最新刊期
卷 16 ， 期 8 ， 2010
- 摘要：Objective: To prepare baicalin water-solubility suppository and to study and research vitro release of this suppository. Method: To adopt fusion method of preparation of the baicalin suppository and apply vitro dissolution testing to inspect release characteristics of this suppository. Result: Hardness and melt time limit of this suppository are conformed to requirement. this suppository release faster, achieve maximum releasing within 40 minutes and it's releasing consistent with Weibull Distribution Model. Conclusion: This preparation method was easy to operate;the quality was stable and controllable. The excellent ratio of PEG 4000/PEG 400 is 7/6.关键词：baicalin;Suppository;polyethylene glycol;vitro release
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发布时间：2024-01-04 - 摘要：Objective: To compare the extracts of Yangerju and determine an optimum technique to extract. Method: Use pharmacodynamics test combined with the main index components change and fingerprint to evaluate the different extraction of Yangerju. Result: The anti-inflammatory, antipyretic, anti-bacterial effect of the boiling, alcohol precipitation, macroporous resin purification was no significant difference , fingerprint suggest that the macroporous resin and purification of sample impurities Peak reduction and the Extraction rate of 3,4-O-dicaffeoyl-quinic acid were more than 60%. Conclusion: Macroporous resin purification was an optimum technique to extract.关键词：Yangerju;active constituents;extraction
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发布时间：2024-01-04 - 摘要：Objective: To determine the dispersible tablets formulation and investigate its stability. Method: We determine the dispersible tablets formulation by one-factor investigation and orthogonal experimentmethod,at the same time,we prepare the batch sample,then go on quality investigationand stability test. Result: The formulation can satisfy the needs of dissolution rate of the dispersible tablets in vitro in ChP. Conclution: The preparation technology the dispersible tablets is simple and easy progress, and can be used in industrialized production.关键词：total alkaloid of menispermum dauricum;dispersible tablets;stability
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发布时间：2024-01-04 - 摘要：Objective: To study the effect of three different deproteinization methods on the total antioxidant ability(TAA) of polysaccharide from Valeriana jatamansi . Method: Sevag method, Trichloroacetic acid method and HCl method were used to remove protein from crude polysaccharide of V. jatamansi and the percentage of deproteinization, the loss of polysaccharide and the loss of TAA were determined. Result: The TAA loss of polysaccharide was minimal by Sevag method. The percentage of deproteinization was 41.71%, the loss of polysaccharide was 46.38%, and the loss of TAA was 11.62%, When the polysaccharide solution was treated for 6 times by Sevag method. Conclusion: Sevag method was suitable for the deproteinization of crude polysaccharide from V. jatamansi .关键词：Valeriana jatamansi;polysaccharide;deproteinization;antioxidant ability
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发布时间：2024-01-04 - 摘要：Objective: To study a environmental and effective separation of alkaloids in sophora flavescens ait. Technology. Method: With the adsorption and desorption of total alkaloids in S. flavescens ait. as parameters,screening a resin from the large-scale,and optimizing condition of absorption and desorption of alkaloids in S. flavescens ait. Result: The nonpolarity macroporous resin X-5 were selected out;The optimized condition of adsorption is that sample solution pH 10, saltion concentration is 1 mol·L-1, adsorption flow rate is 6 BV·h-1. The adsorption is 9.74 mg·mL-1; The optimized condition of desorption is that the alkaloids are desorpted by 60% ethanol (pH 1),the desorption is 95.5%. Conclusions: Macroporous resin X-5 can directly and fast adsorpte alkaloids from S. flavescens ait. percolation fluid, and desorption of alkaloids is easy, does not pollute products and environment,it has great potential for development of green technology.关键词：alkaloids in Sophora flavescens ait.;macroporous resin;adsorption and separation
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发布时间：2024-01-04 - 摘要：Objective: To select a accurate stable and convenient method for determining Polysaccharide content in Erjing Wan. Method: Polysaccharide content in Erjing Wan was determined by two methods: athranone-sulfuric acid method and phenol-suifuric acid method. Result: The sugarin athranone-sulfuric acid method and phenol-suifuric acid method was liner in the range of 1.2~12 mg·L-1(r=0.999 3) and 1.5~15 mg·L-1(r=0.999 1) respectively. Athranone-sulfuric acid method was stable in 3 h, phenol-suifuric acid method was stable in 2 h; the sugar content was 53.79% and 58.92% respectively. Conclusion: Phenol-suifuric acid method is sensitive、stable and convenient and can be applied to determine polysaccharide content in Erjing Wan.关键词：Erjing Wan.;polysaccharide content;anthranone-sulfuric acid method;phenol-suifuric acid method
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发布时间：2024-01-04 - 摘要：Objective: To provide scientific basis for the quality standard of Semen Descurainiae Tostum in 2010 edition of Pharmacopoeia. Method: The study of TLC identification and content determination was according to the appendix of 2005 edition of Pharmacopoeia. Result: In the 11 batches of the Semen Descurainiae Tostum , the content of quercetin-3-O-β-D-glucopyranosyl-7-O-β-D-gentiobioside was in the range of 0.076%~0.132%. The reference substance was well separated in the polyamide thin-layer chromatography and the solvent system consisted of acetoacetate-methanol-water(7 ∶2 ∶1). Conclution: The content limit of quercetin-3-O-β-D-glucopyranosyl-7-O-β-D-gentiobioside was set not less than 0.08%. The Stir-Frying did not affect the content of quercetin-3-O-β-D-glucopyranosyl-7-O-β-D-gentiobioside, the indicator substance. There was no distinction in reference substance content between Semen Descurainiae and Semen Descurainiae Tostum in TLC and HPLC.关键词：Semen Descurainiae Tostum;quality standard;content determination;TLC
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发布时间：2024-01-04 - 摘要：Objective: To establish a quantification method for quercetin and kaempferol in the leaves of Phyllanthus emblica by HPLC. Method: HPLC is applied on the determination of quercetin and kaempferol in the leaves of P. emblica with C18 column(4.6 mm×250 mm,5 μm) and a mixture of acetonitrile-0.1% phosphoric acid (27:73) as a mobile phase with the flow rate at 1.0mL·min-1. Quercetin and kaempferol were detected at 360nm, column temperature was set at 30 ℃. Result: Quercetin and kaempferol were linear in the range of 0.06~1.2 μg and 0.021~0.43 μg. The average recovery of quercetin and kaempferol was 98.83% with RSD 2.73% and 101.58% with RSD 2.21% (n=6) respectively. Conclusion: The method can be applied to the quality control of the leaves of P. emblica L.关键词：the leaves of Phyllanthus emblica L .;quercetin;kaempferol;RP-HPLC
