最新刊期
      卷 13 ， 期 11 ， 2007
      • CHEN Yan~1,CAI Yin~2,JIA Xiao-bin~2,DING An-wei~
        Issue 11, Pages: 1-3(2007) DOI: 10.13422/j.cnki.syfjx.2007.11.002
        摘要：Objective:To develop a HPLC method of simultaneous determination of Icarrin,Epimedin A,Epimedin B,Epimedin C,Baohuoside I in Xianlingpi granules.Method:The samples were separated at 30℃ on a ZORBAX SB-C18 column（4.6 mm×250 mm,5 μm） eluted with acetonitrile and water in gradient mode.The ratio of acetonitrile increased from 10% to 25% in 15 min,and kept constant for 23 min,then from 25% to 71% during 23 min.The detection wavelength was 270 nm,and the flow rate was(1 mL·min-1).Result:Five compounds were baseline-isolated,the linear relationships of lcarrin,Epimedin A,Epimedin B,Epimedin C,Baohuosiede I were excellent.Conclusion:The method was rapid and precise,and can be use for controlling the quality of Xianlingpi granules.  
        关键词：Xianlingpi Granules;flavonoids;content determination;RP-HPLC   
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        发布时间：2024-09-23
      • CHEN Yan1,CAI Yin2,JIA Xiao-bin2,DING An-wei1
        Vol. 13, Issue 11, Pages: 1-3(2007)
        摘要：Objective:To develop a HPLC method of simultaneous determination of Icarrin,Epimedin A,Epimedin B,Epimedin C,Baohuoside I in Xianlingpi granules.Method:The samples were separated at 30℃ on a ZORBAX SB-C18 column(4.6 mm×250 mm,5 μm) eluted with acetonitrile and water in gradient mode.The ratio of acetonitrile increased from 10% to 25% in 15 min,and kept constant for 23 min,then from 25% to 71% during 23 min.The detection wavelength was 270 nm,and the flow rate was(1 mL·min-1).Result:Five compounds were baseline-isolated,the linear relationships of lcarrin,Epimedin A,Epimedin B,Epimedin C,Baohuosiede I were excellent.Conclusion:The method was rapid and precise,and can be use for controlling the quality of Xianlingpi granules.  
        关键词：Xianlingpi Granules;flavonoids;content determination;RP-HPLC   
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        发布时间：2024-09-23
      • ZHAO Jing-kun1,WANG De-sheng1,WANG Jian-xiu1,DUAN Shu-rong1,LI Wen-lan2,BAI Jing2
        Vol. 13, Issue 11, Pages: 4-6(2007)
        摘要：Objective:To establish the chromatographic fingerprints of Fu Zhi San by RP-HPLC.Methods:By RP-HPLC,acetonitrile and water including 0.1% Phosphoric acid were mobile phase with gradient elution,flow rate was 1.0 mL·min-1,the detection wavelength was 335 nm,and the temperature was 30℃.The fingerprints of different samples were compared with similarity evaluation software published by committee codex.Results:The RSD of relative peak areas and relative retention time of common peak in the test of precision,repeatability,and stability has not reached 2%,respectively.19 peaks were identified as the characteristic fingerprints.Average similarity was 0.996.Conclusion:This method is precise,practicable,well-repeated and simple.It can be used as the method to judge the quality of Fu Zhi San.  
        关键词：Fu Zhi San;fingerprints;HPLC   
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        发布时间：2024-09-23
      • ZHAO Jing-kun~
        Issue 11, Pages: 4-7(2007) DOI: 10.13422/j.cnki.syfjx.2007.11.003
        摘要：Objective:To establish the chromatographic fingerprints of Fu Zhi San by RP-HPLC.Methods:By RP-HPLC,acetonitrile and water including 0.1% Phosphoric acid were mobile phase with gradient elution,flow rate was 1.0(mL·min-1),the detection wavelength was 335 nm,and the temperature was 30℃.The fingerprints of different samples were compared with similarity evaluation software published by committee codex.Results:The RSD of relative peak areas and relative retention time of common peak in the test of precision,repeatability,and stability has not reached 2%,respectively.19 peaks were identified as the characteristic fingerprints.Average similarity was 0.996.Conclusion:This method is precise,practicable,well-repeated and simple.It can be used as the method to judge the quality of Fu Zhi San.  
