最新刊期
卷 16 ， 期 4 ， 2010
- 摘要：Objective:To establish the optimal extraction technology and to determine the quantity of ci-choric acid from Echinacea purpurea.Method: Nine experiments were carried out through L9（34） orthogonal de-sign.The contents of cichoric acid were determined by HPLC.Result: The best extraction condition obtained was 12 times amount 60% alcohol and extracted for 3 times,1.5 hours each time.Cichoric acid was linear within the range of 0.011 ～ 1.100 mg,r = 0.999 8.The average recovery is 99.51%（RSD = 1.01%,n = 6）.Conclusion: This optimal technology is stable and workable,can be used in industrial production.The determination method is suitable for quality control.关键词：Echinacea purpurea;cichoric acid;extraction technology;HPLC
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发布时间：2024-09-23 - 摘要：Objective: To establish the optimal extraction technology and to determine the quantity of cichoric acid from Echinacea purpurea. Method: Nine experiments were carried out through L9(34) orthogonal design. The contents of cichoric acid were determined by HPLC. Result: The best extraction condition obtained was 12 times amount 60% alcohol and extracted for 3 times, 1.5 hours each time. Cichoric acid was linear within the range of 0.011~1.100 mg, r =0.999 8. The average recovery is 99.51%(RSD=1.01%,n=6). Conclusion : This optimal technology is stable and workable, can be used in industrial production. The determination method is suitable for quality control.关键词：Echinacea purpurea;cichoric acid;extraction technology;HPLC
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发布时间：2024-09-23 - 摘要：Objective:To study the formation technology of Rujining capsule. Methods: The influence of different excipients on the hygroscopicity of extract powder was investigated by screening the best processing technology conditions and inspecting the critical relative humidity, angle of repose, and bulk density. Result: Microcrystalline cellulose as excipients had a good anti-wet performance, the extract powder and microcrystalline cellulose were mixed evenly in proportion of 7∶3, the 95% alcohol was used as the weting agent, its amount was 25% of extract powder. The granules of end product had a good fluidity , the critical relative humidity was about 50%, bulk density was 0.466 g ·mL-1. Conclusion: The molding technology is reasonable, and can provide reliable basis for production.关键词：Rujining capsule;formation technology;critical relative humidity
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发布时间：2024-09-23 - 摘要：Objective:To study the formation technology of Rujining capsule.Methods: The influence of different excipients on the hygroscopicity of extract powder was investigated by screening the best processing technol-ogy conditions and inspecting the critical relative humidity,angle of repose,and bulk density.Result: Microcrys-talline cellulose as excipients had a good anti-wet performance,the extract powder and microcrystalline cellulose were mixed evenly in proportion of 7∶ 3,the 95% alcohol was used as the weting agent,its amount was 25% of ex-tract powder.The granules of end product had a good fluidity,the critical relative humidity was about 50%,bulk density was 0.466 g.mL-1.Conclusion: The molding technology is reasonable,and can provide reliable basis for production.关键词：Rujining capsule;formation technology;critical relative humidity
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发布时间：2024-09-23 - 摘要：目的:测定中药单味与复方饮片煎煮过程中的吸水量。方法:通过对50种中药饮片和3个经方在煎煮过程中的吸水量进行研究。比较不同用药部位中药饮片的吸水系数;比较整体复方实测吸水量与按吸水系数计算所得吸水量之间差异。结果:不同用药部位的饮片吸水系数差异较大,复方实测吸水量与计算所得吸水量误差较小。结论:建议将单味饮片吸水系数作为饮片的属性之一输入计算机系统,利用微机系统计算处方总的吸水量。关键词：中药饮片;吸水系数;吸水量;煎煮
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发布时间：2024-09-23 - 摘要：Objective:To investigate the procedure of Rehmannia glutinosa oligosaccharide capsule.Meth-od: To optimize excipients mainly by moisture absorption percentage.Result: Lactose was optimized as the excipi-ents of the better damp proof function,and the fluidity of particle diameter can be satisfied the requriement of pro-duction.Conclusion: The preparation technics of Rehmannia glutinosa oligosaccharide capsule can provides experi-ment basis for the industry.关键词：Rehmannia glutinosa oligosaccharide capsule;preparation technics;moisture absorption per-centage
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发布时间：2024-09-23 - 摘要：Objective: To investigate the procedure of Rehmannia glutinosa oligosaccharide capsule. Method: To optimize excipients mainly by moisture absorption percentage. Result: Lactose was optimized as the excipients of the better damp proof function, and the fluidity of particle diameter can be satisfied the requriement of production. Conclusion: The preparation technics of Rehmannia glutinosa oligosaccharide capsule can provides experiment basis for the industry.关键词：Rehmannia glutinosa oligosaccharide capsule;preparation technics;moisture absorption percentage
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发布时间：2024-09-23 - 摘要：目的:优选狗皮膏贴的最佳基质配方比例,制备性能优良的狗皮膏贴。方法:采用均匀设计,以膜残留量、黏着力为考察指标,以配方原料为因素,对狗皮膏贴基质组成比例进行优选。结果:通过对数据的分析,优选出最佳的基质配方比例为柠檬酸-蒸馏水-甘油-聚丙烯酸钠-氢氧化铝-微晶纤维素（0.204∶15∶3.2∶1.250∶0.072∶0.73）。结论:所得配方较优,制备的狗皮膏贴性能优良。关键词：狗皮膏贴;基质配方;均匀设计;膜残留量;黏着力
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发布时间：2024-09-23 - 摘要：目的:研究壳聚糖澄清剂对枳实薤白桂枝汤颗粒提取液的纯化效果。方法:以纯化前后枳实薤白桂枝汤颗粒提取液中柚皮苷、橙皮苷含量和浸膏率为考察指标,对壳聚糖澄清剂和乙醇沉淀法对提取液的纯化效果进行比较。采用L9（34）正交试验设计,确定壳聚糖澄清剂的最佳纯化工艺。结果:壳聚糖澄清剂要优于乙醇沉淀法,最佳纯化工艺为药液质量浓度为0.5 g.mL-1、静置温度为30℃、1%壳聚糖溶液的加入量为药液体积的40%、药液pH为6。结论:壳聚糖澄清剂可以用于枳实薤白桂枝汤颗粒提取液的纯化。关键词：壳聚糖;枳实薤白桂枝汤颗粒;纯化
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发布时间：2024-09-23 -
GC/MS analysis of chemical constituents of P-ether extract from trogopterus xanthippes milne-edwards
摘要：Objective:To study on the chemical constituents of the petroleum ether extract of Trogopterus xanthippes Milne-Edwards.Method: The ethanol extract of Trogopterus xanthippes Milne-Edwards underwent silica gel chromatography and was eluted by petroleum ether,ethyl acrylate and n-buthanol in turn.The composition of petroleum ether part was analysed and identified by GC /MS and the relative content of composition was calculated by area normalization method.Result: 21 components were identified,and all of them were first discovered from the Excreta of Trogopterus xanthippes Milne-Edwards.Conclusion: Hentetracontan-1-ol（21.72%）,sclareol（14.08%） and n-hexadecanoic acid（9.11%） were the main chemical compositions of the petroleum ether extract,and the content of alcohol components was more than 40% in total.关键词：Trogopterus xanthippes Milne-Edwards;chemical constituents;GC /MS- 0
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发布时间：2024-09-23 -
GC/MS analysis of chemical constituents of P-ether extract from trogopterus xanthippes milne-edwards
摘要：Objective: To study on the chemical constituents of the petroleum ether extract of Trogopterus xanthippes Milne-Edwards. Method: The ethanol extract of Trogopterus xanthippes Milne-Edwards underwent silica gel chromatography and was eluted by petroleum ether, ethyl acrylate and n-buthanol in turn. The composition of petroleum ether part was analysed and identified by GC/MS and the relative content of composition was calculated by area normalization method. Result: 21 components were identified, and all of them were first discovered from the Excreta of Trogopterus xanthippes Milne-Edwards. Conclusion : Hentetracontan-1-ol(21.72%),sclareol(14.08%) and n-hexadecanoic acid(9.11%) were the main chemical compositions of the petroleum ether extract, and the content of alcohol components was more than 40% in total.关键词：Trogopterus xanthippes Milne-Edwards;chemical constituents;GC/MS- 0
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发布时间：2024-09-23 - 摘要：Objective:To explore the quality control standard of Alpinia officiarum Formula Granules and to provide reference for it.Method: TLC was used to identify Alpinia officiarum Formula Granules in different bat-ches.HPLC was used for the determination of galangin and kaempferol.The chromatographic column was phenome-nex Gemini C18（4.6 mm × 250 mm,5 μm）;the mobile phases were methanol-0.4% phosphoric acid（58∶ 42）;the detection wavelength was set at 360 nm;the flow rate was at 1.0 mL.min-1 and the column temperature was at 30 ℃ respectively.Result: The TLC spots were clear and well divided.Galangin was linear in the range of（0.104 ～ 1.044）μg,r = 0.999 3,and the average recovery was 98.05% with RSD = 1.96%（n = 6）;Kaempferol was also linear in the range of（2.2 ～ 21.6）ng,r = 0.999 2,and the average recovery was 99.71% with RSD 1.86%（n = 6）.Conclusion: This method can be used as a quality control standards for Alpinia officiarum Formula Granules.关键词：Alpinia officiarum Formula Granules;TLC;HPLC;galangin;Kaempferol
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发布时间：2024-09-23 - 摘要：Objective: To explore the quality control standard of Alpinia officiarum Formula Granules and to provide reference for it. Method : TLC was used to identify Alpinia officiarum Formula Granules in different batches. HPLC was used for the determination of galangin and kaempferol. The chromatographic column was phenomenex Gemini C18 (4.6 mm×250 mm,5 μm); the mobile phases were methanol-0.4% phosphoric acid (58 ∶42); the detection wavelength was set at 360 nm; the flow rate was at 1.0 mL ·min-1 and the column temperature was at 30 ℃ respectively. Result : The TLC spots were clear and well divided. Galangin was linear in the range of (0.104~1.044)μg, r=0.999 3, and the average recovery was 98.05% with RSD=1.96% (n=6); Kaempferol was also linear in the range of(2.2~21.6)ng, r=0.999 2, and the average recovery was 99.71% with RSD 1.86% (n=6). Conclusion : This method can be used as a quality control standards for Alpinia officiarum Formula Granules.关键词：Alpinia officiarum Formula Granules;TLC;HPLC;galangin;Kaempferol
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发布时间：2024-09-23 - 摘要：Objective:To establish the qualitative and quantitative methods for Puyi Granules.Method: Radix Polygoni Eultiflori,Herba Taraxaci,Semen Coicis and Ganoderma were identified by TLC,and the content of emodin in the preparation was determined by HPLC.Result: Radix Polygoni Eultiflori,Herba Taraxaci,Semen Coicis and Ganoderma could be identified well by TLC.The regression curve of emodin showed a good linear rela-tionship in the range of 0.073 ～ 1.171 μg.The average recovery was 99.0%,RSD was 2.2%.Conclusion: The method is accurate,simple and has good repeatability.It can be used for quality control of Puyi Granules.关键词：Puyi Granules;TLC;HPLC;emodin
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发布时间：2024-09-23 - 摘要：Objective: To establish the qualitative and quantitative methods for Puyi Granules. Method: Radix Polygoni Eultiflori, Herba Taraxaci, Semen Coicis and Ganoderma were identified by TLC, and the content of emodin in the preparation was determined by HPLC. Result: Radix Polygoni Eultiflori, Herba Taraxaci, Semen Coicis and Ganoderma could be identified well by TLC. The regression curve of emodin showed a good linear relationship in the range of 0.073~1.171 μg. The average recovery was 99.0%, RSD was 2.2%. Conclusion: The method is accurate, simple and has good repeatability. It can be used for quality control of Puyi Granules.关键词：Puyi Granules;TLC;HPLC;emodin
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发布时间：2024-09-23 - 摘要：Objective: Study on extracting technology and assay of astragaloside in Astragalus. Method :70% ethanol circumfluence extraction was used.Total astragaloside was enriched and purified by extraction refine through water saturated of n-butanol and D101 mcroporous adsorption resin.Different components of astragaloside were isolated by silica gel laminar analysis.Identification by using TLC method and determination the contents by using HPLC-RID Method. Result :Six compounds were isolated from total astragaloside(AS-Ⅰ~AS-Ⅵ), and 29.4% astragaloside Ⅱ was identified in As-Ⅰ part. AS-Ⅲ which content is 22.82% is mainly contained AstragalosideⅣ by identification.The rest four compounds are required to be identified. Conclusion: The method can be used for astragaloside,HPLC-RID method can be used to determine the content of astragaloside.关键词：astragaloside;extraction;HPLC;Assay
