最新刊期
卷 16 ， 期 7 ， 2010
- 摘要：Objective: To optimize the preparation technology of Licorice Flavone-β-cyclodextrin encapsulation compounds. Method: The optimum preparation condition was studied by orthogonal test, the inclusion compounds were prepared with solution-agitating technique at the same time, UV was adopted in determining the solubility and dissolution rate. Rusult: The optimum condition was: licorice flavone:β-CD 1 ∶6;inclusion time 2 h;and the inclusion temperature 40 ℃. Conclusion: The solubility and dissolution rate of licorice flavone was improved.关键词：licorice flavone;β-CD;optimization;solubilizing
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发布时间：2024-01-04 - 摘要：Objective: To optimize the extraction technology of Chaiqin Qinggan Formular. Method: A HPLC method was established to simultaneously determine the contents of baicalin, paeoniflorin and glycyrrhizin in the extractions of Chaiqin Qinggan Formular. Based on the orthogonal design of L9(34) and the weighted method, three factors including the multiple water, decocting time, and extracting times were evaluated. Result: Significant effect was observed in extracting times. The best extraction process is A3B1C3. Conclusion: The extraction technology optimized with multiple components evaluation is reasonably practicable.关键词：Chaiqin Qinggan formular;orthogonal design;baicalin;paeoniflorin;glycyrrhizin
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发布时间：2024-01-04 - 摘要：Objective: To research the best preparational technics of Shaoshi Securing Eyes Capsules. Method: Using orghogonal design to optimize the process, determine the water-absorption rate, drying tempreture, moist-absorption rate and fluent character. Result: Shaoshi Securing-Eyes Capsules was prepared with best technics. Conclusion: The method of preparation of capsules is simple and feasible.关键词：paeoniflorin;Shaoshi Securing-Eyes Capsules;preparation
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发布时间：2024-01-04 - 摘要：Objective: To study the extraction and assaying of Safflower polysaccharide (SPS), and to provide suitable experimental drug specimen for exploreing the anti-carcinoma effect of SPS. Method: Water extracting and ethanol precipitating methods were applied to extract polysaccharide from Safflower. By Sevage method, protein can be removed,and by oxidation method to decolor the polysaccharide. After phenol-sulphuric acid coloring, the polysaccharide content was determined by the method of absorption spectrometry. Result: The standard curve was liner in the concentration range of 5~50 μg·mL-1 with correlation coefficient of r=0.9994, the linear regression equation was Y=0.01749X-0.03165, the contents of polysaccharide from Safflower was 96.048%. Conclusion: This methods have advantages of simple operation, good stability, high accuracy and good reproducibility.This extraction technology could be used to extract Safflower polysaccharide for studies on its anti-carcinoma effect.关键词：safflower polysaccharide(SPS);spectrophotography;extraction;purification;assaying
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发布时间：2024-01-04 - 摘要：Objective: To establish the method of dissolution test for Danning Dispersible Tablets. Method: Paddle method was used at the rotary speed of 100 r·min-1, the dissolving time was 30 minutes and the dissolving medium was 0.5% sodium laurylsulfate. The dissolution rate of berberine hydrochloride was determined by HPLC with a ZORBAX RX-C18 (4.6 mm×150 mm,5 μm)column. The mobile phase was consisted with acetonitrile-0.1 mol·L-1 monopotassium phosphate-0.025 mol·L-1 sodium laurylsulfate (50 ∶25 ∶25) and the flow rate was 1.0 mL·min-1. The detection wavelength was at 288 nm. Result: The cumulate dissolution rate of Danning Dispersible Tablets had little difference in and between batches. The cumulate dissolution percentage tended to be stable after 30 minutes, and the average cumulate dissolution rate was 89.39%. Conclusion: The method established is simple, accurate and repeatable for the quality control of Danning Dispersible Tablets.关键词：Danning Dispersible Tablets;dissolution rate;berberine hydrochloride;HPLC
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发布时间：2024-01-04 - 摘要：Objective : To optimize the matrix formula of Rouguiyou cataplasm. Method : Orthogonal experiment was used to design formula by measuring tack, cohesion and physical properties; percutaneous permeability in vitro was tested by using the franz diffusion cell, the permeation amount of cinnamaldehyde within 12h in vitro was examined by HPLC. Result : The optimal formula was acquired with carbomer 1.3g, glycerol 30 g and PAAS 5.5g, and the percutaneous rate is 13.44 μg ·cm-2 ·h-1. Conclusion : The established preparation technique of cataplasm was feasible, and its percutaneous permeability in vitro was stable.关键词：Rouguiyou cataplasma;orthogonal test;percutaneous permeability
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发布时间：2024-01-04 - 摘要：Objective: Analyzes the quality of commercialized magnetitum,which offer the basic materials for setting up the scientific and feasible quality standards. Method: 27 samples were collected from different areas, which were analyzed through the appearance shape, internal structure and the iron content. Result: The appearance shape of commercialized Magnetitum was difference. The main content of the Magnetitum was magnetite. The iron content 9 samples in all 19 fresh samples was more than 50% and only 3 samples in all 8 processed samples was more than 45%. Conclusion: On the market at present,the qualified commercialized magnetitum was low. In order to ensure the safe and effective in clinical medication and control the quality, its necessary to improve the cleaning technology of magnet materials.关键词：Magnetitum;characters analysis;iron content;quality analysis
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发布时间：2024-01-04 - 摘要：Objective: To determine the chlorogenic acid in Yinhuang granulesn by near-infrared spectroscopy(NIRS) combined with TQ software. Method: The near-infrared spectra and HPLC values of the chlorogenic acid in Yinhuang granules from different pharmaceutical factories were collected,and the quantitative calibration model was established with the TQ software.And then,the prediction samples were anylized by the model. Result: The correlation coefficients(R2) , the root-mean-square error of calibration(RMSEC) and the root-mean-square error of cross-validation(RMSECV) of the quantitative calibration model for chlorogenic acid were 0.995 ,0.123 and 0.412 respectively;the correlation coefficients of prediction(r2)and the root-mean-square error of prediction(RMSEP) were 0.984 and 0.166. Conclusion: The medel was applied for the directed determination of chlorogenic acid in Yinhuang granules.The method is simple,non-polluted and accurate ,and could be applied for the fast determination of Yinhuang granules quantities.关键词：nearinfrared spectroscopy;TQ software;chlorogenic acid;Yinhuang granules
