最新刊期
卷 16 ， 期 16 ， 2010
- 摘要：Objective: To optimize the shaping technology of the Genhuang Dispersible Tables and study the release characteristics in vitro. Method: The orthogonal design was used to obtain the optimal formulation with the disintegration of tablets;dissolution method and RP-HPLC method were used to study the release curve in vitro. Result: The proportion of each adjuvant in the optimal formulation consisted of 40% MCC as bulking agent,15% PVPP and 7% L-HPC as disintegrant.The prepared dispersible tables could be totally disintegrated within three minutes and crossed No.2 sieve,which subjected to the Chinese pharmacopoeia.The percentage of dissolution was more than 99%. Conclusion: The dispersible tables were in accordance with the standard.The process was operable,repeatable and suitable to the batch manufacture.关键词：Genhuang Dispersible Tablet;orthogonal design;disintegration time;dissolution
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发布时间：2024-01-04 - 摘要：Objective: To investigate the purification of Ginkgo biloba by macroporous adsorption resin. Method: Four types of macroporous adsorption resin were evaluated for separating efficiency by measuring the asorption and eluting ratio of flavone and lactone. Result: The DA201 macroporous adsorption resin had the best separating efficiency. Conclusion: This method was fit for industry production.关键词：macroporous adsorption resin;leaves of Ginkgo;flavone;lactone
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发布时间：2024-01-04 - 摘要：Objective: To prepare Coptis effect components pellets by extrusion-spheronization and study the formulation and new technology process. Method: Based on the physical characters of Coptis effect components,the fast-release pellets of Coptis effect components were prepared by extrusion-spheronization. The formulation and process were studied by direct comparison. Then their characters were evaluated such as powder properties,yield,dissolution etc. Result: The active components could release more than 85% in 15 minutes and the pellets presented perfect sphericity and high yield. Conclusion: Extrusion-spheronization was suitable to produce Chinese herbal medicine pellets. The preparation process was simple and feasible. The spherical degree and yield were high,and active components could release quickly in vitro关键词：Coptis effect components;extrusion-spheronization;pellets;fast-release
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发布时间：2024-01-04 - 摘要：Objective: To study the application of the crude cellulase in the culture of endophytic Penicillium sp.G-6 to total flavonoids extraction from leaves of Ginkgo biloba. Method: The process was studied by single factor analysis and orthogonal design L9(34) with the extraction rate of total flavonoids as comprehensive index,and the effect of the ratio of dry G. biloba leaves to crude enzymatic extracts,temperature,time,and pH value on extraction rate were also studied. Result: The extraction rate of total flavonoids was 1.33%,increased by 18.75% than that in regular extraction process,under the condition that dry G. biloba leaves were incubated with crude enzymatic extracts with 15 ∶1 (pH 5.0) at 50 ℃ for 3 h. Conclusion: The results presented a practical method of cellulase-assistant extraction process on total flavonoids in leaves of Ginkgo biloba.关键词：cellulose;endophytic Penicillium;Ginkgo biloba L.;total flavones;extraction
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发布时间：2024-01-04 - 摘要：Objective: To separate neferine from total alkaloids of Nelumbo nucifera. Method: An orthogonal test was adopted in the study.The neferine content and extraction ratio were adopted as index.Data processing was carried out with the multiple guidelines grading method for optimizing the extraction. Result: The optimum condition was as follows:chloroform and 2.5% sodium hydroxide solution were used as extraction solvent with volume ratio of 1 ∶1;the neferine content and extraction ratio were 91.6% and 45.6% respectively. Conclusion: The separation of neferine by extraction with sodium hydroxide solution was effective and easy,which could provide the good information for further studies.关键词：Nelumbo nucifera;separation;neferine
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发布时间：2024-01-04 - 摘要：Objective: To establish mathematical model between the both. Method: Prepare water-paste pills accordingly.Determine its dissolution,and then take the dissolution parameters through distribution model,disposal data with SPSS,finally obtain non-linear mathematical model. Result: For T20,the mathematical model was y =-3+3/x ;For T50,the mathematical model was y =-3+3/x ,y =596-5 984x +27 489x2-41 704x3.A relationship of positive correlation was found between the contents and the dissolution rate of TCM containing cellulose in prescription of water-paste pill. Conclusion: The dissolution rate Water-paste pill can be controlled by regulating the contents of traditional Chinese medicine which contains cellulose in prescription.关键词：water-paste pill;dissolution rate;TCM containing cellulose;mathematical model
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发布时间：2024-01-04 - 摘要：Objective: To establish a method for determining the contents of ferulic acid(FA) in dandelion by high-performance capillary electrophoresis (HPCE). Method: Dandelion was determined at 328nm using high-performance capillary electrophoresis (HPCE),under the optimized conditions achieved with a elastic fused-sillia capillary tube(75 μm×57/50 cm)and 20 mmol ·L-1borate running buffer solution (pH 9.18) at a constant voltage of 18 kV and injecting pressure time of 5 s at 25 ℃. Result: FA was linear within the range of 0.002 to 0.012 g ·L-1 ( r =0.999 8). The average recovery 98.22%,RSD 1.78%. Conclusion: This method is simple,rapid,accurate and good repeatability in separation and determination of FA in Dandelion.关键词：dandelion;ferulic acid;HPCE;determination
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发布时间：2024-01-04 - 摘要：Objective: To study on the quality standard in the seeds of Sinapis alba before and after roasted. Method: The presence of 4-hydroxybenzylglucosinolate,4-hydroxy benzoylcholine and sinapine was identified by TLC.The separation of sinapine was determined by HPLC on a Agilent TC-C18(2) column at 35 ℃ with the acetonitrile-0.1% phosphoric acid as the mobile phrase in gradient elution.The detection wavelength was set at 326 nm and the flow rate was 1.0 mL ·min-1. Result: The TLC chromatograms showed the little differences,and the contents of sinapine reduced after roasted by HPLC. Conclusion: The established methods were simple and could provide a scientific basis for the quality evaluation of S.alba.关键词：Sinapis alba;quality evaluation;TLC;HPLC
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发布时间：2024-01-04 - 摘要：Objective: To establish an HPLC method for the simultaneous determination of oleanolic acid and ursolic acid in Uygur medicine Ziziphora clinopodioides. Method: A ODS C18(4.6 mm×150 mm,10 μm) column was adopted. The mobile phase consisted of methanol and 0.03 mol ·L-1 phosphate buffer (pH 3,90:10). Detection wavelength was at 214 nm. The flowrate was 0.5 mL ·min-1. The injection volumn was 10 μL. Result: oleanolic acid was linear in the range was 0.4-1.2 g ·L-1 (r=0.999 6).ursolic acid was linear in the range was 0.6-1.8 g ·L-1 (r=0.999 6),and the linear relationship is accurate. The average recovery (n=6) of oleanolic acid was 99.5% (RSD 1.19%) and ursolic acid was 102.3%(RSD 1.25%). Conclusion: The method was simple,feasible and reproducible,and can be used for the simultaneous determination of oleanolic acid and ursolic acid in Z. clinopodioides.关键词：Ziziphora clinopodioides Lam.;HPLC;oleanolic acid;ursolic acid;determination