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发布时间：2024-09-23 - 摘要：Objective:Study on extracting technology and assay of astragaloside in Astragalus.Method: 70% ethanol circumfluence extraction was used.Total astragaloside was enriched and purified by extraction refine through water saturated of n-butanol and D101 mcroporous adsorption resin.Different components of astragaloside were isolated by silica gel laminar analysis.Identification by using TLC method and determination the contents by u-sing HPLC-RID Method.Result: Six compounds were isolated from total astragaloside（AS-Ⅰ ～ AS-Ⅵ）,and 29.4% astragaloside Ⅱ was identified in As-Ⅰ part.AS-Ⅲ which content is 22.82% is mainly contained Astraga-losideⅣ by identification.The rest four compounds are required to be identified.Conclusion:The method can be used for astragaloside,HPLC-RID method can be used to determine the content of astragaloside.关键词：astragaloside;extraction;HPLC;Assay
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发布时间：2024-09-23 - 摘要：目的:测定东北山梅花根总皂苷的含量,并初步研究总皂苷镇痛活性。方法:以人参皂苷Rb1为标准品,采用分光光度法测定东北山梅花根总皂苷含量。采用醋酸致小鼠扭体法,研究东北山梅花根总皂苷镇痛活性。结果:东北山梅花根总皂苷含量为1.54%;回归方程Y=1.891 4 X-0.003 9,r=0.998 9;平均加样回收率为97.17%（n=5）,RSD为1.78%。东北山梅花根总皂苷能显著降低醋酸致小鼠扭体次数（P<0.01或P<0.05）。结论:东北山梅花根总皂苷具有显著的镇痛活性,值得深入研究。关键词：东北山梅花;虎耳草科;山梅花属;分光光度法;总皂苷;镇痛活性
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发布时间：2024-09-23 - 摘要：目的:测定鲜地黄中砷、汞、铅和镉的含量。方法:采用ICP-AES法同时测定中药材鲜地黄中砷、汞、铅和镉的含量。结果:2005年4月1日开始实施的中华人民共和国外贸部药用植物及制剂外经贸绿色行业标准中对重金属及砷盐的限量要求是镉（Cd）≤0.3 mg.kg-1、汞（Hg）≤0.2 mg.kg-1、砷（As）≤2.0 mg.kg-1、铅（Pb）≤5.0 mg.kg-1。样品测定的结果表明,11个不同产地的鲜地黄中铅、砷和镉的含量均低于上述标准,而汞的含量均超过上述标准。故应尽快制定中药材外源性有害物质安全限量。结论:本方法准确、快捷、操作简单,适用于中药中有害元素含量的测定。关键词：电感耦合等离子体发射光谱仪;中药;砷;汞;铅;镉
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发布时间：2024-09-23 - 摘要：目的:建立铁笛丸中甘草酸的高效液相含量测定方法。方法:采用高效液相色谱法,Diamonsil C18（4.6 mm×250mm,5μm）;流动相甲醇-[0.2mol.L-1醋酸铵∶冰醋酸（33∶1）]（64∶36）;流速1 mL.min-1;柱温30℃;检测波长250 nm。结果:线性范围为0.15～0.75μg,精密度试验RSD 2.07%,回收率99.50%,RSD 2.15%（n=6）。结论:该方法快速、简便、准确、重复性较好,结果可靠,可为铁笛丸的质量评价提供有效手段。关键词：铁笛丸;甘草酸;高效液相色谱法
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发布时间：2024-09-23 - 摘要：目的:建立千斤脑康宁胶囊中丹酚酸B的含量测定方法。方法:采用高效液相色谱法,kromasilC18柱（4.6 mm×250 mm,5μm）,甲醇-乙腈-1%甲酸溶液（24∶10∶66）流动相,286 nm检测波长,柱温室温。结果:丹酚酸B在0.24～4.04μg,峰面积与其浓度呈良好线性关系（r=0.999 8）,平均回收率97.5%,RSD 1.27%（n=6）。结论:该方法简便、准确、重复性好,可作为该制剂含量测定方法。关键词：千斤脑康宁胶囊;丹酚酸B;含量测定;高效液相法
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发布时间：2024-09-23 - 摘要：Objective:To evaluate the uncertainty of measurement for determination of total flavonoids in Luoyin soft capsules by UV spectrometery.Method:Through establishing UV spectrometery method determination mode,the factors affecting the uncetainty were deduced,including standard solution preparation,sample pretreat-ment,color reaction,calibration curve and recovery tests.Each component of uncertainty was evaluated,from which the combined uncertainty and finally the extended uncertainty were obtaine in 95% confidence intervals.Result: The determined content of total flavonoids in Luoyin soft capsules of this test is（31.13 ± 1.61） mg.g-1.Conclu-sion:The established mathematic model is applicable to the uncertainty analysis of UV spectrometery method in the determination of traditional Chinese medicine.关键词：measurement uncertainty;method validation;UV spectrometery;Luoyin soft capsules;fla-vonoids
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发布时间：2024-09-23 - 摘要：Objective: To evaluate the uncertainty of measurement for determination of total flavonoids in Luoyin soft capsules by UV spectrometery. Method: Through establishing UV spectrometery method determination mode, the factors affecting the uncetainty were deduced, including standard solution preparation, sample pretreatment, color reaction,calibration curve and recovery tests. Each component of uncertainty was evaluated, from which the combined uncertainty and finally the extended uncertainty were obtaine in 95% confidence intervals. Result : The determined content of total flavonoids in Luoyin soft capsules of this test is (31.13±1.61) mg ·g-1. Conclusion: The established mathematic model is applicable to the uncertainty analysis of UV spectrometery method in the determination of traditional Chinese medicine.关键词：measurement uncertainty;method validation;UV spectrometery;Luoyin soft capsules;flavonoids
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发布时间：2024-09-23 - 摘要：Objective:To supply evidence for cultivation research of Rhizoma Panacis Majoris by establis-hing the method for quality analysis.Method:The HPLC method was established to determine the content.60% ethanol was used in the ultrajoaic for 40 minutes extraction,the filtrate was used as the test solution after filtration.Result:The average content of cikusetsusaponin IVa in Rhizoma Panacis Majoris within 2 years transplantation was significantly higher;compared with 1 year transplantation.The contents of cikusetsusaponin IVa in different nodes of the same plant seemed to be in normal distribution.Conclusion:The established method can be applied for quality control of the transplantaded Rhizoma Panacis Majoris.关键词：Rhizoma Panacis Majoris;transplantation;quality analysis;HPLC
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发布时间：2024-09-23 - 摘要：Objective: To supply evidence for cultivation research of Rhizoma Panacis Majoris by establishing the method for quality analysis. Method: The HPLC method was established to determine the content.60% ethanol was used in the ultrajoaic for 40 minutes extraction,the filtrate was used as the test solution after filtration. Result :The average content of cikusetsusaponin IVa in Rhizoma Panacis Majoris within 2 years transplantation was significantly higher;compared with 1 year transplantation. The contents of cikusetsusaponin IVa in different nodes of the same plant seemed to be in normal distribution. Conclusion :The established method can be applied for quality control of the transplantaded Rhizoma Panacis Majoris.关键词：Rhizoma Panacis Majoris;transplantation;quality analysis;HPLC
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发布时间：2024-09-23 - 摘要：目的:对工业生产中不同商品规格三七总苷提取原料药的质量进行综合评价。方法:采用高效液相法测定3种商品规格原料药（剪口,120～200头,80～120头）中有效成分的含量,并经过相同的提取工艺后分别得到各三七总苷提取物,测定提取物中各有效成分的含量,并计算出膏率及有效成分转移率,综合评价3种商品规格原料药的优劣。结果:3种商品规格（剪口,120～200头,80～120头）原料药中人参皂苷Rg1和Rb1的含量分别为:4.98%和2.98%,2.81%和1.78%,2.67%和2.00%;三七总皂苷提取物中人参皂苷Rg1和Rb1的含量分别为:12.36%和7.48%,10.72%和6.57%,10.24%和7.51%;出膏率为分别39%,25%,25%;3种原料药中人参皂苷Rg1和Rb1的转移率分别为97%和98%,95%和92%,96%和94%。结论:3种商品规格的三七总苷提取原料中以剪口原料最优,120～200头和80～120头之间没有明显区别。关键词：三七;商品规格;人参皂苷Rg1和Rb1
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发布时间：2024-09-23 - 摘要：目的:采用RP-HPLC法建立苏孜阿甫片中没食子酸的含量测定方法。方法:甲醇-四氢呋喃-磷酸-水（0.5∶0.2∶0.5∶99）流动相,YMC-Pack ODS-A（6.0 mm×150 mm,5μm）色谱柱,检测波长270 nm,柱温35℃,流速为0.7 mL.min-1。结果:没食子酸在10.4～83.2μg.mL-1线性关系良好,r=0.999 8（n=5）,平均回收率102.4%（n=9,RSD 1.1%）。结论:该方法简便易行,重复性好,结果准确,可用于该制剂的质量控制。关键词：苏孜阿甫片;没食子酸;高效液相色谱法
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发布时间：2024-09-23 - 摘要：目的:分析豫西产3种柴胡中挥发油的主要化学成分,以从中找出鉴别特征。方法:采用水蒸汽蒸馏法从3种柴胡中提取挥发油,利用GC-MS联用仪对其化学成分进行分析。并且用面积归一化法计算含量。结果:共分离97个化合物,鉴定了其中63个组分。结论:为柴胡药材的进一步开发研究提供了科学依据。关键词：柴胡根;挥发油;GC-MS分析
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- 270
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- 4
发布时间：2024-09-23 - 摘要：目的:考察夏枯草药材的重金属含量情况。方法:收集不同产地的夏枯草药材,以原子吸收光谱法测定样品中的铅、镉、砷、汞和铜的含量。结果:部分产地的样品铅的含量超出限量范围;镉、砷、汞和铜重金属均在限量范围内。结论:该法快速、准确,为夏枯草中重金属元素的测定提供了一种可靠方法。关键词：夏枯草;重金属;原子吸收光谱
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- 437
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- 13
发布时间：2024-09-23 - 摘要：Objective:To establish the quality standard of Huanglianjiedu Hydrogel.Method: The high performance liquid chromatography was developed for the determination the contention of jasminoidin,berberine and baicalin;Luna C18 column（4.6 mm × 250 mm,5 μm） was used in the determination and the mobile phase of jasminoidin,berberine and baicalin were a mixture of acetonitrile-water（13 ∶ 87）,acetonitrile-0.1 mol.L-1 K2HPO4（30∶ 70）,and methanol-water-phosphoric acid（47∶ 53∶ 0.2） respectively.Result: The average content of jasminoidin was no less than 0.4%,and the average recovery and RSD were 97.21% and 1.5% respectively;The average content of berberine was no less than 1.2%,and average recovery and RSD were 99.11% and 2.45% respectively;The average content of jasminoidin was no less than 1.4%,and the average recovery and RSD were 98.74% and 1.6% respectively;Conclusion: This method can be adopted as a standard for the quality control of Huanglianjiedu Hydrogel.关键词：Huanglianjiedu;Hydrogel;jasminoidin;berberine;baicalin;HPLC
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- 101
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- 2
发布时间：2024-09-23 - 摘要：Objective: To establish the quality standard of Huanglianjiedu Hydrogel. Method: The high performance liquid chromatography was developed for the determination the contention of jasminoidin,berberine and baicalin;Luna C18 column(4.6 mm×250 mm,5 μm) was used in the determination and the mobile phase of jasminoidin,berberine and baicalin were a mixture of acetonitrile-water(13 ∶87), acetonitrile-0.1 mol·L-1 K2HPO4(30 ∶70), and methanol-water-phosphoric acid (47 ∶53 ∶0.2) respectively. Result: The average content of jasminoidin was no less than 0.4%, and the average recovery and RSD were 97.21% and 1.5% respectively; The average content of berberine was no less than 1.2%, and average recovery and RSD were 99.11% and 2.45% respectively; The average content of jasminoidin was no less than 1.4%,and the average recovery and RSD were 98.74% and 1.6% respectively; Conclusion: This method can be adopted as a standard for the quality control of Huanglianjiedu Hydrogel.关键词：Huanglianjiedu;Hydrogel;jasminoidin;berberine;baicalin;HPLC
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发布时间：2024-09-23 - 摘要：Objective:To establish a method of determining the content of astragaloside IV in Zhuaikang Capsule.Method: The separation was performed on a Diamonsil C18（250 mm × 4.6 mm,5 μm） column with acetonitrile-water（33∶ 67） as the mobile phase.The flow rate was 1.0 mL.min-1.Temperature of drift tube was set at 105 ℃.The gas flow rate was at 2.7 L.min-1.Result:Astragaloside IV was linear in the range of 1.515 ～ 7.575 μg（r = 0.999 96）.The average recovery rate of astragaloside IV was 98.83%,RSD 1.8%.Conclusion: This method is sensitive,accurate,and simple with little interference for the determination of astragaloside IV content.The method can be used for controlling the quality of Zhuaikang Capsule.关键词：Zhuaikang Capsule;astragaloside IV;HPLC-ELSD
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- 93
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发布时间：2024-09-23 - 摘要：Objective: To establish a method of determining the content of astragaloside IV in Zhuaikang Capsule. Method: The separation was performed on a Diamonsil C18(250 mm×4.6 mm,5 μm)column with acetonitrile-water(33 ∶67) as the mobile phase. The flow rate was 1.0 mL ·min-1. Temperature of drift tube was set at 105 ℃. The gas flow rate was at 2.7 L ·min-1. Result: Astragaloside IV was linear in the range of 1.515~7.575 μg(r=0.999 96). The average recovery rate of astragaloside IV was 98.83%, RSD 1.8%. Conclusion: This method is sensitive, accurate, and simple with little interference for the determination of astragaloside IV content. The method can be used for controlling the quality of Zhuaikang Capsule.关键词：Zhuaikang Capsule;astragaloside IV;HPLC-ELSD
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发布时间：2024-09-23 - 摘要：目的:制定复方调经止痛颗粒的质量标准。方法:采用高效液相色谱法对当归、川芎中阿魏酸进行含量测定。结果:阿魏酸的回归方程Y=8.748+3 708.55X,r=0.999 9,平均回收率97.58%,重复性RSD为2.64%。结论:阿魏酸的含量测定方法稳定,重复性好,可作为复方制剂的质量控制方法。关键词：调经止痛颗粒;阿魏酸;高效液相色谱法
