最新刊期
      卷 15 ， 期 2 ， 2009
      • ZHOU Ling,FAN Xin-sheng,WU De-kang,TANG Yu-ping~,DUAN Jin-ao
        Vol. 15, Issue 2, Pages: 1-4(2009) DOI: 10.13422/j.cnki.syfjx.2009.02.003
        摘要：Objective:To evaluate the correlativity between volatile components of San-ao Decoction and its major constituting herbs.Methods: The chemical compositions of essential oils,obtained by hydrodistillation from San-ao Decoction and its major constituting herbs（Herba Ephedrae and Semen Armeniacae Amarum.）, were analyzed by GC-MS.Results: The volatile components of San-ao Decoction were mostly derived from Herba Ephedrae and Semen Armeniacae Amarum.Conclusion: The method of GC-MS appears to bethe potential method to analyze the bioactive components of TCM and TCM formulae.  
        关键词：San-ao decoction;volatile components;GC-MS   
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        发布时间：2024-09-23
      • XU Qun~1,WU Lu-ling~2,WANG Cai-ping~1,WANG Shui-juan~1,KONG Ling-dong~
        Vol. 15, Issue 2, Pages: 5-10(2009) DOI: 10.13422/j.cnki.syfjx.2009.02.004
        摘要：Objective:To study the species and relative contents of volatile oils in the well-known Banxiahoupu Decoction and its related combinations and to explore the connections between the different compatibility of Banxiahoupu Decoctions and changes of volatile oils.Method: GC-MS method was used to analyze seven kinds of Banxiahoupu combinations: Banxiahoupu Decoction,Magnolia officinalis,Perilla frutescens,Zingiber officinale,Magnolia officinalis with Perilla frutescens,Magnolia officinalis with Zingiber officinale,Perilla frutescens with Zingiber officinale.Result:Differences were found in volatile oils: 54 oil in Banxiahoupu Decoction,44 in Magnolia officinalis,15 in Perilla frutescens,53 in Zingiber officinale,26 in compatibility of Magnolia officinalis and Perilla frutescens,51 in compatibility of Magnolia officinalis and Zingiber officinale,75 in compatibility P.frutescens and Zingiber officinale.Magnolia officinalis and Zingiber officinale contributed mostly to components of compatibility of Magnolia officinalis and Perilla frutescens,Magnolia officinalis and Zingiber officinale,as well as Perilla frutescens and Zingiber officinale,respectively.The volatile oils of Banxiahoupu decoction were a summation of components of Magnolia officinalis,Perilla frutescens and Zingiber officinale,and of which most components were identical with those in Zingiber officinale.Conclusion:[WTBZ] There is a great difference in species and relative contents of volatile oils beforo and-after compatibility,indicating the deliquescent of volatile components changed or certain chemical reactions taken place in the decoction process.  
        关键词：Banxiahoupu Decoction;compatibility;volatile oils;GC-MS;total ion chromatogram   
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        发布时间：2024-09-23
      • YOU Xiu-qi,LI Xian-duan,GU Xue-zhu,MAO Shu-jie~
        Vol. 15, Issue 2, Pages: 11-14(2009) DOI: 10.13422/j.cnki.syfjx.2009.02.005
        摘要：Objective:To study the effects of quantity of processing vinegar and processing methods on the components of Rhizoma Corydalis.Methods: HPLC was used to detect the content of tetrahydropalmatine and protopine in processing products of Rhizoma Corydalis.The column was Hypersil BDS（250 mm×4.6 mm,5 μm）,the flow rate was 1.0 mL·min-1.For tetrahydropalmatine,mobile phase was methanol-0.1% phosphoric acid（adjust PH 6.0 with triethylamine）（65∶35）,The UV detector was set at 280 nm;For protopine,mobile phase was acetonitrile-triethylamine acetic acid,The UV detector was set at 289 nm.Results: The extraction solubility of tetrahydropalmatine and protopine in Rhizoma Corydalis processed with 30% vinegar（100 g Rhizoma Corydalis with 30 mL vinegar） is the hightest,vinegar-sauted has better effects than vinigar-boiled.Conclusion: The components of Rhizoma Corydalis by repetitive processed with high dose vinegar or boiled in vinegar for long time was decreased.  
