最新刊期
卷 17 ， 期 24 ， 2011
- 摘要：Objective : Study on adsorption and separation effect of Chinese medicine decoction by different pre-treatment methods with macro-porous resin, and determined its inherent laws. Method : The content of Salidroside as an indicator to select decoction of Rhodiola herb with once-alcohol precipitation, twice-alcohol precipitation by adding precipitant, precipitant added with alcohol and centrifugation procedure. In order to observe different methods of decoction refined have an effect on macro-porous resin adsorption. Result : The effect of purity of the water extract of Rhodiola and macro-porous resin separation is the best by the way of using twice-alcohol precipitation and adding precipitant and alcohol precipitation. Conclusion : Chinese medicine decoction by different pre-treatment methods had significant impact on adsorption and separation of macro-porous resin.关键词：macroporous absorbent resin;salidroside;different pre-treatment methods;adsorption
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发布时间：2024-01-04 - 摘要：Objective : To contrast preparation technology of the Shuangbai spray and Shuangbai film spraying agent. Method: Adopted water extraction and alcohol sink method to produce Shuangbai spray and adopted ethanol extraction method to produce Shuangbai film spraying agent, compared dosage of medicinal materials,the content of index components and transfer rate, film performance. Result: In Shuangbai spray,dosage of medicinal materials was 1 001 g and the content of the Emodin was 82.70 mg with it's transfer rate was 8.63%, and the content of hydrochloride berberine was 97.61 mg with it's transfer rate was 6.63%. It couldn't become film when Shuangbai spray was sprayed onto skin. But in Shuangbai film spraying agent, dosage medicinal materials was 140 g and the content of emodin was 99.67 mg with it's transfer rate was 74.38%, and the content of hydrochloride berberine was 113.79 mg with it's transfer rate was 55.24%. It could become film with a good performance in five minutes when Shuangbai film spraying agent was sprayed onto the skin. Conclusion: Preparation technology of Shuangbai film spraying agent was simple, improved utilization rate of medicinal materials, had good film performance, and better than preparation technology of Shuangbai spray.关键词：Shuangbai spray;Shuangbai film spraying agent;preparation process;transfer rate;film
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发布时间：2024-01-04 - 摘要：Objective :Taguchi experimental design method was used to optimize of microwave extraction process for Rukuaixiao oral liquid. Method :L9 (34) orthogonal test was used to optimize extraction process of medicine from Rukuaixiao oral liquid with active ingredient in orange (hesperidin) as index. Investigation factors included extraction power, extraction time, the amount of solvent. Result :The best microwave extraction technology was as follows: microwave extraction power was 6 000 W, extracted 45 minutes with 6 times the amount of water,compared with traditional boiled extraction,extract ratio of hesperidin increased 80%, and extraction time was shorten, the amount of water was only 27.3% to original technology. Conclusion :Optimum technology saved energy and time of medicine extraction and concentration process.关键词：Rukuaixiao;taguchi test;microwave extraction;orthogonal test
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发布时间：2024-01-04 - 摘要：Objective :To optimize extraction technology of Coptis chinensis. Method :Determined the content of epiberberine,coptisine,berberine and palmatine with multi-components quantitation by one marker,orthogonal design was used to optimize extraction technology of C. chinensis with total content of epiberberine,coptisine,berberine and palmatine. Result :The best extracting condition was as follows:extracted 3 times with 10 times the amount of 70% ethanol for 1.5 h each time. Conclusion : Optimum extraction technology was effective for extracting multiphasic alkaloid from C. chinensis.关键词：multi-components quantitation by one marker;Coptis chinensis;extraction technology;HPLC;alkaloid
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发布时间：2024-01-04 - 摘要：Objective :To optimize extraction technology of Jianwei Xiaoshi orally disintegrating tablet. Method :Orthogonal test was used for optimizing extraction technology of Jianweixiaoshi orally disintegrating tablet with extract yeild of hesperidin, chlorogenic acid and dry extract as indexes. Three factors were investigated including the amount of water, extraction time and extraction times. Result :Optimum extraction technology was as follows: boiled 2 times,first with 6 times amount of water for 2 h and then boiled with 5 times amount of water for 1 h. Conclusion :Optimized technology was reasonable, stable and reliable.关键词：Jianwei Xiaoshi orally disintegrating tablet;orthogonal test;extraction technology;heperidin;chlorogenic acid
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发布时间：2024-01-04 - 摘要：Objective :To study on main phase,chemical composition,thermal stability of calamine before and after processing. Method :Analyzed phase and chemical composition of calamine X-ray diffraction (XRD), infrared spectrophotometry (IR) and titration method;studied thermal stability of calamine by differential thermal analysis. Result: Main phase of calamine after processing changed from monoclinic system of Zn5(CO3)2(OH)6 to hexagonal system of ZnO;Stretching vibration and bending of carbonate obviously weaked; The content of zinc oxide increased from 63.36% to 82.95%; Sample released heat when heated to about 250 ℃ and heat did not change when heated close to 315 ℃. Conclusion : Not only main phase changed of calamine after processing,but also chemical composition changed.Differential thermal analysis (DTA) could regulate calcined temperature of calamine.关键词：Calamine;processing;component analysis;thermal stability
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发布时间：2024-01-04 - 摘要：Objective : To optimize extraction technology of Geranium wilfordii and study on matrix prescription and preparation technology of G. wilfordii gel. Method: L9(34)orthogonal test was used to optimize extraction process with dry extraction ratio and the content of gallic acid as indexes;matrices were selected according to appearance and stability of preparation, and prescription factors were selected according to comprehensive scores of appearances. Result: Optimum extraction technology of G. wilfordii gel was boiled 2 times with 10 times the amounts of water for 1 h each time; Optimum matrix prescription was carbopol 940-glycerin-propylene glycol-triethanolamine(1.5% ∶2% ∶2% ∶5%). Conclusion : Optimum extraction technology was simple and feasible, preparation technology was stable and finished products are easy to be coated with delicate texture.关键词：Geranium wilfordii gel;extraction technology;matrix prescription;preparation technology
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发布时间：2024-01-04 - 摘要：Objective : To prepare silybin gelatin microsphere, and evaluate its in vitro release performance. Method : Silybin gelatin microsphere were prepared by emulsion chemical cross-linking method.Based on result of single-factor test,preparation technology was optimized by orthogonal test.And studies on particle size,shape,in vitro release characteristics and preliminary stability. Result : The microsphere were round and smooth.Average particle size was(1.45±0.27)μm,drug loading rate was(56.24±3.17)% and average entrapment was(79.54±5.07)%.Drug release in vitro profile could be described by Higuchi equation Q = 15.627 5t1/2-1.502 8 ( r = 0.998 5).The microsphere was stable at room temperature for 3 months. Conclusion :In this study,silybin gelatin microsphere was preliminary stable,its in vitro release characteristics conformed with characteristics of sustained-release formulations.关键词：silybin;gelatin microsphere;in vitro release
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发布时间：2024-01-04 - 摘要：Objective : To investigate factors of the content of hesperidin from Huoxiang Zhengqi solution,and improve transfer rate of hesperidin. Method : Transfer rate of hesperidin in different factors was determined by HPLC. Result : Controlled size of Citrus reticulata under 10 mm, soaked with 70% ethanol at 60 ℃,and concentrated below 65 ℃, transfer rate of hesperidin was highest. Conclusion: This method could effectively improve transfer rate of hesperidin, and ensure the content of hesperidin from finished product.关键词：Huoxiang Zhengqi;hesperidin;transfer rate
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发布时间：2024-01-04 - 摘要：Objective :To develop efficient and rapid of paeonol self-emulsifying drug delivery system,improve onset time and bioavailability. Method :Selected appropriate oil phase,emulsifier,cosurfactants,drew pseudoternary phase diagram on this basis.Determined optimum formulation and prepared tablets by screening proportion of formulations,combining drug loading of prescription and stability of microemulsion.Investigated size,shape and in vitro dissolution condition of emulsified microemulsion. Result :Optimum prescription was as follows:octyl decyl acid triglycerate, cremophor EL and propylene glycol were screened as oil phase, emulsifier and co-emulsifier respectively.The percentage of paeonol was 30% in co-emulsifier. Dissolution of self-emulsifying tablets reached 80% in 20 min. Conclusion :Advantages of developed self-emulsifying tablets were small size,high drug loading,stable,and could significantly improve in vitro dissolution.关键词：paeonol;self-emulsifying;pseudoternary phase diagram;drug loading
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发布时间：2024-01-04 - 摘要：Objective : To establish a reliable and useful method for assessment of the quality of Flos Genkwa from different habitats. Method : Flos Genkwa from different habitats were analyzed by HPLC-DAD chromatographic fingerprint, some characteristic peaks were identified preliminarily based on the MS spectra and literature data. Results : Sixteen main characteristic peaks were selected from the fingerprint spectrum of 21 batches of samples, ten constituents of which were preliminarily identified as flavonoids and flavonoid glycosides. Conclusion : The method is valuable for quality control of Flos Genkwa.关键词：Flos Genkwa;HPLC;fingerprint;ESI-MS analysis