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发布时间：2024-01-04 - 摘要：Objective: To investigate the content variation of jujuboside A and schisandrin before and after the combination of Semen Ziziphi Spinosae with Schisandra chinensis. Method: Jujuboside A and Schisandrin Contents were decocted with water separately and the separate aqueous extract were combined partly. Then the contents of Jujuboside A and Schisandrin determined by high performance liquid chromatography (HPLC). Results: Both contents of Jujuboside A and Schisandrin were declined significantly when Semen Ziziphi Spinosae and Schisandra Chinensis decocted together. Conclusion: The great influence of the combination of Semen Ziziphi Spinosae with Schisandra chinensis on the contents of main chemical constituents was mainly carried on in the decoction process which provides a certain scientific basis for the reasonable Chinese herbal medicine.关键词：Semen Ziziphi Spinosae;Schisandra chinensis;jujuboside A;schisandrin;HPLC
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发布时间：2024-01-04 - 摘要：Six compounds were isolated from the 90 percent ethanol extracts of Euonymus alarus (Thunb.)Sieb by silica gel,macroporous resin and sephadex LH-20. They were identified as:aromadendrin(1),epifriedelanol(2),protocatechuic acid(3),β–sitosterol(4),quercetin(5) and rutin(6). And rutin was firstly isolated from this plant.关键词：Euouymus alatus;hypoglycemic extracts;chemical constituents
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发布时间：2024-01-04 - 摘要：Objective: Objective To determine the content of harpagoside in granules of Yangyin Qinfei. Method: A Rp-HPLC method was established . The chromatographic column was Hypersil ODS(4.6 mm×250 mm),and acetonitile-water (containing 1%acetic acid ) (15 ∶85~60 ∶40 )(0~25 min ) was wsed as mobile phase. The flow rate was 1 mL ·min-1,the detection wavelength was at 278 nm,and the column temperature was 25 ℃. Result :The average recovery of harpagoside was 97.02%,and RSD was 0.6%(n=9). Conclusion: The method established can be used to determine the content of Harpagoside in Granules of Yangyin Qinfei.关键词：Granules of Yangyin Qinfei;harpagoside;HPLC;content determination
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发布时间：2024-01-04 - 摘要：Objective: Lily polysaccharide was extracted from lily,then lily polysaccharide-Fe(Ⅲ)complex(LPC) was synthesized with lily polysaccharide and FeCl3.We will establish the method of determination of iron in LPC. Method: Lily polysaccharide was abstracted with warm water; LPC was synthesized with lily polysaccharide and FeCl3 under the alkaline condition; Thedetermination of Fe(Ⅲ) was done with the method of ferroin- Fe(Ⅱ) and atomic absorption spectrophometry. Result: LPC was heavy brownish red and shapeless powder. Content of Fe(Ⅲ) at LPC was 20.81%( ferroin- Fe(Ⅱ)) and 20.10%( atomic absorption). Conclusion: The results are about the same.关键词：lily polysaccharide;polysaccharide-Fe(Ⅲ)complex;synthesis;determination of iron
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发布时间：2024-01-04 - 摘要：Objective: To establish a HPLC method for the determination of shanzhiside methylester in the preparations of Lamiophlomis rotata . Method: HPLC analysis was performed on Symmetry C18 (5 μm) column and gradient elution ∶91), 9-20 min, acetonitrile-water (15 ∶85)] was used as the mobile phase at a flow rate of 1.0 ml ·min-1. The column temperature was 20 ℃ and the detection wavelength was at 235 nm. Result: The linear range of shanzhiside methylester was 9.6~115.2 μg ·mL-1 (r=0.999 8) and the average recovery was 97.69%. Shanzhiside methylester could be detected from all preparations and the content variedgreatly. Conclusion: The method can be applied to determine the content of shanzhiside methylester in the preparations of L. rotata .关键词：HPLC;Lamiophlomis rotata;shanzhiside methylester;assaying
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发布时间：2024-01-04 - 摘要：Objective :To establish the quality standard of Shexiang Niuhuang pill. Method : Angelica sinensis Diels, borneolum Syntheticum, Coptis chinensis Franch and Phellodendron chinense Cortex were identified by TLC. The content of emodin and chrysophanol in Shexiang niuhuang pill was determined by HPLC. The separation was performed on Kromasil ODS column with Methanol-0.1% phosphoric acid (75 ∶25) as mobile phase,The UV detector was set at 254 nm. Result :The average recovery and RSD was 99.63% and 2.9%,The calibration curve was linear in the range of 0.007 59~0.037 93 μg ·μL-1 (r=0.999 9). Conclusion :The method can be used of the preparation.关键词：Shexiang Niuhuang pill;TLC;HPLC;emodin;chrysophanol
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发布时间：2024-01-04 - 摘要：Objective : Aim to establish a HPLC-ELSD method for determination of betaine in Lycium barbamm . Method : HPLC-ELSD method was used Luna 5 u SCX 100A (4.6 mm×250 mm,5 μm),was used with methanol-0.10 mol ·L-1 ammonium acetate (15 ∶85),the flow rate was 1.0 mL ·min-1,the column temperature was at 30 ℃; Detector parameter were as follow:the nebulizar temperature was at 60 ℃,and the evaporation temperature was at 90 ℃,the flow rate was 1.0 L·min-1. Result :The linear range of betaine was in 0.75~3.75 μg (r=0.999 7);The average recovery (n=6 ) was 99.86%,with RSD 2.05%. Conclusion :The method is suitable for the determination the contents of the betaine in L. barbamm .关键词：Lycium barbamm L;betaine;HPLC-ELSD
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发布时间：2024-01-04 - 摘要：Objective :To study the contents of ferulic acid in chinese herbal compound (Xiongqiongtang,Shenghuatang and Siwutang ) that contain Danggui-Chuanxiong pair compatibility. Method :The contents of ferulic acid was determined by RP-HPLC. Result : The ferulic acid contents in Xiongqiongtang,Shenghuatang and Siwutang was(109.4±3.0)mg ·L -1 ,(95.3±1.9)mg ·L -1 and(85.6±2.0)mg ·L -1 respectively. Conclusion :The contents of ferulic acid decreased both in the decoctions combined with peach kernel,roasted ginger,baked licorice,and in the decoctions combined with peony root,prepared radix rehmanniae.关键词：Danggui-Chuanxiong pair;compatibility;chinese herbal compound;ferulic acid;RP-HPLC
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发布时间：2024-01-04 - 摘要：Objective : To establish a rapid resolution liquid chromatography tandem mass spectrometry (LC-MS/MS) method for determination of luteolin in Herba Lamiophlomis . Method :A LC-MS/MS method was set up using Eclipse Plus C18 (2.1 mm×100 mm,3.5 μm),methanol- 0.1% acetic acid (80 ∶20) as the mobile phase with a flow rate of 0.2 mL·min-1. Result :The luteolin was linear in the range of 5 to 160 ng ·mL-1and the average recovery was 99.27% for luteolin. Conclusion : The method was simple,rapid and accurate and could be used for the determination of luteolin in Herba Lamiophlomis .关键词：LC-MS/MS;Herba Lamiophlomis;luteolin