        关键词：Theory of processing with vinegar;HPLC;Components of Rhizoma Corydalis   
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        发布时间：2024-09-23
      • SUN Zhuo-ran,LIU Yuan~,MENG Qing-yan,LI Ying,LIU Chao
        Vol. 15, Issue 2, Pages: 15-17(2009) DOI: 10.13422/j.cnki.syfjx.2009.02.006
        摘要：Objective:To determine the chlorogenic acid in stem bark and leaf of Acanthopanacis giraldii from different collection time. Methods: Chromatography parameter: kromasil C18（4.6 mm×250 mm,5 μm）;column temperature:30 ℃;the mobile phase: acetonitrile-（2 ‰） and phosphoric acid water（10∶90） aqueous solution;detection wavelength: 327 nm;flow rate:1 mL·min-1.Results: The method showed good linearity within the concentration ranges of 0.355～3.55 μg（r=（0.999 5））.The average recovery was 100.1%.The contents in the anthesis（from June to July）were lower,and the contents in the fructescence（from August to September） were higher and the content in leaf was higher than that in the bark.Conclusion: This method is simple,accurate,roducible and suitable for the determination of chlorogenic acid in stem bark and leaf of Acanthopanacis giraldii.Giving the consideration of chlorogenic acid,we suggested that the leaf of Acanthopanacis giraldii Harms can be used a new recourse of chlorogenic acid and the best collection time of Cortex Acanthopanacis giraldii were in the frutescence（August～Desember）.  
        关键词：cortex and leaf of Acanthopanacis giraldii Harms;chlorogenic acid;content;RP-HPLC   
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        发布时间：2024-09-23
      • YU Cui-cui,JIN Xiang-qun~,YUE Jun-wei,WANG Xu
        Vol. 15, Issue 2, Pages: 17-19(2009) DOI: 10.13422/j.cnki.syfjx.2009.02.007
        摘要：Objective:To develop an HPLC method for quantitative determining of cinobufagin and resibufogenin in Bangqinmanyan Drop Pills.Methods: Diamonsil C18 column（250 mm×4.6 mm,5 μm） was used as the stationary phase,the mixfure of acetonitrile-KH2PO4 （the pH of solution was adjusted to 3.2 by phosphate acid）（32∶68） was served as mobile phase.The wavelength for detection was 296 nm,the column temperature was 40 ℃.Results:The linearity range were 0.2～1.0 μg（r=（0.999 7）） and 0.224～1.12 μg（r=（0.999 6））.The average recovery were 99.91%（RSD=（0.796 0%）） and 99.84（RSD=（1.002 3%））.Conclusion: The method is simple and reliable.  
        关键词：HPLC;Bangqinmanyan Drop Pills;cinobufagin;resibufogenin   
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        发布时间：2024-09-23
      • GUANG Qin~
        Vol. 15, Issue 2, Pages: 20-22(2009) DOI: 10.13422/j.cnki.syfjx.2009.02.008
        摘要：Objective:To determine the concents of proanthocyanidins in Apocynum venetum L.of different habitats and compare the differences between the different samples.Methods: A spectrophotometry was used for the determination of cyanidin chloride,and the wavelength was 545 nm.Results: The content of proanthocyanidins in the leaves produced in Tianjin was highest in the five producing areas,and the content of proanthocyanidins in the leaves produced in Xingjiang was lowest in the five producing areas.The contents of proanthocyanidins in the leaves produced in Tianjin,Shandong,Shanxi,Shanxi and Xingjiang are 10.95%,7.96%,7.30%,6.56%,2.16% respectively.Conclusion: The contents of proanthocyanidins in the leaves of different habitats are markedly different.We should have a choice in use.  