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发布时间：2024-01-04 - 摘要：Objective: To determine murrayone and 5'-murrayone in Murraya paniculata from different habitats in Guangxi. Method: A Global Chromatography SP-120-5-ODS-AP C18 Column(4.6 mm×150 mm,5 μm)was used with methanol-water(60 ∶40) as the mobile phase and UV detection was at 332nm. Result: The calibration curves were linear in the range of 0.589 6~5.896 μg for murrayone and 0.564 4~5.64 μg for 5'-murrayone,and the both correlation coefficients ( n =5) were 0.999 9;the average recovery ( n =6) for murrayone and 5'-murrayone were 100.2% (RSD 1.39%) and 100.3% (RSD 2.01%) respectively. Conclusion: There were large differences in the contents of murrayone and 5'-murrayone among murraya paniculata with different habitats in Guangxi.The highest content was found in Longzhou.关键词：Murraya paniculata;murrayone;5'-murrayone;HPLC
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发布时间：2024-01-04 - 摘要：Objective: To compare the contents of daphnetin in the raw medical material and the different processed products of Cortex Daphnes. Method: The contents of daphnetin in 18 samples of Cortex Daphnes and its processed drugs were determined by HPLC.Chromatographic conditions included Hypersil C18 column and the mobile phase consisted of a mixture of methanol 0.5% phosphoric acid (20 ∶80).Daphnetin was detected at 327 nm. Result: Daphnetin was linear in the range of 0.102~0.510 μg with correlation coefficient 0.999 9.The average recovery was 98.09% with RSD 0.92% (n=6). The contents of daphnetin in 18 samples was big difference (0.01%~1.11%).But the change of contents was small before and after processed. Conclusion: The method of analysis was fast,accurate and practicable.The study would provide theoretical and experimental data in order to evaluate the quality of Cortex Daphnes and its processed drugs systematically.关键词：Cortex Daphnes;processed drugs;daphnetin;HPLC
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发布时间：2024-01-04 - 摘要：Objective: To establish quality standard of Mangankang pills. Method: Angelica sinensis,Atractylodis Macrocephalae Rhizoma,Astragali and Bupleurum were identified by TLC.The content of paeoniflorin of Paeonine Radix Alba in the Mangankang pills was determined by HPLC. Result: TLC method was specific for the identification of Angelica sinensis,Atractylodes,Astragalus and Bupleurum,and no interference was found for negatives.Paeoniflorin was linear in the range of 0.058~1.16 μg.The regression equation was Y=1.07×106X-7.78×103(r=0.999 9).The average recovery was 98.6% (n=6,RSD 1.19%). Conclusion: This method is convenient,accurate,higher sensitivity,and can be used for controling the quality of Mangankang pills.关键词：Mangankang pills;TLC;HPLC;quality standard
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发布时间：2024-01-04 - 摘要：Objective: To analyze and compare the chemical constituents of the volatile oil from fresh and dried peach juvenile branchlet. Method: The volatile oil was extracted by steam distillation and analyzed by GC-MS.The relative content of each constituent was calculated by normalization. Result: Fourty five and 43 components were separated and identified respectively from fresh and dried branch of Prunus persica.19 and 29 components were separated and identified respectively from fresh and dried branch of Prunus davidiana. Conclusion: The main components of fresh branch of P. persica and fresh and dried branch of Prunus davidiana were benzaldehyde.The main component of dried branch of P. persica was palmitic acid.The relative contents of other chemical constituents were different关键词：peach juvenile branchlet;essential oil;GC-MS
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发布时间：2024-01-04 - 摘要：Objective: To establish a method for the determination of mangiferin and timosaponin BⅡin Anemarrhenae Rhizoma from different areas. Method: The mobile phase for the determination of mangiferin consisted of acetonitrile-0.85% phosphoric acid (12 ∶88),with the flow rate of 1.0 mL ·min-1,at 35 ℃. The detection wave length of magiferin was set at 258 nm;And the mobile phase for the determination of timosaponin BⅡconsisted of acetonitrile-water (25 ∶75),with the same flow rate of 1.0 mL ·min-1,at 25 ℃. An evaporative light-scattering detector (ELSD) was used as detector to determine timosaponin BⅡwith the drift tube temperature at 105 ℃. Result: The content of mangiferin and timosaponin BⅡ in Anemarrhenae Rhizoma from different areas were 0.99%~1.68% and 3.90%~10.25% respectively. Conclusion: The method for determination of mangiferin and timosaponin BⅡhere proved to be accurate and suitable,which can be used for the quality control of Anemarrhenae Rhizoma from different areas.关键词：Anemarrhenae Rhizoma;HPLC;mangiferin;timosaponin BⅡ;ELSD
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发布时间：2024-01-04 - 摘要：Objective: To establish an HPLC method for determination of baicalin in Chaihu Jiangan Capsules. Method: The chromatogram column was Diamonsil C18(4.6 mm×250 mm,5 μm),the mobile phase composition was the methanol-water-glacial acetic acid (54 ∶46 ∶0.2) the flow rate was 1.5 mL ·min-1,the detection wavelength was at 315 nm. Result: The linear range of baicalin was 8.072~48.43 g ·L-1,the average recovery was 99.54% with RSD 0.88% (n=6). Conclusion: the method was convenient,quick and accurate.It can be used for quality control of Chaihu Jiangan Capsules.关键词：Chaihu Jiangan Capsules;baicalin;HPLC;determination
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发布时间：2024-01-04 - 摘要：Objective: To establish an HPLC method for the simultaneously determination of chlorogenic acid,caffeic acid and mangiferin in Shiwei Dispensing Granule. Method: Chlorogenic acid,caffeic acid and mangiferin were separated on Shim-pack VP-ODS (4.6 mm×250 mm,5 μm) column and detected at 323 nm (0~30 min) and 258 nm (30.1~45 min),with acetonitrile-0.1% phosphoric acid solution (9 ∶91) as mobile phase. The flow rate was 1.0 mL ·min-1. Result: Chlorogenic acid,caffeic acid and mangiferin were linear within the range of 129.6~302.4 mg ·L-1 ( r =0.999 8),13.8~32.2 mg ·L-1 ( r =0.999 9) and 151.2~352.8 mg ·L-1 ( r =0.999 9) respectively. The average recovery were 98.15% (RSD 1.69%),99.93% (RSD 2.98%) and 101.43% (RSD 2.00%). Conclusion: The method is simple,reproducible,and it can be used for the quality control of Shiwei Dispensing Granule.关键词：Shiwei Dispensing Granule;chlorogenic acid;caffeic acid;mangiferin;HPLC
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发布时间：2024-01-04 - 摘要：Objective: To investigate the α-glucosidase inhibitory,antioxidant and antibacterial activity of compound recipe of Lobeliae chinese (CRLC). Method: Fractions were eluted by methnol-water in macroporous resin.All the fractions were assayed for the inhibitory activity of α-glucosidase,antioxidant activity and antibacterial activity by the method of 96-microplates,DPPH,ABTS and FRAP,K-B and dilution method respectively. Result: Active fractions were mainly concentrated in the 100%,60% and 40% methanol-water eluent.100% methanol eluent F (IC50=411.50 mg ·L-1) and G (IC50=543.70 mg ·L-1) were higher than that of Acarbose (IC50=1 081.27 mg ·L-1) which was used as positive control on inhibitory activity of α-glucosidase. 100% methanol eluent F (IC50=11.23 mg ·L-1) and G (IC50=10.81 mg ·L-1) had good ABTS free radical scavenging activity,which was slightly lower than that of BHT (IC50=7.47 mg ·L-1)as positive control. 100% methanol eluent G and 60% methanol eluent E had the highest antibacterial of SA,both of MIC were 62.5 μg ·disc-1. Conclusion: Bioactivity on CRLC was assayed for the first time,and it had good α-glucosidase inhibitory activity,antioxidant activity and antibacterial activity.