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发布时间：2024-01-04 - 摘要：Objective :To develop a RP-HPLC method for the determination of Geniposide in Qinggan Lidan capsule. Method :Diamonsil C18 (4.6 mm×250 mm,5 μm) was used,the mobile phase was acetonitrile-water(10 ∶90)at a flow rate of 1.0 mL · min-l. The UV detection wavelength was at 238 nm,and the column temperature was at 25 ℃. Result : The linear range was 0.054 48~1.634 4 μg ( r = 0.999 9)for Geniposide. The average recovery(n=6)was 99.77%. Conclusion :The method is found to be simple and accurate for analysis of Geniposide in Qinggan Lidan capsule.关键词：Qinggan Lidan capsule;geniposide;HPLC;determination
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发布时间：2024-01-04 - 摘要：Objective :To establish HPLC-fingerprints and compare the differences of processed Rhizoma Atractylodis Macrocephalae. This study was aimed at supplying reference for the quality control of processing technology. Method :Kromasil C18(4.6 mm×250 mm,5 μm) column was used with gradient elution of acetonitrile - water as the mobile phase. The detection wavelength was 242 nm and flow rate was 1.0 mL ·min-1. The "Chromatographic Fingerprint Similarity Evaluation" software was used to analyze similarity and compare the fingerprints. Result :There are obvious identical peaks between fried and crude Rhizoma Atractylodis Macrocephalae. But the samples of different processed materials had obvious differences in fingerprints. Conclusion :The HPLC-fingrerprint is repeatable and feasible in analysis and can be used in quality control.关键词：Rhizoma Atractylodis Macrocephalae;fry;fingerprint;HPLC
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发布时间：2024-01-04 - 摘要：Objective: To investigate the volatile constituents from Lysimachia circaeoides Hemsl. Method: The volatile constituents of L. circaeoides were analyzed by head-space solid micro-extraction, coupled with GC-MS for the first time. Result: 17 compounds were identified, 98.75% of the total essential constituents. Conclusion: The main volatile constituent of L. circaeoides were n -hexadecanoic acid(48.00%),6,10,14-trimethyl-2-pentadecanone (12.93 %) and ( Z,Z )-9,12-octadecadienoic acid(7.42%).关键词：Lysimachia circaeoides Hemsl.;volatile constituents;SPME;GC-MS
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发布时间：2024-01-04 - 摘要：Objective: To establish HPLC method for the Determination of glycyrrhizic acid, 6-gingerol, honokiol and magnolol in Wenfei Zhike Capsule. Method: LUNA ODS C18 BDS(4.6 mm×200 mm,5 μm)was used with methanol-0.05 mol·L-1 ammonium acetate-glacial acetic acid (65 ∶35 ∶0.5)as a mobile phase. The flow rate was 1.0 mL·min-1. The detection wavelength was 250 nm. The column temperature was 30℃. Result: The average recovery of was 98.17%, 99.14%, 98.31% and 99.49% for glycyrrhizic acid, 6-gingerol, honokiol and magnolol respectively. Conclusion: The method can be used for quality control of Wenfei Zhike Capsule.关键词：Wenfei Zhike Capsule;glycyrrhizic acid;6-gingerol;honokiol;magnolol;HPLC
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发布时间：2024-01-04 - 摘要：Objective: The aim of this study was to isolate the endophyte of Ficus carica and screen of its antibiotic activities. Method: The endophytic fungi were indentified by morphology, Staphylococcus aureus , Escherichia coli , Alternaria brassicae , Valsa mali, Fusarium graminearum , F. oxysporumf. sp. fragariae, Penicillium notatum were selected as the indicator to test the inhibitory activity of the isolated strains. Result: Sixty-one strains of endophytic fungi were isolated from the healthy root, stem and leaf of F. carice , which belonged to twenty genera, twelve families, seven orders and five classes. Of them forty strains were antimicrobial. The percentage of antimicrobial strains to tested strains is 65.57%. Conclusion: It indicated that the endophyte of F. carica were diversity and rich and has the best research and application value.关键词：Ficus carica;endophytic fung;isolation;identification;antimicrobial activity
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发布时间：2024-01-04 - 摘要：Objective: By determination of total tannin content to evaluation the quality of excrement of the wild and breeding of Trogopterus xanthipes . Method :Using spectrophotometry to determination total tannin content of different sources excrement of T. xanthipes . Result :The total tannins of excrement of Animals feed Cacumen Platycladi were higher than the simple of natural state, feed Folium Rhusii, F. Fraxini and C. Platycladi the tannin content is higher than only feed Cacumen Platycladi simple and natural state simple. Conclusion :This method can be used the quality evaluation of excrement of T. xanthipes and provided scientific basis for prepare breeding materials.关键词：excrement of natural state Trogopterus xanthipes;excrement of breeding Trogopterus xanthipes;total tannin;spectrophotometry
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发布时间：2024-01-04 - 摘要：Objective: To analyse and compare the volatile components which were extracted from hull and seed of Magnolia grandiflora . Method: The volatile components were extracted from hull and seeds of Magnolia grandiflora by steam distillation and the chemical components of them were identified by GC-MS. Result: One hundred and eleven compounds were extracted from the hull, seventy-eight compounds were identified, accounting for 56.54%of the total volatile oil, and eighty-nine compounds were extracted from seed , fifty-eight compounds were identified, accounting for 46.02% of the total volatile oil. Twenty-one compounds were common in both of hull and seeds. Conclusion: The results of the studies can be referenced when the hull and seeds of Magnolia grandiflora need to be further studied.关键词：Magnolia grandiflora;volatile chemical constituents;GC-MS