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发布时间：2024-01-04 - 摘要：Objective :To explore the effects of different extracts from Cibotium barometz on proliferation of Osteoblasts.To compare the effects on proliferation of osteoblasts between crude and processed products,to explore the mechanism of anti-osteoporosis for C. barometz. Method :Osteoblasts with petroleum ether layer extract,chloroform layer extract,ethylacetate layer extract,butanol layer extract and polysaccharide from crude and processed products of C. barometz were cultured respectively. Meanwhile, after the rats were fed with each layer extract, the rat serum together with osteolastes was cultured. The proliferation was tested by MTT method. Result :In the different extract with osteoblasts test and the rat serum with osteoblasts test, the butanol layer extract had the most significant effect on cell proliferation of osteoblasts. And the effect of the processed product was more significant than that of crude product. Conclusion :The butanol layer extract from processed products of C. barometz had the most significant effect on cell proliferation of Osteoblasts.关键词：Cibotium barometz;osteoblasts;osteoporosis;MTT
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发布时间：2024-01-04 - 摘要：Objective: To compare the content of liquiritin in Sini traditional decoction,the granules and the ingle-flavor granules. Method :To determine the content of liquiritin by HPLC method Diamonsil C18 column (4.6 mm×150 mm, 5 μm)was, used, the mobile phase of acetonitrile-0.1% acetic acid-water(20 ∶80). The flonrate was 0.7 mL·min-1 and the detection wave length was at 276 nm. The tem perature of colcomn was 25 ℃. Result :The content of liquiritin was 31.13 mg in traditional decoction,48.48 mg in the granules and 31.95 mg in the ingle-flavor granules in a prescription. Conclusion :The content of liquiritin is significantly different formulations,which can provide the scientific basis for further research of Sini decoction type.关键词：Sini Decoction;liquiritin;HPLC
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发布时间：2024-01-04 - 摘要：Objective :To establish a microwave-assisted extraction method for the extraction of the astilbin from Smilax glabra. Comparison of the determination of astilbin from Smilax glabra between microwave-assisted extraction and Chinese pharmacopeia method. Method :Dikma Diamonsil C18 column(4.6 mm×150 mm,5μm)was used. The mobile phase of methanol-0.1%acetic acid-water (39 ∶61). The temperature of column was 30 ℃. The flow rate was 1.0 mL·min-1 and the detection wavelength was at 291 nm. Result :Microwave extractive time was 10 min,the temperature was 60 ℃,the extraction solvent was 60%ethanol. The calibration curve was in good linearity with in the range from 0.04 to 0.8 μg(r=0.999 9). The average recovery was 99.80% (n=6). Conclusion :The method is simple,rapid,as well as precise and reliable,and can be used for the determination of astilbin from Smilax glabra.关键词：microwave-assisted extraction;Smilax glabra;astilbin;determination
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发布时间：2024-01-04 - 摘要：Objective: To establish a method for determining polysaccharides in Cibotium barometz,then compare different place of production the content of polysaccharides in Cibotium barometz and its processed product. Method : The content of the polysaccharides in Cibotium barometz was determined by phenol-sulfuric acid method, and calculated using a conversion factor, and the determination of the wavelength was 489 nm. Result : The glucose concentration value C and absorbance A were linear in the range of 2.46-14.79 mg·L-1(r=0.999 5),The average recovery was 98.7％,RSD 1.48％.The content of polysaccharides in Cibotium barometz from various cultivation locations varied from 2.48%-10.06%,and 5.56%-15.17% in its processed product. Conclusion : The method is simple, effective and feasible. It can be used for the determination of the content of polysaccharides in Cibotium barometz. The content of polysaccharides in Cibotium barometz which were collected at Fujian City was the highest.There is great diference in polysaccharides content in Cibotium barometz from various cultivation locations,and the content of polysaccharides was increased after processed.关键词：Cibotium barometz;processing;polysaccharides;content determination
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发布时间：2024-01-04 - 摘要：Objective : To establish the quality standard of Sare Shisanwei Pengniao Pills. Method: Radix Auckland iae, Rhizoma Acori Calami, Lignum aquilariae Resinatum, Radix et Rhizoma Glycyrrhizae, Moschus were identified by TLC. Gallic acid content in Fructus Chebulae was determined by HPLC. Result: The gallic acid showed good linear relationship (r = 0.999 7) in the range of 0.242 5-3.637 5 μg.The average recovery was 99.31% with RSD 1.80%(n = 9). Conclusion This method has a strong specificity,high sensitivity and can be used in quality control of the Sare Shisanwei Pengniao pill.关键词：Sare Shisanwei Pengniao pills;gallic acid;TLC;HPLC
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发布时间：2024-01-04 - 摘要：Objective: To prepare breviscapine gel and use scutellarin content and pH as the major effective index to establish an accurate method for its quality control. Method : The gel was prepared by taking breviscapine as main component and carbopol as materia1.Valuation the gel with appearance and pH. The content of the component in the gel was determined by HPLC. Result : The properties is stabilization, pH between 6.00-7.00 all in line with the rules of The Pharmacopoeia of PRC(2010), content of scutellarin in breviscapine gel is above 8 mg·g-1. Moreover, the gel was uniformity and stability. Conclusion : The method is simple,reliable and accurate, and can be used for the quality control of breviscapine gel.关键词：breviscapine gel;scutellarin;HPLC;quality control;stability
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发布时间：2024-01-04 - 摘要：Objective: To determine content of adenosine in Dioscorea opposita from the various cultivation areas. Method : A SunFire C18 Colum (4.6 mm×250 mm,5 μm) was used with Methanol- phosphate buffer(15 ∶85)as the mobile phase. The detective wavelength was set at 260 nm and the flow rate was 1.0 mL·min-1. Result: Ten batches of the samples were analyzed. The content of adenosine ranged from 0.035 9-0.104 0 mg·g-1. Conclusion : The method was simple, reproducible and reliable. It can be used to control the quality of D. opposita.关键词：HPLC;Dioscorea opposita Thunb;adenosine
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发布时间：2024-01-04 - 摘要：Objective: To analyze the chemical constituents of volatile oil from the leaves of Illicium verum.in Rongxian. Method : The volatile oil was extracted from the leaves by ultrasonicwave assisted steam distillation. The constituents of volatile oil were identified by GC-MS technology. Result: The yield of the collected oil of the leaves was 1.65%. Relative content of volatile oil was determined by peak area normalization and 35 kinds of chemical constituents were identified accounting for 98.08% of its total content. Conclusion: The principal chemical constituents of the essential oils are trans-anethole(71.69%), estragole (5.00%), α-pinene (3.52%), cis-anethole (2.86%), caryophyllene (1.56%), limonene (1.37%), linalool (1.29%).关键词：leaves of Illicium verum;volatile oil;GC-MS;components analysis
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发布时间：2024-01-04 - 摘要：Objective: Using HPLC method to investigate the four main ingredients including curdione,curcumol,germacrone and β-elemene,in different processing, storage products of Curcuma wenyujin. Method : Kromasil C18 column(4.6 mm×250 mm,5 μm)was adopted by agradient elution with acetonitrile-water as the mobile phase, the flow rate was 1 mL·min-1. The detection wavelength was at 214 nm,column temperature was at 25 ℃. Injection volume was 10 μL. Result : The content of curdione,curcumol,germacrone and β-elemene in fresh C. wenyujin were 0.001 201%,0.039 760%,0.061 458%,1.313 8%;in the new processed products were 0.000 711%,0.054 358%,0.007 630%,0.439 7%;in the storaged ones were 0.001 168%,0.113 253%,0.016 493%,0.512 7%. Conclusion : The content of β-elemene, curdione and germacrone in fresh C. wenyujin were obviously higher than the new processed products and the storaged one. The processing and storage process have some influence on the four ingredients in C. wenyujin.关键词：Curcuma wenyujin;processing;storage;HPLC
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发布时间：2024-01-04 - 摘要：Objective: To determine atractylodin in ermiao pill to provide scientific basis for its quality control. Method :A kromasil C18 (4.6 mm×150 mm,5 μm) liquid chromatographic column was used. The mobile phase was alcohol -water.Walvelength was at 340 nm. Result :The linear range of atractylodin was within 42.2-675.0 mg·L-1(r=0.999 7), sample recovery rate was 99.18%, RSD 1.49%. Conclusion :This method has good repeatabilityand flexibility. It can be used for quality control in production of ermiao pill.关键词：Ermiao pill;atractylodin;HPLC
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发布时间：2024-01-04 - 摘要：Objective : To study the difference in fingerprints and chromatographic peak area of different batches of Huanglian Shangqing pills from different manufacturers. Method: HPLC was used to compare the difference of characteristics fingerprints of different batches of Huanglian Shangqing tablets from different or same manufacturers. The similarity was analyzed with the similarity evaluation software. Result: There were big differences in the number of peaks and peak area of Huanglian Shangqing tablets from different manufacturers. The number of peaks of different batches of Huanglian Shangqing tablets from the same manufactures were almost similar, while the contents of them existed a certain difference. Relative to the different manufacturers, the difference of the content of different batches of Huanglian shangqing tablets was smaller among the same manufacturers. Conclusion : The variation of fingerprint of Huanglian Shangqing tablets is relatively obvious among different manufacturers, but the quality of Huanglian Shangqing tablets from the same manufactures is basically stable at a certain level.关键词：Huanglian Shangqing tablets;HPLC;fingerprints;Anthraquinone;quality control