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发布时间：2024-01-04 - 摘要：Objective :To establish a HPLC method for simultaneous determination of chlorogenic acid and hesperidin in Zhike Ningsou Capsule . Method :The sample was extracted with methanol under ultrasonication. The HPLC separation was performed on a Zorbax SB C18 (3.0 mm ×250 mm,5 μm) column,using water containing 1% acetic acid(A) –acetonitrile(B) as the mobile phase,in stepwise elution:0 min(82 ∶18)~5 min(82 ∶18)~5.1 min(75 ∶25)~20 min(75 ∶25),at a flow rate of 0.35 mL ·min-1. Result :The linear range was 0.4~10.0 μg ·mL-1 and 6.2~155.0 μg ·mL-1 for chlorogenic acid and hesperidin; the average recovery was 99.2% and 99.6%; RSD 1.0% and 0.9%,respectively. Conclusion :This method can be applied for the quality control of Zhike Ningsou Capsule.关键词：Zhike Ningsou Capsule;chlorogenic acid;hesperidin;HPLC;Assay
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发布时间：2024-01-04 - 摘要：Objective: To analyze and compare the chemical components of oleum rhododendri daurici from different regions of Heilongjiang province. Method: The volatile oils were extracted by steam distillation. Chromatographic peak of complete separation were analyzed by capillary gas chromatography-mass spectrometry (GC-MS) and overlapping chromatographic peaks analyzed by heuristic evolving latent projections (HELP) of chemometrics. The relative content of each component in volatile oil was calculated by normalization of peak area, and the method of principal component analysis is taken to analyze the data of qualitative and quantitative. Result: A total of 85 components were identified, of which 32 compounds were existed in all the samples. According to chemical components, 15 samples were divided into four categories. No germacrone was detected in 6 samples. Conclusion: More information can be obtained from oleum rhododendri daurici, combined GC-MS analysis with chemometric method.关键词：oleum Rhododendri Daurici;GC-MS;chemometrics
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发布时间：2024-01-04 - 摘要：Objective: To establish the HPLC fingerprint of five Fritillaria species according to the low-polarity for the identification. Method: Samples was prepared with static three-phase extraction, HPLC was used the gradient eluted solvert system composed of CH3CN-0.1%H3PO4, the flow rate was 1.0 mL·min-1, the detection wavelength was 250 nm. The HPLC fingerprints were evaluated by similarity evaluation system. Result: Published the fingerprints of five Fritillaria species, determined 16 common peaks and special peaks of five Fritillaria species. The result of similarity indicated that differences exist in five Fritillaries species. Conclusion: The established HPLC fingerprint has desirable accuracy, repeatability and stability, it can be used for one of the quality control of Fritillaria species.关键词：Fritillaries;HPLC;fingerprint;similarity evaluation
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发布时间：2024-01-04 - 摘要：Objective: To establish the qualitative and quantitative methods for Xiyue Granule. Method: Rhizoma Curcumae Longae,Radix Angelicae Sinensis,Radix Bupleuri and Radix Dipsaci in Xiyue Granule were identified by TLC. Astragaloside Ⅳwas determined by HPLC. Result: The characteristic identification by TLC was distinct and specific;Astragaloside Ⅳ was linear in the range of 0.53~13.28 μg,and the average recovery was 99.1%(RSD 0.78%). Conclusion: The method can be used for the quality control of Xiyue Granule.关键词：Xiyue Granule;Rhizoma Curcumae Longae;Radix Angelicae Sinensis;Radix Bupleuri;Radix Dipsaci;astragaloside Ⅳ;HPLC
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发布时间：2024-01-04 - 摘要：Objective :To establish a HPLC method for the determination of hesperidin in Cuqingpi Dispensing Granule. Method :After using the orthogonal test to optimize extracting conditions,hesperidin was separated on Shim-pack VP-ODS (4.6 mm×250 mm,5 um)column and detected at 284 nm,with methanol-0.1% phosphoric acid solution (35 ∶65) as amobile phase,and the flow rate was 1.0 mL ·min-1. Result :Hesperidin was linear in the range of 0.112 0~1.120 μg (r=0.999 9) . The average recovery of hesperidin was 102.63% with RSD 1.24%. Conclusion :The method is simple and rapid which can be used for the quality control of Cuqingpi Dispensing Granule.关键词：Cuqingpi Dispensing Granule;hesperidin;RP-HPLC
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发布时间：2024-01-04 - 摘要：Objective: To establish a HPLC method for determination of tetrahydropalmatine in Yuanhuzhitong Oral Liquor. Method: 10 batches of Oral Liquor were collected. The HPLC determination method was established after comprehensive and standardized methodology validation: C18 column(4.6 mm×250 mm, 5 μm) was used. The mobile phase was acetonitrile-0.1% phosphoric acid solution(adjusted to pH6.0 with triethylamine) (40 ∶60). The detecting wavelength was 280 nm. Result: The linear detection ranges of tetrahydropalmatine were 5.09~71.23 μg ·mL-1 (r＝0.999 97), and the average recovery was 101.28％(RSD 2.05％); The content of tetrahydropalmatine shall not be less than 80 μg per mL. Conclusion: This method is convenient, rapid and accurate, which could be used for quality control in Yuanhuzhitong Oral Liquor.关键词：Yuanhuzhitong oral liquor;tetrahydropalmatine;HPLC;determination of concentrations
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发布时间：2024-01-04 - 摘要：Objective: A HPLC method for the determination of Geniposide of Huang-Zhi-Hua oral solution was established. Method: The HPLC system consisted of methanol-water (62 ∶38) mixture as a mobile phase, detecting wavelength was set at 238 nm. The flow rate was 1.0 mL·min-1 and column temperature was at 30 ℃. Result: Geniposide was linear in the rang of 5.44~162.84 μg·mL-1, r=0.999 7; the average recovery rate was 98.4% (RSD=0.75%) respectively. Conclusion: The method can be used in the quality control of Huang-Zhi-Hua oral solution.关键词：HPLC;Huangzhihua oral solution;geniposide
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发布时间：2024-01-04 - 摘要：Objective: To establish a quality control method for Danning Dispersible Tablets. Method: TLC and HPLC were used. Result: Calculus Bovis Antifactus, Rhizoma Corydalis, Radix et Rhizoma Rhei were identified by TLC. Silybin was determined by HPLC. ZORBAX RX-C18(4.6 mm×150 mm,5 μm)column was used and the column temperature was set at 40 ℃. The mobile phase was consisted with methanol-water-acetic acid (42 ∶58 ∶1) and the flow rate was 1.0mL ·min-1. The detection wavelength was at 288 nm. Conclusion: The method established can be used to control the quality of Danning Dispersible Tablets.关键词：Danning Dispersible Tablets;quality control;TLC;HPLC
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发布时间：2024-01-04 - 摘要：Objective :To establish the HPLC method for determination of geniposide liquiritin and naringin in Zhongyaotuihuangwaixiye Lotion. Method :A Agilent SB-C18 Column(4.6 mm×250 mm,5 μm) was used.The mobile phase was methanol-H2O. The column temperature was 30 ℃. The waveleng detection was at 238 nm and 283 nm,,flow rate was 1.0 mL ·min-1. Result :The linear range of Geniposide was within 5.1~127.5 ng(r=0.999 7).The average recovery was 99.41％,RSD was 0.24％(n=6).The linear range of Liquiritin was within2.3~53 ng (r=0.999 5).The average recovery was 98.49％,RSD was 1.23％(n=6).The linear range of naringin was within4.9~123 ng (r=0.999 9).The average revovery was 99.41％,RSD was 0.48％(n=6).The negative sample had no interference. Conclusion :This method is simple,accurate and suitable for its assaying.It can be used for quality control in production of Zhongyao Tuihuang Waixiye Lotion.关键词：Zhongyao Tuihuang Waixiye Lotion;HPLC;geniposide;liquiritin;naringin