        关键词：Fu Zhi San;fingerprints;HPLC   
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        发布时间：2024-09-23
      • Issue 11, Pages: 7-8(2007) DOI: 10.13422/j.cnki.syfjx.2007.11.004
        摘要：目的:建立扁桃叶中没食子酸的含量测定方法,测定不同产地扁桃叶中没食子酸的含量。方法:采用反相高效液相色谱（RP-HPLC）法,外标法定量,Shim pack CLC-ODS柱分离;流动相:甲醇-0.5%冰醋酸（5∶95）;检测波长:267 nm;柱温:25℃;流速:1 mL.min-1。结果:没食子酸在进样量0.2010μg1.005μg范围内线性关系良好;平均回收率101.7%,RSD=2.0%（n=5）;3批扁桃叶样品中没食子酸平均含量分别为0.2504,0.2520,0.2499 mg.g-1。结论:所建立的RP-HLPC含量测定方法灵敏度高,准确,快速,专属性强,重复性好,为控制扁桃叶的内在质量提供了指标和方法。  
        关键词：高效液相色谱法;扁桃叶;没食子酸;含量测定   
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        发布时间：2024-09-23
      • FAN Min-wei,MA Neng-yi,WANG Bing~,ZHU Wei-jie,QIAN Jia-hua
        Issue 11, Pages: 9-11(2007) DOI: 10.13422/j.cnki.syfjx.2007.11.005
        摘要：Objective:To develop an HPLC method for the determination of hyperin in Hypericum perforatum L.extract sustained-release capsules.Methods:The analysis was performed on an Agilent ZORBAX SB-C18（5 μm,4.5 mm×150 mm） column eluted with the mobile phase consisted of water-acetonitrile-phosphoric acid（825∶175∶1）.The detection wavelength was set at 368 nm.Result:The linear range for hyperin was（0.06～0.30）μg（r=（0.999 9）.）Conclusion:This method can be used effectively for the quality control of the capsules.It was simple,rapid,accurate and feasible.  
        关键词：Hypericum perforatun L.;extract sustainedrelease capsules;HPLC;hyperin;determination   
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        发布时间：2024-09-23
      • FAN Min-wei,MA Neng-yi,WANG Bing,ZHU Wei-jie,QIAN Jia-hua
        Vol. 13, Issue 11, Pages: 9-10(2007)
        摘要：Objective:To develop an HPLC method for the determination of hyperin in Hypericum perforatum L.extract sustained-release capsules.Methods:The analysis was performed on an Agilent ZORBAX SB-C18(5 μm,4.5 mm×150 mm) column eluted with the mobile phase consisted of water-acetonitrile-phosphoric acid(825∶175∶1).The detection wavelength was set at 368 nm.Result:The linear range for hyperin was(0.06～0.30)μg(r=(0.999 9).)Conclusion:This method can be used effectively for the quality control of the capsules.It was simple,rapid,accurate and feasible.  
        关键词：Hypericum perforatun L.;extract sustainedrelease capsules;HPLC;hyperin;determination   
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        发布时间：2024-09-23
      • Issue 11, Pages: 11-12(2007) DOI: 10.13422/j.cnki.syfjx.2007.11.006
        摘要：目的:建立克郁舒神颗粒中阿魏酸含量测定方法。方法:采用高效液相色谱法测定克郁舒神颗粒中阿魏酸的含量。以C18化学键合硅胶为固定相,甲醇-0.05%冰醋酸（2∶3 v/v）为流动相,检测波长为320 nm。结果:阿魏酸在（0.55）μg进样量与峰面积呈良好的线性关系,r=0.999 7。平均回收率为99.78%,RSD为0.47%,精密度试验的RSD为2.03%。结论:该法结果准确,重复性好,可用于克郁舒神颗粒中阿魏酸的含量测定。  
        关键词：克郁舒神颗粒;阿魏酸;高效液相色谱   
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        发布时间：2024-09-23
      • JIANG Hao,XIE Jing-yu,LONG Hai-dong,WANG Qi,SUN Wan-jing,ZHANG Yu-jie
        Vol. 13, Issue 11, Pages: 13-16(2007)
        摘要：Objective:To prepare the Xuanshi Liniment and evaluate its quality of transdermal absorption.Methods:Optimized extracting method of Xuanshi Liniment was determined by using the orthogonal experiment.Best film material was selected based on capability,stablity and solubility.In vitro permeation behavior was studied in vertical diffusion cell.Samples were assayed by the HPLC method.Results:The 4 h cumulative permeated rate of osthole from Xuanshi Liniment through mouse skin was much higher than that from original lotion.Conclusion:The Xuanshi Liniment is more effective in transdermal absorption with high extraction,simple and feasible preparation,and may be supersession of the original lotion.  
        关键词：Xuanshi Liniment;preparation;transdermal absorption   
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        发布时间：2024-09-23
      • JIANG Hao,XIE Jing-yu,LONG Hai-dong,WANG Qi,SUN Wan-jing,ZHANG Yu-jie
        Issue 11, Pages: 13-16(2007) DOI: 10.13422/j.cnki.syfjx.2007.11.026
        摘要：Objective:To prepare the Xuanshi Liniment and evaluate its quality of transdermal absorption.Methods:Optimized extracting method of Xuanshi Liniment was determined by using the orthogonal experiment.Best film material was selected based on capability,stablity and solubility.In vitro permeation behavior was studied in vertical diffusion cell.Samples were assayed by the HPLC method.Results:The 4 h cumulative permeated rate of osthole from Xuanshi Liniment through mouse skin was much higher than that from original lotion.Conclusion:The Xuanshi Liniment is more effective in transdermal absorption with high extraction,simple and feasible preparation,and may be supersession of the original lotion.  