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发布时间：2024-01-04 - 摘要：Objective : To establish a method for determing diosgenin in Tongfengning mini-pill. Method : HPLC deternination of Diosgenin in Tongfengning mini-pill. Column: Agilenttc SB-C18 (4.6 mm×250 mm, 5 μm),mobile phase was acetonitrile-water (10 ∶90), flow rate 1.0 mL·min-1, column temperature: 17 ℃, detection wavelength was 203 nm. Result : Diosgenin in 1.000-5.000 μg range and peak area was linear regression,r=0.999 7, the average recovery was 101.95%, RSD 0.08%. Conclusion : The method is simple and reproducible for the determination of diosgenin in decoction of Tongfengning mini-pill by HPLC.关键词：HPLC;Tongfengning mini-pill;diosgenin;determination
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发布时间：2024-01-04 - 摘要：Objective :To establish an UPLC-MS method for the determination of medicinal ingrediants in Clindamycin Phosphate Glucose injection sterilized with high temperature. Method : LC condition: Adopted Acquity UPLC BEH C18column(2.1 mm×50 mm,1.7 μm, eluted gradiently with mobile phase consisted of acetonitrile and 0.02 mol·L-1 ammonium acetate buffer solution adjusted pH 3.0 with acetic acid)at a flow rate 0.25 mL·min-1.MS condition, adopted electrospray ionization(ESI),and multiple reaction monitoring. Result :Clindamycin phosphate,clindamycin and lincamycin were detected in the clindamycin phosphate glucose injection sterilized with high temperature, and clindamycin is the maxest impurity. Conclusion :This method is selectivity and sensitive,it is suitable for detection of the medicinal ingrediants in clindamycin phosphate glucose injection sterilized with high temperature.关键词：clindamycin phosphate glucose injection;sterilized with high temperature;clindamycin;lincamycin;UPLC-MS
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发布时间：2024-01-04 - 摘要：Objective :To establish the quality standard for Qianqu. Method :Radix et Rhizoma Rhei, Radix aucklandiae and Fructus Aurantii immaturus were identified by TLC.Strychnine was determinated by HPLC,and chromatographic conditions was as follows: column of Dikma Diamonsil C18(4.0 mm×250 mm,5 μm),mobile phase consisting of acetonitrile-0.02% H3PO4(19 ∶81),flow rate of 1mL min-1,and detection wavelength of 283 nm. Result :The characteristic identification by TLC was distinct and highly specific. Strychnine showed a good linear relationship at a range of 10.568-528.4 mg·L-1(r=0.999 98),the average recovery was 100.18%(RSD 2.73%),precision with RSD of 0.37% (n=6),repetition with RSD of 0.88% (n=6)and stability with RSD of 0.70%. Conclusion :The method is reliable,accurate,specific and can be used for quality control of the production.关键词：Qianqu;hesperidin;HPLC;Radix et Rhizoma Rhei;Radix Aucklandiae;TLC
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发布时间：2024-01-04 - 摘要：Objective :To establish a method for simultaneously determining geniposide and baicalin in Fangfengtongsheng pill. Method :A double wavelength RP-HPLC method was developed. The analysis was performed on a Hibar C18 column (4.6 mm×150 mm,5 μm)with gradient elution using acetoniterile-0.2% phosphoric acid, the flow rate was 1.0 mL·min-1. Geniposide and baicalin were detected at 240 nm and 278 nm respectively. The column temperature was 30 ℃. Result :The calibration curves of geniposide and baicalin showed good linearity in the ranges of 0.16-0.8 μg and 0.24-1.2 μg. The average recoveries were 96.0% and 100.7% with RSD of 2.96% and 2.86%. Conclusion :The method is simple, accurate and reproducible for simultaneous determining geniposide and baicalin in Fangfengtongsheng pill.关键词：RP-HPLC;Fangfengtongsheng pill;geniposide;baicalin
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发布时间：2024-01-04 - 摘要：Objective: The method of HPLC was established for the quality control of Chrysanthemum morifolium. Method : The scopoletin was performed on a column C18 with a mobile phase of MeOH-NaH2PO3(15.6-1 000 mL,pH 2.7), flowrate was 1.0 mL·min-1, detected at 328 nm. Result : The calibration curve was linear(r=0.999 9) within the range of 0.2-1.0 mg·L-1 for chlorogenic acid. The average recovery was 98.78% and RSD is 0.97% (n=6) The method was simple and accurate. Conclusion : The method of high performance liquid chromatography can be used for the quality control of C. morifolium.关键词：HPLC;Chrysanthemum morifolium;chlorogenic;acid content determination
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发布时间：2024-01-04 - 摘要：Objective :To investigate the changes of chemical compositions before and after the compatibility of Ramulus Cinnamomi and Rhizoma Zingiberis in order to explore the effective material base through.comparative study on supercritical fluid extraction and steam distillation in extracting chemical constituents and relative contents of the volatile oil from the compatibility of Ramulus Cinnamomi and Rhizoma Zingiberis. Method: Using supercritical fluid extraction and steam distillation, chemicals in Ramulus Cinnamomi, Rhizoma Zingiberis and herbal pair Ramulus Cinnamomi-Rhizoma Zingiberis were extracted. The chemicals were indenified before and after mixing the medicines by using GC-MS. The changes in the mixture were summerized and recorded. Result: The mass percentage of extractions from Ramulus Cinnamomi, Rhizoma Zingiberis, and the herbal pair by SFE-CO2 were 0.69%, 3.66%, 1.82%, respectively, and 44, 57, and 65 chemical components were identified from the three extractions. The identified components were 84.22%, 91.25%, and 90.13% of the extractions, respectively. Though steam distillation, the mass percentage of collected volatile chemicals were 0.25%, 1.75%, 1.05% from Ramulus Cinnamomi, Rhizoma Zingiberis, and the herbal pair. 19, 50, 57 chemical components were identified. The identified components were 85.35%, 93.47%, and 93.11% of the extractions, respectively. Conclusion : The compatibility of Ramulus Cinnamomi and Rhizoma Zingiberis can promote dissolution of the chemicals in the medicines, and the compatibility is not in simple mixture of the components, and extraction efficiency by SFE-CO2 is higher than that by steam distillation.关键词：Ramulus Cinnamomi(RC);Rhizoma Zingiberis(RZ);GC-MS;steam distillation;supercritic fluid extraction
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发布时间：2024-01-04 - 摘要：Objective : To study the chemical constituents from Kalopanax septemlobus and to obtain a more understanding of its active principles. Method: Compounds were extracted with 80% ethanol and isolated by column chromatography on silica gel, ODS and prepared with HPLC; the structures were identified by spectroscopic analysis (1H NMR,13C NMR and EIMS). Result: Seven compounds were obtained and identified as 3-O-α-L-arabinopyranosyl-28-O-α-L-rhamnopyranosyl-(1→4)-O-β-D-glucopyranosyl-(1→6)-O-β-D-glucopyranosyl ester of hederagenin (Ⅰ), kalopanaxsaponin I (Ⅱ), 3-O-α-L-rhamnopyranosyl-(1→2)-O-α-L-arabinopyranoside-28-O-β-D-glucopyranosyl-(1→6)-O-β-D-glucopyranosyl ester of hederagenin (Ⅲ), kalopanaxsaponin B (Ⅳ), liriodendrin(Ⅴ),2-methoxyhydroquinone 4-O-[6-O-(4-O-α-L-rhamnopyranosyl)-syringyl]-β-D-glucopyranoside (Ⅵ), syringin (Ⅶ). Conclusion : Compound Ⅰ, Ⅲ, Ⅴ, Ⅵ were obtained from this cdrus plant for the first time.关键词：Kalopanax septemlobus;chemical constituents;saponin
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发布时间：2024-01-04 - 摘要：Objective : To investigate pharmacokinetics of panax notoginseng saponins (PNS) enteric pellets in Beagle dogs and study correlation between in vivo absorption and in vitro release of PNS enteric pellets. Method : Two-cycle crossover test design was used,six Beagle dogs oralled self-made PNS ordinary capsules or self-made PNS enteric pellets(capsule mode),and determined plasma concentration by HPLC,calculated pharmacokinetic parameters.Then compared bioavailability,adopted linear regression of in vitro cumulative release percentage and in vivo cumulative absorption. Result: Bioavailability of Notoginsenoside R1, Ginsenoside Rb1and Ginsenoside Rg1 in PNS enteric pellets were 520.56%, 367.70% and 251.66% respectively. Their mean residence time was longer than referenced preparation in vivo. Correlation coefficient of R1, Rb1 and Rg1 were 0.784 9, 0.877 2 and 0.691 2 respectively. Conclusion : Bioavailability of PNS enteric pellets was higher than PNS capsule. There was a bad correlation of R1, Rb1 and Rg1 between in vivo absorption and in vitro release in pH 6.8 buffer liquid.关键词：panax notoginseng saponins;enteric pellets;pharmacokinetics;correlation in vivo and in vitro;bioavailability
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发布时间：2024-01-04 - 摘要：Objective :To study the metabolism of Gegen Qinlian dispensing granule in rat. Method : The urine samples containing metabolites of Gegen Qinlian dispensing granule were analyzed by HPLC-DAD-MS. Chromatographic systemwas composed of lichrospher C18 column (4.6 mm×250 mm, 5 μm), 0.1% formic acid (A)-acetonitrile ∶methanol(6 ∶4)(B) as the mobile phase, detection at 272 nm; ESI source, positive and neglative mode. Result: Eleven components were identified as puerarin -glucoside, scutellarein-6-O-glucoside, puerarin, 3' -methoxypuerarin, 7-xylosidepuerarin, daidzein-4'-O-sulfate, Baicalein-6, 7-O-diglucuronide, isoliquiritigenin, liquiritigenin, wogonin, oroxylin A. Conclusion: Metabolites of Gegen Qinlian dispensing granule in rat were conjugated to glycuronic acid and sulphuric acid or excreted as aglycone, some components such as puerarin were mainly excreted unchanged in the urine.关键词：Gegen Qinlian dispensing granule;metabolite;HPLC
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发布时间：2024-01-04 - 摘要：Objective: To study the influence of Aidi injection on pharmacokinetics of ifosfamide(IFO) in rabbit providing evidence for rational and safe application. Method: The experiment was designed in a randomized cross-over study. The control group was given ifosfamide and NS,and the test group was given ifosfamide and Aidi. Plasma sample was treated with the C18 solid phase extraction column,then concentrationof ifosfamide was determined by HPLC. The pharmacokinetic parameters and bioequiabailability of two groups were analyzed. Result: The main pharmacokinetic parameters of the control group and experimental group were as follows: AUC0-∞ were (140.53±39.26), (120.02±25.89)mg·L-1·h-1,AUC0-t were (128.37±34.2), (119.18±25.51) mg·L-1·h-1,Cmax were(158.63±16.35), (132.61±21.07) mg·L-1. The relative bioabailability of the test group were that F0-∞ was (91.13±34.50)%,F0-t was (97.62±32.59)%. The result of statistical analysis showed that there was no bioequibalence between the control and the test groups and the latter was smaller. Conclusion: The pharmacokinetics of ifosfamide is belong to two compartments model. When ifosfamide and Aidi are administered to the rabbits,the bioavailability of ifosfamide is reduced significantly, which may suggest that the drug metabolism of ifosfamide can be affected significantly. In addition, Aidi injection can decrease the concentration of IFO in rabbits significantly, so the effect of IFO can be attenuated probably.关键词：ifosfamide;Aidi injection;HPLC;pharmacokinetics;bioavailability
