        关键词：马钱苷含量;总浸出物;煮散;传统汤剂   
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      • CAO Zhen-hua,YIN Jun-xiang,TIAN Jin-zhou,SHI Jing,WANG Wen-jie,LI Le-Jun,WANG Peng-wen,REN Ying,ZHU Zhi-hui,SUN Hai-yun
        Vol. 15, Issue 7, Pages: 50-53(2009) DOI: 10.13422/j.cnki.syfjx.2009.07.005
        摘要：Objectives:To observe the changes of the tongues in rats with blood-stasis syndrome induced mainly by cold.To explore the evidence that tongues were the target of blood stasis syndrome and the target of medication.Methods: Rats with blood-stasis syndrome induced by cold（BSC group） were dipped into ice water（0 ℃） for 5 minutes every day and lasted 20d individually.Different drugs were given orally after the model establishment.And then we took photos of tongues of all rats by digital camera,analyzed the gray scale value of all rats’ tongues using image analysis software,and observed the capillaries in tongues by electron microscope.Results: The tongues of rats which had been frozen in ice water for 20 d（once a day） were dark purple,the same as that of models induced by chemical materials.While as for the normal rats,the tongues were lustrous and ruddy.The changes of color of the tongues persisted about 1 week and were great obvious at the 3rd day after the model establishment among different time-points.After given different drugs,the degree of dark purple tongue degraded,showed significant difference（P<0.01） from that of model rats.The capillary stegnosis and nucleus turgescence of vascular endothelial cell were observed in tongues in BSC group by using electron microscope.After medication,the above changes recovered.Conclusion:The degree of dark purple tongue indicates the degree of diseases with blood-stasis syndrome.The tongue probably is a target of drug treatment.  
        关键词：tongue;target;cold irritation;blood-stasis syndrome   
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      • LIU Ming-ping1,HUANG Zhao-sheng2,YANG Ni-zhi3,WEI Ping-qing1,WU Qing-guang1
        Vol. 15, Issue 7, Pages: 54-57(2009) DOI: 10.13422/j.cnki.syfjx.2009.07.027
        摘要：Objective:To observe the therapeutic effects of effective compounds which were extracted from TongMai.Methods: SD rats experimential model with MsPGN were induced by subcutaneously injection rabbit anti-rat thymocyte serum（ATS） and forced swim.The rats were respectively ig with different dose（1.2,0.6,0.3 g·kg-1） of effective compound of TongMai for 4 weeks.Then the proliferative degree of mesangium was examined by HE stain,PAS stain and immunfluorescent respectively.Mesagium area proportion in glomerular capillaries area was calculated using image analyzing system.The expression of PCNA in the glomeruli was examined by immunohis to chemistry.Results: The effective compounds of TongMai can control the hyperplasia of the glomerular mesangial cells（GMC）and the mainifold of the mesangial matrix,and prevent the deposit of IgG in mesangium.The proportions in glomerular capillaries area in model control group were significantly higher than that in the treatment groups;The express of proliferative cell nuclear antigen（PCNA） were ascended either.Conclusion: The effective compound of TongMai can improve the damage s of pathology in glomerular.  
        关键词：Effective compounds of Tongmai;MsPGN;Pathological injury   
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      • JIA De-xian1,JI Xiao-mei2,Wang Qian1,HAO Yu1,ZHANG Qiu-xia2,CHAI Xin-lou1,LIU Ying-shu1,TIAN Peng-fei1,SU Wei-lian3,REN Li-wei1
        Vol. 15, Issue 7, Pages: 57-59(2009) DOI: 10.13422/j.cnki.syfjx.2009.07.026
        摘要：Objective:To observe the changes of glycemia,urine protein,serum creatinine,blood urea nitrogen and glycosylated hemoglobin in diabetic nephropathy rats and treating effects of Xiaokekang.Methods: Streptozotocin（STZ） was abdominally administered and was feeded by high lipid diet to establish diabetic nephropathy model in rats.Animals were divided into three groups: model group,Xiaokekang treatment group and normal group.Changes in glycemia,serum lipids,serum creatinine,blood urea nitrogen were measured at the 8th,12th and 16th week after STZ injection.Glycosylated hemoglobin was measured at the 16th weeks after STZ injection.Results: Glycemia,serum lipids,serum creatinine were higher at the 8th,12th and 16th week compared with normal group.Serum creatinine was higher at the 12th and 16th week,and glycosylated hemoglobin was also highter than that of the normal group.Xiaokekang reduced these changes.Conclusion: Xiaokekang can reduce glycemia,serum lipids and protect renal function.  