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发布时间：2024-01-04 - 摘要：Objective: To establish a method of determination of bilirution in Niuhuang Zhibao Pills. Method: Bilirubin was determined by UV spectrophotometry according to Pharmacopoeia.The detection wavelength was at 533 nm. Result: The arerage levels of bilirubin in the Niuhuang Zhibao Pills was 29.8 μg one pill.Bilirubin was linear in the range of 0.009 8~0.049 8 mg ·mL-1with r=0.999 9,(n=5).The average recovery (n=6) was 98.74%(RSD 0.45%). Conclusion: The methods were proved to be simple sensitive and reproducible.It can be used for the qualitycontrol of Niuhuang Zhibao Pills.关键词：Niuhuang Zhibao Pills;artificial bezoar;bilirubin;UV spectrophotometry
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发布时间：2024-01-04 - 摘要：Objective: A method was developed for simultaneous determination of five lignans (schizandrin,schisandrol B,schisantherin A,deoxyschizandrin and schisandrin B) from Schisandrae shinensis in different environment in Liaoning Fengcheng by HPLC to look for the best growing environment of high-quality S. shinensis. Method: Lichrosphe Agilent TC-C18 (4.6 mm×250 mm,5 μm) column in an oven at 35 ℃ with the mobile phase MeOH-MeCN-H2O in a gradient elution mode and DAD detector at 220 nm were applied. Result: Lignans content and total content of S. shinensis in different environment were various.The lignans content of S. shinensis growing at the foot of the mountain with jungle next the stream was the highest and best in quality. Conclusion: This method has the advantage of convenience,accuracy and reproducibility.关键词：Schisandrae shinensis;different environment;lignans;HPLC
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发布时间：2024-01-04 - 摘要：Objective: To establish a RP-HPLC method for determination the content of hesperidin in Muxiang Shunqi Pills. Method: The analytical column was Diamonsil (diamonds) C18 column (4.6 mm×250 mm, 5 μ);mobile phase was a mixture of acetonitrile-water (20 ∶80);flow rate was 1.0 mL ·min-1;the detection wavelength was set at 286 nm;injection volume 10 μL,column temperature was 30 ℃. Result: Withing the range of 0.02~6.40 μg,hesperidin showed a good linear relationship between the injection amount and peak areas(Y=6×107X+1×106,r=0.999 5), average recovery rate was 99.15%,RSD was 1.32% respectively. Conclusion: The method is sensitive,repeatable,specific with the practicality.关键词：Muxiang Shunqi Pills;hesperidin;HPLC
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发布时间：2024-01-04 - 摘要：Objective: To establish a method for the determination of ginsenoside Rg1,Re,Rb1in Shenqi Particle. Method: The contents of ginsenoside Rg1,Re,Rb1 in Shenqi Particle were determined by HPLC. Result: The resolutions of the determined peaks were fine.The linearity ranges for ginsenoside Rg1,Re,Rb1 were 0.26-4.2 μg(r=0.999 8), 1.0-16.2 μg(r=0.999 9) and 2.5-40.2 μg(r=0.999 9) respectively.The average recoveries were 99.4% with RSD 0.7%,99.6% with RSD 0.7%,99.2% with RSD 0.7%. Conclusion: The quantitative method for the determination was feasible,and beneficial to the quality control of Shenqi Particle.关键词：Shenqi Particle;ginsenoside Rg1, Re, Rb1;HPLC
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发布时间：2024-01-04 -
Comparison for Essential Oils from by Steam Distillation and Supercritical Carbon Dioxide Extraction
摘要：Objective: To analyze the chemical constituents of the essential oils from Forsythis suspense by different extraction method. Method: The essential oils were extracted by steam distillation (SD) and by supercritical carbon dioxide extraction (SFE) accordingly,and then the constituents were separated and identified by GC-MS. Result: Eighty-seven compounds were isolated and 58 compounds were identified by SD that composed about 96.99% of the total essential oils;And 100 compounds were isolated and 39 compounds were identified by SFE that composed about 60.50% of the total essential oils. Conclusion: The principal chemical constituents of the essential oils by SD are β-pinene, α-pinene (-)-4-terpineol,p-cymene.And the principal chemical constituents of the essential oils by SFE are nootkatone, β-pinene, transethyl-p-methoxycinnamate.There are differences in the chemical constituents and contents by the two extraction methods.关键词：Forsythis suspense;essential oils;steam distillation;supercritical carbon dioxide extraction;GC-MS- 2
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发布时间：2024-01-04 - 摘要：Objective: To analyze the chemical constituents of essential oils from Illicium difengpi in Guangxi. Method: The essential oils were extracted by steam distillation,and then the constituents were separated and identified by GC-MS. Result: 118 compounds were isolated and 58 compounds were identified in the leaves that composed about 98.02% of the total essential oils;63 compounds were isolated and 25 compounds were identified in the stem stripped of the bark that composed about 94.90% of the total essential oils;And 124 compounds were isolated and 68 compounds were identified in the stem bark that composed about 92.10% of the total essential oils. Conclusion: There are some differences in the chemical constituents and contents in the above mentioned three parts,the principal chemical constituents of the essential oils are Isosafrole,especially containing in the stem stripped of the bark, reaching to 68.75%.关键词：Illicium difengpi;essential oils;different parts;GC-MS
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发布时间：2024-01-04 - 摘要：Objective: To investigate the correlation between the content of its secondary metabolites, steroidal saporins and the infection ratio and spore density of arbuscular mycorrhizal fungi of P. polyphylla. Method: By Phillips and Hayman staining,the arbuscular mycorrhizal of P. polyphylla were selected,and by Gendemanns Wet-screening method,the AMF spores were obtained and counted.Meanwhile,content of four steroidal saporins (paris saporinⅠ,Ⅱ,Ⅵ,Ⅶ) were determined by HPLC. Result: Through mathematic model analysis,the infection ratio showed conspicuous positive correlation with the spore density of mycorrhizal structures of P. polyphylla,while the infection ratio and spore density showed some positive correlation with the total steroidal saporin content in the rhizome. Conclusion: Arbuscular mycorrhizal fungi may be an important factor which affect the content of active moiety in P. polyphylla.关键词：Paris polyphylla;arbuscular mycorrhizal fungi;arbuscular mycorrhizal;propagulum density;infection;steroidal saponin