        关键词：Apocynum venetum L.;proanthocyanidins;spectrophotometry;content determination   
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        发布时间：2024-09-23
      • Vol. 15, Issue 2, Pages: 22-23(2009) DOI: 10.13422/j.cnki.syfjx.2009.02.009
        摘要：目的:应用高效液相色谱法测定茸血补心丸中大黄素的含量。方法:采用Agilent C18柱（4.6 mm×250 mm,5μm）,以乙腈-0.1%磷酸溶液（42∶58）为流动相,检测波长为254 nm。结果:大黄素平均回收率为99.4%,RSD=1.4%（n=6）,线性范围为0.050.6μg（r=0.999 98）。结论:该方法重复性好,结果准确,可用于茸血补心丸的质量控制。  
        关键词：茸血补心丸;大黄素;高效液相色谱法   
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        发布时间：2024-09-23
      • Vol. 15, Issue 2, Pages: 24-25(2009) DOI: 10.13422/j.cnki.syfjx.2009.02.010
        摘要：目的:制定健胃胶囊的质量标准。方法:采用薄层色谱法对制剂中的栀子、香附、苍术、川芎进行TLC鉴别;采用高效液相色谱法测定复方制剂中的栀子苷含量,色谱柱为ZORBAX RX-C18（4.6 mm×250 mm,5μm）,采用乙腈-水（10∶90）为流动相;检测波长为238 nm;柱温35℃,流速1.0 mL.min-1。结果:栀子苷在0.190.95μg范围内线性良好,r=0.9997,平均回收率100.4%,RSD为1.25%。结论:该法分离好,快速、简便,可作为该复方制剂的质量控制方法。  
        关键词：高效液相色谱法;健胃胶囊;薄层色谱法;栀子苷   
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        发布时间：2024-09-23
      • YANG Xiao-li~1,LI Bin~1,LI Da-jin~1,JIN Wei-fang~2,ZHOU Wen-jiang~3,WANG Wen-jun~
        Vol. 15, Issue 2, Pages: 26-29(2009) DOI: 10.13422/j.cnki.syfjx.2009.02.011
        摘要：Objiective:To observe the effect of Gengnianchun Decoction（GNC） on the mRNA expression of osteoprotegerin（OPG）,osteoclast differentiation factor（RANKL） and macrophage colony stimulating factor（M-CSF） in bone marrow microenvironment of ovariectomized rats,and investigate the possible pathway of GNC in preventing and treating postmenopausal osteoporosis.Methods:Forty-two healthy adult SD rats were randomly divided into sham operation group（S group）,saline group（N group）,Different concentrations of GNC groups: high,moderate and low level groups（H,M,and L group）and nilestriol group（E group）.All rats were ovariectomized except those in the sham operation group.After feding with medicines for three days,the total RNA was extracted from the lumbar vertebra to examine mRNA expression of RANKL,OPG and M-CSF by real-time PCR.Results:H group up-regulated the expression of OPG of the ovarietomized rat,whereas down-regulated the expression of M-CSF and decreased RANKL∶OPG ratio.Conclusion:The effect of GNC in treating postmenopausal osteoporosis is closely correlated with the regulation of OPG and M-CSF expressions and RANKL/OPG.  
        关键词：Gengnianchun Decoction;osteoprotegerin;osteoclast differentiation factor;macrophage colony stimulating factor   
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        发布时间：2024-09-23
      • SHAN Li-mei~1,ZHAO Yan-ling~
        Vol. 15, Issue 2, Pages: 30-32(2009) DOI: 10.13422/j.cnki.syfjx.2009.02.028
        摘要：Objective: To establish rat gastric hot model for relevant Chinses medicine pharmacological study.Methods: The rat gastric hot model was established by oral administration with red pepper and alcohol mixture for two weeks and irritated for three days by clipping tails.The temperature,amount of food,water,urination and defecation of every rats were detected by the help of metabolism cage.The content of IL-8,IL2,INF-α,TXB2,6-keto-PGF1α in blood of rat was examined.Meanwhile,the injury extent of gastric mucosa and the histological characteristics of gastric mucosa were observed.Results: Two weeks after modeling,the model rats had the symptoms of temperature,weight and defecation decreecing and thirst for drinking.Congestion in gastric mucosa occurred and the blood level of IL8,IL-2,（INF-α,）TXB2,6-keto-PGF1α were higher than those in the control group.However,in model rats pretreated with Zuojin pills,the symptoms and signs of hot-syndrome and histological changes were relieved.Conclusion: Under the controlled condition,feeding rats with red pepper and alcohol mixture combined with clipping tails can be successfully used to establish rat gastric model of hot-syndrome.  
        关键词：hot-syndrome;animal model;Zuojin Pills   
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        发布时间：2024-09-23
      • FAN Qin~
        Vol. 15, Issue 2, Pages: 33-35(2009) DOI: 10.13422/j.cnki.syfjx.2009.02.012
        摘要：Objective:To explore the effects of Fructus Schisandrae Sphenantherae on proliferation and differentiation of rat osteoblast cell in vitro.Methods:Serum pharmacology was applied to the investigation.Osteoblast cell was isolated from calvaria of newborn SD rats by means of modified sequential collagenase digestion and incubated in RPMI 1640 medium. The cell morphology was observed under a phase contrast inverted microscope.MTT assay,ALP activity,mineral node count were carried out to determine the status and activities of proliferation and differentiation.Results:In 10%,15% concentration groups after cultured 48 h and 5%,10% after cultured 72 h,95% ethanol extracts of Fructus Schisandrae Sphenantherae significantly stimulated the proliferation（P<0.01）,In 10% concentration groups after cultured 72 h,and 15% after cultured 48h and 72 h increased ALP activity.（P<0.05,P<0.01）.In 10% concentration group,95% ethanol extracts of Fructus Schisandrae Sphenantherae increased the number of mineral nodes after cultured 2w（P<0.01）.Water extracts of Fructus Schisandrae Sphenantherae had no significantly effects on proliferation and differentiation of rat osteoblast cell in vitro.Conclusion: 95% ethanol extracts of Fructus Schisandrae Sphenantherae had the effects on proliferation and differentiation of rat osteoblast cell in vitro.  