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发布时间：2024-01-04 - 摘要：Cyclic AMP is one of the bioactive components in the extract of Fructus Jujubae, which is reported to be involved with the treatment of depression. To investigate the content of cAMP in the plasma and hippocampus according to the time variation after a single administration of the extract orally at the dose of 0.35 g ·kg-1 in mice, the plasma and hippocampi were collected at the time of 0.5, 1, 2, 4, 6, 8, 12 and 24 h and the ELISA method is used to determine the content of cAMP. As a result, the content of cAMP in plasma reaches to the maximum at the 0.5 h, and then decreases gradually from the 0.5 h to the 8 h. However, the content reversely increases rapidly from the 8 h to the 12 h, while decreases again in the following 12 hours. As to the hippocampi, differences are significant. The cAMP content in hippocampi is ascending gently in the first 6 hours and increasing quickly in the following hours. It is an indication that some bioactive substances in the extract of Fructus Jujubae are likely to be the specific inhibitor of Phosphodiesterase type Ⅳ (PDE4). Therefore, the extract treated to the mice can inhibit the activity of PDE4 and increase the content of cAMP in the plasma and hippocampi during the time of 6 to 12 h. Thus, a possible mechanism for the antidepressant like effect of the extract of Fructus Jujubae is involved with the inhibition of PDE4.关键词：extract of Fructus Jujubae;ELISA method;cyclic AMP;inhibitor of PDE4;antidepressant
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发布时间：2024-01-04 - 摘要：Objective: To investigate effect of different dose Shenmai Injection (SMI) on blood concentration of TNF-α,IL-1β,IL-6. Method: Twenty model dogs with heart failure (HF) were randomly divided into 4 groups: the control one(0.9% NaCl injection 20 mL iv qd ×7 , n=5)and the low, middle and high dose ones of SMI (administrated by 0.517,1.034 and 1.551 mL ·kg-1,diluted to 20 mL with 0.9% NaCl injection,iv qd ×7,n=5). Blood samples (2 mL) were collected before administration and at 72 h and 144 h after that,refrigerated (at -80 ℃) to be determined for the blood concentration of TNF-α,IL-1β,IL-6 by radio-immunity assay. Results: Blood concentration of TNF-α,IL-1β,IL-6 in the different dose SMI groups was higher than that in the control one, and it showed some dose-effect relationship. Conclusions: SMI could effectively reduce blood concentration of TNF-α,IL-1β,IL-6 in the model dogs with heart failure and showed some dose-effect and time-effect relationships.关键词：Shenmai injection;heart failure;TNF-α;IL-1β;IL-6
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发布时间：2024-01-04 - 摘要：Objective: To observe the effect of Guizhi Mahuang Geban Tang (GMGT, Integrated Decoction of Ramulus Cinnamomi Decoction and Herba Ephedrae Decoction), Yinqiao San (YS, Powder of Flos Lonicerae and Fructus Forsythiae), and Xinjia Xiangru Yin (XXY, Modified Herba Moslae Powder) on interleukin 2 (IL-2) and T lymphocyte subgroups in mice infected with influenza A virus of type 1 or type 3. Method: NIH mice with specific pathogen free were given GMGT, YS and XXY(0.4mL·d-1,ig) respectively one day before the mice were attacked by intranasal dripping of 0.05 mL influenza A virus solution. After establishing the model, blood sample was collected on the fourth day, and the amount of IL-2 and CD＋3,CD＋4,CD＋8 in the blood was examined. Result: After infection, the peripheral IL-2 level in infected mice was decreased as compared with the normal group (P<0.05). YS had no significant effect on mice infected with type 3 influenza A virus. Both virazole and three exterior-releasing therapies increased the peripheral IL-2 level in mice infected with influenza A virus, and three exterior-releasing therapies increased the peripheral IL-2 level in mice infected with type 1 influenza A virus (P<0.05, compared with the normal group). CD＋3 and CD＋ 4 percentage in the mice infected with type 1 influenza A virus decreased as compared with those in the normal group (P<0.05), and the decrease of CD＋4percentage in the infected mice was obvious, resulting in the lower CD+4/CD+8 (P<0.05 compared with the normal group). Three exterior-releasing therapies increased the total amount of CD＋3 and CD＋4(P<0.05, compared with the model group), and increased the CD+8 (P<0.05, compared with the normal group) and CD+4/CD+8(P<0.05, compared with the model group), being close to the normal level. Conclusion : The anti-virus mechanism of the three exterior-releasing therapies, GMGT, YS and XXY, is probably related with elevation of the cellular immune function.关键词：influenza;virus;Chinese herbal prescriptions;interleukin 2;T lymphocyte subgroups
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发布时间：2024-01-04 - 摘要：Objective: To compare the differences of Radix Paeoniae Rubra and Radix Paeoniae Alba by pharmacodynamical studies accordingly. Method: The influences of elution parts of Radix Paeoniae Rubra and Radix Paeoniae Alba on inflammation and blood coagulation were investigated. Result: The experimental extracts showed the effects of anti-inflammation, anti-platelet aggregation and delaying of blood coagulation. Conclusion: The extract of Radix Paeoniae Alba has obvious effect of anti-inflammation. The extract of Radix Paeoniae Rubra has marked effect on inhibition of platelet aggregation.关键词：Radix Paeoniae Rubra;Radix Paeoniae Alba;anti-inflammation;coagulation
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发布时间：2024-01-04 - 摘要：Objective: To investigate the effect of Shuangshenling Granules on treating chronic renal failure (CRF) and explore its mechanism to provide experimental basis for clinical application. Method: Rat model of CRF was induced by adenine and the effect of Shuangshenling Granules was tested. The effect on hemorheological indexes of blood stasis in rats,such as blood viscosity at low shear rate, was investigated; and the effects on microcirculatory disturbance and immunological function in mice were also tested. Result: Shuangshenling Granules could decrease the increased BUN and Crea induced by adenine in rat. The Granules could also improve the hemorheological indexes, microcirculation and immunological function in the experimental animals. Conclusion: Shuangshenling Granules have the function of delaying the progress of CRF which is related with hemorheological indexes, microcirculation and immunological function.关键词：Shuangshenling Granules;chronic renal failure;experimental study
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发布时间：2024-01-04 - 摘要：Objective: To investigate the stachydrine (Sta) on norepinephrine (NE)-induced hypertrophy of neonatal rat cardiac myocyte sarcoplasmic reticulum calcium uptake capacity and activity of SERCA. Method: different concentrations of stachydrine (10-4,10-5,10-6 mol·L-1) on the NE-induced cardiac hypertrophy model group intervention, by rat cardiac sarcoplasmic reticulum calcium uptake of protein levels and the ability to Stachydrine reflect on NE-induced hypertrophy of neonatal rat cardiac myocytes studied. Result: Stachydrine can significantly reduce the protein content of myocardial cells and reduce Protein / DNA ratio; Stachydrine in a dose-dependent increase NE-induced cardiac mast cells in sarcoplasmic reticulum calcium uptake and activity of SERCA. Conclusion: Stachydrine on NE-induced cardiac mast cells in sarcoplasmic reticulum calcium uptake have a certain degree of increased dose-dependent relationship between certain, with the concentration of Stachydrine improvement of sarcoplasmic reticulum calcium uptake rate and activity of SERCA has improved markedly.关键词：stachydrine;Myocardial cells;cardiac hypertrophy;calcium uptake capacity;activity of SERCA