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发布时间：2024-01-04 - 摘要：Objective: To compare the analgesic effects and chemical components for two kinds of extracts of Danggui Shaoyao San (DSS) by water and 50% ethanol accordingly,so as to provide some evidence for its clinical use and exploration of its material basis. Method: Two kinds of extracts of DSS were prepared by water reflux and ultrasonic wave-assisted extraction by 50% ethanol respectively,and their analgesic activities were evaluated in acetic acid-induced wringing and oxytocin-induced menorrhalgia in mice.Meanwhile,chemical constituents and total sugar content of two kinds of extracts were analyzed by high-performance liquid chromatography with Diode Array Detector (HPLC-DAD) and phenol-sulfuric acid method,respectively. Result: Water reflux extract of DSS (2.5 g ·kg-1,10 g ·kg-1) and ethanol extract of DSS (10 g ·kg-1) significantly decreased writhing times induced by acetic acid and oxytocin,while the inhibition rate of water extract was higher than that of ethanol extraction of DSS.Meanwhile,about 20 fingerprint peaks were found in ethanol extract of DSS.However,the chromatographic peak area of 4 compounds possibly come from Paenonia lactiflora Pall and total sugar contents in water extract of DSS were higher than that of ethanol extract. Conclusion: The analgesic effect of water reflux extraction of DSS was better than that of ultrasonic wave-assisted extraction by 50% ethanol,which might be partly due to the higher contents of the polar compositions and polysaccharides.关键词：Danggui Shaoyao San;analgesic;chemical composition;HPLC;phenol-sulfuric acid assay
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发布时间：2024-01-04 - 摘要：Objective: To explore the mechanism underlying preventive effects of ginseng on neuron damage induced by hypercortisolism. Method: Mouse model of hypercortisolism was developed by subcutaneous corticosterone injection.Different dosage of ginseng water decoction (7.2,3.6,1.8 g ·kg-1) was orally administrated to mice during reproducing animal model.After four weeks,the mice were sacrificed by decapitation after behavioral tests.Then,the hippocampal tissues were rapidly collected for Western blot analysis of four important proteins,neurofilament light chain protein (NF-L),synaptic vescle protein (SYP),brain-derived neurotrophic factor (BDNF) and glial-derived neurotrophic factor (GDNF). Result: In contrast to the control,depression-like behavior was obviously increased,and protein levels of NF-L,SYP,BDNF and GDNF were significantly decreased in the model group.In contrast to the model group,all dosage of ginseng water decoction not only could significantly improve depression-like behavior,but also obviously up-regulate protein levels of NF-L,SYP,BDNF and GDNF in the hippocampal tissues. Conclution: Ginseng can provide neuroprotection by up-regulating protein expression of neurotrophic factors.关键词：Panax ginseng;corticosterone;neurotrophic factors;neuron damage
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发布时间：2024-01-04 - 摘要：Objective: To study the inhibitory effect of dihydromyricetin from Ampelopsis grossedentata (Hand-Mazz) W.T. Wang (Vine tea dihydromyricetin,VTD) on hepatocyte apoptosis induced by the cessation of phenobarbital sodium (SP) injection treatment in mice,and to explore its mechanism of hepatoprotective effect. Method: The mouse model with hepatocellular apoptosis induced by removing SP was established.The mice were randomly divided into blanks,negative controls,positive controls and test groups.Test groups of mice were given intragastric gavage of 200, 50 mg ·kg-1 VTD.Hepatic apoptosis was detected by flow cytometry,terminal deoxynucleotidyl transferase dUTP nick-end(TUNEL),and pathological changes in the liver tissue were observed after HE staining. Result: The histopathological analysis of the liver showed normal liver morphology in blanks and negative controls,and varying degrees of liver cell apoptosis in positive controls and low- and high-dose VTD groups.The outcome from flow cytometry and TUNEL showed hepatocelluar apoptosis rate in low dose of VTD group were 17.7%, 2.9% respectively.All of these values were lower than those in positive controls (P<0.01). Conclusion: The mouse hepatocellular apoptosis induced by removing SP can be markedly inhibited by treating with VTD in 50 mg ·kg-1,and it might be one of the hepatoprotective mechanisms for VTD to inhibit the hepatocelluar apoptosis.关键词：vine tea;dihydromyricetin;hepatocelluar apoptosis
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发布时间：2024-01-04 - 摘要：Objective: This study was to evaluate the effect of two benzofuran derivatives on human liver hepatocellular carcinoma cells HepG2 and human hepatic L02 cells in vitro. Method: 5,6-dimethoxy-2-isopropenyl-benzofuran (compound 1) and 5-acetyl-6-methoxy-2-isopropenyl-benzofuran (compound 2) were isolated from Ligularia veitchiana (Hemsl.) Greenm.Trypan blue exclusion staining,2',7'-dichlorofluorescin diacetate(DCFH-DA) fluorescence spectrophotometry,and ammonium molybdate colorimetric assay were used to evaluate cytotoxicity,reactive oxygen species (ROS) generation,and catalase activity respectively. Result: The results showed that IC50 of compound 1 and 2 on L02 cells are (171.2±3.3) mg ·L-1 and (79.0±4.1) mg ·L-1,higher than that on HepG2, (84.2±6.5) mg ·L-1 and (65.2±1.9) mg ·L-1,exhibited more potent cytotoxic effect on tumor cells.After treated with the half inhibitory concentration (IC50) of compound 1 and 2 for 48 hours,ROS generated in HepG2 cells were 1.6 and 3.2 folds to the control group,and 1.2 and 1.8 folds in L02 cells respectively.Higher ROS generations in HepG2 cells than L02 were found.The catalase activity decreased from the control group (17.2±1.7) U ·mg-1 to (12.8±0.4) and (6.4±0.1) U ·mg-1 after treated with compound 1 and 2 in HepG2 cell respectively, and decreased from the control group (17.7±1.2) U ·mg-1 to (14.3±1.5) and (8.6±0.5) U ·mg-1 in L02 cells. Higher catalase activity reduced in HepG2 cells than L02. Conclusion: According to the more potent cytotoxicity,the ROS generation increasing in HepG2 than L02,and the decreasing of catalase activity in HepG2 cells,we suppose that the mechanism of the cytotoxicity for these two benzofuran deravatives may relate to ROS theory.关键词：Ligularia veitchiana (Hemsl.) Greenm;benzofuran;cytotoxicity;reactive oxygen species
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发布时间：2024-01-04 - 摘要：Objective: To study the Sini Powders and the different compatibilities in intervening experimental ulcerative colitis. Method: The experimental rats were divided into 14 groups and modeled with immunization.The status,colon organization and its pathological changes,thymus index,spleen index,activity of nuclear factor-Kappa B (NF-κB) of rats were observed. Result: All parameters of model group showed significant difference with that of the normal group(P<0.01).Compared with model group(4.40±1.07),the degrees of colonic injury of all drug groups were significantly lower(P<0.01).Compared with the model,pathological changes in colon for Sini powders group(2.80±0.79),Chaishaozhi group(3.20±0.79),Chaishaogan group(3.40±0.70),Chaishao group(3.20±0.79) and Chaizhi group(3.33±0.71)were all evident.The Sini Powders and the different compatibilities could improve thymus index and spleen index.And activities of NF-κB of all drug groups were decreased significantly,especially for the Sini Powders(0.023±0.006)(P<0.01). Conclusion: We speculate that the Sini Powders can intervene with the experimental UC by stimulating the immune organs to excrete the immune cells and inhibiting NF-κB to be activated.Bupleurum and peony,as the monarch drug and the ministerial drug in the prescription,play the important roles.Licorice plays a coordinating role through stimulating thymus cells proliferation as the conducting drug.