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- 54
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发布时间：2024-09-23 - 摘要：Objective: To develop an HPLC-ELSD method for the content determination of Chonglou SaponinⅠand Chonglou Saponin Ⅱin Qingyan capsule.Method:The analysis was carried out on a Hypersil C18 analytical column（4.6 mm × 250 mm,5 μm） with the mobile phase consisting of acetonitrile-water（48∶ 52）.The detector drift tube temperature was set at 45 ℃ and the nitrogen flow rate was 1.5L.min-1.Result: The recoveries for Chonglou SaponinⅠand Chonglou Saponin Ⅱ were 97.27% and 97.09% with RSD 1.22% and 1.40%（n = 6）,respectively.Conclusion: The developed method is simple,rapid,replicable,and can be used for the quality control of Qingyan capsule.关键词：Qingyan capsule;HPLC-ELSD;chonglou saponinⅠ;chonglou saponin Ⅱ
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- 232
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发布时间：2024-09-23 - 摘要：Objective: To develop an HPLC-ELSD method for the content determination of Chonglou SaponinⅠand Chonglou Saponin Ⅱin Qingyan capsule. Method: The analysis was carried out on a Hypersil C18 analytical column (4.6 mm×250 mm,5 μm) with the mobile phase consisting of acetonitrile-water(48 ∶52). The detector drift tube temperature was set at 45 ℃ and the nitrogen flow rate was 1.5L ·min-1. Result: The recoveries for Chonglou SaponinⅠand Chonglou Saponin Ⅱ were 97.27% and 97.09% with RSD 1.22% and 1.40%(n=6), respectively. Conclusion: The developed method is simple, rapid, replicable, and can be used for the quality control of Qingyan capsule.关键词：Qingyan capsule;HPLC-ELSD;chonglou saponinⅠ;chonglou saponin Ⅱ
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发布时间：2024-09-23 - 摘要：目的:采用高效液相色谱法测定安胎丸中黄芩苷的含量。方法:高效液相色谱法,Kromasil C18（5μm,250 mm×4.6 mm）,0.1%磷酸溶液-甲醇（45∶55）为流动相,流速1 mL.min-1,检测波长280 nm,柱温25℃。结果:黄芩苷在5.096～30.576μg线性关系良好,r=0.999 9,回归方程Y=72 808.17X-41 785.27,仪器精密度的RSD（n=5）为0.03%;方法重复性的RSD（n=6）为0.5%。平均回收率（n=6）为100.23%,RSD1.7%。结论:本法快速简便,重复性好,测定准确灵敏。关键词：安胎丸;黄芩苷;高效液相色谱法
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- 98
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- 9
发布时间：2024-09-23 - 摘要：目的:建立复方栀黄胶囊的质量控制方法。方法:采用薄层色谱法对处方中大黄和栀子进行了鉴别,用薄层扫描法测定复方栀黄胶囊中大黄素的含量。结果:通过方法学考察,大黄素点样量在0.299 4～1.769 4μg稳定,点样量与斑点积分值呈良好线性关系,大黄素平均加样回收率为98.1%,RSD为1.63%。结论:该方法简单、准确、重复性好,可用于控制复方栀黄胶囊的质量。关键词：薄层鉴别;薄层扫描;大黄素;大黄;栀子;含量测定;复方栀黄胶囊
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- 111
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- 3
发布时间：2024-09-23 - 摘要：目的:建立参柏胶囊的质量标准。方法:采用薄层色谱法对参柏胶囊中苦参和黄柏进行定性鉴别,并采用高效液相色谱法测定苦参碱含量。结果:薄层色谱鉴别无干扰。苦参碱线性范围为0.037～0.740μg,相关系数为0.999 5,平均回收率98.6%,RSD3.1%。结论:该方法简便可靠,结果准确,可作为参柏胶囊的质量控制方法。关键词：参柏胶囊;苦参碱;薄层色谱法;高效液相色谱法
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- 45
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- 3
发布时间：2024-09-23 - 摘要：目的:研究光照对黄芩悬浮细胞内源激素与有效成分相关性的影响。方法:采用HPLC法检测黄芩悬浮细胞中黄芩苷含量,酶联免疫吸附法检测内源激素。结果:研究结果表明在光照条件下,伴随着IAA含量的降低,黄芩苷含量也随之降低,两者变化曲线显著相关（r=0.972）。相对较高的IAA含量和相对较低的GAs含量有利于黄芩苷的积累,而绝对的GAs含量在本研究中并没有表现出与黄芩苷有很强的相关性。结论:黄芩悬浮细胞有效成分与内源激素绝对含量以及相对含量具有相关性。关键词：黄芩;黄芩苷;悬浮细胞;光照;内源激素
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- 268
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- 19
发布时间：2024-09-23 - 摘要：Objective:To establish a quality analysis method for Venenum Bufonis and to study influence of different producing area on active composition.Method: TLC and HPLC were applied with analysis and determination of the content of cinobufagin and resibufogenin.Result: Venenum Bufonis from different producing area had the similar compositions.But the content of compositions was significantly different especially for resibufogenin in that the Venenum Bufonis produced in Shandong had the highest content of cinobufagin and resibufogenin.The difference of compositions displayed majorly in spot 2（resibufogenin）,spot 3（cinobufagin）,spot 4,spot 6 and spot 9 in TLC chromatogram and peak 3,peak 4,peak 6,peak 7,peak 8,peak 9,peak 14 and peak 15 in HPLC chromatogram.The HPLC chromatogram could also see that the content of peak 7,peak 8 and the content of peak 14（cinobufagin）,peak 15（resibufogenin） had possible relationship.Conclusion: The quality of Venenum Bufonis from different producing area has significant difference.The established method is stable,feasible with a good reproducibility and specificity,and suitable for identification and quantitative analysis of Venenum Bufonis.关键词：venenum bufonis;quality;HPLC;TLC
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- 485
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- 14
发布时间：2024-09-23 - 摘要：Objective: To establish a quality analysis method for Venenum Bufonis and to study influence of different producing area on active composition. Method: TLC and HPLC were applied with analysis and determination of the content of cinobufagin and resibufogenin. Result: Venenum Bufonis from different producing area had the similar compositions. But the content of compositions was significantly different especially for resibufogenin in that the Venenum Bufonis produced in Shandong had the highest content of cinobufagin and resibufogenin. The difference of compositions displayed majorly in spot 2(resibufogenin), spot 3(cinobufagin), spot 4, spot 6 and spot 9 in TLC chromatogram and peak 3, peak 4, peak 6, peak 7, peak 8, peak 9, peak 14 and peak 15 in HPLC chromatogram. The HPLC chromatogram could also see that the content of peak 7, peak 8 and the content of peak 14(cinobufagin), peak 15(resibufogenin)had possible relationship. Conclusion: The quality of Venenum Bufonis from different producing area has significant difference. The established method is stable, feasible with a good reproducibility and specificity, and suitable for identification and quantitative analysis of Venenum Bufonis.关键词：venenum bufonis;quality;HPLC;TLC
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发布时间：2024-09-23 - 摘要：Objective: To study the influence of sun shade net cultivation on plant growth, premature bolting in Angelica sinensis and growth environmental factors. Method: Four treatments with 1 level at random were designed and repeated 4 times. Large, middle and small seedlings were planted separetly in each test plot. Result: Sun shade cultivation promoted Angelica sinensis plant growth: the plant height increased 13.1~23.1 cm; percentage of Ditylenchus destructor infected plants decreased 17.5%~33.19%; average fresh root weight increased 26.49~37.35g; yield increased 1 791~2 445 kg/hm2; and ethanol extracts content increased 7.08%~10.02%. Premature bolting of middle size seedlings decreased 5% and 5.5% respectively when covered with 75% and 50% sun shade net. 50% sun shade net cultivation demonstration showed that monthly average air temperature at 8:00 decreased 0.8~1.5 ℃, and that at 14:00 decreased 1.4~1.7 ℃; 10 days average air temperature in 8:00 decreased 0~3.1 ℃, and that in 14:00 decreased 1.0~2.0 ℃. Monthly average soil temperature in 14:00 decreased 2.1~3.8 ℃; 10 days average soil temperature in 14:00 decreased 1.4~5.4 ℃. 10 days average air relative humidity increased 1%~7%; soil water content increased 1.8%~3.7% 3 days after flurry rain. Conclusion: Sun shade cultivation could effectively promote Angelica sinensis plant growth, improve quality, inhibit premature bolting of middle size seedlings, enhance air humidity and soil water content, significantly enhance yield, reduce Ditylenchus destructor infected plants percentage.关键词：Angelica sinensis;sun shade cultivation;premature bolting;yield;quality;temperature;humidity
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发布时间：2024-09-23 - 摘要：Objective:To study the influence of sun shade net cultivation on plant growth,premature bolting in Angelica sinensis and growth environmental factors.Method: Four treatments with 1 level at random were designed and repeated 4 times.Large,middle and small seedlings were planted separetly in each test plot.Result: Sun shade cultivation promoted Angelica sinensis plant growth: the plant height increased 13.1 ～ 23.1 cm;percentage of Ditylenchus destructor infected plants decreased 17.5% ～ 33.19%;average fresh root weight increased 26.49 ～ 37.35g;yield increased 1 791 ～ 2 445 kg /hm2;and ethanol extracts content increased 7.08% ～ 10.02%.Premature bolting of middle size seedlings decreased 5% and 5.5% respectively when covered with 75% and 50% sun shade net.50% sun shade net cultivation demonstration showed that monthly average air temperature at 8:00 decreased 0.8 ～ 1.5 ℃,and that at 14:00 decreased 1.4 ～ 1.7 ℃;10 days average air temperature in 8:00 decreased 0 ～ 3.1 ℃,and that in 14:00 decreased 1.0 ～ 2.0 ℃.Monthly average soil temperature in 14:00 decreased 2.1 ～ 3.8 ℃;10 days average soil temperature in 14:00 decreased 1.4 ～ 5.4 ℃.10 days average air relative humidity increased 1% ～ 7%;soil water content increased 1.8% ～ 3.7% 3 days after flurry rain.Conclusion: Sun shade cultivation could effectively promote Angelica sinensis plant growth,improve quality,inhibit premature bolting of middle size seedlings,enhance air humidity and soil water content,significantly enhance yield,reduce Ditylenchus destructor infected plants percentage.关键词：Angelica sinensis;sun shade cultivation;premature bolting;yield;quality;temperature;humidity
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- 256
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- 20
发布时间：2024-09-23 - 摘要：Objective: To observe and compare the effects of Chaihu Shugan San,Sijunzi Tang and Chaishu Sijun Tang on the apperant syndrome of Liver-gi stagnation and Spleen-qi deficiency (GYPX) in rat. Method : Rats were randomly divided into normal control group, GYPX group, Chaihu Shugan San group, Sijunzi Tang group and Chaishu Sijun Tang group,10 rats in each group. The animals except the controls were experienced by chronic restraint stress+excess fatigue+improper diet to form the model. The model rats were astricted for 3 hours in every morning, swimed for 10 minutes in water(22±1) ℃ and fed every other day, for 28d;normal control group without any stimulation and with natural feeding. On the 15th day, medicated group rats were given Chaishu Sijunzi Tang 4.27 g ·kg-1, Chaihu Shugan San 4.2 g ·kg-1, Sijunzi Tang 4.53 g ·kg-1, 1 time/d accordingly; model group and normal group were given distilled water for 14 days. All the changes in behavior,body weight and temperature were observed and recorded. Result: Compared with normal group, the model rats shown the abnormal changes of behavior and the decrease of their weight and body temperature. Compared with model group, the behavior of the three medicated groups had improvement to some degrees. Chaihu Shugan San group’s rats increased the level of activity, emotional state of stability; Sijunzi Tang group’s rats improved markedly on the skin-fur appearance,appetite and the state of stool; Chaishu Sijun Tang rats had all respects such as the skin-fur, the level of activity, emotional reaction, sleep or appetite improved clearly. The three treatment groups’body weight and temperature all increased, of which Chaishu Sijun Tang group’s difference was obvious(P<0.05).There were significant differences among the three treatment groups in the increased body temperature(P<0.01).Compared with Chaihu Shugan San group, there was difference of the increased temperature(P<0.05)in Chaishu Sijun Tang group. Conclusion : Chaishu Sijun Tang had better effect on the model rats’apperant GYPX syndrome. There were some relativities among the three prescriptions,of which Chaishu Sijun Tang had the markest relativity with GYPX syndrome.关键词：syndrome of liver-qi stagnation and spleen-qi deficiency;Chaihu Shugan San;Sijunzi Tang;Chaishu Sijun Tang;relativity between formula and syndrome