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发布时间：2024-01-04 - 摘要：Objective : To observe the effects of Youguiyin decoction on the mice with Kidney-Deficiency Syndrome in protein expression level. Method : Kunming male mice were randomly divided into three groups as follows: the kidney-deficiency model group, the Youguiyin group (5.6 g·kg-1 daily for 2 months)and the youth normal group. The proteins in liver,kidney,testis tissue and serum of the mice were separated and analysed by two-dimensional gel (2-DE) to find the proteins regulated and corrected by Youguiyin. These proteins were identified by mass spectrograph. Result : Tenty two regulated and corrected protein spots were detected, and 17 proteins spots were identified. Conclusion : This paper screens and identifies 17 proteins regulated and corrected by Youguiyin decoction.关键词：Youguiyin decoction;kidney deficiency syndrome;proteomics
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发布时间：2024-01-04 - 摘要：Objective : To investigate the vascular effects of extracts from leaves of Apocynum venetum (ELA) and its mechanisms. Method : Phenylephrine(PE) was used to contract isolated rat thoracic aorta. Concentration relaxation curve of ELA (1× 10-6-3×10-3 g·mL-1) was constructed in cumulative doses manner. Moreover, vasodilator effects of ELA were re-determined after pre-incubated with several antagonists. Result : ELA showed significant vasodilator properties. At low concentration, vascular effects of ELA were inhibited by hemoglobin, methylene blue(MB), NG-nitro-L-arginine methyl ester (L-NAME) and S-methylisothiourea sulfata (SMT). At high concentration, Ca2+-induced contraction was suppressed by ELA. In addition, the K+ channel blocking agents tetraethylammonium (TEA), 4-aminopyridine (4-AP) and glibenclamide (GLB) inhibited the vasodilator responses of ELA. Conclusion : ELA showed vasodilator effects with property of endothelium-dependency at low concentration and endothelium-independency at high concentration. At low concentration, the vasodilator response of ELA was related to the release of NO, but at high concentration, this action may be associated with Ca2+ and K+.关键词：extracts from leaves of Apocynum venetum;thoracic aorta;vasodilator effects
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发布时间：2024-01-04 - 摘要：Objective : To investigate the applicability of the detection of bacterial endotoxin in five kinds of traditional Chinese medicine injections by nonspecific and specific tachypleus amebocyte lysate(TAL) of kinetic turbidimetric assay. Method: Yuxingcao, Shuanghuanglian, Qingkailing, Gegensu, and Xiangdan injections were detected by nonspecific and specific TAL lysate of kinetic turbidimetric assay. Result: There were less interferences during detective process of achromaticity injections such as Yuxingcao and Gegensu, on the other hand, there were more interference of multi-component and dark color such as Shuanghuanglian, Qingkailing, and Xiangdan injections using TAL of kinetic turbidimetric assay, interference was big and the result was instable. The interference could be removed effectively by using specific TAL of kinetic turbidimetric assay, such as the case of Qingkailing. However, the interference for shuanghuanglian, Xiangdan injections could not be eliminated interference using this method. Conclusion : It is feasible to perform the bacterial endotoxin test on Yuxingcao and Gegensu injection using normal TAL and specific TAL through kinetic turbidimetric assay, using specific TAL of kinetic turbidimetric assay as a substitute for nonspecific is a effective method in removing the interference for Qingkailing injection, the detection result of Shuanghuanglian and Xiangdan injection are instable.关键词：Detection of bacterial endotoxin;kinetic turbidimetric assay;specific tachypheus amebocyte lysate;traditinal Chinese medicine injections
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发布时间：2024-01-04 - 摘要：Objective : To study the anti-inflammatory and analgesic effects of extracts from the leaves of Nauclea officinalis Pierre ex Pitard (ELN). Method : ICR mice were divided into 7 groups randomly, namely normal group, model group(0.39 g·kg-1), Sanqi Shangyao pian group (1.56 g·kg-1), aspirin group, Danmu Jingao pian group and ELN(0.390,0.195,0.098 g·kg-1)groups. Each drug was administrated to mice orally once a day for 3 days. 1 h after the last administration, analgesic and anti-inflammatory effects were observed by methods of hot-plate, acetic-acid induced writhing, xylene-induced ear edema and acetic acid-induced peritoneal capillary permeability, respectively. The model of carrageenin-induced paws edema in rats were also selected to observe the anti-inflamatory activity 1 h after the last administration of ELN(0.195,0.098,0.049 g·kg-1). Contol group, model group and Danmu Jingao pian group (0.78 g·kg-1) were parallelly setted. Drugs was administrated to rats orally once a day for 3 days before determination. Result : ELN (the content of its main constituent strictosamide is about 16%) could prolong the latent period of pain and decrease the number of writhing induced by acetic acid markedly. The permeability increase of blood capillary induced by acetic acid in mice, the swelling of ear induced by xylene in mice, as well as the edema of paw induced by carrageenin in rats were also significantly inhibited by ELN respectively. Additionally, the amounts of prostaglandin E2(PGE2) in the inflammatory diffusate induced by carrageenin were significantly reduced. Conclusion : ELN has significant analgesic and anti-inflammatory activities which may correlate with the inhibition of production and relase of PGE2.关键词：Nauclea officinalis;anti-inflammatory;analgesic;prostaglandin E2
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发布时间：2024-01-04 - 摘要：Objective: To study the antipyretic effect and the mechanism of gentianine by comparing with variances of the antipyretic effect among from water extract of Gentianae Radix Et Rhizoma, gentianine and gentiopcroside. Method: The rat febrile models induced by injecting fresh yeast subcutaneously and treated with gentianine,gentiopcroside intraperitoneally and fed with water extract of Gentianae Radix Et Rhizoma, then the rectal temperature was monitored to show the differences of effect from those groups. The contents of tumor necrosis factor(TNF-α),interleukin-1(IL-1),interleukin-6(IL-6) in blood serum and cyclic adenosine monophosphate (cAMP),prostaglandin E2 (PGE2) in the hypothalamus were measured by radioimmunoassav (RIA),respectively. Result: Three drug administration groups(including gentianine, gentiopcroside and water extract of Gentianae Radix Et Rhizoma)showed marked antipyretic effect on the yeast-induced fever(P<0.05) and the effects were stronger on the getianine group than other treated groups.Each treatment group showed remarkable decreased the contents of IL-6 in blood serum and PGE2 in the hypothalamus of febrile rats. Conclusion: Gentianine, gentiopcroside and water extract of Gentianae Radix Et Rhizoma all have obvious antipyretic effect, but the effect of gentianine is strongest of them and probably plays a more direct role in the antipyretic effect from Gentianae Radix Et Rhizoma,which might be related with decreasing the levels of IL-6 in serum and the interferencing the content of PGE2 in the hypothalamus.关键词：getianine;gentiopcroside;fresh yeast;Antipyretic effect
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发布时间：2024-01-04 - 摘要：Objective :To investigate the effects of Aucklandia lappa,bran-roasted products and the two active monomer on gastrointestinal motility in mice. Method : The normal mice were randomly divided into nine groups in average: blank control group, mosapride control group,Jianwei Xiaoshi pian control group, the raw and bran-roasted A.lappa group (5,10,20 g·kg-1 ).The blank control group was given distilled water and the other groups were given appropriate extracts by intragastic admistration once a day for two weeks. The mice with reserpine induced were divided into fifteen groups:blank control group, model control group, Mosapride control group, the raw and bran-roasted A.lappa group (5,10,20 g·kg-1 ),costunolide group (1.25,2.5,5.0 mg·kg-1)and dehydrocostuslactone group (2.5,5.0,10.0 mg·kg-1). The blank control group were injected distilled water subcutaneously,the other groups were given reserpine by subcutaneous injection. The blank and model control groups were given distilled water. mosapride control group, the raw and bran-roasted A. lappa group (5,10,20 g·kg-1 )were given appropriate extracts by intragastic admistration (20 mL·kg-1),costunolide and dehydrocostuslactone groups were injected(5 mL·kg-1) intraperitoneally for two weeks. Charcoal as a marker was orally administered to determine the propulsive function of small intestine and gastric emptying. Result : The results of gastric emptying and intestine propulsion experiments in normal mice suggested that the effects of the raw and bran-roasted A. lappa on gastric emptying is not significance. The raw materials (10, 20 g·kg-1 ) promoted the intestine propulsion(P<0.05). The bran-roasted products(5,10 g·kg-1),costunolide and dehydrocostuslactone had significance effects on gastric emptying for the reserpine treated mice, the raw materials and costunolide(5 mg·kg-1)promoted the intestine propulsion for the reserpine treated mice(P<0.05). Conclusion : The raw A. lappa has effective in the promoting the circulation of qiand is benefit for spleen deficiency,the active conponent costunolide plays an important role especially.关键词：Aucklandia lappa;gastric emptying;intestine propulsion