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发布时间：2024-01-04 - 摘要：Objective: To study the qualitative and quantitative methods for Jieshitong Tablets. Method: Desmodii Styracifolii Herba , Plantaginis Herba and Pyrrosiae Folium in Jieshitong Tablets were identified with the method of TLC. Quercetin and kaempferol were determined with the method of HPLC. Result: By TLC, the spots of three herbal drugs were well separated and without interference. Quantitative analysis of HPLC showed that the linear range of quercetin and kaempferol was 0.128 4~0.342 4 μg and 0.118 8~0.316 8 μg, respectively. The average recovery of uercetin and kaempferol was 97.7% and 97.3%, respectively. The RSD (n=6) was 0.7% and 0.8%, respectively. Conclusion: The method set up could effectively control the quality of Jieshitong Tablets.关键词：Jieshitong Tablets;quality standards;TLC;HPLC
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发布时间：2024-01-04 - 摘要：Objective: To study polar constituents of Mosla chinensis 'jiangxiangru'. Method: Silica gel column chromatography, Sephadex LH-20 gel column chromatography and MPLC were employed for the isolation and purification.The structures were identified on the basis of spectral data and chemical methods. Result: Six polar compounds were identified as follows:methyl-3-(3',4'-dihydroxyphenyl)lactate(1),corchoionoside C(2),prunasin(3),sambunigrin(4),benzyl-D-glucopyranoside(5)and (s)-pencedanol-7-O-β-D-glucopyranoside(6). Conclusion: These compounds were isolated for the first time from Mosla chinensis 'jiangxiangru'and have not been previously described in genus Mosla.关键词：Mosla chinensis jiangxiangru;genus Mosla;polar constituents
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发布时间：2024-01-04 - 摘要：Objective: In the florescence of Cornus officinalis ,we observe the change in temperature and humidity for exploring the relationship between ecological factors and the flowering habit of C. officinalis . Method: We measure temperature , humidity and the number of blooming every 2 h in the sequence 5 day and night of the florescence of C. officinalis . Result: we find that in a day,the blooming time of C. officinalis is from 6 ∶00 to 16 ∶00,and the blooming time is from 8 ∶00 to 14 ∶00 when more than 84 percent buds effloresced.The best temperature of blooming is from 10 ℃ to 14℃,and the needful humidity is from 45 percent to 55 percent. Conclusion: Appropriating temperature and humidity is a necessary condition for flowering of C. officinalis . So we think the ecological factors is closely related to flowering of C. officinalis .关键词：Cornus officinalis;habit of blooming;temperature;humidity
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发布时间：2024-01-04 - 摘要：Objective: We studied the extracted method of informational active components alignment of scorpion, groped the best electrophoresis conditions, determined the molecular mass of informational active components alignment, assured the expressing characteristic of the electrophoretic bands, and set up the bioassay method of informational active components alignment of Scorpion. Method: We extracted scorpion by water and salt fractionation to obtain informational active components alignment, Coomassie brilliant blue method determined its protein content, and SDS-PAGE electrophoretic technique and Alpha Ease FC 4.0.0 software determined its protein molecular weight. Result: The protein content of informational active components alignment was 50.37%. There were ten bands in the informational active components alignment. Ten bands in the SDS-PAGE were 94.162 0,66.400 0,40.357 0,27.541 0,22.518 0,19.520 0,12.766 0,11.190 0,9.665 3,8.534 2 KD. Conclusion: These ten bands were the characteristic bands of informational active components alignment, and might be used to identify the informational active components alignment.关键词：Scorpion;informational active components alignment;bioassay method
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发布时间：2024-01-04 - 摘要：Objective: To investigate the effects and related pathways of Zengyetang on lowering blood glucose. Method: The normal mice and alloxan (70 mg ·kg-1)-induced diabetic mice were administrated for 7 d in order to investigate the effects of aquatic extract of Zengyetang (5, 10 and 15 mg ·kg-1) on the levels of blood glucose, insulin and oral glucose tolerance. Then we investigated the effects of extract (12.5, 25, 50,100 μg ·mL-1) on insulin secretion in MIN6 islet cells. Result: After 7 days of administration, the extract could significantly lower blood glucose, and it also could ameliorate the oral glucose tolerance in normal and diabetic mice and improve insulin secretion. Meanwhile, the extract could improve insulin secretion in MIN6 cells with stimulation of 16.7 mmol ·L-1 glucose. Conclusions: The Zengyetang could lower blood glucose and ameliorate the oral glucose tolerance through improving insulin secretion, whose pathways were maybe different from sulphonylurea hypoglycemic drugs.关键词：Zengyetang;oral glucose tolerance;MIN6 islet cells;hypoglycemic effect;glibenclamide
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发布时间：2024-01-04 - 摘要：Objective: To investigate the relativity between the body surface characteristics indicated by Evans blue and the hemorrheological parameters in rats with blood-stasis syndrome induced by macromolecule dextran. Method: The rats were treated by injected 10% macromolecule dextran solution confected by 0.5% Evans blue, 10% macromolecule dextran solution confected by sodium chloride, 0.5% evans blue, or sodium chloride respectively through the caudal vein, then observed and photoed the exosymptom change presented by Evans blue in ear and tongue of the rats, and detected the hemorrheologic variation of the rats at 30, 60, 120, and 240 minutes after the treatment, and analyzed the relativity between the body surface characteristics indicated by Evans blue and the hemorrheological parameters in rats with blood-stasis syndrome. Result: In the rats treated by 10% macromolecule dextran solution confected by 0.5% Evans blue, the blue petechia in rat auricle and tongue were observed after 30 minutes, which aggravated as the time went by, and the whole ear of rat changed to dark blue and the blue petechiae of tongue enlarged to more than half of tongue after 240 minutes, while in the rats treated by 0.5% Evans blue,the rat auricle was semitransparent and the tongue color was uniform. In therats treated by 10% macromolecule dextran solution confected by Sodium Chloride, the blood viscosity increased significantly in different shear rate in 30 and 60 minutes, and the plasma viscosity, the aggregation index of erythrocyte, and the integral of aggregation index significantly increased at 30, 60, 120, and 240 minutes compared with the rats injected by sodium chloride. The index of red blood cell deformation and the integral area of deformation index at 30, 60, 120, and 240 minutes in the rats injected by sodium chloride are slightly lower than that in rats treated by 10% macromolecule dextran solution confected by sodium chloride, though there was no significantly difference can be detected. Conclusion: The surface characteristics in rat model with blood-stasis syndromcan be observed directly through the exosymptom change of ear and tongue when 0.5% Evans blue was confected into the 10% macromolecule dextran solution, and it correlated with the degree of blood stasis showed by the hemorrheologic variation. It indicates that the exosymptom changes in rats with blood-stasis syndrome induced by macromolecule dextran can be reflected objectively by Evans blue.关键词：Evans blue;macromolecule dextran;blood-stasis syndrome;surface characteristics;hemorheology