        关键词：Xuanshi Liniment;preparation;transdermal absorption   
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        发布时间：2024-09-23
      • Issue 11, Pages: 17-18(2007) DOI: 10.13422/j.cnki.syfjx.2007.11.027
        摘要：目的:对艾奇康胶囊提取精制工艺进行优选。方法:采用正交设计的方法,以甘草中甘草酸的含量为指标,考察了煮提时间,煮提次数和加水量等。结果:最佳工艺为煎煮3次,加水8倍量,时间为2 h,浓缩至相对密度1∶1.2,加入95%乙醇使药液含醇量为70%,放置12 h,离心,浓缩,真空干燥,制粒。结论:该工艺简单合理,易于操作。  
        关键词：艾奇康胶囊;甘草;甘草酸单铵盐;提取工艺;正交设计   
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        发布时间：2024-09-23
      • Issue 11, Pages: 19-20(2007) DOI: 10.13422/j.cnki.syfjx.2007.11.028
        摘要：目的:优选乳康酊的最佳渗漉提取工艺条件。方法:采用正交设计法以丹皮酚含量为考察指标,对影响乳康酊渗漉提取工艺的因素进行研究。结果:乳康酊的最佳提取工艺:药材粉碎度为15目,乙醇浓度为80%,浸泡时间为72 h,渗漉速度为2 mL.min-1。结论:该提取工艺方法可行、工艺稳定、重复性好。  
        关键词：正交试验;提取工艺;徐长卿;丹皮酚   
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        发布时间：2024-09-23
      • LI Hao~1,WANG Qiu-juan~
        Issue 11, Pages: 21-23(2007) DOI: 10.13422/j.cnki.syfjx.2007.11.007
        摘要：Objective:To observe the effects of total glycosides of Polygala aureocauda Dunn（PTS） on blood hemorheological parameters.Methods:The model of acute blood stasis was established with high-molecular weight dextran in rat and the hemorheological parameters of the model were observed.The rabbits model of blood stasis was established with hyperlipidemic diet and the hemorheological parameters were observed.Results:As compared with model groups,high,middle and low groups of PTS could effectively prevent the ascending of whole blood viscosity and fibrinogen.Conclusion:The results suggest that the effect of PTS may be related to hemorheological improvement with decreased whole blood viscosity and improved circulatation in blood stasis rat and hyperlipemia rabbit.  
        关键词：Polygala aureocauda Dunn;hemorheology;high molecular weight dextran   
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        发布时间：2024-09-23
      • LI Hao1,WANG Qiu-juan1,ZHU Dan-ni2
        Vol. 13, Issue 11, Pages: 21-23(2007)
        摘要：Objective:To observe the effects of total glycosides of Polygala aureocauda Dunn(PTS) on blood hemorheological parameters.Methods:The model of acute blood stasis was established with high-molecular weight dextran in rat and the hemorheological parameters of the model were observed.The rabbits model of blood stasis was established with hyperlipidemic diet and the hemorheological parameters were observed.Results:As compared with model groups,high,middle and low groups of PTS could effectively prevent the ascending of whole blood viscosity and fibrinogen.Conclusion:The results suggest that the effect of PTS may be related to hemorheological improvement with decreased whole blood viscosity and improved circulatation in blood stasis rat and hyperlipemia rabbit.  
        关键词：Polygala aureocauda Dunn;hemorheology;high molecular weight dextran   
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        发布时间：2024-09-23
      • WANG Qiu-jing~1,LIU Jie~1,LIU Fen~1,LU Hang~
        Issue 11, Pages: 24-26(2007) DOI: 10.13422/j.cnki.syfjx.2007.11.008
        摘要：Objective:To observe the effects of Xue Fu Zhu Yu Granule（XFZHYG） on cardial oxygen metabolism and its influmce on acute myocardial infarction EECG in anesthetic dogs.Methods:Twenty-four dogs were devided randomly in four groups: normal conrol group,positive control group,2.5 g·kg-1 XFZHYG group;5.0 g·kg-1 XFZHYG group.The cardial oxygen metabolism parameters were measured in the anaesthetiz dogs.The degree and range of myocardial ischemia,were determined by using the acute myocardial infarction model of ligation of left anterior descending（LAD） in the anaesthetized open-chest dogs.Results:Compared with normal control group,the cardial oxygen consumption decreased in 2.5 g·kg-1 XFZHYG group and 5.0 g·kg-1 XFZHYG group,the degree and range of myocardial ischemia also decreased.XFZHYG has protective effects on myocardial ischemia in dogs.Conclusion:XFZHYG can decrease cardial oxygen consumption in dogs.XFZHYG has protective effects on myocardial ischemia in dogs.  