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发布时间：2024-01-04 - 摘要：Objective: To study the effects of Peitu Yunkang Decoction on abortion model of rat and to investigate the mechanism. Method: The abortion model was established in pregnant rats by giving mifepristone combined with misoprostol.The model was treated with 12,6,3 g ·kg-1 ·d-1 Peitu Yunkang Decoction and 8 mg ·kg-1 ·d-1 progesterone respectively for the model group and normal pregnancy group,normal saline of the same volume was given.All rats were sacrificed on the 14th day after pregnancy.Miscarriage rate,organ coefficient and morphological changes in uterine ovarian tissue were determined. Serum progesterone and β-Human chorionic gonadotropin(β-HCG) were also measured. Result: The group of 12,6,3 g ·kg-1 ·d-1 Peitu Yunkang Decoction increased the content of serum progesterone and β-HCG and the rate of anti-abortion significantly;The 6 g ·kg-1 ·d-1 Peitu Yunkang Decoction group had a better effect than the progesterone group in increasing β-HCG level and reducing the damage in the uterus. Conclusion: Peitu Yunkang Decoction has good effect for the treatment of rat model of threatened abortion,and the dose of 6 g ·kg-1 ·d-1 shows impressive effect.关键词：Peitu Yunkang Decoction;threatened abortion;progesterone;β-human chorionic gonadotropin
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发布时间：2024-01-04 - 摘要：Objective: To study the effect of Scutellaria baiculensis stem-leaf total flavonoid (SSTF) on myocardial apoptosis and Janus Kinases 2 protein expression during ischemia reperfusion in rats. Method: Forty SD rats were randomly divided into sham operation group,Ischemia reperfusion group and SSTF group.Rats in SSTF group were perfused with SSTF 17.5, 35, 70 mg ·kg-1 ·d-1 respectively prior to ischemia reperfusion.Other two groups were given NS instead of SSTF equally at a week before the operation.Myocardial ischemia reperfusion injury model was established by ligating the left descend coronary artery (LDA) 30 min and reperfusing 2 hours.Apoptosis of myocardial cell was detected after operation in all groups by flow cytometry with AnnexinⅤ-EGFP and propidium iodiode (PI) staining.The protein expression of JAK2 gene was determined by using immunohistochemical staining. Result: Compared with sham group,the occurrence rate of myocardial apoptosis in IR group was increased obviously(P<0.01);JAK2 protein expression was up-regulated in IR group(P<0.01).Compared with IR group,the occurrence rate of myocardial apoptosis in SSTF group was decreased obviously(P<0.05,P<0.01);The JAK2 protein expression was higher than that in SSTF group(P<0.05,P<0.01). Conclusion: SSTF attenuates cardiomyocytes apoptosis during ischemia reperfusion injury by down-regulating the protein expression of JAK2 gene.关键词：Scutellaria baicalensis stem-leaf total flavonoid;apoptosis;JAK2;ischemia reperfusion
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发布时间：2024-01-04 - 摘要：Objective: To observe the effect of Shangke Zhitong Plaster(SKZT) on nitric oxid(NO) and superoxide dismutase(SOD) level of the located soft tissue in rat model of acute soft tissue injury. Method: Model of acute soft tissue injury in rats was made,then they were divided into groups and given with drugs.Such dynamic items as index numbers of injury symptoms,parameters of histological anatomy and morphometry were investigated,and changes of NO and SOD in soft tissue were determined. Result: SKZT Plaster had favorable improvement on rat models of acute soft tissue injury,drug group was super to control group on index numbers of injury symptoms and histological anatomy recovery.SKZT Plaster could significantly decrease the elevation of NO in injured soft tissue and increase the contents of SOD in injured soft tissue in a dose-dependent way. Conclusion: SKZT Plaster could increase the level of SOD and inhibit the elevation of NO in injured soft tissue,this may be one of the mechanisms that SKZT Plaster can be used to treat acute soft tissue injury.关键词：Shangke Zhitong Plaster (SKZT Plaster);acute soft tissue injury;nitric oxide;superoxide dismutase
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发布时间：2024-01-04 - 摘要：Objective: To observe the effects of Wuzi Yanzong Pill on the memory,immune function,anti-hypoxia and anti-fatigue in mice. Method: Wuzi Yanzong Pill was administered to ICR mice at oral doses of crude drug 0.6,1.2,2.4 g ·kg-1.The learning and memory ability in mice were tested by Morris water maze experiment.Carbon expurgation method and delayed allergy were used to determine the immune function.Fatigue and acute anoxia in mice were produced by swimming and hypoxia under normal pressure respectively and survival time was determined. Result: Compared with control group,the escape latency and swimming distance of all dose groups were shorter (P<0.05 or P<0.01).High dosage increased the expurgatory index(P<0.01)but all dose groups had no effect on swelling of ear.High and middle dosage significantly prolonged the survival time under hypoxia(P<0.01).High dosage prolonged the swimming time of mice(P<0.05). Conclusion: Wuzi Yanzong Pill has remarkable effect on enhancing the ability of learning and memory in ICR mice,improving the tolerance of hypoxia and fatigue,promoting non-specific immune function but has no effect on cellular immune function.