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发布时间：2024-01-04 - 摘要：Objective: To observe anti-hepatic fibrosis(HF) effect of Guangxi Curcuma kwangsiensis (GGYJ). Method: The models of rat with HF were duplicated by hypodermic injection CCl4.Colchicine(Col) were used as a positive control.The quantities of hydroxyproline(Hyp),Malondialdehyde(MDA),superoxide dismutase(SOD) and Glutathione peroxidase(GSH-Px) in liver tissue were determined.The pathological shapes of liver tissue and the level of HF by using HE and Masson staining were observed. Results: GGYJ could reduce remarkably the quantities of Hyp and MDA,and rise the quantities of SOD and GSH-Px.Compared with model group,there are obvious differences in high dose and mid-dose groups of GGYJ(P＜0.01) .And there are differences in low dose groups of GGYJ(P＜0.05) .Meanwhile,high dose and mid-dose groups of GGYJ could reduce remarkably the level of fibrosis in liver tissue(P＜0.01, P＜0.05),while low dose groups of GGYJ did’nt have this action. Conclusions: GGYJ has anti-HF action. The actions of high dose group of GGYJ are better.Its mechanisms may relate to clearing out free radical,anti-lipoid peroxidation and anti-liver injury.关键词：Guangxi Curcuma Kwangsiensis;hepatic fibrosis;histopathology
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发布时间：2024-01-04 - 摘要：Objective: The purpose of this research is to explore the effects that Shuanggen Qingnao Granules towards vascular dementia(VD) by observing animal behavior and superoxide dismutase, malondialdehyde,nitric oxide and nitric oxide synthase levels in serum of VD rat model. Method: Vascular dementia (VD) rat models was made by injecting the same kinds of thrombotic emboli to the catheter of the external carotid artery. Morris water maze test is used for measuring the learning and memory ability. The photochemical reaction for contents of SOD in serum and MDA as well as NOS activity and nitratase method for NO levels were used. Result: The time for the rats taken Shuanggen Qingnao Granules to escape the latent period and to cross the platform for the first time was significantly shortened(P<0.05,P<0.01). SOD activity increased in medium and low-dose rehabilitation groups. And the MDA content decreased. The ratio of SOD and MDA(SOD/MDA) in the treated groups has all elevated(P＜0.01).Besides, the NO contents in the treated groups decreased (P<0.05, P<0.01). And the NOS activity in the medium and low-dose groups increased(P＜0.01). Conclusion : Shuanggen Qingnao Granules can significantly improve the learning and memory ability of the rats with VD. It can also increase SOD activity. Meanwhile, it decreases MDA and NO contents as well as NOS activity.关键词：Shuanggen Qingnao Granules;vascular dementia;superoxide dismutase;malondialdehyde;nitric oxide;nitric oxide synthase
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发布时间：2024-01-04 - 摘要：Objective: To investigate the therapeutic effects of Shenxiong Huayu Capsule on cerebral ischemia reperfusion and its underlying mechanism in rats. Method : Male Sprague-Dawley rats (n=48) were divided randomly into four groups: sham group,model group, low dose of Shenxiong Huayu Capsule treatment group and high dose of Shenxiong Huayu Capsule treatment group. Global cerebral ischemia model was formed by improved four-vessel occlusion as described in the Pulsinelli's method. Changes in cerebral tissue morphous in hippocampal region were observed with light and electron microscopes 1d after operation. Learning and memory function (Morris water maze) were performed daily from 3d to7d after injury. Result: Compared with the sham group, the neurons, axons and capillaries in the models were damaged,and the latency to find the platform was prolonged(P＜0.05). Compared with the model group,the damage of brain tissue in the Capsule treated rats was decreased,latency to find the platform were shortened (P＜0.05). The above mentioned improvements were more significant in high dose of Shenxiong Huayu Capsule group. Conclusion: Shenxiong Huayu Capsule has good therapeutic effect on global ischemia-reperfusion injury and the mechanism is related to the attenuating of cerebral ultrastructure damage.关键词：cerebral ischemia-reperfusion;ultrastructure;learning;memory;Shenxiong Huayu Capsule
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发布时间：2024-01-04 - 摘要：Objective: To establish an analytical method for the determination of puerarin in dog plasma with HPLC-FLD, and to evaluate the pharmacokinetics and relative-bioavailability of puerarin of tested multi-absorption enhancer and puerarin tablet after a single oral dose in healthy dogs. Method: Six healthy dogs took muti-absorption enhancer and puerarin tablets with a single oral dose in a randomized cross-over design in the case. The serum concentration of puerarin was determined by HPLC-FLD method. Result: The puerarin in test and reference formulations were Cmax (0.326±0.121) and (0.272±0.083) ng ·mL-1, tmax (2.750±0.957) and (4.500±1.732) h, t1/2α (1.157±0.748) and (1.223±0.311) h, t1/2β (6.679±2.552) and (1.987±0.386) h, AUC(0-t) (2.513±1.046) and (1.951±0.442) mg ·h ·L-1, AUC(0-∞) (5.035±2.190) and (3.001±1.382) mg ·h ·L-1, respectively. The relative bioavailability of puerarin was (128.8±31.2)%. Cmax,AUC(0-t) and AUC(0-∞) were not bioequivalent through the bioequivalent tests. Conclusion: The method is proved to be accurate, sensitive and rapid. Puerarin in the test formulation is not bioequivalent to the reference formulation. The relative-bioavailability of puerarin of tested multi-absorption enhancer and puerarin tablet is enhanced by 28.8 percents.关键词：puerarin;multi-absorption enhancer;pharmacokinetics;bioequivalence
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发布时间：2024-01-04 - 摘要：Objective: To study the effects of ICA on HCY-induced vascular endothelial cells endoplasmic reticulum stress, and to explore ICA anti-atherosclerotic mechanisms. Method: HCY-induced rabbit endothelial cell injury models were established, and co-cultured with different concentrations of ICA for 48 hours, then apoptosis rate was assayed by TUNEL ; Glucose-regulated protein 78 (GRP78) gene expression was done by RT-PCR detection; The wanted gene was cloned, identified and sequenced. Result: The fluorescence microscope observation showed that there were majority of apoptotic cells in HCY model group, and in ICA group there was no significant morphological changes of apoptosis. Compared with HCY group, cell GRP78 mRNA expression in ICA treatment group significantly reduced (P<0.01). Sequencing results showed that full-length 648bp gene fragment derived from vascular endothelial cells was highly homologous with rabbit GRP78 gene. Conclusion: ICA can resist HCY-induced endothelial cell apoptosis and slow down vascular endothelial cells endoplasmic reticulum stress, which may be one of the mechanisms of its role.关键词：icarinn;homocysteine;vascular endothelial cells;endoplasmic reticulum stress