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发布时间：2024-01-04 - 摘要：Objective: To investigate the effect of Weichangshu Tablet on gastric dynamics. Method : Fifty SD rats were divided into 5 groups randomly: normal control,L-Arg,L-Arg and cisapride,L-Arg and Weichangshu. Except the normal control group, the other four groups were injected with L-Arg intraperitoneally. All animals were orally given the same volume of medicine. Motilin content in plasma was determined by radioimmunoassay, and nitrate reductase was used for detecting serum level of NO. Result: Compared with L-Arg, L-Arg and weichangshu could increase plasma motilin and reduce serum NO effectively (P < 0.01). Conclusion : The possible mechanism of Weichangshu Tablet for promoting gastrointestinal motility: It can increase plasma motilin and reduce serum NO,and these changes may increase Ca2+ and promote the contraction of gastrointestinal smooth muscle.关键词：Weichangshu Tablet;L-arginine;gastric dynamics;motilin;nitric oxide
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发布时间：2024-01-04 - 摘要：Objective: To explore the pharmacokinetics of sinomenine hydrochloride by using microdialysis method. Method: The microdialysis probe was introduced to right ventricle of rats as sampling tools for real-time and in vivo collecting samples after intramscular injection. The dialysate samples were determined by HPLC. After the dialysate concentration was calibrated, the blood-drug concentration was fitted with compartment and noncompartment model. Result: The results shows that physiological disposition of Sinomenine Hydrochloride was fitted to first order rate and open one-compartment model. The main pharmcokinetics parameters were as following: Cmax 3.127 mg·L-1,Tmax 101 min,MRT 191 min. Conclusion: The pharmacokinetics characteristics of Sinomenine Hydrochloride was collected by using microdialysis method which could been selected as study tool.关键词：sinomenine hydrochloride;intramuscular injection;microdialysis technology;pharmacokinetics
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发布时间：2024-01-04 - 摘要：Objective: To explore the Zedoary oil on A549 cell line inhibiting the proliferation and cathepsin K expression. Method : The effects of Zedoary oil on the proliferation of lung adenocarcinoma cell line A549 were determined by MTT assay. The cells cyclic retardation were examined by using flowcytometry. Cathepsin K expression of level were detected by using western blot. Result : MTT showed that Zedoary oil had an inhibitory effect on the proliferation of A549 cells in 60~200 mg ·L-1. Flow cytometry showed that Zedoary oil increased the percentage of G0/G1 phase cells and reduced the percentage of S phase cells. The results of western blot showed that the expression of cathepsin K was up-regulated significangly in A549 cells of Zedoary oil groups compared with that in controls. Conclusion :Zedoary oil can significantly inhibit the growth of A549 cells,blocking the cell cycle. The effects may due to the up-regulation of cathepsin K.关键词：Zedoary oil;A549 cell;cell cycle;cathepsin k
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发布时间：2024-01-04 - 摘要：Objective: To explore the relationship between the changes in interleukin-11(IL-11) and transforming growth factor-beta1(TGF-β1) and occurrence of idiopathic thrombocytopenic purpura(ITP)by investigating content of IL-11 and TGF-β1 in peripheral blood of the mouse model with ITP. Method: Contents of IL-11 and TGF-β1 in peripheral blood of the mouse model with ITP were measured by ELISA. Result: Contents of IL-11 and TGF-β1 in peripheral blood of model group increased significantly,and it was statistically significant(P<0.05). Conclusion: IL-11 and TGF-β1 play an important role in occurrence of ITP,and Purpura Granules can cure ITP effectively by regulating contents of IL-11 and TGF-β1 in peripheral blood.关键词：Purpura Granules;idiopathic thrombocytopenic purpura;interleukin-11;transforming growth factor-beta1
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发布时间：2024-01-04 - 摘要：Objective: To investigate the effects of Panax notogiuseng(PN) , Gynostemma pentaphyllum(Gp) and their total saponins(PNs and Gps) on vascular remodeling in experimental atherosclerosis rabbit and to explore the possible mechanism. Method: Forty healthy male Zelanian white rabbits were used in the experiment. They were randomly selected and allocated as 5 groups:group 1 nomlal control group, group 2 treated with PN and Gp, group 3 treated with PNs and Gps, group 4 treated with captopril , group 5 positive control group. Normal control group were fed with normal diet, the other groups were fed with hypercnolesterol diet. After administered for 12 weeks,histopathological examination of abdominal aorta with the most obvious lesion was performed, and the changes of related vascular remodeling indexes were observed using computerized image analyzing system. Result: PN and Gp could significantly decreased the number of VSMC(P<0.01). The area of medial membrane of group 2 were significantly lower than that in the positive control group. Conclusions: PN,Gp and their total saponins played its action in preventing and treating atherosclerosis through inhibiting intimal proliferation and intervening pathological vascular remodeling.关键词：Panax notogiuseng;Gynostemma pentaphyllum;PNS;Gps;atherosclerosis
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发布时间：2024-01-04 - 摘要：Objective: To evaluate the effects of Xiangfu Siwu Decoction (XFSW) and Siwu Decoction (SW) on hemorheological indexes and ovarian function in rat model of acute blood stasis. Method: A model of blood stasis was established by means of giving rats an injection of adrenalin and making them swim in ice-cold water. The indexes of hemorheology, TT, PT, APTT, FIB, E2 and P were detected. Results: XFSW showed improvements in the indexes of rats in the model of acute blood stasis, prolonged TT, APTT, degraded FIB to normal level and regulated the secretion of E2 and P. However, SW showed weak effects on these indexes.关键词：Xiangfu Siwu Decoction;SIWU decoction;acute blood stasis;hemorheology;ovarian function
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发布时间：2024-01-04 - 摘要：Objective: To study the eugenol contents of micropowder and coarse powder of Flos Caryophylli and the effects on intestinal motility in mice. Method: HPLC was used to determine the contents of eugenol in ultramicro-powder and coarse powder of Flos caryophylli. Charcoal powder propelling test of intestine was used to observe the effects on intestinal mobility in mice for coarse powder and different doses of micropowder. Result: The contents of eugenol were the same in the two kinds of power, Flos caryophylli can obviously inhibit intestinal motility. The effects were the same when the dose of micropowder was 25 percent of that of coarse powder. There was a dose-effect relationship in inhibiting intestinal motility for micropowder. Conclusion: The application of super-crash in Flos caryophylli is significant. The dose of micropowder can be reduced correctly for saving medical material when it is used in clinic.关键词：Flos Caryophylli;micropowder;charcoal powder propelling test;intestinal mobility