        关键词：Fructus Schisandrae Sphenantherae;serum-containing drug;Osteoblast;rat;ethanol extracts   
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        发布时间：2024-09-23
      • DING Zhi-guo~1,SHI Xiao-guang~1,LI Lan-fang~2,WANG Tang-shun~1,CHEN Zhen-zhou~1,YANG Qing~2,ZHANG Jian-song~1,YE Guang-duo,LI Nai-qing~
        Vol. 15, Issue 2, Pages: 36-38(2009) DOI: 10.13422/j.cnki.syfjx.2009.02.013
        摘要：Objective:To compare effects of Shenqi Fuzheng Injections prepared by two different crafts on the ability of reticuloendothelial system,the ability to restrain tumor and the protection to some important organs in S180-bearing mice.Methods: 42 tumor-bearing mice were randomly divided into five groups:the model group,the high dose group(8 g·kg-1)and the clinical equivalent dose group(4 g·kg-1) of Shenqi Fuzheng Injection on current craft,the high dose group(8 g·kg-1) and the clinical equivalent dose group(4 g·kg-1) of Shenqi Fuzheng Injection on previous craft.The model group was given physiological saline by intraperitoneal injection once a day,while the other groups were given different Shenqi Fuzheng Injections in the same way.Twelve days later,blood samples were collected from the mice and phagocytic index K was determined,Then the mice were sacrificed,the weights of body,tumor,spleen,liver and thymus gland were collected.Results:The weights of tumors and tamor indexes in four Shenqi Fuzheng Injection groups were lower than the model group, and the difference between groups of Shenqi Fuzheng Injection on current craft and the model group was significant（P<0.01～0.05）.However the groups of the current craft and the previous one had no significant difference;phagocytic index K in four Shenqi Fuzheng Injection groups were higher than that in the model group,and the difference between groups of Shenqi Fuzheng Injection on current craft and the model groups was significant（P<0.01～0.05）;and in(4 g·kg-1) groups,the current group was better than the previous one（P<0.05）.The spleen indexes in four Shenqi Fuzheng Injection groups were higher than that in the model group（P<0.05）,the liver indexes and the thymus gland one have no significant difference.Conclusion:In clinical equivalent dose(4 g·kg-1),the ability of reticuloendothelial system in Shenqi Fuzheng Injection on current craft was better than the model group and the previous craft group;Shenqi Fuzheng Injection on current crafts could restrain tumors and protect spleens.However,there was no difference between the current and previous crafts in these aspects.  
        关键词：Shenqi Fuzheng injection;crafts;S180cells;reticuloendothelial system   
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        发布时间：2024-09-23
      • WANG Bin,SUN Jian-ning~,ZHANG Shuo-feng,SUN Wen-yan
        Vol. 15, Issue 2, Pages: 39-41(2009) DOI: 10.13422/j.cnki.syfjx.2009.02.014
        摘要：Objective: To study the role and mechanism of Qing-nao-xuanqiao Dropping pill（QNXQD） on acute cerebral ischemic injury.Methods:The middle cerebral artery occlusion（MCAO）model induced by inserting a monofilament suture was adopted.The content of NO,and the activity of cNOS,iNOS,total NOS in brain homogenate was determined.Results: QNXQD 45,90,180 mg·kg-1,can significantly reduce the content of NO in the rat brain homogenate of the troubled side;180 mg·kg-1 can significantly decrease the increased cNOS,iNOS;total NOS activity in the side of the brain surgery（P<0.05）;90 mg·kg-1 can significantly decrease the increased total NOS activity（P<0.01）;and 45 mg·kg-1 can significantly decrease the increased total NOS activity（P<0.01）.Conclusion: QNXQD has protective effect on cerebral ischemia and the possible mechanism may be related to reducing content of NO,decreasing the activity of cNOS,iNOS,total NOS.  