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发布时间：2024-09-23 - 摘要：Objective:To observe and compare the effects of Chaihu Shugan San,Sijunzi Tang and Chaishu Sijun Tang on the apperant syndrome of Liver-gi stagnation and Spleen-qi deficiency（GYPX） in rat.Method: Rats were randomly divided into normal control group,GYPX group,Chaihu Shugan San group,Sijunzi Tang group and Chaishu Sijun Tang group,10 rats in each group.The animals except the controls were experienced by chronic restraint stress + excess fatigue + improper diet to form the model.The model rats were astricted for 3 hours in every morning,swimed for 10 minutes in water（22 ± 1） ℃ and fed every other day,for 28d;normal control group without any stimulation and with natural feeding.On the 15th day,medicated group rats were given Chaishu Sijunzi Tang 4.27 g.kg-1,Chaihu Shugan San 4.2 g.kg-1,Sijunzi Tang 4.53 g.kg-1,1 time /d accordingly;model group and normal group were given distilled water for 14 days.All the changes in behavior,body weight and temperature were observed and recorded.Result: Compared with normal group,the model rats shown the abnormal changes ofbehavior and the decrease of their weight and body temperature.Compared with model group,the behavior of the three medicated groups had improvement to some degrees.Chaihu Shugan San group’s rats increased the level of activity,emotional state of stability;Sijunzi Tang group’s rats improved markedly on the skin-fur appearance,appetite and the state of stool;Chaishu Sijun Tang rats had all respects such as the skin-fur,the level of activity,emotional reaction,sleep or appetite improved clearly.The three treatment groups’body weight and temperature all increased,of which Chaishu Sijun Tang group ’s difference was obvious（P < 0.05）.There were significant differences among the three treatment groups in the increased body temperature（P < 0.01）.Compared with Chaihu Shugan San group,there was difference of the increased temperature（P < 0.05） in Chaishu Sijun Tang group.Conclusion: Chaishu Sijun Tang had better effect on the model rats’apperant GYPX syndrome.There were some relativities among the three prescriptions,of which Chaishu Sijun Tang had the markest relativity with GYPX syndrome.关键词：syndrome of liver-qi stagnation and spleen-qi deficiency;Chaihu Shugan San;Sijunzi Tang;Chaishu Sijun Tang;relativity between formula and syndrome
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- 484
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- 25
发布时间：2024-09-23 - 摘要：Objective:To study the rationality of combination prescription of Pearl Dropping Pills.Method: The pharmacodynamic study on healing of oral ulcerative macous membrane in rats was used as evaluation index.The interaction and variance analysis of orthogonal design were employed to explore the primary-secondary and correlation of all herbs in combination prescription.The orthogonal t-value experiment was adopted to research the proportion of prescription.Result:The importance of each herb in combination prescription of Pearl Dropping Pills was appeared to be:herba Inulae cappae > licorice > borneol > pearl.The obvious interactions between borneol and pearl and the synergistic effect of four herbs had been found to exist.The proportion of herba Inulae cappae,licorice,borneol and pearl were 100∶ 20∶ 2∶ 1.Conclusion:The combination of Pearl Dropping Pills is established and the rationality of the folk medicine is verified by this experimental study.关键词：Pearl Dropping Pills;the rationality of combination prescription;pharmacodynamics;interaction
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- 160
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发布时间：2024-09-23 - 摘要：Objective: To study the rationality of combination prescription of Pearl Dropping Pills. Method: The pharmacodynamic study on healing of oral ulcerative macous membrane in rats was used as evaluation index. The interaction and variance analysis of orthogonal design were employed to explore the primary-secondary and correlation of all herbs in combination prescription. The orthogonal t-value experiment was adopted to research the proportion of prescription. Result: The importance of each herb in combination prescription of Pearl Dropping Pills was appeared to be:herba Inulae cappae>licorice> borneol> pearl. The obvious interactions between borneol and pearl and the synergistic effect of four herbs had been found to exist. The proportion of herba Inulae cappae,licorice,borneol and pearl were 100 ∶20 ∶2 ∶1. Conclusion: The combination of Pearl Dropping Pills is established and the rationality of the folk medicine is verified by this experimental study.关键词：Pearl Dropping Pills;the rationality of combination prescription;pharmacodynamics;interaction
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发布时间：2024-09-23 - 摘要：目的:考察大鼠肠道菌群对延胡索总碱（TA）中延胡索乙素（tetrahydropalmatine,TET）的代谢情况及白芷香豆素（coumarin,Cou）和白芷挥发油（volatile oil,VO）两种提取物与TA配伍对延胡索乙素在大鼠体内代谢的影响,探讨元胡、白芷有效组分配伍规律。方法:分别将TA,TA-Cou,TA-VO,TA-Cou-VO 4组药物与新鲜配制的大鼠肠内容物混悬液在37℃孵化,采用HPLC-FLD测定孵化不同时间大鼠肠内容物混悬液中TET的浓度。结果:TA-Cou组明显减缓了TET的降解速度。结论:从代谢的角度证实了元胡白芷配伍的合理性。关键词：元胡白芷配伍;延胡索乙素;大鼠肠道菌群;代谢;荧光检测
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- 577
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- 9
发布时间：2024-09-23 - 摘要：Objective: To make a comprehensive and quantitative evaluation of the interactions at different ratios between pinellia total alkaloid (PTA) and uncaria total alkaloid (UTA) based on the published data of anticonvulsant and toxicity in combinations. Method: The isobologram and a computer simulation have been used to analyze the interactions of the different levels ED and LD in the combinations. Result: Combinations in the three ratios (PTA ∶UTA=1 ∶4, 1 ∶1, 4 ∶1) show a synergistic trend. However, it is difficult to obtain accurate parameters because of the responses (ED,%) at the maximum dose are less than 70%. Combinatin in the ratio of PTA ∶UTA=4 ∶1 shows an antagonism in toxicity, and at other two ratios (1 ∶4, 1 ∶1) the combinations do not provide robust results. In the comprehensive efficacy and toxicity of quantitative parameters, the values of benefit index (BI) in all three ratios are more than 1. The ratio of PTA ∶UTA=4 ∶1 could reduce toxicity and increase efficacy. Conclusions : The combination at the ratio of PTA ∶UTA=4 ∶1 shows a significant advantage at the safety and efficacy. This study also provides the performance of methods for design and analysis.关键词：isobologram;drug interactions;pinellia total alkaloid;uncaria total alkaloid
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发布时间：2024-09-23 - 摘要：Objective:To make a comprehensive and quantitative evaluation of the interactions at different ratios between pinellia total alkaloid（PTA） and uncaria total alkaloid（UTA） based on the published data of anticonvulsant and toxicity in combinations.Method: The isobologram and a computer simulation have been used to analyze the interactions of the different levels ED and LD in the combinations.Result: Combinations in the three ratios（PTA∶ UTA = 1∶ 4,1∶ 1,4∶ 1） show a synergistic trend.However,it is difficult to obtain accurate parameters because of the responses（ED,%） at the maximum dose are less than 70%.Combinatin in the ratio of PTA∶ UTA = 4∶ 1 shows an antagonism in toxicity,and at other two ratios（1∶ 4,1∶ 1） the combinations do not provide robust results.In the comprehensive efficacy and toxicity of quantitative parameters,the values of benefit index（BI） in all three ratios are more than 1.The ratio of PTA ∶ UTA = 4 ∶ 1 could reduce toxicity and increase efficacy.Conclusions: The combination at the ratio of PTA ∶ UTA = 4 ∶ 1 shows a significant advantage at the safety and efficacy.This study also provides the performance of methods for design and analysis.关键词：isobologram;drug interactions;pinellia total alkaloid;uncaria total alkaloid
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- 256
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发布时间：2024-09-23 - 摘要：Objective: To study on the compatibility between Rheum palmatum L., Coptis chinensis Franch. and Scutellaria Georgi in Xiexin decoction. Method: Mice were ig the extractives of the Rheum palmatum L., Coptis chinensis Franch or Scutellaria Georgi to determine the acute toxicity. Result: The extractives of Rheum palmatum L.or Coptis chinensis Franch had some acute toxicity when they was used alone, and the LD50 of Rheum palmatum L. was 48.92 g/kg, Coptis chinensis Franch was 2 047.9 mg/kg; and the extractives of Scutellaria Georgi had little acute toxicity to mice. But Scutellaria Georgi could significantly decrease the acute toxicity of Coptis chinensis Franch when they were used together. Conclusion: In Xiexin decoction, the acute toxicity of Coptis chinensis Franch may be decreased by Scutellaria Georgi, the mechanism may be related to the reactions between the alkaloid of Coptis chinensis Franch and flavone of Scutellaria Georgi. Perhaps this is the reason why Xiexin Decoction has little acute toxicity on clinical.关键词：Xiexin decoction;acute toxicity;compatibility
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发布时间：2024-09-23 - 摘要：Objective: To study on the compatibility between Rheum palmatum L.,Coptis chinensis Franch.and Scutellaria Georgi in Xiexin decoction.Method: Mice were ig the extractives of the Rheum palmatum L.,Coptis chinensis Franch or Scutellaria Georgi to determine the acute toxicity.Result: The extractives of Rheum palmatum L.or Coptis chinensis Franch had some acute toxicity when they was used alone,and the LD50 of Rheum palmatum L.was 48.92 g /kg,Coptis chinensis Franch was 2 047.9 mg /kg;and the extractives of Scutellaria Georgi had little acute toxicity to mice.But Scutellaria Georgi could significantly decrease the acute toxicity of Coptis chinensis Franch when they were used together.Conclusion: In Xiexin decoction,the acute toxicity of Coptis chinensis Franch may be decreased by Scutellaria Georgi,the mechanism may be related to the reactions between the alkaloid of Coptis chinensis Franch and flavone of Scutellaria Georgi.Perhaps this is the reason why Xiexin Decoction has little acute toxicity on clinical.关键词：Xiexin decoction;acute toxicity;compatibility
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发布时间：2024-09-23 - 摘要：目的:探讨三七、茜草治疗宫环出血的作用机制,筛选其有效部位。方法:通过建立置铜-宫内节育器（Cu-IUD）家兔的动物模型,观察三七、茜草中提取的有效部分对置Cu-IUD家兔的6-酮前列腺素F1α（6-K-PGF1α）、血栓素B2（TXB2）含量的影响。结果:三七总皂苷、三七素、大叶茜草素均能使家兔子宫匀浆6-K-PGF1α/TXB2比值明显降低,而三七、茜草提取后的剩余物无相应作用或作用较弱。结论:三七总皂苷、三七素、大叶茜草素是三七、茜草治疗宫环出血的主要有效部位。关键词：宫环出血;三七总皂苷、三七素、大叶茜草素;6-酮-前列腺素F1α;血栓素B2
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发布时间：2024-09-23 - 摘要：Objective:To study the effect on antipyretic and anti-inflammatory of Qingkailing Ingection（QKL） processed by ultrofiltration（UF）.Method: By using antipyretic and anti-inflammatory as the major pharmacodynamic indicators,to investigate the effect of QKL on inhibition of rabbit increasing temperature induced by LPS,of rat hind paw edema induced by carrageenan and of rat cotton ball granuloma.Result:Both the group of QKL processed by UF and the group of original procedure have obvious effect on antipyretic after 1 hour.Compared with model group,P < 0.01,P < 0.05;They have obvious effect on anti-inflammatory after 2 hour.Compared with model group,P < 0.05,There is no significant difference between the two groups;14 mL.kg-1 dose group of QKL processed by UF and group of original procedure have inhibition of proliferative inflammation.Compared with model group,P < 0.01,P < 0.05,There is significant difference on dry weight of cotton balls between the two groups,P < 0.01.Conclusion:Compared with QKL processed by original procedure,QKL processed by UF has similar action of antipyretic and anti-inflammatory,to some extent,stronger effects.关键词：Qingkailing Ingection;ultrafiltration;antipyretic and anti-inflammatory
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- 310