        关键词：XFZHYG;oxygen metabolism;myocardial infarction;the degree and range of myocardial ischemia   
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        发布时间：2024-09-23
      • WANG Qiu-jin1,LIU Jie1,LIU Fen1,LU Hang2
        Vol. 13, Issue 11, Pages: 24-26(2007)
        摘要：Objective:To observe the effects of Xue Fu Zhu Yu Granule(XFZHYG) on cardial oxygen metabolism and its influmce on acute myocardial infarction EECG in anesthetic dogs.Methods:Twenty-four dogs were devided randomly in four groups: normal conrol group,positive control group,2.5 g·kg-1 XFZHYG group;5.0 g·kg-1 XFZHYG group.The cardial oxygen metabolism parameters were measured in the anaesthetiz dogs.The degree and range of myocardial ischemia,were determined by using the acute myocardial infarction model of ligation of left anterior descending(LAD) in the anaesthetized open-chest dogs.Results:Compared with normal control group,the cardial oxygen consumption decreased in 2.5 g·kg-1 XFZHYG group and 5.0 g·kg-1 XFZHYG group,the degree and range of myocardial ischemia also decreased.XFZHYG has protective effects on myocardial ischemia in dogs.Conclusion:XFZHYG can decrease cardial oxygen consumption in dogs.XFZHYG has protective effects on myocardial ischemia in dogs.  
        关键词：XFZHYG;oxygen metabolism;myocardial infarction;the degree and range of myocardial ischemia   
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        发布时间：2024-09-23
      • MA Xiao-bin1,WANG Yang-hui1,LIU Jian-xun1,ZHU Qing-lei2,WANG Shi-wen2
        Vol. 13, Issue 11, Pages: 27-29(2007)
        摘要：Objective:To study the effects of Shenqiyixin Granule on hemodynamics parameters of pressure overload heart failure rat model.Methods:A model of heart failure induced by coarctation of abdominal aorta was treated in the study.The drugs were taken by oral for 4 weeks from 4 weeks to 8 weeks after operation.Results:To compere with model,Shenqiyixin Granule can decreased LVEDP、LVSP、dp/dtmax、SAP、cardiac index、high-level of plasma AⅡ and increased lower-level K+ in cardiac tissue.Conclusions:Shenqiyixin Granule may significantly improve hemodynemics and left ventricular function of heart failure rat.  
        关键词：heart failure;hemodynemics;Shenqiyixin Granule;rats   
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        发布时间：2024-09-23
      • MA Xiao-bin~1,WANG Yang-hui~1,LIU Jian-xun~
        Issue 11, Pages: 27-29(2007) DOI: 10.13422/j.cnki.syfjx.2007.11.009
        摘要：Objective:To study the effects of Shenqiyixin Granule on hemodynamics parameters of pressure overload heart failure rat model.Methods:A model of heart failure induced by coarctation of abdominal aorta was treated in the study.The drugs were taken by oral for 4 weeks from 4 weeks to 8 weeks after operation.Results:To compere with model,Shenqiyixin Granule can decreased LVEDP、LVSP、dp/dtmax、SAP、cardiac index、high-level of plasma AⅡ and increased lower-level K+ in cardiac tissue.Conclusions:Shenqiyixin Granule may significantly improve hemodynemics and left ventricular function of heart failure rat.  
        关键词：heart failure;hemodynemics;Shenqiyixin Granule;rats   
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        发布时间：2024-09-23
      • Yang Qing,LIANG Ri-xin,YE Jin-xia,WANG Lan,YANG Bin,FU Mei-hong,HUANG Lu-qi
        Vol. 13, Issue 11, Pages: 30-33(2007)
        摘要：Objective:To observe the function of decreasing blood-lipid by extract from Flos carthami in rat with hyperlipidemia and safety of water extract.Methods:Using hyperlipidemia animal model replicated by hyperlipidemia forage,the levels of TC,TG,HDL,LDL were assayed;actue toxicity test and thirty days feeding study were employed.Results:The levels of TG,TC,LDL-C in all groups treated with the water extract of Flos Carthami were significantly reduced.The alcohol extract of Flos carthami showed a decreased action for TC.For safety,water extract showed no death nor toxic symptom.All the observed index showed no relationship between postponing time and increasing doses during 30 d feeding period.And in teratogenicity tests,pregnant rats grew well;fetuses developed naturally,and the ratio of abnormal fetues was in the range of natural abnormal ratio.Conclusions:The extract of Flos carthami indicaterd the function of decreasing the blood-lipid,and no obvious toxic effects have been observed.  