        关键词：Qing-nao-xuan-qiao Dropping Pill;cerebral ischemia;NO;NOS   
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        发布时间：2024-09-23
      • XIA Xin-hua~
        Vol. 15, Issue 2, Pages: 42-45(2009) DOI: 10.13422/j.cnki.syfjx.2009.02.015
        摘要：Aim:To investigate the effect of Musk with Borneol on brain damage in the rat model of cerebral focal ischemia with reperfusion.Methods:The model of MCAO-reperfusion was induced by the method of nylon monofilament via the internal carotid artery.Technique of image analysis was used to calculate the volume of cerebral infarction and evaluate the scores of nerves function;Method:of dry and wet weight was used to observe water content and Evans blue（EB） was used to observe the changes of BBB permeability.Results:After cerebral ischemia for 2 hours and reperfusion for 24 hours,the volume of cerebral infarction of the model group increased significantly（P<0.01）,the scores of the function of nerves increased（P<0.01）;the volume of cerebral infarction of the Musk with Borneol group was significantly lower than that of the model group（P<0.05）;the scores of the function of nerves of Musk with Borneol group,Musk group were significantly lower than that of the model group（P<0.05～0.01）;the content of water and EB in the model group increased significantly compared with sham operation group（P<0.01）,which indicated the BBB was damaged;The water content in Musk with Borneol group was significantly lower than that of the model group（P<0.05） and the content of BBB in Musk with Borneol group and Borneol group was significantly lower than that of the model group（P<0.01）.Conclusion:Musk with Borneol can decrease the volume of cerebral infarction and improve the nervous symptom,decrease the water content and permeability of BBB after focal cerebral ischemia with reperfusion,therefore protect the brain after focal cerebral ischemia with reperfusion.  
        关键词：Musk;borneol;cerebral ischemia-reperfusion;Brain protection;BBB   
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        发布时间：2024-09-23
      • Vol. 15, Issue 2, Pages: 45-48(2009) DOI: 10.13422/j.cnki.syfjx.2009.02.016
        摘要：目的:研究黄芪加红花对脑缺血再灌注大鼠脑神经细胞凋亡的影响,并通过对缺血周围区caspase-3的检测,进一步探讨黄芪加红花减少神经细胞凋亡的分子机制。方法:采用大鼠脑缺血再灌注模型,分假手术组、模型组、黄芪加红花组、黄芪组、红花组。术后分12 h,24 h,48 h 3个时间点行神经功能评分;TUNEL法观察凋亡的情况;免疫组化观察缺血周围区caspase-3表达强度。结果:神经功能评分显示:与模型组比较,黄芪组、黄芪加红花组神经功能有显著改善;凋亡阳性细胞数:与模型组比较,各治疗组均显著减少;在治疗组中,黄芪加红花组与红花组比较数目减少显著,与黄芪组比较也减少,差别有统计学意义;caspase-3阳性细胞表达水平:缺血再灌注12 h,与模型组比较,黄芪组、黄芪加红花组阳性细胞数显著减少,红花组差别不明显;与红花组比较黄芪加红花组阳性细胞数减少差别显著,与黄芪组比较则差别不显著。缺血再灌注24 h和48 h,治疗组与模型组比较,阳性细胞数均显著减少,黄芪加红花组与红花组、黄芪组比较也显著减少。结论:黄芪加红花为代表的益气活血法比单纯益气或单纯活血具有更好的减轻缺血再灌注后神经细胞凋亡的作用,其作用机制可能通过抑制caspase-3的表达,阻断caspase级联反应的最终执行而实现。  
        关键词：脑缺血再灌注;凋亡;半胱氨酸蛋白酶-3;黄芪;红花   
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        发布时间：2024-09-23
      • HE Shuang,ZHU Jia,LI Li,ZHANG Wan-qiang,KONG Huan-yu
        Vol. 15, Issue 2, Pages: 49-51(2009) DOI: 10.13422/j.cnki.syfjx.2009.02.017
        摘要：Objective: To investigate the effect of Chinese Medicine Suifukang（SFK） on the expression of Nogo-A mRNA and protein after spinal cord injury in rhesus monkeys.Methods: Ten out of fourteen adult rhesus monkeys received the left spinal cord hemisection on T12,and then was randomly divided into two groups: SFK groups（5） and control group（5）.The other four monkeys were served as the normal controls.The expression of Nogo-A mRNA was detected by in-situ hybridization technique and the expression of Nogo-A protein was detected by immunohistochemistry technique.Results: The positive cells of Nogo-A mRNA and its OD value in the model group were more than those in other groups（P<0.05）;The Nogo-A mRNA positive cells and its OD value in SFK group were less than those in the model group（P<0.05）.The changes of Nogo-A protein positive cells number and its OD value was similar with that of Nogo-A mRNA.Conclusions:SFK can restrain the expression of Nogo-A obviously.It is possible to improve microenvironment in the injured spinal cord and to regenerate of nervous tissue.  