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发布时间：2024-09-23 - 摘要：Objective: To study the effect on antipyretic and anti-inflammatory of Qingkailing Ingection(QKL) processed by ultrofiltration(UF). Method: By using antipyretic and anti-inflammatory as the major pharmacodynamic indicators, to investigate the effect of QKL on inhibition of rabbit increasing temperature induced by LPS, of rat hind paw edema induced by carrageenan and of rat cotton ball granuloma. Result: Both the group of QKL processed by UF and the group of original procedure have obvious effect on antipyretic after 1 hour. Compared with model group, P<0.01,P<0.05; They have obvious effect on anti-inflammatory after 2 hour. Compared with model group, P<0.05, There is no significant difference between the two groups; 14 mL ·kg-1 dose group of QKL processed by UF and group of original procedure have inhibition of proliferative inflammation. Compared with model group, P<0.01, P<0.05, There is significant difference on dry weight of cotton balls between the two groups, P<0.01. Conclusion: Compared with QKL processed by original procedure, QKL processed by UF has similar action of antipyretic and anti-inflammatory, to some extent, stronger effects.关键词：Qingkailing Ingection;ultrafiltration;antipyretic and anti-inflammatory
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发布时间：2024-09-23 - 摘要：Objective: To study the effects and mechanisms of Chinese herbal medicine—Weikangning on gastric cancer. Method: Total of 120 SD rats were divided into control group, high dose group, medium dose group and low dose group,and fed with natural saline, 20, 10 and 5 g/kg of Weikangning decoction respectively. The experimental animals were finally killed for the preparation of drug-containing serum. The gastric cancer cell MGC-803 was cultured with the drug-containing serum drawn from the rats in different groups. The expressions of CyclinD1,CyclinD2,Cdk4,Cdk6 and p16INK4a were detected with immunohistochemistry method-SABC. The expression of mRNA of CyclinD1,CyclinD2,Cdk4,Cdk6 and p16INK4a were detected with RT-PCR. Result: In high,medium and low dose group, the gray scales and the OPDTI value of CyclinD1 had no remarkable change;the gray scales of CyclinD2, Cdk4,Cdk6 and the OPDTI values of p16INK4a increased significantly, but the gray scales of p16INK4a and the OPDTI values of CyclinD2,Cdk4,Cdk6 decreased remarkably, compared with those in control groups. Conclusion: The Chinese herbal medicine Weikangning decoction can decrease the expressions of CyclinD2,Cdk4,Cdk6, increase the expression of p16INK4a. This effect may be involved in mechanism of gastric cancer cell growth inhibition gain by the Weikangning decoction.关键词：Weikangning;gastric cancer;mechanism
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发布时间：2024-09-23 - 摘要：Objective:To study the effects and mechanisms of Chinese herbal medicine—Weikangning on gastric cancer.Method:Total of 120 SD rats were divided into control group,high dose group,medium dose group and low dose group,and fed with natural saline,20,10 and 5 g /kg of Weikangning decoction respectively.The experimental animals were finally killed for the preparation of drug-containing serum.The gastric cancer cell MGC-803 was cultured with the drug-containing serum drawn from the rats in different groups.The expressions of CyclinD1,CyclinD2,Cdk4,Cdk6 and p16INK4a were detected with immunohistochemistry method-SABC.The expression of mRNA of CyclinD1,CyclinD2,Cdk4,Cdk6 and p16INK4a were detected with RT-PCR.Result:In high,medium and low dose group,the gray scales and the OPDTI value of CyclinD1 had no remarkable change;the gray scales of CyclinD2,Cdk4,Cdk6 and the OPDTI values of p16INK4a increased significantly,but the gray scales of p16INK4a and the OPDTI values of CyclinD2,Cdk4,Cdk6 decreased remarkably,compared with those in control groups.Conclusion: The Chinese herbal medicine Weikangning decoction can decrease the expressions of CyclinD2,Cdk4,Cdk6,increase the expression of p16INK4a.This effect may be involved in mechanism of gastric cancer cell growth inhibition gain by the Weikangning decoction.关键词：Weikangning;gastric cancer;mechanism
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发布时间：2024-09-23 - 摘要：Objective: To explore the effect of ligustri-astragali casein co-peptid(LACP) on human lung adenocarcinoma A549 cell differentiation and the related mechanism. Method : MTT assay for human lung adenocarcinoma A549 cells; containing 5%, 10%, 15%, 20% concentration of LACP serum was used. The influence of LACP containing serum on differentiation was evaluated by investigation of cellular nuclear-mass ratio and telomerase activity. Immunocytochemical method was used to observe the effect of LACP drug serum on the A549 Bax/bcl-2 expression. Results : The four kinds of different concentrations of LACP serum inhibited A549 cell proliferation. Among them, 20% of LACP showed the highest inhibitory rate; and reduced the cells nuclear -mass ratio. LACP serum promoted A549 cell bax/ bcl-2 gene expression for apoptosis, and compared with the serum-free control group, the difference was significant ( P <0.05). Conclusion : LACP containing serum has certain inhibitory effect on human lung adenocarcinoma A549 cells. LACP complex shows promotion to human lung cancer cell A549 differentiation. The mechanism may be linked to inhibition of telomerase activity. The complex induced apoptosis of A549 cells may be related to promotion of bax/bcl-2 gene expression.关键词：Ligustri-Astragali Casein co-peptid(LACP);drug serum;human Lung adenocarcinoma A549 cell;cell differentiation;apoptosis
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发布时间：2024-09-23 - 摘要：Objective:To explore the effect of ligustri-astragali casein co-peptid（LACP） on human lung adenocarcinoma A549 cell differentiation and the related mechanism.Method: MTT assay for human lung adenocarcinoma A549 cells;containing 5%,10%,15%,20% concentration of LACP serum was used.The influence of LACP containing serum on differentiation was evaluated by investigation of cellular nuclear-mass ratio and telomerase activity.Immunocytochemical method was used to observe the effect of LACP drug serum on the A549 Bax /bcl-2 expression.Results: The four kinds of different concentrations of LACP serum inhibited A549 cell proliferation.Among them,20% of LACP showed the highest inhibitory rate;and reduced the cell’s nuclear-mass ratio.LACP serum promoted A549 cell bax / bcl-2 gene expression for apoptosis,and compared with the serum-free control group,the difference was significant（P < 0.05）.Conclusion: LACP containing serum has certain inhibitory effect on human lung adenocarcinoma A549 cells.LACP complex shows promotion to human lung cancer cell A549 differentiation.The mechanism may be linked to inhibition of telomerase activity.The complex induced apoptosis of A549 cells may be related to promotion of bax /bcl-2 gene expression.关键词：Ligustri-Astragali Casein co-peptid（LACP）;drug serum;human Lung adenocarcinoma A549 cell;cell differentiation;apoptosis
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- 163
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发布时间：2024-09-23 - 摘要：Objective: To study protective effects of Huanglian Jiedu Tang (HLJDT) and its components Coptidis Rhiyoma(CR), Scutellariae Redix (SR) on oxidative stress- induced PC12 cell injury. Methods : Serum pharmacological method was used to study effects of HLJDT, CR, SR on the cell oxidative injury. The herb-contained serum, obtained at different time after dosing in rats, was added to the cultured oxidative PC12 cells. The viability of PC12 cells was determined by MTT colormetric microassay. Effects of decoctions of HLJDT,CR,SR, herberine and baicalin were investigated as well. Result: The herb-contained serum of HLJDT, SR,CR, baicalin and the decoctions of HLJDT, SR, baicalin had protective effects on cell injury so did baicalin at 0.15~10 μg ·mL-1. But herberine and the decoctions of CR had no effect. Conclusion: Obtained serum after ig. HLJDT and its components in rats have protective effect on oxidative stress-induced PC12 cell injury in a dose-dependent and time-dependent manner. Baicalin may act as an antioxidant in the herb-contained serum of HLJDT as well as in the decoctions.关键词：Huanglian Jiedu Tang;serum pharmacology;PC12 cell;hydrogen peroxide;oxidative stress- induced injury
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发布时间：2024-09-23 - 摘要：Objective:To study protective effects of Huanglian Jiedu Tang（HLJDT） and its components Coptidis Rhiyoma（CR）,Scutellariae Redix（SR） on oxidative stress-induced PC12 cell injury.Methods: Serum pharmacological method was used to study effects of HLJDT,CR,SR on the cell oxidative injury.The herb-contained serum,obtained at different time after dosing in rats,was added to the cultured oxidative PC12 cells.The viability of PC12 cells was determined by MTT colormetric microassay.Effects of decoctions of HLJDT,CR,SR,herberine and baicalin were investigated as well.Result: The herb-contained serum of HLJDT,SR,CR,baicalin and the decoctions of HLJDT,SR,baicalin had protective effects on cell injury so did baicalin at 0.15 ～ 10 μg.mL-1.But herberine and the decoctions of CR had no effect.Conclusion: Obtained serum after ig.HLJDT and its components in rats have protective effect on oxidative stress-induced PC12 cell injury in a dose-dependent and time-dependent manner.Baicalin may act as an antioxidant in the herb-contained serum of HLJDT as well as in the decoctions.关键词：Huanglian Jiedu Tang;serum pharmacology;PC12 cell;hydrogen peroxide;oxidative stress-induced injury
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- 1114
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发布时间：2024-09-23 - 摘要：目的:通过观察当归补血汤对异丙肾上腺素（ISO）诱导的慢性心衰模型大鼠左室射血分数（LVEF）、短轴缩短率（FS）、血浆脑钠肽（BNP）水平的影响,探讨当归补血汤治疗慢性心衰的作用机制。方法:采用ISO sc制作心力衰竭模型。用心脏彩色多普勒检测大鼠的LVEF,FS;用ELISA法检测大鼠血浆BNP。结果:经LVEF,FS检测造模成功;治疗后各治疗组与模型组相比LVEF和FS均提高（P<0.01）,加用当归补血汤两组优于常规治疗组（P<0.05）。各治疗组与模型组相比血浆BNP均降低（P<0.01）,以加用当归补血汤的两组下降更为明显。结论:在西药常规治疗的基础上加用当归补血汤能够进一步改善模型大鼠的心功能,降低血浆BNP含量。关键词：心力衰竭;脑钠肽;当归补血汤;左室射血分数
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发布时间：2024-09-23 - 摘要：目的:通过对自由活动大鼠睡眠时相影响的研究,为百麦安神冲剂改善睡眠,治疗神经衰弱提供实验依据。方法:将埋好电极的大鼠24只随机分成百麦安神冲剂低、中、高剂量组。术后第8d给予药量同等体积的0.5%的羧甲基纤维素钠（CMC-NA）溶液,记录给药前大鼠的脑电（EEG）信号。描记时间为9:00～17:00,共计8 h。次日上午8:30经ig给予实验动物0.675,1.35,2.7 g.kg-1的百麦安神冲剂,连续给药7 d,于末次给药30 min后,对大鼠进行8 h的脑电描记。计算大鼠觉醒（Wake）,慢波睡眠1期（SWS1）,慢波睡眠2期（SWS2）,快动眼睡眠（REMS）,总睡眠时间（TST）内的总时间,应用自身配对t检验法进行统计比较。结果:百麦安神冲剂中、低剂量均能显著性延长自由活动大鼠的SWS2期,REMS期和TST;高剂量虽不能显著性延长TST,但其仍显著性延长SWS2期和REMS期。结论:百麦安神冲剂对自由活动大鼠具有改善睡眠的作用。关键词：百麦安神冲剂;脑电图;睡眠时相
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- 139
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发布时间：2024-09-23 - 摘要：Objective: To observe the role of Phellinus Linteus and Coriolus Versicolor Capsules(PLCVC)on anti-tumor and anti-metastasis in Lewis lung cancer tumor mice model. Methods : Lewis lung cancer cells were inoculated subcutaneously into right axillary of C57BL/6 mice, after continuous treatment of 21 d, we sacrificed the mice, removed tumor and weighed, and calculated the rate of tumor growth inhibition. We stripped lungs, fixed by Bouins solution, and counted colony number of metastases on the surface of the lungs and between the lobe under anatomical microscope. Results : High, medium and low doses of PLCVC inhibited significantly Lewis lung cancer tumor growth in the tumor-bearing mice (compared with the model group, P<0.05), inhibitory rates were respectively 21.2%, 21.0% and 24.6%. The colony number of metastases of high dose of PLCVC was less than the model group(P<0.05). Conclusion : PLCVC can inhibit significantly Lewis lung cancer tumor growth of the tumor-bearing mice, and inhibit lung metastases of Lewis lung tumor-bearing mice, and the effect of high dose is the most obvious.关键词：Phellinus Linteus and Coriolus Versicolor Capsules;Lewis lung cancer;inhibitory rate of tumor