        关键词：Flos Carthami;lipid;safety   
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        发布时间：2024-09-23
      • YANG Qing,LIANG Ri-xin,YE Jin-xia,WANG Lan,YANG Bin,FU Mei-hong,HUANG Lu-qi
        Issue 11, Pages: 30-33(2007) DOI: 10.13422/j.cnki.syfjx.2007.11.010
        摘要：Objective:To observe the function of decreasing blood-lipid by extract from Flos carthami in rat with hyperlipidemia and safety of water extract.Methods:Using hyperlipidemia animal model replicated by hyperlipidemia forage,the levels of TC,TG,HDL,LDL were assayed;actue toxicity test and thirty days feeding study were employed.Results:The levels of TG,TC,LDL-C in all groups treated with the water extract of Flos Carthami were significantly reduced.The alcohol extract of Flos carthami showed a decreased action for TC.For safety,water extract showed no death nor toxic symptom.All the observed index showed no relationship between postponing time and increasing doses during 30 d feeding period.And in teratogenicity tests,pregnant rats grew well;fetuses developed naturally,and the ratio of abnormal fetues was in the range of natural abnormal ratio.Conclusions:The extract of Flos carthami indicaterd the function of decreasing the blood-lipid,and no obvious toxic effects have been observed.  
        关键词：Flos Carthami;lipid;safety   
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        发布时间：2024-09-23
      • REN Jian-xun,LIN Cheng-ren,WANG Min,XU Hui,LIU Jian-xun~
        Issue 11, Pages: 34-36(2007) DOI: 10.13422/j.cnki.syfjx.2007.11.011
        摘要：Objective:To study the effect and mechanism of Niuhuang Jiangya Capsule on the function of platelet in rats.Methods:Healthy SD rats were fed with Niuhuang Jiangya Capsule(0.3,0.15,0.075 g·kg-1)for 7days;then the platelet adhension rates and the ADP-induced platelet agglutinate rate as well as the contents of CaM and TXA2 in platelets were measured.Results:Niuhuang Jiangya Capsule could reduce the platelet adhension rate and the ADP-induced platelete agglutinate rate,as well as the contents of CaM and TXA2 in platelets.Conculsion:Niuhuang Jiangya Capsule can suppress platelet agglutinate and adhension by interventing different pathways of platelet activation.  
        关键词：Niuhuang Jiangya Capsule;platelet;mechanism   
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        发布时间：2024-09-23
      • REN Jian-xun,LIN Cheng-ren,Wang Min,XU Hui,LIU Jian-xun
        Vol. 13, Issue 11, Pages: 34-36(2007)
        摘要：Objective:To study the effect and mechanism of Niuhuang Jiangya Capsule on the function of platelet in rats.Methods:Healthy SD rats were fed with Niuhuang Jiangya Capsule(0.3,0.15,0.075 g·kg-1)for 7days;then the platelet adhension rates and the ADP-induced platelet agglutinate rate as well as the contents of CaM and TXA2 in platelets were measured.Results:Niuhuang Jiangya Capsule could reduce the platelet adhension rate and the ADP-induced platelete agglutinate rate,as well as the contents of CaM and TXA2 in platelets.Conculsion:Niuhuang Jiangya Capsule can suppress platelet agglutinate and adhension by interventing different pathways of platelet activation.  
        关键词：Niuhuang Jiangya Capsule;platelet;mechanism   
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        发布时间：2024-09-23
      • Li Wen,ZHANG Cun,Chen Hong,YIN Xiao-jie,WANG Lan,XIAO Yong-qing
        Vol. 13, Issue 11, Pages: 37-39(2007)
        摘要：Objective:In order to provide the scientific evidence for clinical use of Fructus Gardeniae with different processing form,the comparative pharmacodynamical study was carried out on elution Parts of Fructus Gardeniae and Fructus Gardeniae Praeparatus eluted by 50% or 95% alcohol separately.Methods:To observe the influence of elution parts of Fructus Gardeniae and Fructus Gardeniae Praeparatus eluted by 50% or 95% alcohol on inflammatory,sedative,blood coagulation,and hepatic injury induced by CCl4.Results:The experimental eluted parts have shown significant effects of anti-inflammatory,while neither of them has shown sedative effects or protective effect against hepatic injury induced by CCl4.In addition,the elution part of Fructus Gardeniae Praeparatus eluted by 95% alcohol,has effect of promoting blood coagulation.Conclusion:The experimental elution parts of Fructus Gardenia and Stir-baked Fructus Gardeniae Praeparatus have show obvious effects of anti-inflammatory.Eluted part of Stir-baked Fructus Gardeniae Praeparatus by 95% alcohol has shown better effect of promoting blood coagulation.None of the eluted parts showed obvious sedative or hepatic protective effects.  