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发布时间：2024-01-04 - 摘要：Objective: To determine the in vitro effect of Radix Saposhnikoviae (RS), Largehead Atractylodes Rh (LA) and white paeony root (WPR) on the colonic smooth muscle strips of rats and study the possible mechanisms. Method: The colonic longitudinal smooth muscle strips of rats were prepared. Sodium chloride (9 g ·L-1) was used as the control groups. We observed the effects of WPR, LA and RS on the spontaneous contraction of the muscle strips. To study its mechanisms further, we also observed the effects of three tool drugs (naloxone, propranolol and phentolamine) on the strips. Result: Compared with the control group, both LA and WPR had the promoting role on the in vitro contraction of colonic smooth muscle strips. In addition, the activity of LA was stronger than WPR. RS of different concentrations showed dose-dependent inhibitive effects on 10~40 g ·L-1 in the spontaneous contraction of colonic muscle strips. When acetylcholine was Added, RS showed dose-dependent inhibitive effects on the contraction of muscle strips. Compared with the NS+RS group, the area of NLT+RS group had significant difference (P<0.05), so were the peak and area of FTLM+RS group (P<0.01), while NS group was insignificant. Conclusion: RS showed inhibitive effect on the spontaneous in vitro contraction of colonic smooth muscle strips of rats, while LA and WPR showed promoting effect. The mechanisms of inhibition are supposed to have close relations with the α-adrenoceptor and maybe also related with the M-cholinergic receptor.关键词：Chinese herbs;Radix Saposhnikoviae;Atractylodes Rh;white paeony root;smooth muscle;colon;rat
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发布时间：2024-01-04 - 摘要：Objective: To investigate the effect of Shenfu Decoction, Qifu Decoction, Jiangfu Decoction on cardiomyocyte apoptosis through the mitochondrion signaling pathway of cardial injury model induced by adriamycin in rat. Methods : Enzyme-linked immunosorbent assay(ELISA) was applied to measure the content of Caspase-9, Caspase-3, Bcl-2, Bax and cytochrome C in cardiomyocyte mitochondria. Results : In adryamycin-induced rat group: the content of Bcl-2 in myocardial mitochondria decreased, the content of Bax increased, the content of Caspase-9, Caspase-3 and cytochrome C increased, with statistical significance (P<0.05). In Shenfu Decoction group, Qifu Decoction group and Jiangfu Decoction group: the content of Bcl-2 in myocardial mitochondria increased, the content of Bax decreased, the content of Caspase-9, Caspase-3 and cytochrome C decreased, with statistical significance (P<0.05). Conclusion : There is relationship between the content of Caspase-9, Caspase-3, Bcl-2, Bax and cytochrome C and the ocurrence and development of adriamycin-induced cardial injury. Shenfu Decoction, Qifu Decoction, Jiangfu Decoction can protect myocardium by inhibiting adriamycin-induced cardiomyocyte apoptosis through the mitochondria signaling pathway.关键词：adriamycin;cardiotoxic injury;mitochondrion;apoptosis;Shenfu Decoction;Qifu decoction;Jiangfu Decoction
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发布时间：2024-01-04 - 摘要：Objective: To explore effect of Phyllanthus emblica on immune hepatic fibrosis in liver fibrosis rats caused by porcine serum. Method: The rats were injected with porcine serum, so the rats were got the illness of liver fibrosis, and the rats were given the medicine P. emblica, then the content of ALT, AST, Alb, GLO and TP were tested. Result : P. emblica was able to decrease the content of ALT, AST, GLO, TP, HA, PⅢNP and LN, P. emblica could increase the ALB content also. It was able to improve the inverted protein, rnduce the hepatic weight coefficient and improve the pathological injury of hepatic tissue. Conclusion : P. emblica has protective role in liver fibrosis rats.关键词：Phyllanthus emblica;porcine serum;immune fibrosis of liver
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发布时间：2024-01-04 - 摘要：Objective: To observe the The therapeutical effect and toxicologic study of Lixin granule on the adriamycin-induced heart failure rats. Method: sixty adult male Wistar rats were divided into 5 groups: normal control group, adriamycin(ADR) group,L- Lixin granule group, H- Lixin granule group, captopril group. Then ADR of 5 mg·kg-1 was given intraperitoneally once to copy the model of heart failure once 5 days, totally 3 frequency. Objective to monitor the hemodynamic index on the adriamycin-induced heart failure rats through left ventricle intubatton.Pathological changes were observed by HE staining.The LD50 and maximum tolerance of heart failure rats were determined on toxicologic study.Another three-dose group )-1] and blank control group were oral administrated.8 weeks later, the body weight were measured.The conditions of blood, the liver and renal functions were determined after treatment as well as following seven days. The rats were sacrificed after the experiment.Meanwhile,the coefficient of organ was calculated and the pathology was also tested. Result: As compared with ADR group,the LVSP the Lixin granule group were significantly higher and HE staining showed that the myocardial tissue damage were significantly improved. By tests of mouse toxicity, sixtyfold-weight Lixin granule than sdult is revealed that the rats was orally administered through a stomach and Lixin granule is an actually nonpoisonous material. After a long period of time,the weight, routine blood test, liver , kidney function and main viscera of rats were not influenced obviously. Conclusion: Lixin granule treatment can improve the cardiac contractility of adriamycin-induced heart failure rats; and also obviously be provided with better security.关键词：Lixin granule;adriamycin-induced heart failure rats;heart function;toxicity test
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发布时间：2024-01-04 - 摘要：Objective: To investigate anti-tumor effect and possible mechanism of N-butanol extract of Daphne odora Var.Marginata in vivo. Method: Solvent extraction method was used for obtaining extraction from D. odora. Mouse model of transplanting tumor was used to study the in vivo anti-tumor effect of N-butanol extract of D. odora at different concentrations. MTT method was used to examine the effect of NK cell. ELISA method was used to examine IL-2 secreted by spleen cell. Result : N-butanol extract of D. odora could decrease the tumor weight in S180-bearing mice. It could raise IL-2 secreted by spleen cell, and obviously enhance the effect of NK cell. Conclusion: N-butanol extract of D. odora has anti-tumor activity in vivo and promote spleen cell secrete IL-2 and enhance the effect of NK cell.关键词：Daphne odora Var.Marginata;N-butanol extracte;anti-tumor effect
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发布时间：2024-01-04 - 摘要：Objective: To investigate different extracts of Polygonum capitatum on inhibitory activity to α -glucosidase. Method: Different extracts were extracted by Soxhlet, and the inhibitory activity to α- glucosidase was screened by the 96-microplate-based method. Results: The results showed that P. capitatum had good inhibitory activity. The methanol extract had the highest inhibitory activity to α -glucosidase (IC50 1.68 μg·mL-1), and then the ethyl acetate extract (IC50 7.27 μg·mL-1) and the petroleum ether extract (IC50 116.81 μg·mL-1), three extracts of P. capitatum showed higher activity than Acarbose (IC50 1 081.27 μg·mL-1). And all of the extracts showed dose dependent for the inhibitory activity. Conclusion: The methanol extract of P. capitatum showed very significant inhibitory activity to α -glucosidase, and could be exploited the diabetes drugs as α- glucosidases inhibitors in future.关键词：Polygonum capitatum;α -glucosidase;inhibitory activity