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发布时间：2024-01-04 - 摘要：Objective: To study the effect of Glycyrrhiza uralensis on metabolism, distribution and excretion of triptonide in rat and disclose the attenuation mechanism of G. uralensis on triptonide in vivo. Method: The SD rats were divided into single and combined administration groups. The combined group was injected with triptonide after orally treated with extracts of Glycyrrhiza , while the single group was injected only with triptonide. The concentration of triptonide in plasma, tissue and excreta in vivo were determinated by LC-MS-MS method to compare with the difference of metabolism, distribution and excretion of triptonide under two administration models. Result: The determination methods with good precision and stability were suitable for the assay of triptonide in biological samples. The difference of metabolism, distribution and excretion of triptonide under single and combined administration models were significant. AUC and t1/2Zof triptonide under combined administration model were decreasing, while CL was increasing compared with single administration model. The concentration of triptonide in tissue under combined administration model was decreasing, while excretion of triptonide was accelerated compared with single administration model. Triptonide was mainly distributed in the lung under two administration models. Conclusion: Glycyrrhiza can decrease the concentration of triptonide in tissue and accelerate the excretion of triptonide in rats. It may be one of the attenuation mechanisms of Glycyrrhiza on triptonide.关键词：Glycyrrhiza uralensis;triptonide;metabolism;distribution;excretion
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发布时间：2024-01-04 - 摘要：Objective: To observe influences of the modified Banxia Baizhu Tianma Tang on experimental hyperlipidemia in rats. Method: Rats were given high fat diet for 4 weeks, resulting in model of hyperlipidemia, meanwhile the modified Banxia Baizhu Tianma Tang was given in three doses. During the drug administration, body weight, and the levels of TG, CHOL, LDL, HDL, apoA1, apoB, SOD, MDA were measured. Result: Compared with the model group, body weight in the rats of the high-dose group increased significantly. In the three drug dosage groups, serum triglyceride was significantly reduced.In the high-dose group, the serum CHOL and LDL levels were significantly reduced, compared with the model group (P <0.05). The serum HDL levels in the drug groups were elevated to some degree, but compared with the model group there was no significance. No significant difference in levels of serum apo A1 was found. The drug groups and the positive control of Xuezhikang lowered apo B levels, the high dose group showed the most obvious effect compared with the model group. The drug groups increased SOD activity, reduced MDA content to various degrees, among them the effect of high doses was most obvious. Conclusion: The modified Banxia Baizhu Tianma Tang shows clear improvement for hyperlipidemia-related indicators.关键词：modified Banxia Baizhu Tianma Tang;rat model of hyperlipidemia;experimental study
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发布时间：2024-01-04 - 摘要：Objective: To investigate effect of Yishen Yifang decoction on insulin resistance and sex hormone in rats with polycystic ovary syndrome (PCOS). Method: The model of PCOS rats induced by testosterone undecanoate and human chorionic gonadotropin (HCG), afterwards metformin, different doses of Yishen Yifang decoction were taken by intragastric administration for 6 weeks. At the end the contents of fasting blood-glucose (FBG), 2-hours blood glucose after oral glucose tolerance test(OGTT-2hBG), testosterone (T) insulin-like growth factor-Ι (IGF-1), estrogen (E2), progesterone (P), prolactin (PRL), insulin(Ins), tumor necrosis factor (TNF)-α were determined; the changes of insulin sensitivity index (ISI) were counted. Result: Compared with the normal group, the concentrations of FB, OGTT-2hBG, TNF-α, T, IGF-1,E2 and PRL were increased obviously( P <0.01), but ISI, P were decreased significantly ( P <0.01) in model rats. metformin and Yishen Yifang decoction could improve the pathologic changes in PCOS rats ( P <0.01 or P <0.05); but Yishen Yifang decoction the effects of low-dose group did not change P and ISI ( P >0.05). Conclusion: Metformin and Yishen Yifang decoction can improve the pathologic changes, IR, sex hormone in PCOS rats.关键词：Yishen Yifang;PCOS;insulin resistance;sex hormone
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发布时间：2024-01-04 - 摘要：Objective: To study the anti-tumor effect in vitro of total flavone from rubrus suavissimus(RSTF). Method: RSTF was extracted with 60% alcohol,separated by polyamide column, determined by chemical reaction, TLC and HPLC.MTT method was adopted to screen for mouse tumor cells S180(transplanted sarcoma cell in mice),H22 (transplanted ascitic type of liver cancer cell in mice) and L1210(leukemia cells in mice). Results :RSTF could inhibit the proliferation on S180,H22 and L1210 in vitro,while the best inhibitory effect on H22(IC50 46.31 μg ·mL-1)and the better inhibitory effect on S180(IC50 71.48 μg ·mL-1). Conclusion : The results show that RSTF can inhibit the growth of S180, H22 and L1210.关键词：rubrus suavissimus;Total flavone;anti-tumor effect
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发布时间：2024-01-04 -
Protective Effects of Xiaoyao Powder Administrated in the Morning or Evening on Liver Injury in Rats
摘要：Objective: To investigate the hepatoprotective effect and its circadian variations of Xiaoyao Powder and the possible mechanisms for protection on liver injury in rats. Method: The rat model of liver injury was induced by subcutaneous injection of 40% CCl4 .The rats were given Xiaoyao Powder by gavage in the morning or evening for 12 days. General behavior state,body weight change,the levels of ALT,AST in serum and SOD and MDA activites in liver homogenate were detected.The pathology of liver was observed. Result: Compared with the model group,the Xiaoyao Powder was found to significantly improve the body weight and general behavior state,reduce the serum levels of ALT,AST and MDA,increase the activity of SOD,improve the pathological changes of liver tissue.Meanwhile,evening administration and the low dose was displayed a very good effect in most of the indexes. Conclusions: Xiaoyao Powder shows significant protective action on liver injury in rats.The effect of Xiaoyao Powder may be closely related to administration time.关键词：Xiaoyao Powder;liver injury;circadian rhythm;carbon tetrachloride;hepatoprotection- 2