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发布时间：2024-01-04 - 摘要：Objective : To study relationship between ‘pungent dispersing bitter evacuant’ antiasthmatic effect and the chemical split fraction of Ephedrae Herba and to provide scientific evidence for the verification of the new assumption on the theory of properties and flavors of Chinese medicine ‘one herbal contains X flavors and Y properties (Y≤X)’. Method :Equal volume of acetylcholine chloride and histamine phosphate solution were used to induce abnormalism asthma in guinea, and water decoction(775 mg·kg-1), alkaloids fraction(7.8 mg·kg-1), naphtha fraction(3.87×10-4 mL·kg-1), polysaccharide fraction(45.6 mg·kg-1), phenolic acids fraction(36.4 mg·kg-1), alkaloids and polysaccharide fraction(7.8 mg·kg-1+45.6 mg·kg-1) were given The latent period of asthmatic convulsion was observed The effects of water decoction fraction, alkaloids fraction, naphtha fraction, polysaccharide fraction, phenolic acids fraction on spasm tracheal smooth muscle caused by histamine and acetylcholine in guinea was observed. Result : Compared with blank control group, water decoction, alkaloids fraction and polysaccharide fraction inhibited abnormalism asthma occurrence(P<0.01), Compared with water decoction,alkaloids fraction and polysaccharide fraction showed significant difference(P<0.05). Compared with water decoction, alkaloids fraction compatibility with polysaccharide fraction according to the former proportion, there was no significant difference. Compared with blank control group, water decoction and alkaloids fraction take the effect to normal tracheal strips from guinea body showed significant difference(P<0.05); water decoction, phenolic acids fraction, alkaloids fraction and naphtha fraction take the effect to spasticity tracheal strips caused by histamine showed significant difference(P<0.01,P<0.05); water decoction and alkaloids fraction showed significant difference(P<0.01)to spasticity tracheal strips caused by acetyl choline. Conclusion : Ephedrae Herba has significant antiasthmatic effect, and it is the comprehensive embodiment of ‘Pungent, Bitter’, Material base are alkaloids fraction, naphtha fraction, phenolic acids fraction and polysaccharide fraction from the chemical split fractions of Ephedra, among them alkaloids fraction is the material base of ‘Flavor Pungent Property Warm’, and naphtha fraction, phenolic acids fraction and polysaccharide fraction are the material base of ‘Flavor Bitter’.关键词：Ephedrae Herba;pharmacology of property and flavor;chemical split fractions;Pungent Dispersing Bitter Evacuant;antiasthmatic effect
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发布时间：2024-01-04 - 摘要：Objective : To investigate the protective effects of Naoerkang(NEK) on Alzheimer disease (AD) mince induced by chronic Al(AlCl3) toxicity involved in regulating protein expression of amyloid precursor protein(APP) and β-amyloid(Aβ). Method : Sixty male mice were randomly divided into normal control group, model group,piracetam group,low-dose NEK group,medium-dose NEK group,and high-dose NEK group,with 10 mice in each group, AlCl3(100 mg·kg-1) were injected into abdominal cavity in mice to establish AD model whereas the normal control mice were injected with same volume of saline for comparisom.The mice in the NEK groups were intragastrically treated respectively with high,medium and low dose(1.36,0.68,0.34 g·mL-1) NEK for 50 days consecutively; piracetam(10 g·mL-1) was intragastrically administered to mice in the piracetam group; and normal saline was applied in the control and model groups. Jumping stand was used to examine their abilities in learning and memory. The positive protein expression of APP and Aβ in cortex and hippocampal region of the mice in each group were detected by immunohistochemistry, and the results were analyzed by gray scale adopting Qwin550CW images and signals cllection and analysis system. Result : Compared with the control group,the Latent Period of memory was shortened significantly (P<0.01),while that of learning had been prolonged obviously (P<0.05)and the times of mistakes for learning and memory increased significantly (P<0.01) for the mice of the model group. Compared with the model group,the Latent Period memory in the groups treatment with drug shortened significantly (P<0.01),while that of learning had been prolonged obviously (P<0.05)and the Frequency of Error for learning and memory had been increased evidently(P<0.01). The expressions of APP,Aβ in cortex and hippocampus had been increased significantly(P<0.05 orP<0.01) for the mice of the model group,and it had shown a more obvious reduction campared with the group using Naoerkang (P<0.01). Conclusion : Naoerkang can ameliorate the AD induced by Aβ, the mechanism maybe involve in regulating APP and Aβ.关键词：Naoerkang;Alzheimer’disease;amyloid precursor protein;β-amyloid;anti-dementia
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发布时间：2024-01-04 - 摘要：Objective : To explore JAK-STAT cell signaling pathways adjusting by Gualou Xiebai Banxia decoction precinditioning in myocardial ischemia reperfusion injury. Method :Sixty male SD rats were randomly divided into blank control (A) group, ischemia /reperfusion (B) group (I/R), ischemia preconditioning (C) group (IPC), GXBD pretreatment (D) group, AG490 processing (E) groups, there were 8 rats in each group. Ligation of the left anterior descending coronary artery for 30 minutes and 90 minutes reperfusion was performed, to make myocardial ischemia reperfusion injury, A, B, group were were given physiological saline, group D and E were treated with 4.95 g·kg-1 doses of GXBD and 2 mg·kg-1 dose of AG490.before 1 h of modelling. The serum adenosine (Ado) and gentle shock peptide (BK) level were measured, myocardial infarction area and JAK2, STAT3 protein expression of the myocardial tissue were detected. Result : The serum Ado and BK level in the model group and AG490 group were significantly decreased (P<0.05), myocardial infarction area expanded significantly (P<0.01), JAK2, STAT3 protein expression significantly reduced (P<0.05); GXBD group and the IPC group could make Ado, BK, JAK2, STAT3 level significantly increased (P<0.05), myocardial infarction area reduced significantly (P<0.01). Conclusion: GXBD can raise the protein expressionof JAK2, STAT3, Adoand BK level and reduce myocardial infarction area to protect ischemia-reperfusion myocardial injury.关键词：Gualou Xiebai Banxia decoction(GXBD);myocardial ischemia reperfusion injury;JAK-STAT;adenosine;genthe shock peptide;myocardial infarction area
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发布时间：2024-01-04 - 摘要：Objective :To investigate the protective effects of compatibility of dioscin and borneol on the focal cerebral ischemia in rats. Method :Rats were randomly divided into control group,model control group,groups with prescription 1-6 of compatibility of diosgenin and borneol,compatibility of diosgenin and borneol was based on the method of increase-decrease design method of experiment with baseline geometric proportion. Rats were given medicine of 10 mL·kg-1intragastrically,once a day, lasting 7 days, after 1 h of the last administration, focal cerebral ischemia model was established in rats of the middle cerebral artery,determining neurological behavior score after the rats were awake immediately,TTC staining was used to determine method infarction area and brain water content after 24 h of model . Result :Compared with model group,rescription 2,3 could alleviate neurological score,decrease infarct size,brain water content(P< 0.05,P< 0.01),prescription 1 can reduce neurological score,infarct size and brain water content(P< 0.05),prescription 4,5,6 have no significant differences. Conclusion :The best ratio of dioscin and borneol are 8 ∶2 and 6 ∶4 in terms of protection on focal cerebral ischemia in rats.关键词：dioscin;borneol;focal cerebral ischemia;increase-decrease design method of experiment with baseline geometric proportion
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发布时间：2024-01-04 - 摘要：Objective : To research the effect of Basil capsule on expression of osteopontin(OPN) and inducible nitric oxide synthase(iNOS) for transplanted liver cancer in rat after transcatheter arterial chemoembolization(TACE),and to discussion the effect of basil capsule on hypoxia environmental. Method :Ten days after transplanted rat liver cancer model established, the successful rats model were randomly divided into five groups:without TACE group(A);TACE+ Saline group(B); TACE+ high-dose Basil capsule group(C); TACE+middose Basil capsule group(D); TACE+ low-dose Basil capsule group(E). For B to simulate the heal of TACE and give normal saline 10 mL·kg-1·d-1.For C,D and E to carry out Basil capsules 300, 150, 75 mg·kg-1·d-1ig, A of rats only for abdominal operations, without TACE.Ten days after embolism, the rats were sacrificed and the tumors were taken out and treated with chemoembolization. To demonstrate the expression rate of OPN and iNOS. Result : The expression rate of OPN and iNOS on B were higher than A(P<0.01).The expression rate of OPN and iNOS on C and D were lower than B(P<0.01).The expression rate of OPN and iNOS between D and E were higher than C (P<0.01). Conclusion : Basil capsule can obviously improve hypoxia environmental in local of rat hepatoma and can depress the expression of OPN and iNOS, can inhibit rat liver transplant tumor recurrence after TACE.关键词：Basil capsule;transplanted liver cancer in rat;transcatheter arterial chemoembolization;osteopontin;inducible nitric oxide synthase
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发布时间：2024-01-04 - 摘要：Objective :To observe the effect of sanhuatang on neurological function, brain edema and brain morphology of cerebral ischemia-reperfusion in rat. Method :The rats were randomly divided in sham operation group, model group,low dose group of sanhuatang,large dose group of sanhuatang and nimodipine group every group were medicated once each day and lasted for 7 days. The cerebral ischemia reperfusion model was established by blocking middle cerebral artery of rat with suture method prepare. The score of nervous symptoms in rats was made by Zealonga 5 class. The brain water content was calculated through weighing anhydrous brain and hydrous brain. The pathological changes of brain tissue was analyzed by HE staining. Result: In model group the neurological symptoms were severer than in the sham group(P<0.01),brain water content was significantly higher(P<0.01), swelling, denaturation, necrosis, inflammatory cell infiltration and vasodilator od never cells were observed. In large dose group neurological symptoms of rats was significantly relieved (P<0.05), brain water content were significantly reduced (P<0.01). Conclusion : Sanhua decocotiom can protect injure of cerebral ischemia reperfusion in rats.