        关键词：Xiaokekang;diabetic nephropathy;rat   
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      • Vol. 15, Issue 7, Pages: 60-61(2009) DOI: 10.13422/j.cnki.syfjx.2009.07.025
        摘要：目的:探讨补阳还五汤家兔含药血清对PAF诱导的家兔血小板聚集的影响。方法:制备补阳还五汤家兔含药血清,用血小板聚集功能测定法观察补阳还五汤含药血清对PAF诱导的家兔血小板聚集的影响。结果:补阳还五汤含药血清对PAF诱导的家兔血小板聚集有明显的抑制作用,与对照组比较差异有显著性意义（P<0.01）。结论:补阳还五汤家兔含药血清中的某些有效活性成份对PAF诱导的家兔血小板聚集有抑制作用。  
        关键词：补阳还五汤;含药血清;血小板活化因子;血小板聚集   
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      • Vol. 15, Issue 7, Pages: 62-64(2009) DOI: 10.13422/j.cnki.syfjx.2009.07.024
        摘要：目的:研究益智汤的抗氧化作用。方法:大鼠给予益智汤14 d后,采血检测大鼠血清总抗氧化能力（T-AOC）、超氧化物歧化酶（SOD）、丙二醛（MDA）和B型单胺氧化酶（MAO-B）含量,取脑测定脑组织脂褐素（LF）、MAO-B含量;小鼠D-半乳糖注射致衰老,同时给予益智汤4周,采血检测小鼠鼠血清T-AOC、SOD含量。结果:益智汤能明显升高大鼠血清T-AOC、SOD含量,降低血清MDA、MAO-B含量,降低脑组织LF、MAO-B含量,并能升高D-半乳糖衰老小鼠血清T-AOC、SOD含量。结论:益智汤有一定抗氧化作用。  
        关键词：益智汤;抗氧化;衰老   
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      • ZHANG Zheng-xiang1,CAO Ke-gang1,GAO Yong-hong2,FAN Ji-ping3
        Vol. 15, Issue 7, Pages: 65-68(2009) DOI: 10.13422/j.cnki.syfjx.2009.07.038
        摘要：Objective:To determine the appropriate time of early administration of dopamine（DA） before nitroglycerin（GTN） for establishing rat model with vasomotor abnormalities.Methods: Rats were divided into 5 groups: normal group,DA Group and other 3 groups in accordance with DA at different time points（10,30,45 min） plus GTN.Common carotid artery（CCA） blood flow velocity was dynamically measured with pulsed Doppler flow probe to evaluate the influence of DA,GTN on blood flow velocity rate（BFVR）.Results:The blood flow velocity rate induced by DA of All medication administration was different from the normal group within 10 minutes（P<0.05）.However,the differences were not statistically significant after 11 min（P>0.05）.The BFVR of 10min interval group had differences with the DA group at 45min,50min,55min,60min,65min and 70min（P<0.05 or P<0.01）.CCA BFVR of 45 min interval group was statistically significant different from the DA group at 80,85,90,95 min and 100 min（P<0.05）.No statistically significant differences existed between CCA BFVR of 30min interval group and DA group（P>0.05）.Conclusion: Subcutaneous injection of DA,45min after injection of GTN can induce vasomotor abnormalities in rat with phase characters.The model may be useful for vasoactive screening of anti-migraine drugs.  