        关键词：Chinese herbal medicine;spinal cord injury;rhesus monkey;Nogo-A;Suifukang   
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        发布时间：2024-09-23
      • DU Bao-sheng~1,YAN Tian-hua~1,MA Ying~1,WANG Qiu-juan~
        Vol. 15, Issue 2, Pages: 51-54(2009) DOI: 10.13422/j.cnki.syfjx.2009.02.018
        摘要：Objective:To investigate the effects of salidroside on hemorheology of rats,platelet aggregation rate in vitro in rats,coagulation time（CT） and platelet count（PC） in mice.Methods: The model of acute blood stasis was established with high-molecular weight dextran,the parameters were tested,such as blood viscosity,fibrinogen and hematocrit（Hct） etc;the effects of salidroside on platelet aggregation rate of rats,CT and PC of mice were rest after pretreatment with salidroside for 5 days.Results: Salidroside(6,12,24 mg·kg-1) could effectively prevent the ascending of whole blood viscosity,plasma viscosity,fibrinogen and Hct in the acute blood stasis model.Salidroside at all doses could effectively decrease platelet aggregation rate;Salidroside(48.0,24.0 mg·kg-1) could prolong CT and has no effect on PC.Conclusion: The results suggest that salidroside improves the hemorheological parameters of rats with acute blood stasis,and salidroside has some effects on anticoagulation,while it has no effect on PC.  
        关键词：salidroside;hemorheology;platelet aggregation rate;Coagulation Time;platelet count   
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        发布时间：2024-09-23
      • GUO Li-qun,YANG Jie-ren~,KONG Xiang
        Vol. 15, Issue 2, Pages: 55-58(2009) DOI: 10.13422/j.cnki.syfjx.2009.02.019
        摘要：Objective: To investigate the effects of sesamin on lipidemia and the formation of non-alcoholic steatohepatitis（NASH）.Methods: Hyperlipidemia rats model were established by feeding high lipid diet.The liver index,total cholesterol（TC）,triglyeeride（TG）,high density lipoprotein-cholesterol（HDL-C）,low density lipoprotein-cholesterol（LDL-C）,lipoprotein lipase（LPL）,hepatic lipase（HL）,apoproteinA1（ApoA1）,apoproteinB100（ApoB100）,superoxidedismutase（SOD）and malonaldehyde（MDA） were measured after administration with sesamin for 8 weeks.As well as,livers were taken for histopathological examination.Results: Therapeutic groups were significantly decreased TC,TG,LDL-C,ApoB100,MDA and liver index,increased HDL-C,HL,SOD（P<0.05）.The fatty degeneration and steatosis in liver were ameliorated by sesamin.Conclusion: Sesamin can remarkably modulate lipidemia and cure the NASH.Its mechanism is probably mediated through regulating lipids metabolism and anti-oxidation.  
        关键词：sesamin;hyperlipidemia;rat;nonalcoholic steatohepatitis;histopathological examination   
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      • Vol. 15, Issue 2, Pages: 58-60(2009) DOI: 10.13422/j.cnki.syfjx.2009.02.020
        摘要：目的:比较茶叶、槐米、金荞麦、红花的70%乙醇提取物的抗氧化活性。方法:低温条件下制备大鼠肝微粒体,建立Fe2+-ADP-NADPH体外氧化体系,通过计算半数抑制浓度评价上述4种中药的抗氧化活性。结果:茶叶、槐米、金荞麦、红花的IC50分别为0.030,0.041,0.324,0.598 mg.mL-1。结论:4种提取物均有抗脂质过氧化活性,且活性由大到小依次为茶叶、槐米、金荞麦、红花。  
        关键词：茶叶;槐米;金荞麦;红花;脂质过氧化;半数抑制浓度   
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      • CHI Tian-yan,JI Xue-fei,XIA Ming-yu,LI Wei,QIU Feng,ZOU Li-bo~
        Vol. 15, Issue 2, Pages: 61-63(2009) DOI: 10.13422/j.cnki.syfjx.2009.02.021
        摘要：Objective: Our purpose was to compare the antitussive,antiasthmatic and expectorant effects betwen aqueous extract of Wuhu Tang complex prescription and the crude product.Methods: Sulfur dioxide induced cough,citric acid induced cough,histamine-acetylcholine induced asthma attacks in guinea pig and excretion of phenol red in the airway of mouse were used.Results: They both markedly prolonged the latent period of cough induced by sulfur dioxide and citric acid;significantly prolonged the latent period of asthmatia attact by mixture of histamine-acetylcholine in guinea pigs,and had the tendency to increase the secretion of phenol red from the airway in mice.Conclusion: The effective components of Wuhu Tang can reach the same pharmacological effects of the crude product for antitussive,antiasthmatic and expectorant effects.  