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发布时间：2024-09-23 - 摘要：Objective:To observe the role of Phellinus Linteus and Coriolus Versicolor Capsules（PLCVC） on anti-tumor and anti-metastasis in Lewis lung cancer tumor mice model.Methods: Lewis lung cancer cells were inoculated subcutaneously into right axillary of C57BL /6 mice,after continuous treatment of 21 d,we sacrificed the mice,removed tumor and weighed,and calculated the rate of tumor growth inhibition.We stripped lungs,fixed by Bouin’s solution,and counted colony number of metastases on the surface of the lungs and between the lobe under anatomical microscope.Results: High,medium and low doses of PLCVC inhibited significantly Lewis lung cancer tumor growth in the tumor-bearing mice（compared with the model group,P < 0.05）,inhibitory rates were respectively 21.2%,21.0% and 24.6%.The colony number of metastases of high dose of PLCVC was less than the model group（P < 0.05）.Conclusion: PLCVC can inhibit significantly Lewis lung cancer tumor growth of the tumor-bearing mice,and inhibit lung metastases of Lewis lung tumor-bearing mice,and the effect of high dose is the most obvious.关键词：Phellinus Linteus and Coriolus Versicolor Capsules;Lewis lung cancer;inhibitory rate of tumor
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- 445
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发布时间：2024-09-23 - 摘要：Objective:To research the effect of Lianqi Xiaoke Capsule on type 2 diabetic rats.Method: Type 2 diabetic rat model wase induced with high sucrose-fat diet for 4 weeks and streptozotocin ip for 30 mg.kg-1,all animals were grouped and administrated with drugs for 8 weeks.The fasting blood glucose,insulin,insulin sensitivity index,total cholesterol,triglyceride,superoxide dismutase and malondialdehyde were assessed and pancreatic pathological changes were observed.Result: ① model group vs normal control group: the fasting blood glucose,total cholesterol,triglyceride,malondialdehyde were obviously increased（P < 0.05,P < 0.01）,otherwise insulin,insulin sensitivity index,superoxide dismutase decreased（P < 0.05）,pancreatic damage were appeared;② Lianqi Xiaoke Capsule treatment groups vs.model group: the fasting blood glucose,total cholesterol,triglyceride,malondialdehyde were significantly decreased（P < 0.05,P < 0.01）,and insulin,insulin sensitivity index,superoxide dismutase increased（P < 0.05）,pancreatic damage were ameliorated.Conclusion: Lianqi Xiaoke Capsule could decrease fasting blood glucose and blood lipids via ameliorating pancreatic damage and insulin resistance,and inhibition of oxidative stress.关键词：Lianqi Xiaoke Capsule;type 2 diabetic rat;insulin resistance
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发布时间：2024-09-23 - 摘要：Objective: To research the effect of Lianqi Xiaoke Capsule on type 2 diabetic rats. Method : Type 2 diabetic rat model wase induced with high sucrose-fat diet for 4 weeks and streptozotocin ip for 30 mg ·kg-1, all animals were grouped and administrated with drugs for 8 weeks. The fasting blood glucose, insulin, insulin sensitivity index, total cholesterol, triglyceride, superoxide dismutase and malondialdehyde were assessed and pancreatic pathological changes were observed. Result : ① model group vs normal control group: the fasting blood glucose, total cholesterol, triglyceride, malondialdehyde were obviously increased(P<0.05, P<0.01), otherwise insulin, insulin sensitivity index, superoxide dismutase decreased (P<0.05), pancreatic damage were appeared; ② Lianqi Xiaoke Capsule treatment groups vs. model group: the fasting blood glucose, total cholesterol, triglyceride, malondialdehyde were significantly decreased (P<0.05, P<0.01), and insulin, insulin sensitivity index, superoxide dismutase increased (P<0.05), pancreatic damage were ameliorated. Conclusion : Lianqi Xiaoke Capsule could decrease fasting blood glucose and blood lipids via ameliorating pancreatic damage and insulin resistance, and inhibition of oxidative stress.关键词：Lianqi Xiaoke Capsule;type 2 diabetic rat;insulin resistance
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发布时间：2024-09-23 - 摘要：Aim: To investigate the effects of Huachuanbaolie Granules（HCBL） on nonbacterial prostatitis and its anti-inflammatory and analgesia activity.Methods: Acute and chronic nonbacterial prostatitis model in rats were induced by carrageenin,Effects of HCBL on count of white blood cells,density of lecithin corpuscle in secretion and histological changes of prostates were observed.The anti-inflammatory activity was evaluated by xylene-induced ear edema in mice and cotton pellet-induced granuloma in rats.Analgesia activity was tested according to acetic acid-induced writhing in mice.Results: HCBL lowered the count of white blood cells,increased the density of lecithin corpuscle in secretion of prostates,and inhibited inflammatory infiltration,edema and fibroblast proliferation in carrageenin-induced acute or chronic prostatitic rats.Anti-inflammatory activity was confirmed in cotton pellet-induced granuloma in rat.HCBL could obviously decrease the writhing number induced by acetic acid and inhibit the ear edema induced by xylene in mice.Conclusion: The data suggest that HCBL has anti-inflammation and analgesia effects,It is an effective medicine for the treatment of prostatitis.关键词：Huachuanbaolie Granules;nonbacterial prostatitis;anti-inflammation;analgesia
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- 265
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发布时间：2024-09-23 - 摘要：Aim: To investigate the effects of Huachuanbaolie Granules(HCBL) on nonbacterial prostatitis and its anti-inflammatory and analgesia activity. Methods: Acute and chronic nonbacterial prostatitis model in rats were induced by carrageenin, Effects of HCBL on count of white blood cells,density of lecithin corpuscle in secretion and histological changes of prostates were observed. The anti-inflammatory activity was evaluated by xylene-induced ear edema in mice and cotton pellet-induced granuloma in rats. Analgesia activity was tested according to acetic acid-induced writhing in mice. Results: HCBL lowered the count of white blood cells, increased the density of lecithin corpuscle in secretion of prostates, and inhibited inflammatory infiltration,edema and fibroblast proliferation in carrageenin-induced acute or chronic prostatitic rats. Anti-inflammatory activity was confirmed in cotton pellet-induced granuloma in rat. HCBL could obviously decrease the writhing number induced by acetic acid and inhibit the ear edema induced by xylene in mice. Conclusion: The data suggest that HCBL has anti-inflammation and analgesia effects, It is an effective medicine for the treatment of prostatitis.关键词：Huachuanbaolie Granules;nonbacterial prostatitis;anti-inflammation;analgesia
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发布时间：2024-09-23 - 摘要：目的:观察舒筋汤对兔膝关节挛缩模型关节囊病理改变及关节液TGF-β1表达的影响。方法:24只大白兔按Hildebrand法固定右膝关节复制创伤后关节挛模型,造模成功后随机分为舒筋汤组、模型组和正骨水组（n=8）。分别予以舒筋汤、正骨水溶液薰洗,模型组不予用药处理,各组均辅以功能锻炼。给药3,6周末分别测量关节挛缩程度和关节液中TGF-β1含量。6周末处死动物,对关节囊厚度进行测量,Masson染色进行关节胶原纤维表达定量测定。结果:舒筋汤组与正骨水组和模型组比较,在关节囊厚度、关节挛缩程度、胶原蛋白和关节液中TGF-β1的表达等方面均有差异。结论:舒筋汤辅助功能锻炼能有效减轻关节囊挛缩、恢复关节功能。其作用可能是通过减少TGF-β1的表达而实现的。关键词：关节挛缩;舒筋汤;关节囊;转化生长因子β1
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发布时间：2024-09-23 - 摘要：目的:观察加味四物汤对自发性高血压大鼠（SHR）的心肌组织基因表达谱的影响。方法:提取实验组和对照组SHR心肌组织RNA,用Cy-5,Cy-3逆转录荧光标记制作cDNA探针与表达谱基因芯片杂交,Scan Array4000扫描仪扫描杂交信号荧光强度,Ima GENE3.0软件分析扫描结果,筛选比率在0.5至2.0范围之外差异表达的基因。结果:在阳性基因重叠的18条基因中,高表达的有4条,低表达的有14条。结论:该方作用靶点较多,可上调或下调SHR的某些与生物酶、心肌纤维化、脂肪酸代谢有关基因的表达,这可能是该方产生药理作用的重要因素。关键词：加味四物汤;自发性高血压大鼠;基因表达谱
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- 120
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发布时间：2024-09-23 - 摘要：Objective: To investigate the effect of Ge Pi decoction on regulation of monocyte chemoattractant protein-1(MCP-1)level to reverse early diabetic nephropathy(DN). Method: STZ diabetes model were induced by high lipoids and high glucose diet combined with intraperitoneal injection of small dose streptozotocin(STZ)(n=41). STZ-induced diabetes model of Wistar male rats were divided into the control group(n=14), the Traditional Chinese medicine(Ge Pi Decoction)treatment group(n=13), and the western medicine(benazepril)treatment group(n=14). After 8 weeks,detection of each group were carried out about weight, kidney weight index, blood glucose, urinary albumin microdosis, urinary albumin, blood and urine MCP-1,8-iso-prostaglandin F2a(8-iso-PGF2α)and tumor necrosis factor-α(TNF-α), and oservation were performed on the pathological change of the rats renal with light microscope. Result: Compared with those in the control group,the body weight and kidney weight index were decreased in the Ge Pi Decoction treatment(P<0.05). Microdosis urin-albumin, MCP-1, 8-iso-PGF2α and TNF were decreased significantly(P<0.01). There was no significant difference between Ge Pi Decoction treatment group and benazepril treatment group(P>0.05).In addition, there were positive correlation between 8-iso-PGF2α, MCP-1, TNF-α and UAER in each group. Ge Pi Decoction can relieve kidney hypertrophy, mesangial matrix hyperplasia and sclerosis. Conclusion: There are autoimmunity inflammation and oxidative stress in diabetic nephropathy.Ge Pi Decoction can inhibit various inflammatory factors in diabetic nephropathy.关键词：Ge Pi Decoction;monocyte chemoattractant protein-1;8-iso-prostaglandin F2a;diabetic nephropathy
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发布时间：2024-09-23 - 摘要：Objective:To investigate the effect of Ge Pi decoction on regulation of monocyte chemoattractant protein-1（MCP-1）level to reverse early diabetic nephropathy（DN）.Method: STZ diabetes model were induced by high lipoids and high glucose diet combined with intraperitoneal injection of small dose streptozotocin（STZ）（n = 41）.STZ-induced diabetes model of Wistar male rats were divided into the control group（n = 14）,the Traditional Chinese medicine（Ge Pi Decoction） treatment group（n = 13）,and the western medicine（benazepril） treatment group（n = 14）.After 8 weeks,detection of each group were carried out about weight,kidney weight index,blood glucose,urinary albumin microdosis,urinary albumin,blood and urine MCP-1,8-iso-prostaglandin F2a（8-iso-PGF2α）and tumor necrosis factor-α（TNF-α）,and oservation were performed on the pathological change of the rats renal with light microscope.Result: Compared with those in the control group,the body weight and kidney weight index were decreased in the Ge Pi Decoction treatment（P < 0.05）.Microdosis urin-albumin,MCP-1,8-iso-PGF2α and TNF were decreased significantly（P < 0.01）.There was no significant difference between Ge Pi Decoction treatment group and benazepril treatment group（P > 0.05）.In addition,there were positive correlation between 8-iso-PGF2α,MCP-1,TNF-α and UAER in each group.Ge Pi Decoction can relieve kidney hypertrophy,mesangial matrix hyperplasia and sclerosis.Conclusion: There are autoimmunity inflammation and oxidative stress in diabetic nephropathy.Ge Pi Decoction can inhibit various inflammatory factors in diabetic nephropathy.关键词：Ge Pi Decoction;monocyte chemoattractant protein-1;8-iso-prostaglandin F2a;diabetic nephropathy
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- 155
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发布时间：2024-09-23 - 摘要：目的:观察筋骨片对小鼠的急性毒性和对大鼠的长期毒性,为临床用药的安全剂量提供参考。方法:①急性毒性试验:昆明种小鼠40只,随机分成给药组和对照组,采用最大给药量法测定小鼠口服筋骨片最大耐受量;②长期毒性试验:SD大鼠120只,随机分成4组,采用3个剂量（按生药量计为61.4,30.7,15.3 g/kg）ig大鼠。每天给药1次,连续ig6个月,观察大鼠的一般情况,检测血常规及血液生化学、组织病理变化及停药1个月时上述指标的变化。结果:小鼠口服筋骨片的最大耐受量按生药计为842 g/kg,相当于成人临床每日口服剂量的1 477倍。大鼠连续给药6个月后筋骨片各剂量组各项指标未见明显异常改变;2只大鼠的肝、肾细胞有轻度水样变性,1只大鼠的细小支气管周围淋巴细胞浸润。停药1个月后,大鼠体重、摄食量、行为活动、血象、重要器官脏器系数均正常,病理学检查,各组各脏器均未发现明显的改变。结论:筋骨片在规定剂量下服用是安全可靠的。关键词：筋骨片;急性毒性;小鼠;长期毒性;大鼠
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- 230
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发布时间：2024-09-23 - 摘要：目的:探讨龙血竭对大鼠撕脱皮瓣的保护作用及机制。方法:实验大鼠随机分为空白对照组、龙血竭灌胃组、龙血竭外用组。在大鼠背部制作一个蒂在尾部的3 cm×9 cm大小的撕脱伤皮瓣,皮瓣碾压撕脱后原位缝合。分别于术后1,12,24 h取皮瓣近、中、远段组织检测丙二醛（MDA）含量、超氧化物歧化酶（SOD）及髓过氧化物酶（MPO）活性,术后7 d计算皮瓣成活率。结果:龙血竭能降低MDA含量和MPO活性,增加SOD活性。术后7 d皮瓣成活率龙血竭组明显升高。结论:龙血竭可提高撕脱皮瓣组织的抗氧化能力,减轻中性粒细胞在皮瓣中的聚集,从而发挥对撕脱皮瓣的保护作用。关键词：龙血竭;撕脱皮瓣;丙二醛;超氧化物歧化酶;髓过氧化物酶
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- 141