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发布时间：2024-01-04 - 摘要：Objective: To study the therapeutic actions of the Qindaikeyin Pills on animal models of psoriasis. Method: Mice and guinea pigs were randomly divided into blank group,model group,positive group,Qingdaikeyin Pill groups (high,medium,low doses).Each group was orally administered once daily for 14 d.The effects of the pills on epithelial cells mitosis index and number of scale with granular layer in tail epidermis scale in mice were detected by using the pathologic samples of the micevaginal epithelium and scalescuticle at the tails of mice.The model of dermal damage with psoriasis in guinea pigs ears was carried out to observe the pathologic changes in dermal tissue and epidermis thickness. Result: Qindaikeyin Pills showed remarkable inhibitive actions on mitosis of mice vaginal epithelial cell and promotive actions for formation of epidermal granular layer in the scales of the mice tails.Qindaikeyin Pills could decrease the thickness of epidermis with psoriasis in the guinea pigs ears. Conclusion: Qingdaikeyin Pill possesses the significant treatment effect on animal models of psoriasis,which may be attributed to the action of suppressing hyperplasia of epidermal cells and improving imperfect keratinization.关键词：Qingdaikeyin Pills;psoriasis;mitosis index;number of scale;epidermis thickness
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发布时间：2024-01-04 - 摘要：Objective: To investigate the effect of Panax Notoginseng Saponins(PNS)on neuronal apoptosis and mitochondrial apoptosis pathway and c-Jun N-terminal kinase (JNK) activation after cerebral ischemia-reperfusion injury in mice. Method: C57BL／6 mice were randomly divided into sham-operation group,model group,PNS group and edaravone group.Cerebral ischemia-reperfusion injury was prepared by bilateral common carotid artery ligation for 20 min followed by reperfusion for 24 h and 48 h after drug administration for 4 days.Neuronal apoptosis was determined with Tunel and the expression of p-JNK1/2,cysteine-asparate protease -9(caspase-9),caspase-3 and cytochrome C (CytC) protein in brain tissue was detected with Western-blot. Result: After cerebral ischemia for 20 min followed reperfusion for 24 and 48 h,the neuronal apoptosis rate was enhanced significantly(P<0.01),the expression of p-JNK1/2,CytC,caspase-9 and caspase-3 protein in brain tissue was increased (P<0.01).The neuronal apoptosis rate in the PNS group was significantly lower than that of the model group(P<0.01),the expression of p-JNK1/2,CytC,caspase-9 and caspase-3 protein in PNS group was lower than that of the model group significantly(P<0.01 or P<0.05). Conclusion :PNS could attenuate neuronal apoptosis rate by inhibiting activation of signal transduction of JNK and mitochondrial apoptosis pathway after cerebral ischemia/reperfusion injury in mice.关键词：panax notoginseng saponins;ischemia-reperfusion;apoptosis;c-Jun N-terminal kinase;cytochrome C;cysteine-asparate protease
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发布时间：2024-01-04 - 摘要：Objective: To study the effect of Yinxieping Granules on guinea pig model of psoriasis. Method: All guinea pigs were coated propranolol emulsion on the ear twice a day for 2 weeks to establish the model of psoriasis.Then the granules was given daily by oral gavage for 2 weeks.Guinea pigs were sacrificed when the experiment was done.Tumor necrosis factor-α (TNF-α) and cell adhesion molecule (ICAM-1)were determined in the ear homogenates by ELISA kit. Result: Compared with the normal group,TNF-α and ICAM-1 were significantly higher in the model group(P<0.05).Compared with the model group,TNF-α and ICAM-1 were significantly lower in each of the treatment group(P<0.01). Conclusion: Yinxieping granules is a effective treatment for psoriasis.
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发布时间：2024-01-04 - 摘要：Objective: To study the coagulating action of both extracts(alcohol extract and water extract)of Jingxuening Capsule(JXNC) to find the differences between them. Method: Laboratory animals were randomly divided into six groups,namely blank control group,Yunnan Baiyao powder(YBP) group,JXNC1(extracted by water)and three dosages groups(containing crude drug 18,9.0,4.5 g ·kg-1 respectively)of JXNC2(extracted by alcohol).CT,TT,PTT,APTT,Fbg,PLT and PRT of each group were tested after administration by ig for 5 or 6 days. Result: Compared with blank control group,JXNC 2 groups were able to shorten CT,TT,PT,APTT,PRT,and increase the content of Fbg and PLT significantly.Compared with JXNC 1 group,TT,APTT,PRT of JXNC 2 were shorter than that of the former(P<0.05). Conclusion: JXNC 2(alcobol extract) has good action for blood coagulation,and it is better than JXNC 1(water extract).关键词：Jingxuening Capsule;coagulating action;alcohol extract;water extract
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发布时间：2024-01-04 - 摘要：Objective: To observe effects of Jiangtang xiaozhi Tablets on decreasing levels of blood glucose in rat and mouse models of diabetes mellitus. Method: Rats were intravenously given streptozotocin at dose of 50 mg ·kg-1.Mice were intravenously given Alloxan at dose of 90 mg ·kg-1to induce hyperglycemia.The levels of blood glucose in the rats and mice were measured after 3 days for screening model animals.Thereafter,rats were divided into 7 groups ( n =12,each) and were continuously given Jiangtang xiaozhi tablets by intragastric administration for 8 weeks.The levels of blood glucose,HBAlc,insulin and glucagon were assayed.While mice were divided into 7 groups ( n =14,each) and were continuously given Jiangtang xiaozhi tablets by intragastric administration for 4 weeks.The level of blood glucose was assayed. Result: The levels of blood glucose in each Jiangtang xiaozhi treatment group,HBAlc and glucagon levels in high dose group were significantly decreased (P<0.05) comparing to those of model rats while serum insulin levels were increased in the high dose group.The morphological study of pancreas in rats demonstrated that number of islets markedly increased in the high dose group.The levels of blood glucose in mice were significantly decreased (P<0.05-0.001) in middle and high dose groups comparing to that of model mice. Conclusion: Jiangtang xiaozhi Tablets has obvious effect on decreasing blood glucose for model animals of diabetes mellites.关键词：streptozotocin;alloxan;animal model;insulin;HBAlc
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发布时间：2024-01-04 - 摘要：Objective: To discuss the molecular mechanism of Ease Powder decoction treating on sleep deprivation depression by observing the changes of autonomic-behavior and the expression of serum TT3,TT4,FT3,FT4,TSH in a rat experimental model of sleep deprivation depression(SDD). Method: Fouty eight Wistar rats were divided into four groups after first open-field testing (OFT),they were normal group,model group,mirtazapine group and Ease Powder decoction group. Except the normal group,the other groups were received different stress for 21 days.Making day stress before 1 h the model group,mirtazapine,Ease Powder decoction group were intragastric administration of normal saline,mirtazapine,Ease Powder decoction respectively.At the end of 21 days,all the animals were sacrificed.The serum of rats was taken then kept in -20 ℃ freezer and the levels of TT3,TT4,FT3,FT4 and TSH were determined. Result: Compared with the situation before SDD,there was a significant decrease in the autonomic-behavior (P<0.01) of SDD after 21 days.Compared with the model group,the autonomic-behavior of Ease Powder decoction group and the mirtazapine group was increased(P<0.01).Compared with the normal group,there was no difference.The expression of serum TT3 and TT4 was no differences between the groups.However,compared with that in the nomal group,the expression of FT3 in the model group was decreased,FT4 was increased,TSH was nochange. Compare with the model group,the mirtazapine group and Ease Powder decoction group had no statistically significant,while the nomal group has statistically significant(P<0.05). Conclusion: The Ease Powder decoction exert an effect on SDD.However,The Ease Powder decoction has no influence on the expression of thyroxine.关键词：sleep deprivation depression;thyroxine;Ease Powder decoction
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发布时间：2024-01-04 - 摘要：Objective: To investigate the therapeutic action and mechanism of Shenshen Kangxin Drop Pills on the Myocardial Ischemia through observing the diversification of ECG of Myocardial Ischemia,blood NO and ET,myocardium TNF-α and IL-6. Method: Acute myocardial ischemia of rat was esfablished by intravenous injection of ISO. Treatment of the droppills(ig) was givenfor 7 d,ECG waveform,NO in blood,ET in blood,TNF-α,IL-6 in myocardium were measured. Result: ST section of Shenshen Kangxin group(low dose,medium dose and high dose respectively) and Tongxinluo Pills group was lower obviously than that of model group.NO went up and ET went down in Shenshen Kangxin group(low dose,medium dose and high dose respectively) and Tongxinluo Pills group.TNF-α went down in Shenshen Kangxin high dose group.IL-6 went down in Shenshen Kangxin high dose group and Tongxinluo Pills group. Conclusion: Shenshen Kangxin Drop Pills can alleviate myocardum ischemia.It may be related to increast in NO and decrease in ET,TNF-α and IL-6.