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发布时间：2024-01-04 - 摘要：Objective: To study the influence of the formula of benefiting Qi and promoting blood circulation and detoxication on juvenile spontaneously hypertensive rats(SHR)’ endothelium function, and further investigate the prevention mechanism of HBP by the formula. Method: 16 6ws-old male SHR rats were randomly divided into two groups, including the model group and the formula group. After 6 weeks, the changes in blood pressure before and after treatment were detected separately. Besides, the change of serum von Wilebrand factore(vWF) and ET-1 concentration were tested by enzyme linked immunosorbent assay, the content of serum NO was tested by nitrous reductase chromatometry, the SOD was tested by xathine and xanthylic oxidase reaction system, and the MDA was tested by thiobarbital chromatometry. Meanwhile 8 same age WKY rats were used as the blank comparison. Results : In the juvenile plasma, vWF and MDA were significantly (P<0.05) increased, NO and SOD were significantly (P<0.05) decreased. After treatment with the formula of benefiting Qi and promoting blood circulation and detoxication, not only vWF and MDA were significantly (P<0.05) decreased, but also NO and SOD were significantly (P<0.05) increased in the SHP plasma. Conclusion : The insufficiency of endothelium in SHR exists in juvenile stage. The early application with the formula of benefiting Qi and promoting blood circulation and detoxication can improve vascular endothelial function in juvenile SHR.关键词：juvenile spontaneously hypertensive rat;von Wilebrand factor;nitrous oxide;ultraoxydum dismutase;malondialdehyde;endothelin 1
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发布时间：2024-01-04 - 摘要：Objective: To investigate the effect of Jiaotaiwan on action potentials(AP) of isolated ventricular myocytes in guinea pig. Method: The myocytes were enzymatically obtained from the guinea pig hearts and the action potentials were examined by whole-cell patch clamp technique. Result: Jiaotaiwan (0.2% solusion) decreased the resting potential from (-85.91±6.24)mv to (-99.64±6.62) mv (n=8,P＜0.01), increased action potential amptitude(APA) from (128.91±1.39)mv to (139.74±2.67)mv(n=8,P＜0.01), shortened action potential duration of repolarization 50%(APD50) from (505.49±30.97)ms to (329.94±44.32)ms (n=8,P＜0.01), shortened action potential duration of repolarization 90%(APD90) from (524.96±30.99)ms to (358.41±43.51)ms (n=8,P＜0.01), extended action potential duration of repolarization 50% to repolarization 90%(APD50-90) from (16.56±1.48)ms to (27.31±3.62)ms (n=8,P＜0.01), and slowed down the slope of phase 3(V3) from (-2.93±0.33)v.s-1 to (-1.95±0.28) v.s- (n=8,P＜0.01). 0.1% and 0.4% Jiaotaiwan on the various indicators of impact and 0.2% of the change in trend. Conclusion: Jiaotaiwan can induce the following influence for ventricular myocytes: decreased RP, increased APA, shortened APD50, shortened APD90, extended APD50-90 and V3 slowed down. The influences of Jiaotaiwan are likely linked with the electrophysiological mechanism of its anti-arrhythmic effect.关键词：Jiaotaiwan;membrane potential;arrhythmia;patch clamp technique
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发布时间：2024-01-04 - 摘要：Objective: To study the effect of Shenxiong Huayu Capsule on the expression of p38 MAPK in the CA1 area of hippocampus in vascular dementia rats. Method: A model of vascular dementia (VD) was established by combining repeated occlusion of common carotid artery and intraperitoneal injection of sodium nitroprusside. The SD rats were evenly randomized into 4 groups: blank control group, sham-operation group, VD model group and Shenxiong Huayu Capsule intervention group。The learning and memory abilities of rats were detected by Morris water maze, and the expression of P38MAPK was detected by immunohistochemistry. Result: (1) Compared with the sham-operation group and blank control group, the escape latent period was increased in the VD model group(P<0.01),and the times of traversing terrace and the period of staying in the pristine quadrant were obviously decreased in the VD model group(P<0.01, P<0.01).The escape latent period in the Shenxiong Huayu Capsule intervention group was gradually decreased compared with the VD model group (P<0.05,P<0.01),and the times of traversing terrace and the period of staying in the pristine quadrant were increased compared with the VD model group(P<0.05, P<0.05). (2) The expression of p38MAPK in the CA1 area of hippocampus was increased in the VD model group compared with that in the sham-operation group and blank control group (P<0.01). The expression of p38MAPK in the CA1 area of hippocampus was declined in Shenxiong Huayu Capsule intervention group compared with that in the VD model group (P<0.01). Conclusions: The decline of learning and memory abilities of the VD rats is related to the increasing of P38MAPK, and Shenxiong Huayu Capsule could decrease the expression of P38MAPK in the CA1 area of hippocampus in VD rats and improve the abilities of learning and memory for the VD rats.关键词：vascular dementia;p38MAPK;Shenxiong Huayu Capsule
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发布时间：2024-01-04 - 摘要：Objective: To study the effects of Qingrejiedu Fang on expression of multiple adhesion molecules in septic rat model . Method: Using a sepsis model induced by cecal ligation and puncture (CLP) in rat , the septic rats were treated with 2 different doses of Qingrejiedu Fang for 72 hours. The expressions of CD11b/c, CD62L and CD54 of circulating blood cells were determined by flowcytometry. Result: The expressions of CD11b/c and CD54 were increased significantly compared with the control group, while the CD62L was decreased.The Qingrejiedu Fang could reverse this tendency. Conclusion: The high expressions of adhesion molecules and their adhesive effects play an important role in the pathological process of multiple organ dysfumctions in sepsis and the Qingrejiedu Fang has therapeutic effects on septic model by regulating the expressions of multiple adhesion molecules.关键词：Qingrejiedu Fang;sepsis;adhesion molecules;flowcytometry
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发布时间：2024-01-04 - 摘要：Objective: To observe the effect of Xiaozheng decoction(XZD) resolve in treatingendometriosis model mouse and to explore its Liquid of abdominal cavity PGF2a、serum CA125. Method: Divide into four groups, the group treated with physiological saline, the group treated with western medicine, the group treated with traditional Chinese medicine of high dosage, and the group treated with traditional Chinese medicine of low dosage, each group with ten mouses. By ELISA to observeendometriosis model mouse’s serum CA125andliquid of abdominal cavity PGF2a. Result: XiaoZheng Decoction(XZD) reduce the serum CA125,liquid of abdominal cavity PGF2a of endometriosis model mouse and has some restrained function for endometriosis. Conclusion: XZD has an effect may be achieved by reducing the serum CA125,liquid of abdominal cavity PGF2a,restraining unusual proliferation of endometriosis.