        关键词：Wuhu Tang;effective components;pharmacodynamics comparison;antitussive action;Antiasthmatic action   
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      • SU Shu-lan~
        Vol. 15, Issue 2, Pages: 64-67(2009) DOI: 10.13422/j.cnki.syfjx.2009.02.022
        摘要：Objective: To analysis the correlation between bioactivity of inhibiting oxytocin-induced uterine contraction in vitro and volatile components of Danggui-Chuanxiong different ratio.Methods: The essential oil was extracted from Danggui-Chuanxiong by steam distillation and analyzed by GC-MS with the method of programmed temperature.Oxytocin induced female mice isolated uterine contraction model was adopted in the experiment to evaluate biological activity of Myrrh oil.Results: The experiments showed that the activities of volatile oils obtained from different ratio Danggui-Chuanxiong were different: Danggui-Chuanxiong（2∶1） > Danggui-Chuanxiong（3∶1） > Danggui-Chuanxiong（1∶1）>Danggui-Chuanxiong （3∶2）;The results of GC-MS showed that the constituents of volatile oil obtained from Danggui-Chuanxiong（2∶1） were composed with the ratios of（Z）-ligustilide:（Z）-3-butylidene phthalide: 4,5-dihydro-3-butyl-phathalide:（E）-ligustilide: Unknown compound: 8,9-dehydro-Cycloisolongifolene: Neocnidilide:（E）-3-butylidene phthalide（80.75∶4.02∶2.07∶1.66∶0.81∶0.61∶0.53∶0.52）.Conclusion: The different activities of volatile oils derived from different ratio of Danggui-Chuanxiong were resulted from the different composition of components in volatile oils.And the results suggested that the lactone-type components are possible bioactive compounds.  
        关键词：Danggui-Chuanxiong prescription;volatile components;GC-MS;uterus contraction   
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      • Vol. 15, Issue 2, Pages: 68-70(2009) DOI: 10.13422/j.cnki.syfjx.2009.02.023
        摘要：目的:研究大黄灵脾颗粒剂对5/6肾切除慢性肾衰竭（CRF）大鼠残余肾功能的影响及其可能机制。方法:随机分为模型组、福辛普利组、大黄灵脾颗粒剂组和假手术正常组。除假手术组外余动物行5/6肾切除。第1次手术后,各组开始灌胃给药,直至第2次手术后8周结束。期间分时间点检测各组大鼠血清尿素氮（BUN）、血肌酐（SCr）、血管紧张素Ⅱ1型受体（AT1）,观察大黄灵脾冲剂对肾衰大鼠肾功能、肾脏病理及免疫组化的影响。结果:大黄灵脾组大鼠的SCr在第4周开始出现下降,与模型组比较有显著性差异,与福辛普利组比较差异显著;在大鼠肾组织学变化上大黄灵脾组和福辛普利组的肾小球肥大情况较模型组有减轻,大黄灵脾组与模型组比较,差异显著,大黄灵脾组优于福辛普利组;AT1的表达上大黄灵脾组与模型组比较在6周有显著差异（P<0.05）,而福辛普利组与模型组比较在3周就有显著差异。结论:大黄灵脾颗粒剂能够延缓大鼠慢性肾衰的进展,减轻肾脏的损害。  
        关键词：大黄灵脾颗粒剂;慢性肾衰;肾功能恶化;血管紧张素Ⅱ1型受体   
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      • LIANG Zhi-xue~
        Vol. 15, Issue 2, Pages: 71-73(2009) DOI: 10.13422/j.cnki.syfjx.2009.02.024
        摘要：Objective:To research the preventive effects and mechanism of Fuganning（FGN） on rats with hepatic fibrosis.Methods:Adopting intraperitoneal injection of porcine serum to induce rat immuno hepatic fibrosis model,observed the effect of FGN onHA,LN,CIV and the pathological chages of hepatic tissue.Results:The level of HA,LN,CIV were low,the pathological chages and the collagen fibresis decreased significantly in FGN group,this groups has significanc difference compare to model group（P<0.05）.Conclusions:In the experiment with hepatic fibresis rats,FGN can reduce the level of HA,LN,CIV.It can affect the collagen protein metabolism.Thus FGN prescription have effect on preventing hepatic fibresis.  