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发布时间：2024-01-04 - 摘要：Objective: To study the long-term effect of herbal drugs of warming Yang,reinforcing Qi and activating Blood on neuroendocrine of rats with heart failure. Method: Rat model of heart failure after myocardial infarction was established by ligating the left coronary artery.All rats were randomly divided into groups,fed with aconite,ginseng and radix salviae miltiorrhizae for 3 months,to observe the change of feritin,angiotensin Ⅱ,aldosterone and atrial natriuretic peptide. Result: Aconite,ginseng and radix salviae miltiorrhizae could definitely restrain neuroendocrine,among them ginseng was the strongest. Conclusion: Herbal drugs of warming Yang,reinforcing Qi and activating Blood can restrain neuroendocrine of rats with heart failure.关键词：herbal drugs;heart failure;neuroendocrine;long-term effect
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发布时间：2024-01-04 - 摘要：Objective: To study how the Yinaokang affect the atheroma(AS) and AS based acute ischemic apoplexy (AIS) SD mices brain VEGF expression and brain pathological changes,so as to explain its mechanism. Method: 115 SD rats weighted (180±20)g were randomly divided into A group (normal) 15;B-F group (model) 100:C is AS group,D is composite group,B is Yi Naokang foregoing group,E is Yinaokang group,F is lipitor group.On the 8th day the B-F group would be given intraperitoneal injection of VD3 one-time and then begain to supply with high fat feed to copy AS model,on the 65th day,inject ET-1 near the MCA area except group C to copy AIS model.On the 74th,3 rats would be picked out randomLy to test their brain VEGF expression and HE stained to observe the brain pathological changes. Result: The VEGF expression in the Yinaokang group is ++ while the lipitor group is +,the expression of VEGF in the Yinaokang group is stronger than the lipitor group. Conclusion: Yinaokangs treatment effect on AIS maybe is related with its function of upregulating VEGF expression in the ischemic brain.关键词：ischemic stroke;Yinaokang;AIS animal model;VEGF expression
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发布时间：2024-01-04 - 摘要：Objective: To observe the effects of Astragalus Polysaccharide (APS) on activity and morphological Changes in human umbilical vein endothelial cells (HUVEC) induced by serum from patients with blood stasis syndrome (BSS) and hypertension. Method: The HUVEC was affected by the serum of the patient with BSS associated with hypertension and different dosage of APS was applied for intervention.The activity of the HUVEC was determined by MTT assay and the morphological changes were observed by the inverse phase contrast microscope. Result: APS had the protective effect for lightening the HUVEC shape change affected by the serum from patient of BSS associated with hypertension and the activity was increased in a dose-dependent manner. Conclusion: APS can lighten the injury of the HUVEC affected by the serum from the patient of BSS associated with hypertension,increase cells activity and maintenance for the normal shape of the cells.关键词：hypertension;blood stasis syndrome;HUVEC;astragalus polysaccharide
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发布时间：2024-01-04 - 摘要：Objective: To investigate the effect of extract from Sedum lineare Thunb (SLT) on lipid peroxidation in rat with hepatic fibrosis. Method: Male SD rats were divided into six groups randomly. The hepatic fibrosis model was induced by intragastric administration with 50% carbon tetrachloride dissolved in peanut oil. Once the model was formed,the rat was administrated with various doses of SLT (4 g ·kg-1,8 g ·kg-1) or NS through intragastric pathway,and the process was lasted for 9 weeks. After the last administration,the rats blood and liver are taken under anesthesia. The cellular structure and grade of hepatic fibrosis were observed by histological method,as well as the content and activity of MDA,SOD,GSH-Px in serum and hepatic tissue were detected. Result: In the model group,severe degeneration and necrosis of hepatic cells,significant accumulation of collagen fibers was observed,the level of MDA in hepatic tissue and serum was increased,and the activity of SOD and GSH-Px was decreased obviously. After treated with SLT,degeneration and necrosis of hepatic cells and the grade of hepatic fibrosis were inhibited,the level of MDA was descended,and the activity of SOD and GSH-Px was enhanced significantly. Conclusion: SLT has a therapeutic effect on hepatic fibrosis in rats,the mechanism is possibly related with alleviation of the injury induced by lipid peroxidation.关键词：Sedum lineare;hepatic fibrosis;lipid peroxidation
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发布时间：2024-01-04 - 摘要：Objective: To observe the effect of compound modified SiNi powder(JWSNS) on liver fibrosis in Schistosoma japonicum-infected Mice. Method: The NIH mice were successfully induced to liver fibrosis by infection with S. japonicum and then randomly divided into groups B,C,D and E.The mice in groups C,D and E were treated with praziquantel,praziquantel plus JWSNS and praziquantel plus colchicine,respectively.In addition,a group of unfected NIH mice(group A) served as normal control.Histological specimens were stained with HE.Expression of type Ⅰ and type Ⅲ collagen were determined by Immunohistochemistry(IHC). Result: The protein levels of type Ⅰ and type Ⅲ collagen in praziquantel plus JWSNS group(group D) were significantly lower than those in model group(grop B),praziquantel group(group C) and praziquantel plus colchicine group(group E)(P<0.05).These findings showed JWSNS can reduced the hepatic expression of type Ⅰ and type Ⅲ collagen in mice with liver fibrosis. Conclusion: JWSNS combined with praziquantel can decrease the expression of type Ⅰ and type Ⅲ collagen and implove liver fibrosis due to S. japonicum.关键词：JWSNS;schistosomiasis;liver fibrosis;colchicin;praziquantel;collagen
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发布时间：2024-01-04 - 摘要：Objective: To observe the clinical effects using Chinese and western integrative medicine to treat anaphylactoid purpura. Method: 60 patients were randomly divided into two groups.Treatment group (use Chinese and western integrative medicine) and control group (only use Western medicine).Compare and analyze the curative effect,symptoms,clotting function and other index of the two groups after 24 weeks. Result :Cure rate of treatment group (94%) is much better than the control group (62%)(P<0.01).And treatment group has lower fibrinogen levels and platelet counts than the control group(P<0.05). Conclusion: Using erythema elimination electuary and western medicine can significantly improve the clinical symptoms of anaphylactoid purpura and parts of coagulation parameters,worthy for promotion.关键词：anaphylactoid purpura;Chinese and western integrative edicine;hypercoagulability