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发布时间：2024-01-04 - 摘要：Objective : To observe effects of different extracts from Xiongma decoction on migraine. Method : The mice migraine model was induced by, reserpin and acetic acid was used to induce mice writhing model. Mice were injected 1 mg·kg-1 reserpine to induce migraine model. Mice were randomly divided into amitriptyline group (0.033 g·kg-1), extract group of Xiongma decocotion (1.4, 5.6 g·kg-1), alcohol extract group of Xiongma decoction(1.4, 5.6 g·kg-1), volatile oil group (1.4, 5.6 g·kg-1), which were orally given for 7 days. The level of 5-HT and analgesic effect were observed. Result : The extracts from Xiongma decoction significantly increased 5-HT level (P <0.01). Volatile oil extract can significantly prolong the incubation period of acetic acid induced writhing and twisting frequency (P <0.05). Conclusion : Extracts of Xiongma decoction have a certain effect on mice migraine model and an analgesic effect.关键词：extracts Xiongma decoction;migraine model;analgesic;5-hydroxytryptamine
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发布时间：2024-01-04 - 摘要：Objective :To investigate the effects of astragalus injection on cell cycle and in vitro proliferation of rabbit adipose-derived mesenchymal stem cells (ASCs). Method :ASCs were obtained from an experimental rabbit and cultured. Multi experimental and a control group were designed. Different concentrations of astragalus injection were added to the culture fluid in the experimental group, while a conventional culture method was employed in the control group. The distribution of the cell cycle was measured by flow cytometry and the proliferation rates of ASCs by MTT,and compared between the experimental and the control group. Result :After 24 hours of culture, the number of the cells during the proliferative phase was increased significantly from (65.3±4.8)% for the control group to (72.6±5.7)% for the experimental group, and the differences between each experimental and the control groups were not significant. After 48 hours, the optical density was (2.273±0.100)-(1.983±0.125) in each experimental group at 0.390 6-200 g·L-1 of astragalus, while (1.341±0.424) in the control group, and the differences between each experimental and the control groups were significant (P<0.01), suggesting astragalus at the concentrations within the experimental rang might have big promotion on proliferation of ASCs. Conclusion :Astragalus injection has significant promotion effect on the in vitro proliferation of rabbit ASCs.关键词：Astragalus injection;ASCs;proliferation;rabbit
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发布时间：2024-01-04 - 摘要：Objective : To study the mechanism of anti-fatigue effect by Incarvillea mairei(le’vl) Geireson. Methods : The anti-fatigue function of the ethanol extract of I. mairei was determined by swimming test in mice, and blood lactic acid (LD), serum lactale dehydrogenase (LDH), serum urea nitrogen (BUN),muscle glycogen and liver glycogen were detected. Results : I. mairei could increase the liver glycogen and muscle glycogen content, and enhance the activity of lactic dehydrogenase, while decrease the blood urea nitrogen and blood lactic acid. Conclusion : The I. mairei may improve anti-fatigue ability by influencing blood LD, serum LDH, serum BUN,muscle glycogen and liver glycogen.关键词：Incarvillea mairei;muscle glycogen;liver glycogen;lactic acid;Lactale dehydrogonase;urea nitrogen
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发布时间：2024-01-04 - 摘要：Objective : Guizhi Fuling Wan which inhibited hepatic fibrosis in rats was observed and its possible mechanism of action was explored. Method : According to the random-number table, wistar rats of 60 were divided into control group of 8 (group A) and model group of 52.The control group was injected subcutaneously with normal saline by a dose of 3 mL·kg-1, model group was injected subcutaneously with 40% CCl4 to make rat liver fibrosis model by a dose of 3 mL·kg-1 for the consecutive 6 weeks. And according to the random-number table again, model group rats were divided into the model group(group B) and the treatment group which comprised low dose (group C), middle dose (group D) and high dose (group E). Group A and group B were given normal saline by a dose of 9.0 mL·kg-1. Group C, group D and group E were given Guizhi Fuling Wan by the dose of 0.45, 0.9, 1.8 g·kg-1·d-1respectively, and CCl4 would be maintained subcutaneously during period of 4 weeks. After 4 weeks of treatment, general condition, body weight, liver and spleen weight and their coefficient of rats were compared in each group;rats of pathological changes in each group were determined by naked eye,light microscopy and electron microscopy,rspectively. The protein expression of α-SMA, TGF-β1, CTGF, Co-Ⅰ and Co-Ⅲ was detected by using immunohistochemical stains in each group. The mRNA genetic expression of α-SMA, TGF-β1,CTGF,Co-Ⅰ and Co-Ⅲ was detected by using Real-time quantitative PCR in each group. Result : Immunohistochemical stains and real-time quantitative PCR: In model group, protein and mRNA genetic expression of α-SMA,TGF-β1,CTGF, Co-Ⅰ and Co-Ⅲ was significantly increased in liver tissue (P<0.01, vs control group).All the treatment group could bring down protein and mRNA genetic expression of α-SMA, TGF-β1,CTGF,Co-Ⅰ and Co-Ⅲ in liver tissue of rats. Among the treatment group,group D and group E decreased mRNA genetic expression of α-SMA,Co-Ⅰ and Co-Ⅲ significantly (P<0.05 or P<0.01 vs model group), and Group Elessened protein expression of TGF-β1, CTGF obviously(P<0.05 vs model group). Among the treatment group, group D and group E cut down mRNA genetic expression of α-SMA, TGF-β1, CTGF significantly(P<0.01 vs model group), and group E of all the treatment group reduced evidently genetic mRNA expression of Co-Ⅰ and Co-Ⅲ (P <0.01 vs model group). Conclusion : Guizhi Fuling Wan suspension can effectively inhibit liver α-SMA, TGF-β1, CTGF, Co-Ⅰ and Co-Ⅲ gene and protein expression, have a good anti-liver fibrosis.
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发布时间：2024-01-04 - 摘要：Objective :To observe the fluence of Jiming Fengshiwang on anti-inflammation, analgesic and cute soft tissue injury disease. Method : Jiming Fengshiwang were given 10.0,5.0, 2.5 mL·kg-1 daily by external administration for 7 days. The anti-nflammatory effect was investigated by methods of ear swelling in mice, hind paw edema and adjuvant-induced arthritis in rats. The analgesic effect was observed with hot-plate test in mice and tail-contracting test with light-hot stimulus in mice. The effects of Jiming Fengshiwang on soft tissue injury in mice was tested by damages caused by freely falling mass damages models. Results : Jiming Fengshiwang could obviously inhibit ear swelling in mice induced by croton oil, hind paw edema in rats induced by carrageenan and the original and secondary inflammatory changes of adjuvant-induced arthritis in rats, could otviously prolong the pain threshold of temperature stimuli in mice, and resisting the acute soft tissue injury. Conclusion: Jiming Fengshiwang has anti-inflammation, analgesic, treating soft tissue injury effects.关键词：Jiming Fengshiwang;anti-inflammation;analgesia;acute soft tissue injury
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发布时间：2024-01-04 - 摘要：Objective : To observe the influence of Bangxiong Shufeng granlues on the experimental migraine. Method: The mice was divided into blank control group, model group,three doses groups of Bangxiong Shufeng granlues (9.75, 19.5, 39 g·kg-1·d-1), Chinese medicine and western medicine control groups. The chemical and physical pain threshold were observed nitroglycerin was used to make rat migraine model,the change of behavior and plasma serotonin (5-HT) were detected. Result: In test of mice tail flick. Bangxiong Shufeng granlues with high dose increased the pain threshold at 30,60,90,120 min, respectively (P<0.05 or P<0.01). In acetic acid induced writhing model, Bangxiong Shufeng granlues with medium and high dose decreased writhing frequency. In the test of migraine model by nitroglycerin. Bangxiong Shufeng granlues with low, medium and high dose decreased disappeared time of red eras and,high dise group decreased the frequency of scratching head and climbing cage frequency during the period of 30 to 80 min and 30 to 180 min compared with model group,the treatment group increased 5-HT content. Conclusion: Bangxiong Shufeng granlues would have effects on migraine model.关键词：Bangxiong shufeng granules;migraine model;pain threshold;serotonin
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发布时间：2024-01-04 - 摘要：Objective : To observe biological effects of Tianshengyuan oral solution (TSY), a new candidate Chinese medicine, in mice with aplastic anemia(AA) induced by benzene and cyclophosphamide. Method : Male CD1 mice(20~24 g) were given cyclophosphamide (50 mg·kg-1, sc, once a day) for 7 days and benzene (2 mL·kg-1, sc, once every one day) for 30 days to develop AA mouse models. Meanwhile, the animals were treated with TSY at different doses (3.1,6.2,12.4 g·kg-1, ig, twice a day) for 30 days. Then peripheral leukocyte(WBC), erythrocyte(RBC), hemoglobin (HGB), hematocrit(HCT), platelet (PLT), reticulocyte(RET), femoral bone marrow nucleus cell(BMNC), megakaryocyte (MKC), and its pathological features were examined. Result: The values examined in the model group (except WBC) were remarkably lower than those in the normal group(P<0.05~0.001). TSY(24.8 g·kg-1·d-1)could significantly increase the values of RBC(8.3%, P<0.05), HGB(8.8%, P<0.05), HCT(7.4%, P<0.05), PLT(14.8%, P<0.05), RET (102.0%, P<0.01), BMNC(34.7%, P<0.05), MKC(66.7%, P<0.05) compared with model group. But the increase in WBC was not obvious. Besides, the pathological conditions of femoral bone marrow in more than half of AA mice were better in the group of TSY (24.8 g·kg-1·d-1). Conclusion : TSY could promote the proliferation of hematogenic cells in bone marrow, improve the function of hematopoiesis, and show its biological activities for AA mouse models.关键词：aplastic anemia;Tianshengyuan oral solution;hematopoiesis;benzene;cyclophosphamide