        关键词：vasomotion;animal model;blood flow velocity;migraine   
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      • Vol. 15, Issue 7, Pages: 69-71(2009) DOI: 10.13422/j.cnki.syfjx.2009.07.023
        摘要：目的:研究银翘散对流感病毒FM1感染小鼠的保护作用及作用机制。方法:将实验小鼠分为空白对照组、模型组、病毒唑组及银翘散大、中、小剂量组,分别观察实验小鼠行为状态、死亡率、肺指数及肺指数抑制百分率。结果:银翘散各剂量组有明显改善流感病毒FM1感染小鼠行为状态的作用;银翘散中、小剂量组与模型组比较,死亡率显著降低,表明银翘散对流感病毒FM1感染小鼠具有保护作用;银翘散大、中剂量组显著降低流感病毒FM1感染小鼠模型的肺指数,说明银翘散能显著抑制病毒在体内增殖,减轻肺部炎性病变。结论:银翘散中、小剂量组对流感病毒FM1感染小鼠具有保护作用,其作用机制可能与银翘散能显著抑制病毒在体内的增殖、减轻肺部炎性病变有关。  
        关键词：银翘散;流感病毒FM1;病毒感染   
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      • Vol. 15, Issue 7, Pages: 72-73(2009) DOI: 10.13422/j.cnki.syfjx.2009.07.011
        摘要：目的:观察中药内外合治对甲亢模型大鼠甲状腺激素水平的影响。方法:将SD大鼠随机分成6组:正常对照组、甲亢模型组、西药对照组、甲亢方内治组、甲亢平膏外治组,内外合治组。用优甲乐灌服制作大鼠甲亢模型,观察甲亢方内服和甲亢平膏外贴相结合对模型大鼠的影响,21 d后放免法测定血清游离三碘甲状腺原氨酸（FT3）、游离甲状腺素（FT4）、三碘甲状腺原氨酸（T3）、甲状腺素（T4）、促甲状腺激素（TSH）含量。结果:中药内外合治能降低甲亢大鼠血清T3、T4、FT3、FT4含量,提高血清TSH,作用优于单用内服及单用外治。结论:中药内外合治能够显著改善甲亢大鼠甲状腺功能。  
        关键词：内外合治;甲亢;大鼠;甲状腺激素   
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      • BAI Yu-xin1,FU Liang2,GAO Jin2
        Vol. 15, Issue 7, Pages: 74-76(2009) DOI: 10.13422/j.cnki.syfjx.2009.07.037
        摘要：Objective:To investigate the effect of astragalus on the serum levels of hepatocyte growth factor（HGF）,renal function and the damage of renal morphology in ischemic acute renal failure（IARF）.To study the protective mechanism of astragalus in IARF.Methods: The rats were pretreated with astragalus or vehicle for 3 days.IARF was induced by left renal artery clipping for 60 min,after the right kidney was removed.Biochemical parameters for serum HGF,blood urea nitrogen（BUN）,creatinine（Cr） were measured and histological analyses of the kidneys were performed by tubular grading.Results: There have no significant difference between the serum HGF levels of I/R controls and the levels observed in sham-operated group（P>0.05）.Serum HGF levels in astragalus treated group was significantly increased than those of I/R control group（P<0.01）.After 4 h of I/R,serum levels of BUN and Cr were increased in I/R control rats compare with Sham-operated rats（P<0.01）.Astragalus treatment reduced the levels elevation（P<0.05）.Simultaneously,I/R-induced severe damage in renal morphology were significantly ameliorated by astragalus treatment（P<0.01）.Conclusions: Astragalus pretreatment can alleviate the damage of renal function in IARF.It is may be one of the mechanisms of astragalus for protecting renal tissue in IARF that astragalus can induce the expression of HGF.  