        关键词：Fructus Gardeniae;Fructus Gardeniae Praeparatus;alcohol elution;anti-inflammatory;sedative;coagulation;hepatic injury   
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        发布时间：2024-09-23
      • LI Wen,ZHANG Cun,CHEN Hong,YIN Xiao-jie,WANG Lan,XIAO Yong-qing~
        Issue 11, Pages: 37-39(2007) DOI: 10.13422/j.cnki.syfjx.2007.11.012
        摘要：Objective:In order to provide the scientific evidence for clinical use of Fructus Gardeniae with different processing form,the comparative pharmacodynamical study was carried out on elution Parts of Fructus Gardeniae and Fructus Gardeniae Praeparatus eluted by 50% or 95% alcohol separately.Methods:To observe the influence of elution parts of Fructus Gardeniae and Fructus Gardeniae Praeparatus eluted by 50% or 95% alcohol on inflammatory,sedative,blood coagulation,and hepatic injury induced by CCl4.Results:The experimental eluted parts have shown significant effects of anti-inflammatory,while neither of them has shown sedative effects or protective effect against hepatic injury induced by CCl4.In addition,the elution part of Fructus Gardeniae Praeparatus eluted by 95% alcohol,has effect of promoting blood coagulation.Conclusion:The experimental elution parts of Fructus Gardenia and Stir-baked Fructus Gardeniae Praeparatus have show obvious effects of anti-inflammatory.Eluted part of Stir-baked Fructus Gardeniae Praeparatus by 95% alcohol has shown better effect of promoting blood coagulation.None of the eluted parts showed obvious sedative or hepatic protective effects.  
        关键词：Fructus Gardeniae;Fructus Gardeniae Praeparatus;alcohol elution;anti-inflammatory;sedative;coagulation;hepatic injury   
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      • YANG Jun~
        Issue 11, Pages: 40-43(2007) DOI: 10.13422/j.cnki.syfjx.2007.11.013
        摘要：Objective:To observe the depressant effect of the Compound Qingre Granule-Serum（SQ）on extended-spectrum beta-lactamase（ESBLs）.Methods:According to ultraviolet spectrophotometry,different concentration SQ’s β-lactamase inhibiting effect was determined.The effect was tested by changes of optical density in ultraviolet light induced by ampicillin.Results:33.3% SQ can inhibit the β-lactamase effect of ATCC700603 more than 50%,and had significant difference to control group.The β-lactamase inhibiting effect of SQ also showed positive correlation with its concentration.Conclusion:SQ can inhibit the action of ESBLs significantly.It may be one of the mechanisms of the granule for curing drug-resistance bacteria infections.  
        关键词：Compound Qingre Granules;serum;extended-spectrum beta-lactamase   
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      • YANG Jun1,ZHANG Shu-wen2,YIN Cheng-hong2,WANG Hong2,REN Ai-min2,ZHANG Li-xia2,WANG Chao2,WANG Bao-en2
        Vol. 13, Issue 11, Pages: 40-43(2007)
        摘要：Objective:To observe the depressant effect of the Compound Qingre Granule-Serum(SQ)on extended-spectrum beta-lactamase(ESBLs).Methods:According to ultraviolet spectrophotometry,different concentration SQ's β-lactamase inhibiting effect was determined.The effect was tested by changes of optical density in ultraviolet light induced by ampicillin.Results:33.3% SQ can inhibit the β-lactamase effect of ATCC700603 more than 50%,and had significant difference to control group.The β-lactamase inhibiting effect of SQ also showed positive correlation with its concentration.Conclusion:SQ can inhibit the action of ESBLs significantly.It may be one of the mechanisms of the granule for curing drug-resistance bacteria infections.  
        关键词：Compound Qingre Granules;serum;extended-spectrum beta-lactamase   
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        发布时间：2024-09-23
      • CHE Yan-zhong~
        Issue 11, Pages: 44-46(2007) DOI: 10.13422/j.cnki.syfjx.2007.11.014
        摘要：Objective:To investigate the effect of Jichuanjian on gastrointestinal peristalsis of senile rats and study relevant mechanism.Methods:The effect of Jichuanjian on gastrointestinal peristalsis of senile rats was observed by small intestine charcoal powder propelling test.The levels of motilin,substance P and somatostain in small intestine of rats were determinated by radioimmunoassay.Results:Different dosage of Jichuanjian can improve gastrointestinal peristalasis of senile rats and increase the levels of motilin,substance P,with reduce the content of somatostatin in small intestine of senile rats significantly.Conclusions:Jichuanjian can enhance the function of gastrointestinal peristalsis of senile rats by a mechanism of promoting secretion of motilin,substance P and lowering the level of somatostatin in intestine.  
        关键词：Jichuanjian;senile rat;motilin;substance P;somatostatin   
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        发布时间：2024-09-23
      • CHE Yan-zhong1,CHEN Hong-bao1,AN Li-feng2,CHANG Li1,FAN Xiao-yong1
        Vol. 13, Issue 11, Pages: 44-46(2007)
        摘要：Objective:To investigate the effect of Jichuanjian on gastrointestinal peristalsis of senile rats and study relevant mechanism.Methods:The effect of Jichuanjian on gastrointestinal peristalsis of senile rats was observed by small intestine charcoal powder propelling test.The levels of motilin,substance P and somatostain in small intestine of rats were determinated by radioimmunoassay.Results:Different dosage of Jichuanjian can improve gastrointestinal peristalasis of senile rats and increase the levels of motilin,substance P,with reduce the content of somatostatin in small intestine of senile rats significantly.Conclusions:Jichuanjian can enhance the function of gastrointestinal peristalsis of senile rats by a mechanism of promoting secretion of motilin,substance P and lowering the level of somatostatin in intestine.  