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发布时间：2024-01-04 - 摘要：Objective: To investigate therapeutic effects of Wuzi Yanzong recipe by different doses on male animal model with sexual dysfunction. Method: Seventy male rats were used and classified to be 7 groups. Sixty male rats were castrated to be an animal model of sexual dysfunction. Wuzi Yanzong recipe was administrated daily oral by for consecutive 4 weeks. After cessation of the treatment, the latent period of penis erection in each rat was measured and then the rats were sacrificed and dissected. The spleen, thymus and male sex organs were weighed for calculating index. The blood samples were taken for measurement of serum testosterone (T), luteal hormone (LH), follicle stimulating hormone (FSH), nitrogen monoxide (NO), superoxide dismutase(SOD), and maleic dialdehyde(MDA). Results: The latent period of penis erection in each Wuzi Yanzong treatment group was significantly shortened. Serum T in large dose group, NO and SOD were increased while MDA was decreased in large and middle dose group significantly when compared to the animal model control group.Besides, index of levator ani muscle, seminal vehicle and prostate were significantly increased in Wuzi Yanzong each treatment group, the index of preputial glands was increased with large dose of the treatment, respectively. Conclusion : Wuzi Yanzong recipe may have therapeutic effects to improve asthenia of renal Yang and penis erection dysfunction.关键词：castrated rat;latent period of penis erection;Nitrogen monoxide;index of organs
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发布时间：2024-01-04 - 摘要：Objective: To investigate the protective effect and the mechanism of Herbal Lophatheri flavonoids (HLF) on mice loaded with restraint stress. Method: The filtrate of extraction of Herbal Lophatheri was adsorbed by Hp20 macroporous exchange resin, eluted by ethanol. After oral administration of HLF 125, 250 and 500 mg·kg-1 for five days. The mice were restrained for 18 h after 30 min of the last intragastric administration to induce liver injury. The protective effects were evaluated by assessing alanine aminotransferase (ALT) levels in plasma. The contents of NO and malondialdehyde (MDA) in liver were performed respectively. Oxygen radical absorbance capacity (ORAC) assay was used to measure the antioxidant capacity. Results : Compared with the stress model, HLF could decrease activities of ALT in the plasma and the levels of MDA and the contents of NO in liver. And it could significantly increase ORAC activity in the plasma and liver. Conclusion : Herbal Lophatheri flavonoids exert protective effect on liver injury in mice loaded with restraint stress.关键词：Herbal Lophatheri flavonoids;antioxidant capacity;restraint stress;liver injury
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发布时间：2024-01-04 - 摘要：Objective: To investigate the pharmacological action of ginger (Zingiber officinale Roscoe) oleoresin on central nervous system (CNS). Method: : After i.g. administration of ginger oleoresin upon mice, the spontaneous activity of mice was determined, latency and sleeping time induced by pentobarbitol were measured, strychinine-induced convulsion was observed, acetic acid-induced writhing and hot plate-induced pain were tested. Results: Ginger oleoresin could significantly reduced mice locomotor activity, prolonged pentobarbital-induced sleep time of mice,delayed latency of convulsion induced by strychnine, reduced the number of writhing and stretching induced by the acetic acid and delayed latency of reaction to the thermal stimulus. Conclusion: Ginger oleoresin has significant inhibitory effect on CNS.关键词：ginger oleoresin;sedative;hypnotize;analgesia;anti-hyperspasmia
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发布时间：2024-01-04 - 摘要：Objective: To observe the clinical efficacy of oral taking of Oral Antidote Decoction(OAD), a Chinese recipe for nourishing yin to remove pathogenic fire, combined with external applying of OAD on recurrent aphthous ulcer(RAU). Method: A total of 128 patients with RAU were treated with the combined therapy of OAD, and 100 patients in the control group were treated with Western medicine. The clinical efficacy of the two groups was observed. Result: Short-term effect: the reduction of ulcerated and congestive area as well as the degree of pain alleviation in the treated group on the 7th day after treatment were more significant than those in the control group respectively. Long-term effect: after treatment the cure rate was 11.7%(15/128),the markedly effective rate 53.1%(68/128),the effective rate 31.3%(40/128),and the total effective rate 96.1% in the treated group, while the corresponding rates in the control group were 5%(5/100),28%(28/100),40%(40/100) and 73%,respectively,showing significant difference between the two groups(P<0.01). Conclusion: Oral taking combined with external use of OAD can lessen the congestion of mucous membrane around the ulcerated lesion, quickly alleviate the pain and promote the ulcer healing in patients with RAU, and it also can significantly prolong the interval of RAU recurrence.关键词：recurrent aphthous ulcer;oral antidote decoction;clinical effect
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发布时间：2024-01-04 - 摘要：Objective: To discuss the protection of Shenfu injection on lower limb ischemia-reperfusion-induced myocardial injury in human. Method: 40 patients with lower extremity orthopedic surgery were randomly divided into two groups, 20 cases in each group. Combined spinal-epidural anesthesia was selected in all patients. Conventional treatment was used in control group. And on the base of control group, Shenfu injection was used in Shenfu group. Troponin I(cTnI) was detected before relaxing tourniquet (T1), 30 min (T1) and 120 min (T3) after relaxing tourniquet. Result : Compared with that at T1, cTnI at T2 and T3 increased markedly ( P <0.01), and cTnI at T3 was the highest value. Compared with that in control group, the Increased range of cTnI at T2 and T3 in Shenfu group was decreased significantly ( P <0.01). Conclusion : Shenfu injection can protect lower limb ischemia-reperfusion-induced myocardial injury in human.关键词：Shenfu Injection;myocardial injury;troponin I;ischemia-reperfusion-induced;lower limb