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发布时间：2024-09-23 - 摘要：Objective: To explore the effects of splenocytes on chimerism and GVHD after haploidentical MHC matched stem cells transplant with nonmyeloablative conditioning in murine model. Method: Thirty CB6F1 recipient mice were divided into group A, B and C. They were given 60Co of total body irradiation and infused with MHC haploidentical matched bone marrow plus different proportion of splenocytes. The level of the chimerism of the recipient mice was detected by flow cytometry. The manifestations and histopathological examination of GVHD were observed. The mortality of the recipient mice was observed. Result: Engraftments of group A and B were full donor chimerism after 21 days, engraftments of group C were full donor chimerism after 14 days. The clinical GVHD score in group C was obviously higher than that in group B(P<0.01), and that in group B higher than in group A(P<0.01). All the mice survived over 90 days. Conclusion: The higher dose of MHC haploidentical matched splenocytes will help to be full donor chimerism earlier, but it may aggravate GVHD.关键词：murine;nonmyeloablative;haploidentical MHC matched stem cells transplant;GVHD;chimera
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发布时间：2024-09-23 - 摘要：Objective:To explore the effects of splenocytes on chimerism and GVHD after haploidentical MHC matched stem cells transplant with nonmyeloablative conditioning in murine model.Method:Thirty CB6F1 recipient mice were divided into group A,B and C.They were given 60Co of total body irradiation and infused with MHC haploidentical matched bone marrow plus different proportion of splenocytes.The level of the chimerism of the recipient mice was detected by flow cytometry.The manifestations and histopathological examination of GVHD were observed.The mortality of the recipient mice was observed.Result:Engraftments of group A and B were full donor chimerism after 21 days,engraftments of group C were full donor chimerism after 14 days.The clinical GVHD score in group C was obviously higher than that in group B（P < 0.01）,and that in group B higher than in group A（P < 0.01）.All the mice survived over 90 days.Conclusion: The higher dose of MHC haploidentical matched splenocytes will help to be full donor chimerism earlier,but it may aggravate GVHD.关键词：murine;nonmyeloablative;haploidentical MHC matched stem cells transplant;GVHD;chimera
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- 115
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发布时间：2024-09-23 - 摘要：Objective: To observe effects of cordyceps polysaccharides(CP)on reducing cell oxidative damage in cultured fibroblasts. Methods: Oxidative models were induced by 8-MOP/UVA. Cordyceps polysaccharides was administrated before 8-MOP/UVA. MDA,SOD, CAT, GSH-Px enzyme activities were measured for examination of free radicle amount and clearance ability of the cell. Mitochondrial transmembrane potential were tested to examine mitochondria function. Results: In the model group, free radicals increased compared with that in the control group and enzyme activities of free radical scavenging decreased. Severity of mitochondrial transmembrane potential damage were also relieved, which were reversed in CP protected groups. Conclusion: Cordyceps polysaccharide can increase the capacity of antioxidant in skin fibroblast cells.关键词：cordyceps polysaccharides(CP);fibroblast;anti-oxidation;free radicals;mitochondrial transmembrane potential
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发布时间：2024-09-23 - 摘要：Objective: To observe effects of cordyceps polysaccharides（CP） on reducing cell oxidative damage in cultured fibroblasts.Methods: Oxidative models were induced by 8-MOP /UVA.Cordyceps polysaccharides was administrated before 8-MOP /UVA.MDA,SOD,CAT,GSH-Px enzyme activities were measured for examination of free radicle amount and clearance ability of the cell.Mitochondrial transmembrane potential were tested to examine mitochondria function.Results: In the model group,free radicals increased compared with that in the control group and enzyme activities of free radical scavenging decreased.Severity of mitochondrial transmembrane potential damage were also relieved,which were reversed in CP protected groups.Conclusion: Cordyceps polysaccharide can increase the capacity of antioxidant in skin fibroblast cells.关键词：cordyceps polysaccharides（CP）;fibroblast;anti-oxidation;free radicals;mitochondrial transmembrane potential
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发布时间：2024-09-23 - 摘要：Objective: To observe the effect on the treatment for chronic eczema with modified Siwu Xiaofeng powder plus sicorten cream.Method: 143 cases are divided to the therapy group（72 cases） and the control group（71 cases） at random,The therapy group was treated by modified Siwu Xiaofeng powder for oral administration plus sicorten cream for external application,the control group was only treated by sicorten cream for external application.Result: After a course of treatment,the effective rate of two groups are 88.9%,63.4% respectively;the effective rate of the therapy group are higher obviously than that of the control group,the difference between two groups was significant.No obvious side effects were found in two treatment groups.Conclusion: The effect on the treatment for chronic eczema with modified four substances wind-dispersing powder plus sicorten cream is for sure.关键词：Siwu Xiaofeng powder;sicorten;chronic eczema
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- 177
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发布时间：2024-09-23 - 摘要：Objective: To observe the effect on the treatment for chronic eczema with modified Siwu Xiaofeng powder plus sicorten cream. Method : 143 cases are divided to the therapy group (72 cases) and the control group (71 cases) at random, The therapy group was treated by modified Siwu Xiaofeng powder for oral administration plus sicorten cream for external application, the control group was only treated by sicorten cream for external application. Result: After a course of treatment, the effective rate of two groups are 88.9%, 63.4%respectively; the effective rate of the therapy group are higher obviously than that of the control group, the difference between two groups was significant. No obvious side effects were found in two treatment groups. Conclusion: The effect on the treatment for chronic eczema with modified four substances wind-dispersing powder plus sicorten cream is for sure.关键词：Siwu Xiaofeng powder;sicorten;chronic eczema
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发布时间：2024-09-23 - 摘要：Objective: To observe the curative effect of treating facial acne with the method of Qinggan Huoxue flow. Method: Total 67 patients with facial acne were randomly divided into two groups. Thirty-seven patients were in the treatment group who were treated with the method of Qinggan Huoxue flow. And 30 patients were in the control group who were treated with western medicine. The cure duration was 4 weeks. The subsided circumstance of rash was observed. Result: In the treatment group,8 patients were cured(21.6%),14 were excellent(37.8%)and 12 were efficient(32.4%)but 3 failed to respond to the treatment(8.1%). The total effective rate in the treatment group was 91.9%. In the control group,2 patients were cured(6.7%),7 were excellent(23.3%)and 10 were efficient(33.3%)but 11 failed to respond to the treatment(36.7%). The total effective rate in the control group was 63.3%. Conclusion: It has significant effect in treatment of facial acne with the method of purging liver and promoting blood flow( P ＜0.01).关键词：facial acne;clinical study
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发布时间：2024-09-23 - 摘要：Objective:To observe the curative effect of treating facial acne with the method of Qinggan Huoxue flow.Method: Total 67 patients with facial acne were randomly divided into two groups.Thirty-seven patients were in the treatment group who were treated with the method of Qinggan Huoxue flow.And 30 patients were in the control group who were treated with western medicine.The cure duration was 4 weeks.The subsided circumstance of rash was observed.Result: In the treatment group,8 patients were cured（21.6%）,14 were excellent（37.8%） and 12 were efficient（32.4%） but 3 failed to respond to the treatment（8.1%）.The total effective rate in the treatment group was 91.9%.In the control group,2 patients were cured（6.7%）,7 were excellent（23.3%） and 10 were efficient（33.3%） but 11 failed to respond to the treatment（36.7%）.The total effective rate in the control group was 63.3%.Conclusion:It has significant effect in treatment of facial acne with the method of purging liver and promoting blood flow（P < 0.01）.关键词：facial acne;clinical study
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- 220
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发布时间：2024-09-23 - 摘要：Objective:To observe and the efficacy of self-designed formula of Traditional Chinese Medicine for helping sustain health and dispeling disease to treat the nerve root cervical spondylosis.Method: Total 184 patients were randomly assigned two groups.Ninety-four cases were in the treatment group and 90 cases in the control group.The treatment group were applyed the formula for helping sustain health and dispeling disease,and the control group were applyed Nect Pain Capsules.Then we observed and compared the efficacy between them after 15 days.Result: The efficient rate in the treatment group was 68.09% and that in the control group was 53.33%.There were significant difference between them（P < 0.05）.Conclusion:The efficacy of formula for helping sustain health and dispeling disease to treat the Nerve Root Cervical Spondylosis was significant.It is worth promoting and applying clinicaly.关键词：traditional Chinese medicine;helping sustain health and dispeling disease;nect pain capsules;nerve root cervical spondylosis
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- 326
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发布时间：2024-09-23 - 摘要：Objective: To study the effects of shenfu injection on recovery of heart beat in patients undergoing mitral valve replacement surgery. Method: Sixty patients undergoing mitral valve replacement were randomly divided into two equal groups: group S( n =30)and group N( n =30). Shenfu injection at a dose of 1 mL/kg was administered in group S and normal saline of 1 mL/kg was administered in group N before the aorta unclamping 60 s. Clinical data including the incidence of spontaneous recovery of heart beat after aorta unclamping and that of ventricular arrhythmia and the changes of ST-segment one minute after the recovery of heart beat were collected. Meanwhile the time of ante-parallel cycle time, aorta clamping, post-parallel cycle time and the dose of dopamine administered after surgery were recorded. Result: The time from aorta unclamping to spontaneous recovery of heart beat was shorter in group S( P ＜0.01). The incidence of spontaneous recovery of heart beat was higher, while that of ventricular arrhythmia is lower in group S( P ＜0.05). The changes of ST-segment was more mild and the post-parallel cycle time was shorter in group S. The dose of dopamine administered after surgery was fewer in group S( P ＜0.05). Conclusion: The administration of Shenfu injection at a dose of 1 mL/kg before the aorta unclamping one minute facilitated the spontaneous recovery of heart beat and reduced the incidence of ventricular arrhythmia in patients undergoing mitral valve replacement surgery.关键词：Shenfu Injection;mitral valve replacement surgery;cardiac resuscitation