        关键词：Jichuanjian;senile rat;motilin;substance P;somatostatin   
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      • Issue 11, Pages: 47-49(2007) DOI: 10.13422/j.cnki.syfjx.2007.11.015
        摘要：目的:研究复方芦荟胶囊的药理作用。方法:采用小鼠失水致便秘、复方地芬诺酯致便秘和阿托品致胃肠运动障碍动物模型,观察通便作用;用醋酸致扭体动物模型,观察镇痛作用;用失水致便秘动物模型,观察镇静作用。结果:复方芦荟胶囊具有促进便秘模型动物排便,促进阿托品致胃肠运动障碍模型动物的肠推进作用;可延长醋酸致小鼠扭体潜伏期和减少扭体次数;抑制失水致便秘模型动物自主活动。结论:复方芦荟胶囊具有促进肠推进、通便作用以及镇痛、镇静作用。  
        关键词：复方芦荟胶囊;便秘;肠推进;镇痛;镇静   
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      • Issue 11, Pages: 49-51(2007) DOI: 10.13422/j.cnki.syfjx.2007.11.016
        摘要：目的:探讨豨莶草水煎剂对小鼠的毒性作用和可能受损的靶器官,为临床用药剂量提供依据。方法:将昆明种小鼠随机分组,按不同剂量相同容积灌胃给药,测定半数致死量（LD50）并按公式计算脏器系数,测定血液生化指标ALT,BUN;对肝、肾及肺进行了病理组织学检查。结果:豨莶草水煎剂半数致死量LD50为18.02 g.kg-1（相当生药146.7 g.kg-1）,该药给小鼠（0.11.0）g.kg-1剂量下连续灌胃给药两周,对小鼠无明显的毒性作用,在3.0 g.kg-1剂量时,血清BUN高于对照组,肺呈现间质性肺炎病变。结论:豨莶草提取物对小鼠及脏器有一定的毒性作用。临床长期大量使用须慎重。  
        关键词：豨莶草;急性毒性;亚急性毒性;肺脏   
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      • Issue 11, Pages: 52-54(2007) DOI: 10.13422/j.cnki.syfjx.2007.11.017
        摘要：目的:探讨不同浓度的复方杜仲水煎液对肉鸡小肠发育的影响。方法:1日龄AA肉鸡224只,随机分成4组。ⅠⅣ组以0,1.25,2.5,5.0 g.L-1浓度的复方杜仲水煎液饮用,连续6周。（16）周末每组随机抽样6只称重、宰杀,测量小肠各段的长度并称重。结果:复方杜仲组1,2周龄十二指肠,1周龄空肠、回肠相对肠重及单位肠重均较对照组高,（35）周龄各肠管的相对肠重及单位肠重均低于对照组。结论:复方杜仲能够促进肉鸡小肠的早期发育,并能有效防止肉鸡生长中期的肠壁增厚,有利于营养物质的吸收。  
        关键词：复方杜仲;肉鸡;小肠发育   
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      • CHEN Yan,ZHU Quan-hong,LUO Jia-bo,CHEN Fei-long
        Vol. 13, Issue 11, Pages: 55-60(2007)
        摘要：Objective:To study excretion of ephedrines in human urine after oral administration of traditional chinese medicine Mahuang Tang decoction.Methods:After consuming a double clinical dose of Mahuang Tang decoction,urine samples from healthy volunteers were collected at different time.The urine sample and Mahuang Tang decoction were subjected to KOH(5 mol/L)alkalization and acetic ether extraction before gas chromatography-mass spectrometry(GC-MS)analysis.Results:The amount of NMP,NME,E,PE and ME in Mahuang Tang decoction was 4.38,3.24,97.45,26.15 and 6.16 mg,respectively.At 24 h post-administration,the average accumulated excretion rate of ephedrines were 118.84,291.96,70.18,90.74 and 38.10%,respectively.Conclusions:As one of the main active components of Mahuang Tang decoction,E excreted most quickly.ME excreted most slowly.NMP,NME,E,PE and ME were metabolites of Mahuang Tang decoction in human body.NMP,NME,E and PE mainly metabolized as unchanged parent compounds,while a small amount for ME,and then excreted in urine with assistance of kidney.  