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发布时间：2024-01-04 - 摘要：Objective: Summarize the experiences of Professor Deng Zhongjia and discuss about his frequent Traditional Chinese Medicine herbs matching for curing cancers. Method: Cure paitients while following Professor Deng Zhongjia and summarize his experience and research the principles about the TCM herbs matching. Rusult: The effect and principles of TCM herbs matching by Professor Deng are verified in clinics. Conclusion: Professor Deng is good at using TCM herbs matching, which results in good clinical referened value.关键词：Traditional Chinese Medicine herbs matching;treating;principles
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发布时间：2024-01-04 - 摘要：Objective: To observe the therapeutic effect of Jinshuibao capsule and domiciliary oxygen therapy nourishing therapy and its influence on nutritive index and lung function and quality of life (QOL) in patients with chronic obstructive pulmonary disease (COPD) at stationary phase. Method: 85cases of stable stage of COPD(Lung Kidney Concurrent Deficiency) were divided into the treatment group(Jinshuibao capsule and domiciliary oxygen therapy) and the control group(domiciliary oxygen therapy). Both two groups were given oxygen supplement more than 15 hours a day. The treatment group was given Jinshuibao capsule.The two groups were treated for six months.Then to observe the improvement condition of clinical symptoms and lung function and quality of life in both groups before and after treatment. Result: The two groups improved clinical symptoms and lung function.The effect of treatment group(92.68%) was better than the control group (56.41%). The treatment group can improve clinical symptoms on cough、expectoration and pant. The effect of treatment group was better than the control group on stable and impovemet of lung function. Quality of life on somatesthesia and physiological function were very significantily raised in the treatment group. Conclusion: Jinshuibao capsule and domiciliary oxygen can improve clinical symptoms and stabilize lung function and enhance quality of life.关键词：Jinshuibao capsule;domiciliary oxygen therapy;quality of life
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发布时间：2024-01-04 - 摘要：Objective: To observe Brucea javanica oil emulsion combined with radiotherapy for advanced esophageal cancer short-term efficacy and quality of life. Method: 70 cases of esophageal cancer patients were randomly divided into two groups, 35 cases given conventional radiotherapy, 35 cases for Brucea javanica oil emulsion plus radiotherapy. Two groups were observed in the efficacy, toxicity, and quality of life differences. Result: Radiotherapy group and Brucea javanica group CR + PR rates were 72% and 75%, KPS score 90 points or more were 25.7% and 40%,Ⅰ degree of weight loss, 74.3% and 60%, hemoglobin>100 g· L-1 were 97.1% and 85.7%, P＜0.05. Malignant vomiting, leukopenia, radiation esophagitis, Two groups were 34.2% and 20.0%, 22.8% and 25.7%, 51.4% and 40.0%, P＜0.05. Conclusion: Brucea javanica oil emulsion combined with radiotherapy for advanced esophageal cancer does not improve in the short-term effect,But it can significantly improve patient quality of life and reducing radiation toxicity.关键词：Brucea javanica oil;radiotherapy;esophageal carcinoma;efficacy
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发布时间：2024-01-04 - 摘要：Objective: To research the effect and drug resistance of Duhuo Jisheng Tang on knee osteoarthritis (OA). Method: Select 113 patients met the inclusion criteria Were randomly divided into two groups. Patients in treatment group (n=56) were treated with Duhuo Jisheng Tang. Patients in control group (n=57) were treated with Glucosamine sulfate. The therapeutic course was 4 weeks in both groups. Based on Lequesne function index of OA pain evaluation of Signs and symptoms of knee joint functional activities. Result: The total effective 96.43% in treatment group,82.45% in control group, between two groups the differences were statistically significant(P<0.05),The treatment group Superior than the control group.two groups after treatment the Pain and functional index score were significantly lower, before and after treatment, the differences were statistically significant (P<0.001), The treatment group score lower than the control group, the difference was statistically significant (P<0.001).After 4 weeks of withdrawal efficacy of the control group significantly decreased (compared with the end of treatment, P<0.01), while the treatment group was not significantly lower efficacy (compared with the end of treatment, P>0.05). Conclusion: Duhuo Jisheng Tang effect of knee osteoarthritis is superior to the efficacy of Glucosamine sulfate,and has good security.
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发布时间：2024-01-04 - 摘要：Objective: To investigate the intervention effect and its mechanism of treatment of cerebral ischemic injury by baicalin. Method: By analyzing the experimental references on treatment of cerebral ischemic injury by baicalin in recent years, the paper reviews the effects of baicalin on disorders in brain tissue energy metabolism, inflammation, neuronal apoptosis.etc. Result: The results suggest that baicalin has obvious protective effects for the cerebral ischemic injury by several different mechanisms. Conclusion: Baicalin may become effective drug for the treatment of ischemic cerebral injury.关键词：baicalin;cerebral ischemic injury;mechanism;apoptosis;free radicals
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发布时间：2024-01-04 - 摘要：This article introduces modern pharmacological research progress on Tongxieyaofang and its clinical application in detail. These facts show that efficacy of this prescription is often associated with some pharmacological activities such as anti-inflammatory, analgesia, anti-diarrheal. Clinically, it is often adjusted to fit for the cure of irritable bowel syndrome (IBS), colitis, diarrhea, with marked effectiveness. Based on the benefit of modern extraction and analysis techniques, Tongxieyaofang could be further studied to figure out the substances responsible for its efficacy, and then to establish reasonable method of quality control, in order to lay the foundation for its development as a new drug of Chinese medicine.关键词：Tongxieyaofang;analgesia;anti-diarrheal;anti-inflammation;irritable bowel syndrome (IBS)
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发布时间：2024-01-04 -
Advances in Research of Active Components of Traditional Chinese Medicine for Treating Hyperglycemia
摘要：Bioactive components of traditional Chinese medicine for treating hyperglycemia consist of saponins, polysaccharides, flavonoids and alkaloids. This article summarizes their hypoglycemic effects and mechanisms in experimental animal models, and describes the pharmacological references home and abroad in the past five years. The article provides a reference for further studies on active components for treating diabetes.关键词：diabetes;hyperglycemia;pharmacology- 4
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