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发布时间：2024-01-04 - 摘要：Objective: To observe the clinical effect of Sarcandra glabra. Method: Two hundreds patients with untreated nasopharyngeal carcinoma stage in Ⅲ-IVa were divided into test group and control group randomly.Neoadjuvant chemotherapy and conventional radiotherapy were used in trial.People in test group oral sarcandra 3 days before the radiation therapy,once 10 g,3rd day,until the end of treatment. Result: Two groups of primary and cervical lymph node metastases efficient are 100%,the test group primary and cervical lymph nodes CR is 68%,72%,and the control group is 63%,79%.There is no significant difference between them.Two groups of acute radiation reactions,leukopenia,oral mucositis and skin reaction has no difference.The incidence and severity of xerostomia in test group were lower than control group.Test group 1 year,2 years overall survival,disease-free survival,recurrence rate and distant metastasis rates were:99%,88%,93%,73%,2%,10%,5%,20%;control group was 97%,85%,92%,69%,3%,12%,6%,23%.The difference was not statistically significant.There is no statistically difference between two groups of difficulty in opening mouth and skin fibrosis.There is statistically difference between two groups of xerostomia and the rate of radioactive tooth decay,the test group is lower than the control group. Conclusion: Sarcandra combined with chemoradiation for nasopharyngeal carcinoma can significantly reduce damage from radioactive Parotid,improve acute and long-term xerostomia,reduce the incidence of radioactive decay,it does not affect the treatment of cancer and long-term survival,non-toxic side effects.关键词：nasopharyngeal neoplasm;Sarcandra glabra;radiotherapy;neoadjuvant chemotherapy;radiation injury
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发布时间：2024-01-04 - 摘要：Objective: To study the clinical efficacy of using oral medicinal herbs plus auricular-seed-pressing to treat Acne Vulgaris. Methed: 146 patients were randomly divided into 3 groups:therapeutic group (n=78),the 1st control group (n=36),the 2nd control group (n=32).The therapeutic group was treated by oral medicinal herbs plus auricular-seed-pressing;The 1st control group was treated by oral medicinal herbs;The 2nd control group was treated by Auricular-seed-pressing.They all chose 2 weeks as a course of treatment,totally 2 courses. Result: Except for no obvious difference between the 1st control group and the 2nd control group,there was a significant difference between the therapeutic group and the 1st control group,and the therapeutic group and the 2nd control group (P<0.05). Conclusion: It is better to treat acne vulgaris by oral medicinal herbs plus auricular-seed-pressing than simply by oral medicinal herbs,and simply than by Auricular-seed-pressing.关键词：acne vulgaris;oral medicinal herbs;auricular-seed-pressing
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发布时间：2024-01-04 - 摘要：Objective: To observate the effect of Qili Qiangxin capsule on cardiac function and levels of brain natriuretic peptide in patients with chronic systolic heart failure(CHF). Method: One hundred patients with different causes of CHF were randomly divided into 2 groups,control group 48 patients were treated with conventional anti-failure therapy,such as salt restriction,rest,under the conditions used diuretics,angiotensin converting enzyme inhibitors,β receptor blockers,spironolactone,nitrates,etc.,if necessary,apply conditions digitalis,dobutamine inotropic drugs such as antibiotics.Qili Qiangxin group of 52 cases were treated by Qili Qiangxin capsule on the basis of control group,four pills once,three times a day.Treatment for 6 months.Clinical and left ventricular end diastolic diameter (LVEDD),left ventricular ejection fraction (LVEF),6 min walking distance,the serum B-type natriuretic peptide (BNP) and other in two groups were observed before and after treatment. Result: After 6 months,the total effective rate of Qili Qiangxin group was significantly higher than that of the control group (P<0.05).LVEDD and BNP of Qili Qiangxin group were significantly decreased more than before treatment and that of the control group (P<0.01 and P<0.05).LVEF,6 min walk distance of Qili Qiangxin group were significantly increased more than before treatment and that of the control group (P<0.01 and P<0.05).The side effects were not found in both groups. Conclusion: CHF patients in the conventional therapy were added Qili Qiangxin capsule,increased LVEF,improvement of left ventricular function,exercise tolerance,decrease plasma BNP levels,and good security.关键词：Qili Qiangxin capsule;heart failure;left ventricular function;exercise tolerance;brain natriuretic peptide
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发布时间：2024-01-04 - 摘要：Objective: Analyzing the clinical effects and the values about application of the trimethyphloroglucin in the double-balloon enteroscopy examination. Method: There are 198 patients who accepted the double-balloon enteroscopy examination in the 2rd hospital of Zhengzhou university between June 2007 to Semptember 2008.Two groups in random:18 patients are the testing group and 18 patients as control group before the operations.We observed the bellyache,enteroscopy completion time and the changes in blood pressure and heart rate before,during and after examination. Result: Two groups have no significant difference in pain scores.Completion time of test (phloroglucinol) group was shorter than that of the control group.Each group checks blood pressure and heart rate before,during and after examination have no significant difference.The difference of pain and the completion time was not statistically significant. Conclusion: The injection of phloroglucinol before double-balloon enteroscopy examination can partly alleviate the pain and shorten the examination time.Without significant side.关键词：phloroglucinol;enteroscopy;the examination time
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发布时间：2024-01-04 - 摘要：The traditional Chinese medical formulae which can promote the peripheral nerve regeneration were reviewed by the literatures in the latest twenty years from domestic and abroad.The result showed Buyang Huanwutang is the representative of these formulae with good therapeutic effect on the peripheral nerve regeneration.However,there are still many questions to be answered,such as the the active components and the related mechanism,innovation of dosage forms and so on.So we suggest that more work should be done in the future.关键词：traditional Chinese medical formulae;peripheral nerve regeneration;review
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发布时间：2024-01-04 - 摘要：The plant polyphenol widely exists in the vegetables,the fruit,the legumes,tea in plants and so on grain class.The research proved that the plant polyphenol has many kinds of physiological functions,with anti-arteriosclerosis,the anti-tumor,the oxidation resistance,and so on,and gets the widespread application in aspects food,medicine,as well as everyday use chemical.Nowadays,the plant polyphenol has become a hot topic for researchers,and polyphenols from banana peel as a kind of plant polyphenols have also gradually been the concern of researchers. In this paper,it was reviewed that research progress on the extraction and isolation technology and biological activity of polyphenols from banana peel in recent years,in order to offer the reference to in-depth study of plant polyphenols and further rational development and utilization of banana peel.关键词：banana peel polyphenols;extraction and isolation technology;biological activity
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