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发布时间：2024-09-23 - 摘要：Objective: To study the effects of shenfu injection on recovery of heart beat in patients undergoing mitral valve replacement surgery.Method: Sixty patients undergoing mitral valve replacement were randomly divided into two equal groups: group S（n = 30）and group N（n = 30）.Shenfu injection at a dose of 1 mL / kg was administered in group S and normal saline of 1 mL /kg was administered in group N before the aorta unclamping 60 s.Clinical data including the incidence of spontaneous recovery of heart beat after aorta unclamping and that of ventricular arrhythmia and the changes of ST-segment one minute after the recovery of heart beat were collected.Meanwhile the time of ante-parallel cycle time,aorta clamping,post-parallel cycle time and the dose of dopamine administered after surgery were recorded.Result: The time from aorta unclamping to spontaneous recovery of heart beat was shorter in group S（P < 0.01）.The incidence of spontaneous recovery of heart beat was higher,while that of ventricular arrhythmia is lower in group S（P < 0.05）.The changes of ST-segment was more mild and the post-parallel cycle time was shorter in group S.The dose of dopamine administered after surgery was fewer in group S（P < 0.05）.Conclusion: The administration of Shenfu injection at a dose of 1 mL /kg before the aorta unclamping one minute facilitated the spontaneous recovery of heart beat and reduced the incidence of ventricular arrhythmia in patients undergoing mitral valve replacement surgery.关键词：Shenfu Injection;mitral valve replacement surgery;cardiac resuscitation
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- 2
发布时间：2024-09-23 - 摘要：Objective: To observe the effects of berberine on T2DM resistance to external insulin and machine. Method: Berberine were given to patients with T2DM and resistant to external insulin and the dose was adjusted with FBG and 2hPG levels. Then fasting insulin level were determined after 35day and insulin resistance rate was calculated by HOMA formula. Result: All patient were effectively reacting to berberine since the14th day and it was the most obvious at the 21 th day.The dose of insulin was decreased by 30 percent at the 35 th day. Conclusion: Berberine can improve T2DM resistance to external insulin by increasing T2DM insulin sensibility.关键词：berberine;type 2 diabetes mellitus;insulin resistance
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发布时间：2024-09-23 - 摘要：Objective: To observe the effects of berberine on T2DM resistance to external insulin and machine.Method:Berberine were given to patients with T2DM and resistant to external insulin and the dose was adjusted with FBG and 2hPG levels.Then fasting insulin level were determined after 35day and insulin resistance rate was calculated by HOMA formula.Result:All patient were effectively reacting to berberine since the14th day and it was the most obvious at the 21 th day.The dose of insulin was decreased by 30 percent at the 35 th day.Conclusion:Berberine can improve T2DM resistance to external insulin by increasing T2DM insulin sensibility.关键词：berberine;type 2 diabetes mellitus;insulin resistance
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- 223
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- 13
发布时间：2024-09-23 - 摘要：目的:了解儿童药物不良反应（ADR）发生的基本情况及其发生特点。方法:对北京儿童医院2009年1—6月上报到国家药物不良反应监测网的123例ADR报表各项数据进行回顾性统计分析。结果:引起ADR涉及到的药物中单一用药106例（86.18%）,合并用药17例（13.82%）。涉及到抗感染药物的有78例（总数的63.41%）,抗感染药物中头孢菌素类57例（46.34%）。3岁以内幼儿的ADR发生率为53.65%,为各年龄组中最高。结论:儿童药物不良反应发生有其特殊性,应加强儿童药物不良反应的监测并及时上报,以减少其发生率,减少后遗症,降低死亡率。关键词：儿童;药物不良反应;抗感染药物
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- 163
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发布时间：2024-09-23 - 摘要：Objective: To investigate the effects of gargle on radiation stomatitis. Method: Total 45 tumor patients were divided into two groups: the treatment group( n =25)and the control group( n =20).Gan Bing gargle was used to oral cavity rinse in the treatment group, while western medicine was used in the control group. RTOG indicator were used to evaluate the severity of oral mucitis.The efficacy was compared between the two groups. Result: There was no significant differences between the two groups( P ＞0.05)in the efficacy when low dose of the drug was given,but there was significant differences between the two groups( P ＜0.05)when median and high dose of the drug was given. Conclusion: Our study showes that Gan Bing gargle is of obvious curative effect in treating stomatitis and it can reduce stomatitis occurrence for the patients receieved rhinopharyngocele radiotherapy.关键词：radiotherapy;stomatitis;gargle
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发布时间：2024-09-23 - 摘要：Objective:To investigate the effects of gargle on radiation stomatitis.Method:Total 45 tumor patients were divided into two groups: the treatment group（n = 25）and the control group（n = 20）.Gan Bing gargle was used to oral cavity rinse in the treatment group,while western medicine was used in the control group.RTOG indicator were used to evaluate the severity of oral mucitis.The efficacy was compared between the two groups.Result:There was no significant differences between the two groups（P > 0.05）in the efficacy when low dose of the drug was given,but there was significant differences between the two groups（P < 0.05）when median and high dose of the drug was given.Conclusion:Our study showes that Gan Bing gargle is of obvious curative effect in treating stomatitis and it can reduce stomatitis occurrence for the patients receieved rhinopharyngocele radiotherapy.关键词：radiotherapy;stomatitis;gargle
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发布时间：2024-09-23 -
Progress in research on the regulatory functions and mechanisms of rhubarb to gastrointestinal tract
摘要：Gastrointestinal tract is the main target organ that rhubarb acts upon. By analyzing the published papers recently related to rhubarb and gastrointestinal tract, the regulatory functions and the mech -anisms of rhubarb to gastrointestinal tract were outlined. The problems existed in the progress of rhubarb research and the research fields involving rhubarb that should be emphasized were also pointed out. Thus, this paper might pave the way for further development as well as clinical use of rhubarb.关键词：Rhubarb;gastrointestinal tract;mechanism- 0
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发布时间：2024-09-23 - 摘要：<正>依据文献计量学的原理和方法,经研究人员对相关文献的检索、计算和分析,以及学科专家评审,《中国实验方剂学杂志》入编《中文核心期刊要目总览》2008年版（即第五版）之中国医学类的核心期刊。该核心期
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发布时间：2024-09-23 - 摘要：Difference in dosage form for a traditional Chinese medicine (TCM) means distinct processing technology. As the complexity of the therapeutic basis, together with the uncertainty of the active principles, different processing techniques result in great changes in therapeutic material basis. In these cases difference of dosage means not only the difference in dosage forms, but also actually the difference of drugs. It will be significantly important to explore the profound meaning of the dosage form of TCM.关键词：decoction;powder;decoction and powder of a same formula;dosage form;clinical effect
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发布时间：2024-09-23 -
Progress in research on the regulatory functions and mechanisms of rhubarb to gastrointestinal tract
摘要：Gastrointestinal tract is the main target organ that rhubarb acts upon.By analyzing the published papers recently related to rhubarb and gastrointestinal tract,the regulatory functions and the mech-anisms of rhubarb to gastrointestinal tract were outlined.The problems existed in the progress of rhubarb research and the research fields involving rhubarb that should be emphasized were also pointed out.Thus,this paper might pave the way for further development as well as clinical use of rhubarb.关键词：Rhubarb;gastrointestinal tract;mechanism- 0
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发布时间：2024-09-23 - 摘要：YunQi theory proposed unique understanding to the nature of seasonal epidemics and accumulated clinical experience a lot. Its Compatibility of Prescription principle demanded the treatment to epidemics should be Flexibly decided according to the season, disease and symptoms etc. The series prescriptions could be chosen according to 5 Yun and 6 Qi characteristics in different years, or according to No-seasonal Qi, or seasonal diseases. Patent Chinese medicines for epidemics also follow the above principle, such as the King Drug was determined according to YunQi in different years. It is important to have a in-depth study of compatibility of prescription principle for epidemics guided by YunQi theory for the improvement of TCM in prevention and control seasonal epidemics.关键词：YunQi Theory;seasonal epidemics;compatibility of prescription principle
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发布时间：2024-09-23 - 摘要：Difference in dosage form for a traditional Chinese medicine（TCM） means distinct processing technology.As the complexity of the therapeutic basis,together with the uncertainty of the active principles,different processing techniques result in great changes in therapeutic material basis.In these cases difference of dosage means not only the difference in dosage forms,but also actually the difference of drugs.It will be significantly important to explore the profound meaning of the dosage form of TCM.关键词：decoction;powder;decoction and powder of a same formula;dosage form;clinical effect
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- 878
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发布时间：2024-09-23 - 摘要：YunQi theory proposed unique understanding to the nature of seasonal epidemics and accumulated clinical experience a lot.Its Compatibility of Prescription principle demanded the treatment to epidemics should be Flexibly decided according to the season,disease and symptoms etc.The series prescriptions could be chosen according to 5 Yun and 6 Qi characteristics in different years,or according to No-seasonal Qi,or seasonal diseases.Patent Chinese medicines for epidemics also follow the above principle,such as the King Drug was determined according to YunQi in different years.It is important to have a in-depth study of compatibility of prescription principle for epidemics guided by YunQi theory for the improvement of TCM in prevention and control seasonal epidemics.关键词：YunQi Theory;seasonal epidemics;compatibility of prescription principle
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- 1001
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- 13
发布时间：2024-09-23 - 摘要：<正>中华中医药学会中药鉴定分会定于2010年7月在陕西省咸阳市召开"全国第十次中药鉴定学术研讨会",会期3天。会议将邀请著名专家及相关人士就中药鉴定与品质评价、中药质量标准化、信息化、网络化
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- 14
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发布时间：2024-09-23 - 摘要：<正>磺脲类降糖药是目前临床应用较多的口服降糖药,二代磺脲类以格列苯脲、格列吡嗪、格列齐特、格列喹酮为代表,三代磺脲类以格列美脲为代表。为对比二代与三代磺脲类
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- 199
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- 4
发布时间：2024-09-23 - 摘要：<正>急性心肌梗死是心血管系统中发病率和致死率最高的血栓闭塞性疾病。近年来,不断有研究表明,中药成分对于急性心肌梗死的治疗有一定的疗效。笔者对34例急性心肌
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- 78
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发布时间：2024-09-23 - 摘要：<正>肝衰竭是临床上常见的急危重症,主要由于急慢性病毒性肝炎、肝硬化及药物性、酒精性肝炎所致。本文通过采用腺苷蛋氨酸和甲基泼尼松龙联合治疗肝衰竭,观察二者联合
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发布时间：2024-09-23 - 摘要：<正>心脏神经官能症是社区门诊中发病率很高的常见疾病之一。是以心血管疾病的有关症状为主要临床表现,伴有神经症状的临床综合征,是神经症的一种特殊类型。本病多见于青壮年女性,尤其是更年期女性,病理上无器质性脏病证
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- 230
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- 18
发布时间：2024-09-23 - 摘要：<正>胰复敏胶囊（主要由黄芪、丹参、苍术、女贞子、黄连以3∶3∶2∶1∶1煎煮提膏,干燥粉碎,装入胶囊制成）具有益气养阴、化痰活血解毒之功效。在实验研究中胰复敏胶囊对糖尿
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- 115
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- 3
发布时间：2024-09-23 - 摘要：<正>术后早期炎性肠梗阻（early postoperative inflammatorysmall bowel obstruction,EPISBO）为腹部外科手术常见并发症之一,由于手术创伤、炎症、出血、异物等导致肠壁水肿和渗出而形成的一种机械性与动力性同时存在的粘连性肠梗阻[1]。
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发布时间：2024-09-23 - 摘要：<正>《中国实验方剂学杂志》系国家中医药管理局主管,中国中医科学院中药研究所和中国中西医结合学会中药专业委员会主办的专业性学术刊物,系"中国科技论文统计源期刊"（中国科技核心期刊）、"中国中文核
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发布时间：2024-09-23
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