        关键词：Mahuang Tang;urine excretion;metabolite;ephedrine;pseudoephedrine;methylephedrine;norephedrine;norpseudoephedrine   
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        发布时间：2024-09-23
      • CHEN Yan,ZHU Quan-hong,LUO Jia-bo~,CHEN Fei-long
        Issue 11, Pages: 55-60(2007) DOI: 10.13422/j.cnki.syfjx.2007.11.018
        摘要：Objective:To study excretion of ephedrines in human urine after oral administration of traditional chinese medicine Mahuang Tang decoction.Methods:After consuming a double clinical dose of Mahuang Tang decoction,urine samples from healthy volunteers were collected at different time.The urine sample and Mahuang Tang decoction were subjected to KOH（5 mol/L）alkalization and acetic ether extraction before gas chromatography-mass spectrometry（GC-MS）analysis.Results:The amount of NMP,NME,E,PE and ME in Mahuang Tang decoction was 4.38,3.24,97.45,26.15 and 6.16 mg,respectively.At 24 h post-administration,the average accumulated excretion rate of ephedrines were 118.84,291.96,70.18,90.74 and 38.10%,respectively.Conclusions:As one of the main active components of Mahuang Tang decoction,E excreted most quickly.ME excreted most slowly.NMP,NME,E,PE and ME were metabolites of Mahuang Tang decoction in human body.NMP,NME,E and PE mainly metabolized as unchanged parent compounds,while a small amount for ME,and then excreted in urine with assistance of kidney.  
        关键词：Mahuang Tang;urine excretion;metabolite;ephedrine;pseudoephedrine;methylephedrine;norephedrine;norpseudoephedrine   
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      • Vol. 0, Issue 11, Pages: 60-61(2007) DOI: 10.13422/j.cnki.syfjx.2007.11.019
          
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      • Vol. 0, Issue 11, Pages: 69(2007) DOI: 10.13422/j.cnki.syfjx.2007.11.022
          
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      • SHEN Shi-lin1,2,ZHANG Ru-xue1,JIA Zheng-ping1
        Vol. 13, Issue 11, Pages: 64-66(2007)
        摘要：Objective:The anti-radiation of Chinese traditional medical formulae is reviewed by the literatures of latest five years from domestic and abroad.Methods:Literatures are reviewed.Results:Some of the traditional medical formulae are antiradiative,such as Siwu Tang and Yang Yin Kang Du San.Conclusions:The prescription composed of herbs of cleaning heat,promoting body fluid production,invigorating vital energy and nourishing blood is of antiradiative.  
        关键词：radiation injury;traditional medical formulae;advances   
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      • Vol. 0, Issue 11, Pages: 70-71(2007) DOI: 10.13422/j.cnki.syfjx.2007.11.025
          
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      • Vol. 0, Issue 11, Pages: 71(2007) DOI: 10.13422/j.cnki.syfjx.2007.11.024
          
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      • Vol. 0, Issue 11, Pages: 72-73(2007) DOI: 10.13422/j.cnki.syfjx.2007.11.023
          
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      • Issue 11, Pages: 62-63(2007) DOI: 10.13422/j.cnki.syfjx.2007.11.001
        摘要：目的:观察加减凉血活血汤与迪银片对照治疗98例寻常性银屑病临床疗效,探讨治疗前后患者血清白介素-8（IL-8）,白介素-10（IL-10）,泌乳素（PRL）,雌二醇（E2）的变化。方法:分别于治疗前、治疗后第8周检测两组患者血清IL-8,IL-10和PRL,E2。结果:（1）加减凉血活血汤、迪银片治疗后IL-8,PRL水平较治疗前均明显降低（P<0.01,P<0.01）,IL-10水平明显升高（P<0.01）,女性银屑病患者雌二醇含量明显降低（P<0.01）;加减凉血活血汤组与迪银片组之间无显著性差异（P>0.05）。结论:银屑病患者IL-8,IL-10和PRL含量异常,提示其免疫-内分泌功能紊乱,加减凉血活血汤与迪银片均可改善银屑病患者免疫-内分泌紊乱,而加减凉血活血汤组全身症状改善较好,副作用少。  
        关键词：加减凉血活血汤;迪银片;银屑病;白介素-8;白介素-10;雌二醇;泌乳素   
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      • SHEN Shi-lin~
        Issue 11, Pages: 64-66(2007) DOI: 10.13422/j.cnki.syfjx.2007.11.020
        摘要：Objective:The anti-radiation of Chinese traditional medical formulae is reviewed by the literatures of latest five years from domestic and abroad.Methods:Literatures are reviewed.Results:Some of the traditional medical formulae are antiradiative,such as Siwu Tang and Yang Yin Kang Du San.Conclusions:The prescription composed of herbs of cleaning heat,promoting body fluid production,invigorating vital energy and nourishing blood is of antiradiative.  
        关键词：radiation injury;traditional medical formulae;advances   
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      • Issue 11, Pages: 67-68(2007) DOI: 10.13422/j.cnki.syfjx.2007.11.021
        摘要：目的:对牡丹皮的历代炮制衍变过程进行总结,以探究其炮制历史发展轨迹。方法:对汉代以来的中医药文献以及历版国家药典、全国地方炮制规范中有关牡丹皮的炮制资料进行了系统整理和分析,总结。结果与结论:历代曾应用的炮制方法有十多种,经过历代衍变,至今仍沿用的方法有"去心"、"清炒"、"酒制"、"制炭"等,尤其以"去心"净制、切制后生品入药为主要方法。  
        关键词：牡丹皮;炮制;历史沿革   
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