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发布时间：2024-01-04 - 摘要：Objective: To investigate the Effects of sesamin on the metabolism of ethanol. Method: : ①Sprague-Dawley rats were administrated intragastrically with sesamin at a dose of 8, 23,70 mg ·kg-1,respectively.After 15d of treatment, ethanol was administrated intragastrically. Blood samples were collected according to the regular time schedule after sesamin administration through vena caudalis. The concentration of norfloxacin was determined by automatic immunoassay analyzer. ②Mice were administrated intragastrically with sesamin at a dose of 10, 33,100 mg ·kg-1, respectively. After 7d of treatment, ethanol of 2.5g ·kg-1 was administrated by intra peritoneal injection. Locomotor activity was measured according to the regular time schedule after ethanol was administrated. ③Mice were administrated intragastrically with sesamin at a dose of 10, 33,100 mg ·kg-1, respectively. After 7d of treatment, ethanol of 3.5g ·kg-1 was administrated by peritoneal injection. Duration of loss of righting reflex was measured after ethanol was administrated. Result :①Seamin at the dose of 23mg ·kg-1 and 70mg ·kg-1 can reduce the blood concentration of ethonal in mice.②Seamin at the dose of 33mg ·kg-1 and 100mg ·kg-1 can increase the locomotor activity induced by ethanol in mice. ③Seamin at the dose of 33mg ·kg-1 and 100mg ·kg-1 can shorten the ethanol-induced duration of loss of righting reflex in mice. Conclusion: Seamin can accelerate the metabolism of ethanol.关键词：sesamin;ethanol;metabolism;locomotor activity;righting reflex
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发布时间：2024-01-04 - 摘要：Objective: To investigate therapeutic effects of total saponins extracted from leaves of rehmannia on accelerated nephrotoxic nephritis induced by rabbit IgG in rat. Method: Rephrotoxic serum containing antibody to rat basilar membrane was preparcd in rabbits.For establishing accelerated nephrotoxic mephritis in rat,the seruem was obtained and given to rat by injection through tail venule.Total saponins extracted from leaves of rehmannia were orally given to the model rats as treatment for 16 days at doses of 20~40 mg·kg-1.Blood biochemeical parameters,urine protein,hemorheological parameters and pathological changes of nephritis were employed to evaluate the efficacy the efficacy of the treatment. Results :Compared with the model rats, plasma albumin,cholesterol and urea nitrogen were significantly increased. There was also a tendency of normalization for hemorheological parameters.The pathological changes of nephritis were alleviated. Conclusion :Total saponins extracted from leaves of rehamannia has therapeutic effect with a dose-response manner on accelerated nephrotoxic nephritis induced by rabbit IgG in rat.关键词：total saponins from leaves of rehmannia;nephrotoxic nephritis;antibody
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发布时间：2024-01-04 - 摘要：Objective : To observe the immune protection of matrine (Mat) on a rat model of chronic Pseudomonas aeruginosa (PA) biofilm pneumonia. Method : Rats were challenged intratracheally with alginate embedded PA strain PAO579 in the concentration of 1×109 colony-forming units per milliliter(CFU ·mL-1). Mat or sterile normal saline (NS) was injected intraperitoneally once a day for two weeks starting on the second day after challenge. Two weeks post intratracheal challenge with PA, parameters were evaluated. Result : Two weeks after challenge, the Mat-treated group showed a significantly milder pathological changes in lung(P<0.001), and lower lung abscess incidence compared to the model group(P<0.001). Furthermore, a remarkable improved bacterial clearance(P<0.001) and a shift from an acute type to a chronic type of lung inflammation were found in the Mat-treated group compared to the model group. 80% animals have returned to a chronic type of lung inflammation after Mat treatment which were much higher than that in the model group(P<0.05).The lung cells from the Mat-treated group produced more interferon-gamma(IFN-γ)(P<0.001),but less interlerkin-4(IL-4)(P<0.001)as compared to the model group. These results indicate that Mat has an effect of inducing Th1 type of immune response. Conclusion : Mat treatment significantly reduced pathological changes in lung and enhanced lung bacterial clearance, which might be associated with a shift of local immune responding type from a Th2 like to Th1 like. This might provide a better immune protection to the rats with chronic P. aeruginosa bilfilm lung infection.
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发布时间：2024-01-04 - 摘要：Objective: To investigate the effects of Qianlie Shukang Capsule in treating prostatitis. Method : Pharmacological investigations were carried out to study the impact of Qianlie Shukang Capsule on rat's prostate fribrosis inflammation caused by Xiaozhiling and on rat's prostatitis caused by Escherichia coli. Result: Qianlie Shukang Capsule has significant effect for treating prostatitis induced by Xiaozhiling and that induced by E. coli, indicated by prostate weight, leucocyte count and lecithin density(P<0.05 or P<0.01). Conclusion: Qianlie Shukang Capsule can alleviate prostate pathological changes in chronic prostatitis, and is effective in treating bacterial prostatitis incause by E. coli.关键词：Qianlie Shukang Capsule;prostatitis;rat model
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发布时间：2024-01-04 -
Effect of Beisheng Granules on NutritionalStatus in Hemodialysis Patients with Chronic Renal Failure
摘要：Objective: To observe the effects of beisheng granules on nutritional status in hemodialysis patients with chronic renal failure. Method: The 60 patients were divided into beisheng granules group( n =30) and control group( n =30).AMC, Fr and BMI were measured and the serum level of albumin, pre- albumin and transferrin were tested before and after treatment. The score of Subjective global assessment of nutrition were also computed. Result: In treatment group, the level of albumin, pre- albumin ,transferrin and the score of SGA were increased significantly compared with before treated and the control group. There was no difference of AMC,Fr and BMI between two groups. Conclusion: Beisheng granules can improve nutritional status in hemodialysis patients with chronic renal failure.关键词：Beisheng granules;nutritional status;hemodialysis patients- 2
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发布时间：2024-01-04 - 摘要：Objective: To observe the clinical effect of the treatment with Danhong Injection in the patients with vascular dementia. Method: All 80 patients with vascular dementia were randomly divided into Danhong Injection in the treatment group and ginkgoleaf Extract and dipyridamole injection in the control group, in the treatment of essential drugs, based on the above-mentioned two types of intravenous drugs, the 28-day course of treatment, the cognitive ability,the activities of daily living,TCM symptom of VD, hemorrheology, the content of ET-1 in plasma and NO in serum were measured respectively before and after treatment. Results :The effect was equal between the treatment group and the control group in cognitive function, activities of daily living, blood high-shear viscosity, low shear viscosity and red blood cell aggregation index. In the treatment group in TCM symptom of VD, the plasma viscosity and the content of ET-1 in plasma and NO in serum improvement were better than the control group (P<0.05 or P<0.01). Conclusion :The Danhong Injection treatment of vascular dementia have a better clinical effect, the mechanism may be related to reducing the blood viscosity, and promoting cerebral microcirculatory endothelium to excrete NO,while decreasing ET-1, and improving the balance between vasodilator and vasoconstrictor to protect the brain microvascular endothelial cell function.关键词：Danhong Injection;vascular dementia;clinical efficacy;endothelin-1;nitric oxide