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发布时间：2024-01-04 - 摘要：Objective : To explore the regulation of Tianshengyuan oral solution (TSY) for the abnormality of T lymphocyte subsets and the level of hematopoietic cellular factors in mice with immune-mediated aplastic anemia(IAA). Method : T-cell subsets, including CD4+, CD8+, in peripheral plasma were analyzed by flow cytometry. GM-CSF and TNF-α were measured by fluorescence immunoassay. Result : TSY(12.4 g·kg-1·d-1) ig for 14 days could significantly reduce the production of peripheral CD8+ , increase in the ratio of CD4+/CD8+(2.34±1.10, n=7, P<0.001) and in the level of GM-CSF·L-1, n=10, P<0.01], compared with IAA model group·L-1, n=12, respectively]. Meanwhile, the decreased levels of TNF-α were also seen in the same group. Conclusion These results suggest that TSY for the treatment of IAA mice could be by modulating the balance between T-lymphocyte subsets, and the levels of hematopoietic cellular factors.关键词：aplastic anemia;Tianshengyuan oral solution;T-lymphocyte;hematopoietic cellular factor;flow cytometry;fluorescence immunoassay
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发布时间：2024-01-04 - 摘要：Objective : To study the toxicity and absorption of mercury following single dose transdermal administration of Yuhong ointment containing 0.4% calomel in rabbits. Method : Twelve Japanese white rabbits, half in male or female, were divided into three groups: control group, Yuhong ointment group and 0.4% calomel group. The rabbits were given a single transdermal administration of 1.56 g·kg-1(0.039 g·cm-2, corresponding to 2-fold of the human therapeutic dose). The contents of mercury in blood and main organs were measured by HG-AAS. The serum biochemical indexes including creatinine(Cr),BUN,AST,ALT were measured to reflex the function of liver and kidney. Result : The contents of blood mercury in the experimental groups showed no significant difference compared with control group, while the content of mercury didn’t increase obviously after single dose transdermal administration. The mercury contents of the experimental groups in liver and kidney were significantly higher than that of the control group, whereas there were no statistical significance in heart, spleen and brain. Among of the blood biochemical indexes, only ALT increased significantly in the experimental groups compared with that in the control group. Conclusion : There was little absorption of mercury and a definite accumulation of mercury in liver and kidney following single dosage transdermal administration of Yuhong ointment in rabbits.关键词：Yuhong ointment;rabbit;transdermal administration;mercury absorption;safety
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发布时间：2024-01-04 - 摘要：Objective :To investigate correlation between syndromes differentiation typing(SDT) with leptin and insulin resistance in chronic hepatitis C. Method : Screened One handre and sirty cases of chronic hepatitis C patients and Smmarized its syndromes differentiation typing. Serum leptin levels, fasting blood glucose and insulin levels were measured, fifty cases in healthy control group and make the regression analysis with the above indicators and SDT. Result: The type of shi-re stasis is highest proportion in chronic hepatitis C, followed by liver stagnation and spleen deficiency, blood stasis, deficiency in liver-kidney, deficiency in spleen and kidney, compared with the healthy control group, in addition to spleen-kidney deficiency,The remaining syndromes are obvious hyperleptinemia and insulin resistance, followed by spleen-kidney deficiency, liver stagnation and spleen deficiency,shi-re stasisl blood stasis, in which shi-re stasis and blood stasis type is easier to steatosis. Conclusion: The type of shi-re stasis is the main syndromes of chronic hepatitis C, hyperleptinemia and insulin resistance is the indicators in SDT of chronic hepatitis C.关键词：chronic hepatitis C;syndromes differentiation typing;leptin;insulin resistance
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发布时间：2024-01-04 - 摘要：Objective : To observe the clinical efficiency and immunological regulation of Kangdu Buxin capsule in treatment of viral myocarditis. Method : Sixty patients with VMC were randomly divided into treatment group and control group, treatment group was treated with Kangdu Buxin capsule and control group was treated with conventional therapy for 4 weeks. Clinical efficiency and improvement of CK, CK-MB, TNF-α,IL-2 were observed. Result :The total effective rates of treatment and control group were 93.3％ and 76.7％ with significant difference(P<0.05). After treatment,the levels of CK, CK-MB, IL-2,TNF-α were decreased in two groups(P<0.05).Compared with control group, statistical difference was also observed (P<0.05). Conclusion : Kangdu Buxin capsule is effective in the treatment of viral myoearditis, and it also has a good regulation effect on the immune function.关键词：Kangdu Buxin Capsule;viral myocarditis;curative effects;immune
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发布时间：2024-01-04 - 摘要：Objective : To study the effects of the immunologic function and quality of life in the patient with lung cancer treated with Jiajian Shashen Maidong decoction integrated with paclitaxel and cisplatin. Method : Forty-three cases with lung cancer patients were randomly divided into a chemotherapy group and a chemotherapy plus Chinese medicine group. Patients in chemotherapy group were treated with paclitaxel and cisplatin. The chemotherapy plus Chinese medicine group patients were given paclitaxel and cisplatin and Jiajian Shashen Maidong decoction. Immunologic indexes and EORTC QLQ-C43 scale were investigated in all groups. Result : The immunologic function in the patients of Ⅲ-Ⅳstage and lympf node metastases was lower than the patients of early stage and non-lympf node metastases. In chemotherapy group, levels of CD3+,CD4+,CD4+/CD8+were decreased after 2 cycle chemotherapy.In chemotherapy plus Chinese medicine group, levels of CD3+,CD4+,CD4+/CD8+ were increased. Improvement of KPS,leucocyte and quality of life,reducing nausea and vomitting in chemotherapy plus Chinese medicine group after treatment was significantly superior to that in chemotherapy group. The score in the most domains of EORTC QLQ - C43 QOL was decreased in functional scales but increased in symptom scales,which means the quality of life was deteriorated. While in treatment group, the score in symptom scales and EORTC QLQ-LC43 was decreased, Which means the symptom was reduced. The scores of physical functioning,social functioning,role functioning,emotional functioning,cognitive functioning and globle health were increased which shows that patients' QOL was improved. The effective rate of traditional Chinese medicine (TCM) symptom in treatment group was higher than that in control group, there was a ignificant difference between two groups In the treatment group the score of TCM symptom was decreased after two cycles chemotherapy,but in the control group the score was of no change. Conclusion : Jiajian Shashen Maidong decoction has functions of increasing immunologic function and quality of life, and reducing side effect of chemotherapy. The treatment scheme of chemotherapy combined with Chinese medicine may be important.关键词：Jiajian Shashen Maidong decoction;lung cancer;chemotherapy;immunologic function;quality of life
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发布时间：2024-01-04 - 摘要：Objective : By analyzing the compatibility regularity of Chinese medicine in one thousand three hundred and seven prescriptions, to discuss the application regularity of the herbs with neutral nature. Method : One thousand three hundred and seven prescriptions were screened from Herbal Prescription Science and 〈Pharmacopoeia of the People’s Republic of China〉, and the herbal nature was determined according to the Pharmacopoeia, the data were inputted into the database software, Data Analysis System of Traditional Chinese Medicine Herbal Prescription to analyze the relationship between herbal nature and prescription, and the relationship between prescription and syndromes. The paired correlation analysis and two categories of non-conditional logistic regression analysis were carried on by SPSS 13.0 statistic software to analyze the relativity between compatibility of Chinese medicines with neutral nature and different syndromes. Result : The number of the Chinese medicines with neutral nature as a guide drug was 3.9 times more than the Chinese medicines with cold and heat nature. The Chinese medicines with neutral nature as a monarch drug and a minister drug were firstly used in deficiency syndrome, secondly used in blood stasis syndrome and phlegm-dampness syndrome. The total application frequencies of the Chinese medicines with neutral nature which were used in cold syndrome, heat syndrome, the syndrome without obvious cold and heat, and the syndrome of intermingled cold and heat, were 22%, 18%, 25%, and 18%, respectively; the frequencies in deficiency syndrome, excess syndrome, and the syndrome of intermingled deficiency and excess, were 27%,17%,25%, respectively; the frequencies in qi deficiency syndrome, blood deficiency syndrome, cold syndrome, syndrome without obvious cold and heat, and deficiency syndrome, were 1.5, 1.4, 1.6, 1.2 times, respectively,more than the herbs with cold and heat nature. Conclusion : In terms of compatibility regularity, the Chinese medicines with neutral nature are most frequently used as guide drug;in terms of the diseases and syndromes, they are commonly used in deficiency syndrome, and the syndrome of intermingled deficiency and excess. The Chinese medicines with neutral nature are commonly used herbs in Qi deficiency syndrome, blood deficiency syndrome, cold syndrome, the syndrome without obvious cold and heat, and deficiency syndrome, and more appropriate for compatible application than the Chinese medicineswith cold and heat nature.关键词：prescription;neutral-nature chinese medicine;data bank;disease and syndrome;compatibility
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发布时间：2024-01-04 -
Patent Analysis on Traditional Chinese Medicine from 2001 to 2010 in Beijing, Shanghai and Guangdong