        关键词：Fuganning;hepatic fibrosis;serum indicators;the pathological chages   
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      • Vol. 15, Issue 2, Pages: 74-75(2009) DOI: 10.13422/j.cnki.syfjx.2009.02.025
        摘要：目的:观察传统古方痛风灵的抗炎、镇痛、抗痛风等作用。方法:采用了炎症、疼痛及痛风模型进行药效学研究。结果:痛风灵对二甲苯所致小鼠耳肿胀、蛋清及角叉菜胶所致小鼠足肿胀均有明显抑制作用;痛风灵能明显对抗尿酸钠所致大鼠痛风性关节炎,对醋酸所致小鼠扭体反应及热板引起小鼠足痛有对抗作用。结论:痛风灵具有明显的抗炎作用、镇痛作用和抗痛风作用。  
        关键词：痛风灵;抗炎;镇痛;抗痛风   
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      • SUN Ying,LI Ping-ping~
        Vol. 15, Issue 2, Pages: 76-80(2009) DOI: 10.13422/j.cnki.syfjx.2009.02.026
        摘要：Objective:To study the influence of Traditional Chinese Medicine（TCM） Shuganliangxue decoction to TAM and 4OHtam metabolism in patients.Method:All the blood samples were collected from a randomized double blind clinical trial.The serum concentration of TAM,4Ohtam between two groups,and that in one group before and after taking the decoction were compared.TAM and 4OHtam concentration in serum were determined by using HPLC-MS method.The data was analized with t-test and SPSS 13.0 statistics method.Results:Before taking TCM decoction,TAM and 4OHtam concentration were（215.63±95.36） ng·mL-1,（4.49±1.49） ng·mL-1 separately,and after taking TCM decoction,were（233.17±126.48） ng·mL-1,（5.34±2.78） ng·mL-1.In placebo group before taking"decoction" TAM and 4OHtam concentration were（209.80±75.05） ng·mL-1,（5.15±1.67） ng·mL-1,after taking"decoction",were（216.86±98.89） ng·mL-1,（4.21±1.41） ng·mL-1.There were no significant differences between the two groups and for the self control（P>0.05）.Conclusions: TCM Shuganliangxue decoction did not influence the TAM and 4OHtam metabolism in serum of patients.It provides the evidence of safety for using Shuganliangxue decoction combining with TAM in clinical.  
        关键词：Shuganliangxue Decoction;tamoxifen;4-hydroxytamoxifen;HPLC-MS   
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      • Vol. 15, Issue 2, Pages: 80-82(2009) DOI: 10.13422/j.cnki.syfjx.2009.02.001
        摘要：目的:观察健脾祛脂汤对高脂血症（痰浊阻遏证）患者血脂及血管内皮功能的影响。方法:56例高脂血症（痰浊阻遏证）患者随机分为健脾祛脂汤治疗组,普伐他汀治疗组,健脾祛脂汤加普伐他汀治疗组。观测治疗前及治疗8周后患者血脂、ET-1和NO的变化。结果:各治疗组TC、TG、LDL-C、ET-1明显下降,而HDL-C和NO明显升高,其中TG、ET-1和NO的作用以及临床症状的改善方面中西药组优于单用中药组和西药组。结论:健脾祛脂汤能够有效减轻高脂血症痰浊阻遏证患者临床症状,改善血管内皮功能障碍;中西结合组能明显改善临床症状、降脂、改善内皮功能障碍,其作用优于中药组和西药组。  
        关键词：健脾祛脂汤;高脂血症;痰浊阻遏;血管内功能   
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      • Vol. 15, Issue 2, Pages: 82(2009) DOI: 10.13422/j.cnki.syfjx.2009.02.029
          
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      • Vol. 15, Issue 2, Pages: 86-89(2009) DOI: 10.13422/j.cnki.syfjx.2009.02.002
          
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      • Vol. 15, Issue 2, Pages: 87-88(2009) DOI: 10.13422/j.cnki.syfjx.2009.02.031
          
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      • Vol. 15, Issue 2, Pages: 88-89(2009) DOI: 10.13422/j.cnki.syfjx.2009.02.030
          
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      • ZHENG Qin,PENG Chang-chun,SHEN Mei-lan,YANG Ming~
        Vol. 15, Issue 2, Pages: 83-86(2009) DOI: 10.13422/j.cnki.syfjx.2009.02.027
        摘要：This paper gives an overview of recent research and developments about the compatibility of Radix Et Rhizoma Salviae Miltiorrhizae,Radix Et Rhizoma Notoginseng and their efficient components.Different compatibility of Radix Et Rhizoma Salviae Miltiorrhizae,Radix Et Rhizoma Notoginseng influencing on effective constituents,such as its extraction rate and stability,pharmacological and pharmacodynamic effects are analysised and concluded,and it is pointed out that there is a synergistic effect in the compatibility of the two herbs,but obvious discrepancy is existed in the interaction of different proportional compatibility.  
        关键词：Radix Et Rhizoma Salviae Miltiorrhizae;Radix Et Rhizoma Notoginseng;efficient components;compatibility;pharmacological and pharmacodynamic effects   
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      • Vol. 15, Issue 2, Pages: 90(2009)
          
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