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发布时间：2024-01-04 - 摘要：Objective: Explore the efficacy and safety of Guizhi Shaoyao Zhimutang combine methotrexate (MTX) and sulfasalazine (SSZ) on refractory rheumatoid arthritis (RA). Method: Select 81 patients met the inclusion criteria were randomly divided into two groups. Patients in treatment group ( n =40) were treated with Guizhi Shaoyao Zhimutang combine methotrexate (MTX) and sulfasalazine (SSZ). Patients in control group ( n =41) were treated with methotrexate (MTX) and sulfasalazine (SSZ). The therapeutic course was 12 weeks in both groups. Based on American college of rheumatology (ACR) recommended evaluation of RA disease activity core set of indicators to assess the two groups before and after treatment. Result: After treatment, both groups score major indicators of disease activity were significantly decreased ,before and after treatment the differences were highly statistically significant (P<0.01), the treatment group score lower than the control group, the difference was significant (P<0.05 ). The treatment group achieved ACR20, ACR50, ACR90 efficacy criteria were: 37.5%, 32.5%, 20%, with a total effective rate 90%; the control group achieved ACR20, ACR50, ACR90 efficacy criteria were: 46.34%, 19.51%, 4.88 %, the total efficiency of 70.73%. Conclusion: Guizhi Shaoyao Zhimutang combine methotrexate (MTX) and sulfasalazine (SSZ) the efficacy of the treatment of refractory rheumatoid arthritis is superior to the efficacy of methotrexate (MTX) and sulfasalazine (SSZ), and has good security.
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发布时间：2024-01-04 -
Orthopedic Surgery in Patients with I-type Incision Perioperative Analysis of Antimicrobial Drug Use
摘要：Objective: Analysis and evaluation of orthopedic surgery I type incision perioperative use of antimicrobial drugs. Method: Taken in November 2008 -2009 was discharged in April of 120 cases of orthopedic surgical incision in patients with Class I medical records, summary of the use of antibacterial drugs and statistical analysis. Result : I-type incision surgery preoperative medication rate 21.7%, after the rate of 100% medication. Followed by the use of the frequency of the first generation of the first hold 3,4 streptozotocin, 2 on behalf of the first hold streptozotocin, lincomycin category, aminoglycosides, quinolones, penicillins, macrolides. The average time for pre-operative medication 3.2 days, at least 1 day, up to 10 days; after 8.8 days on average use of time, at least three days, a maximum of 17 days. Conclusion : Orthopedic surgical incision I type, there are some indications of perioperative medication lax grasp, after the preventive use of antimicrobial agents for too long, the use of antimicrobial agents, as well as the use of excessive amount of unreasonable and so on.关键词：I-type incision surgery;perioperative;antimicrobial drugs;infection- 2
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发布时间：2024-01-04 - 摘要：Objective: To evaluate the treatment function of ligustrazine in hypertensive disorder complicating pregnancy FGR. Method: 60 pregnant women were randomly selected. The preeclampsia control group(30 patients with preeclampsia), The preeclampsia observe group(30 patients with preeclampsia). The preeclampsia control group: To supply routine method useing MgSO4. The preeclampsia observe group: to supply MgSO4and ligustrazine. And simultaneous determined the levels of BPD,AC,FL,FW and after using drugs in the preeclampsia control group and the preeclampsia observe group. Result: All the values in the preeclampsia observe group before and after therapy: It was found that the expression levels of BPD,AC,FL,FW were significantly difference in all these values after therapy. Conclusion: Ligustrazine could treat FGR of Hypertensive disorder complicating pregnancy.关键词：hypertensive disorder complicating pregnancy;fetal growth restriction;BPD;AC;FL;FW
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发布时间：2024-01-04 - 摘要：Objective: To evaluate the integrated traditional Chinese and western medicine treating ROU effectiveness. Method: 180 patients of ROU were divided into two groups randouly.Each group had 20 patients.The experimental group were treated by integrated traditional Chinese and western medicine..The comparison group were treated by western medicine. Result: The effective rates of experimental group in one year is 97.78%, the effective rates of comparison group in one year is 87.78%. Statistically significant differences were found between two groups.(P<0.05). The effective rates of experimental group after one year is 82.22%, the effective rates of comparison group in one year is 61.11%.Statistically significant differences were found between two groups.(P<0.05). Conclusion: There are excellent effectiveness of integrated traditional Chinese and western medicine treating ROU.关键词：Chinese and western medicine;ROU
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发布时间：2024-01-04 - 摘要：Objective: To provide objective basis for diagnosis of depression by Supper EEG Technology (S-Et) and determination of neurotransmitters, such as 5-HT, acetylcholine, dopamine, norepinephrine. Method: 244 of depression patients and 71 normal controls were involved in the study. TCM syndrome differentiation, S-ET and neurotransmitters determination were applied to the cases. Result: The comparison showed that depression patients and normal controls had significant differences in 5-HT, ACH, DA NE and EXC(p<0.01, with lowered levels in the patients). There were also marked differences in S-ET between TCM syndromes and normal controls (p<0.05). Conclusion: The brain function of depression demonstrated by S-ET is different from the normal persons. The mechanism of depression is not a simple elevation or decrease in all the neurotransmitters.关键词：depression;Supper EEG Technology;neurotransmitter;TCM syndrome differentiation
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发布时间：2024-01-04 - 摘要：The pharmacological role on reproductive and endocrine system is one of the main contents in the research of epimedium, and also the important basis for its clinical efficacy. Most reports show epimedium has both sex hormone-like effect and effect on hypothalamus - pituitary - gonadal / adrenal axis to increase sex hormone levels. It also has effect on sex organ,generative cells and sexual function. However, some different or contrary conclusions have been reported, so more researches need to be done to explain its mechanism of action, and to explore new application fields.关键词：epimedium;hormone;sexual function;reproduction;endocrine
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发布时间：2024-01-04 - 摘要：Gadfly insects is a traditional Chinese herb of blood-activating and stasis-dissolving . Gadfly,in recent thirty years,combined with the investigation results from the author getting the medicine market,is summarized and analyzed in the herbal textual,pharmacognosy,chemical composition,pharmacological effects of the literature. Author has proposed on the direction of research and development of gadfly.关键词：Tabanus bivittatus Matsumura;herbal textual;pharmacognosy;chemical composition;pharmacological action
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发布时间：2024-01-04
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