        关键词：acute renal failure;ischemia/reperfusion;hepatocyte growth factor;astragalus membranaceus   
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      • Vol. 15, Issue 7, Pages: 77-78(2009) DOI: 10.13422/j.cnki.syfjx.2009.07.036
        摘要：目的:研究祛痹舒肩制剂的抗炎镇痛作用。方法:抗炎实验采用角叉菜胶致大鼠足跖肿胀和二甲苯致小鼠耳廓肿胀模型;镇痛实验采用醋酸扭体法和热板法。结果:祛痹舒肩新制剂可抑制角叉菜胶致大鼠足跖肿胀,作用与旧制剂类似,但剂量明显减少;新制剂可明显抑制二甲苯致小鼠耳廓肿胀,作用优于旧制剂祛痹舒肩丸,且剂量也可明显降低;新制剂可减少醋酸致小鼠扭体反应的次数、升高小鼠痛阈值,剂量可明显降低。结论:祛痹舒肩新制剂具有一定的抗炎、镇痛作用,剂量低于旧制剂,抗炎作用效果优于旧制剂祛痹舒肩丸。  
        关键词：祛痹舒肩制剂;抗炎;镇痛   
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      • CAI Ying1,WEI Qun-li1,LU Xiao-he1
        Vol. 15, Issue 7, Pages: 79-82(2009) DOI: 10.13422/j.cnki.syfjx.2009.07.035
        摘要：Objective:To study the effect and mechanism of Rhodobryum giganteum（Schwaegr.） Par.’s anti-atherosclerotic effect.Methods:Vascular endothelial cells were cultivated and the H2O2 were used to induce the oxidative stress injury of human umbilical vascular endothelial cells（HUVEC）.Water extract of Rhodobryum giganteum（Schwaegr.） Par.was added to cultivated HUVEC,and the activity of the cells was carefully determined by OD value with MTT method.The Griess Reagent was used to detect the NO concentration of different groups.At the same time,the NO fluorescence analysis probe,DAF-FM DA（3-amino,4-aminomethyl-2′,7′-difluorescein,diacetate）,was used to determine the activity of NO synthase.Results:The most suitable stimulating concentration of H2O2 on HUVEC is 12.5 mmol·L-1.Water extract of Rhodobryum giganteum（Schwaegr.）Par.was co-cultured with HUVEC damaged by H2O2.The OD values indicate that 3.33,2.50 mg·mL-1 water extract groups increase activity of the cells significantly compared with the model group（P<0.05）,and 3.33 mg·mL-1 is much better than 2.50 mg·mL-1 dose group.To determine the content of NO and NOS,the 2.50 mg·mL-1 dose has significant effect（P<0.05）.Conclusions: The H2O2 concentration of 12.5 mmol·L-1 could be used to establish the injured model of endothelial cell successfully.2.50 and 3.33 mg·mL-1 water extract of Rhodobryum giganteum（Schwaegr.） Par.have protective effect on ECV304 injured by H2O2.2.50 mg·mL-1water extract of Rhodobryum giganteum（Schw aegr.） Par could increase the activity of NOS and promote the synthesis and secretion of NO.  
        关键词：Rhodobryum giganteum（Schwaegr.）Par.;endothelial cells;MTT;NO;NO Synthase   
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      • LI Kun-Xing,ZHU Xue-ping,ZHANG Hai-lin,NIE Ke,GUO Wei
        Vol. 15, Issue 7, Pages: 83-86(2009) DOI: 10.13422/j.cnki.syfjx.2009.07.034
        摘要：Objective: To observe the anti-tumor effect of Phellinus Linteus and Coriolus Versicolor Capsules（PLCVC） in S180 sarcoma and H22 hepatoma animal models in mice.Methods: The sarcoma S180 and hepatoma H22 models were established in mice.After 12 days of treatment,the animals were killed,and the subcutaneous sarcoma were separated and weighted.The levels of vascular endothelial growth factor（VEGF）,CD4 and CD8 of S180 tumor tissue were investigated by immunohistochemical method.KM mice were intraperitoneal injected with H22 hepatoma cells,and treated with different experimental drugs.The survival time was observed and recorded,and life-prolongation rate was calculated.Result: PLCVC could inhibit the growth of S180 and H22 tumor,and inhibit the expression of VEGF,improve the expression of CD4 and CD8.The survival time of the mice treated by PLCVC were significantly longer than the untreated group.Conclusion: PLCVC can inhibit the growth of tumour,the mechanism is partially related to inhibiting angiogenesis and improving the immunological function.  
        关键词：Phellinus Linteus and Coriolus Versicolor Capsule;sarcoma S180;hepatoma H22;vascular endothelial growth factor（VEGF）;survival time   
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      • Vol. 15, Issue 7, Pages: 86-87(2009) DOI: 10.13422/j.cnki.syfjx.2009.07.033
        摘要：目的:观察四珍力维胶囊对小鼠的急性毒性及耐缺氧、抗疲劳作用。方法:ig评价四珍力维胶囊对小鼠的急性毒性。另取小鼠随机分为3组:实验组给予高,低剂量的四珍力维胶囊,对照组给予等量蒸馏水,均ig10 d,观察、测定常压下小鼠的耐缺氧、抗疲劳情况。结果:四珍力维胶囊对小鼠的最大给药量为9.8 g.kg-1,给药后小鼠在饮食、活动、精神状态等体征方面均无异常变化,体重变化也在正常范围内（P>0.05）,经尸检,主要脏器未见明显病理变化。与对照组比较,四珍力维胶囊给药组小鼠常压下耐缺氧和抗疲劳的能力均有所增强。结论:四珍力维胶囊安全性高,且对小鼠耐缺氧、抗疲劳能力有明显的增强作用。  
        关键词：四珍力维胶囊;急性毒性;耐缺氧;抗疲劳   
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      • Vol. 15, Issue 7, Pages: 88-90(2009) DOI: 10.13422/j.cnki.syfjx.2009.07.041
        摘要：目的:观察黄芪颗粒合用洛汀新（简称合用组,下同）对糖尿病肾病的治疗作用。方法:合用组与单纯应用黄芪颗粒、洛汀新进行平行对照研究,观察临床疗效、临床症状积分、血糖、糖化血红蛋白及尿微量蛋白。结果:合用组对糖尿病肾病的总疗效、对肢体浮肿、尿频或尿浊等症状的改善明显优于单纯应用洛汀新组或黄芪颗粒组（P<0.05～0.01）;对24 h尿微量蛋白含量的降低幅度与单纯应用黄芪颗粒有明显差异（P<0.05）。结论:合用组可提高降尿蛋白作用,对早期糖尿病肾病有较好的治疗效果。  
        关键词：黄芪颗粒;洛汀新;糖尿病肾病   
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      • Vol. 15, Issue 7, Pages: 90-91(2009) DOI: 10.13422/j.cnki.syfjx.2009.07.010
        摘要：目的:观察石苇散化裁治疗尿路结石的疗效。方法:采用随机分组的方法,治疗组66例以中药石苇散为主,随证化裁,每日1剂连服3个月;对照组50例,选用口服金钱草冲剂每日1剂,连用3个月。观察两组治疗效果。结果:治疗组治愈41例,好转20例,有效率92.42%;对照组治愈11例,好转32例,有效率86%,两组有显著差异（P<0.05）。结论:石苇散化裁治疗尿路结石有一定的疗效。  
        关键词：尿路结石;石苇散;中医治疗   
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      • ZHANG Lian,WU Yang,CUI Jie
        Vol. 15, Issue 7, Pages: 92-94(2009) DOI: 10.13422/j.cnki.syfjx.2009.07.045
        摘要：Coronary heart disease（CHD） is known as the psychosomatic disease at present.Psycho-society factor is strongly associated with the development,progress and prognosis of CHD,especially the factor of depression.The paper reviews pathogenesis on traditional Chinese medicine for CHD patients with depression,the mechanisms of depreesion on prognosis of CHD,and clinical intervention from the perspective of the Integrated traditional Chinese and western medicine.The incidence of CHD complicated with depression is increasing in recent years.It influences the development,progress and prognosis of CHD.Anti-depression therapy improves the prognosis of CHD with depression.  
        关键词：coronary heart disease;depreesion;Chinese and western medicine   
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      • ZHANG Meng-jia1,ZHANG Jie1
        Vol. 15, Issue 7, Pages: 95-97(2009) DOI: 10.13422/j.cnki.syfjx.2009.07.009
        摘要：Clinical research progress of Traditional Chinese Medicine（TCM） on treatment of diabetic nephropathy in recent ten years was explained from aspects of pathogen and pathogenesis,patterns classification of TCM,Chinese herbal Compound,single drug and the extractive.And the result showed a good therapeutic effect on early stage of TCM treatment for diabetes mellitus which was worthy to be popularized.  
        关键词：diabetic nephropathy;traditional Chinese medicine;clinic;research progress   
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      • XIONG Yan1,ZHU Jing-jing1,WANG Zhi-ming1,LIN Li-mei1,XIA Bo-hou1
        Vol. 15, Issue 7, Pages: 97-99(2009) DOI: 10.13422/j.cnki.syfjx.2009.07.032
        摘要：This paper retrospectively analyzed the quality control methods of Fructus Forsythiae,summarized the corresponding achievements and problems on its quality control.It can provide some available envidences for the quality control of Fructus Forsythiae and its preparations.  
        关键词：Fructus forsythiae;quality control;fingerprints;analytical metrod   
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        发布时间：2024-09-23
      • Vol. 15, Issue 7, Pages: 16-24(2009)
          
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