摘要：Objective :In the present study, patent quantity and distribution of traditional Chinese medicine in Beijing, Shanghai and Guangdong province were selectedand analyzed their from 2001 to 2010, which could offer some clues for its development and distribution. Method : Chinese medical intellectual property web was used to inquire the numbers of traditional chinese medicines in Beijing, Shanghai and Guangdong province from 2001 to 2010.Furthermore, the distribution of patents was also analyzed. Result : The ranking of total patent quantity in the three regions from 2001 to 2010 was Beijing, Shanghai and Guangdong province. The quantity of the three region reached peak from 2003 to 2006.However, the quantity showed decreased trend from 2006 to 2010.From 2001 to 2010, the patents were mainly centered in the individuals and enterprises rather than the institutes and scientific research. Conclusion :The data suggested that the government should give guideline for the institutes, universities and enterprises to improve the research and development in traditional chinese medicine, pay more attention to the intellectual property right protection, push the research achievement to the market and make Chinese traditional medicine into the global.关键词：medical intellectual property;traditional Chinese medicine;patent;patent applicant- 2
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发布时间：2024-01-04 - 摘要：Objectine : To analyze the regularity of Chinese patent medicine and west medicine application for chronic gastritis with text mining technique. Method : Collected large literature about treatment against chronic gastritis in CBM (Chinese Bio Medical Literature Database). Then, We transfer XML type data sets to the structured database of Microsoft SQL and visualize them into different graphs by Excel and Cytoscape software. Result : Sini San, Lizhong Wan were the commonly used Chinese patent medicine. The high frequencies of west medicine against chronic gastritis were amoxicillin, omeprazole and clarithromycin. Chinese patent medicine Sini San as well as west medicine omprazde and ranitidine of the combinated with othor drugs in treatment of the chronic gastrits. Conelusion : The text mining technology can find the medication regularity of Chinese patent medicine and west medicine application for chronic gastritis.关键词：chronic gastritis;text mining;using drugs regularity
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发布时间：2024-01-04 - 摘要：Objective : To explore primary Chinese and western medicines treating chronic hepatitis B and their combination regularity with text mining technique. Method : Literatures on Chinese and western medicines treating chronic hepatitis B were collected from Chinese biomedical literature database (CBM) and access database was established. Above data were processed by SQL, meanwhile, data noise was removed with artificial means. And then, primary Chinese and western medicines treating chronic hepatitis B and their combination regularity were received by text mining technique. Result: Chinese herbs, such as salvia, astragalus, bupleurum, polygonum, licorice, matrine, aspartame, capillaries and gardenia, were main components of Chinese herb compound treating chronic hepatitis B. Danshen injection and interferon were the most commonly used Chinese patent medicine and western medicine for chronic hepatitis B. Some western medicine, for example, Interferon, lamivudine, thymosin, glutathione and vitamin C were often used in combination with Danshen injection. In addition, lamivudine was applied with astragalus injection, yiganling, hugan slices or gansu particles. Conclusion : Primary application of Chinese and western medicines treating chronic hepatitis B and their combination regularity not only reflect clinical practical state, but also expanded the scopes and thingking of clinical application of Chinese and western medicine.关键词：chronic hepatitis B;regularity of Chinese and western medicine application;text mining
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发布时间：2024-01-04 - 摘要：Objective : To find out the occurrence rate of adverse drug reactions (ADR) following the intravenous administration of Xiyanping Injection and to understand the relative factors such as the type and constitution of ADR. To preliminarily explore the methods for reevaluation of the drug after marketing. Method : A comprehensive collection of literature was classified into 3 categories, synchronous clinical study,monitoring of ADR and analysis of medical records, as well as individual or typical case reports. Result: Different study methods indicated that the mean occurrence rate of ADR in Xiyanping Injection was2.02%;ADR manifested mainly as anaphylactic reaction. In addition, a variety of rare types of ADR was discovered, which was not indicated in the instructions of the product. Conclusion: The ADR of Xiyanping injection represented mainly as anaphylactic reaction, especially with anaphylactic shock.关键词：Xiyanping injection;adverse drug rection(ADR);systematic evalution;reevaluation after appeared on market
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发布时间：2024-01-04 - 摘要：Objective : To investigate bleeding risk induced by Danshen injection, and to provide safety data for clinical treatment. Method : Chinese biological medical disc (CBM) was searched by the formulae of ‘Salvia miltiorrhiza injection’ or ‘injection powder’ and ‘side effects’ or ‘adverse events’ or ‘bleeding’ or ‘blood clotting’ or ‘coagulation’, with duration from 1979.01-2009.08 for the literatures with Danshen injection adverse reaction case report. Result: ① A number of 1659 documents is retrieved and 86 medical reports are selected. Among them, 86 cases in the literature reported 7 900 cases of adverse reactions, involving 395 cases of Danshen injection cases (0.05%). The primary diseases of adverse reaction cases are mainly cardiovascular disease and cerebrovascular disease (58.1%). ②Adverse events include bleeding 16 records (18.6%), rash 14 records (16.3%) and shock and death each 7 records (8.1%). Conclusion : The reports indicates that the ratio of adverse events and bleeding events induced by Danshen injection is low.
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发布时间：2024-01-04 - 摘要：The literatures on toxicity and mechanism of different forms of arsenic in realgar were collected and analyzed. Twenty-eight papers in journals home and abroad were consulted and classified. This paper introduces the toxicity and mechanisms of different forms of arsenic in realgar on the liver, kidneys, bladder, nerves, skin, fetal development and etc. The in vivo toxicity of different arsenic compounds is quite different depending on the exiting forms, inorganic arsenic and organic arsenic. AsⅢ can cause liver cells apoptosis and focal necrosis, AsⅤ, MMAⅤ and DMAⅤ can cause liver cells swelling and spotty inflammation. DMAⅤ is more toxic than MMAⅤ. When prolonged exposure to DMAⅤ and MMAⅤ presents, bladder cancer and skin cancer in animals can caused. MMAⅤ and DMAⅤ metabolites are more toxic than iAsⅢ and iAsV to the genes regulating the neurofilament proteins. In addition, iAsⅢ and MMAⅢ can produce significant toxicity to human hematopoietic stem cells. These reports will provide basis for exploring the relations of different forms of arsenic with toxicity.关键词：arsenic;chemical form;toxicity
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发布时间：2024-01-04 - 摘要：Strychnine is one of the main active and toxic ingredients in a Chinese medicine, Semen Strychni, which was found nearly two hundred years ago. In this article,we summarized the progress on studies of the activities、toxicology、pharmacodynamics and main metabolites of strychnine.The strychnine poisoning is mainly due to paralysis because of spinal cord over-excitation and hypoxia. The strychnine has effects on nervous system such as the spinal cord, the medulla oblongata and digestive system. Pharmacokinetic studies reveal its absorption, tissue distribution and metabolism.the paper can provide reasonable theory basis for the in-depth study of the strychnine and clinical application.关键词：strychnine;activities;toxicity;pharmacokinetic
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发布时间：2024-01-04 - 摘要：By resourcing and sorting the references of Wikstroemia indica at home and abroad, it has been summarized the chemical constituents and the pharmacological action of Wikstroemia indica. It has many chemical constituents with biological activities, such as coumarin, flavone and lignanoid. Beside the antitumor activity, which has become one of the hot sports in resent academic research, it has antibacterial, antiviral, anti-inflammatory and analgesic effects etc. As one of the toxic herbs, more attention should be paid to its toxic-side effects to ensure the safety and rationality in clinic and to provide a basis for its further development and application.关键词：Wikstroemia indica;chemical constituents;Pharmacologicol action;summary
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发布时间：2024-01-04 - 摘要：Objective :To review progress in traditional Chinese medicine pellets including classification, excipients and preparation process,and its application in sustained-release and controlled-release preparation were summarized. Method :Accessing to more than 40 domestic and foreign literature in recent years,we analyze and give a brief review at classification, the preparation process and excipients, then we could prospect the development of traditional Chinese medicine. Result : Traditional Chinese medicine pellets, with characteristics of easily-obtained excipients and flexible preparation process, had a unique advantage in field of preparation of traditional Chinese medicine. Conclusion : Traditioral Chinese medicine pellets has much practical and development value in the field of sustained-release preparation.关键词：traditional Chinese medicine pellets;excipients;preparation process;sustained-release and controlled-release preparation
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发布时间：2024-01-04 - 摘要：This article introduced the chemical constituents of medicinal herbs Herba Moslae,summed up the twenty years’ researches in order to provide reference for its future research. As yet,more than 120 compounds have been found from Elsholtua bodinieri, E.splendens, E. Ianthina, E.eriostachya, E.densa, E.critata , E.ciliata , E.ruguloda , E.ciliata (thund.), E.calycocarpa , E.stauntonii , E.blanda,Mosla chinensis and Mosla chinensis. Most of them belongs to flavonoids, monoterpenes, triterpenoid, steroids, coumarins,ignans and organic acids, etc.关键词：Herba Moslae;review;chemical constituents
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发布时间：2024-01-04 - 摘要：Literatures about new dosage forms of medicines with reducing blood sugar were analyzed. Diabetes and complications exert a serious threat on humans, dosage forms play a critical role in efficiency, while commonlj used medicines with reducing blood sugar have some shortages, so it is necessary to develop new dosage forms of medicines. This paper mainly reviewed common dosage forms(tablet, granule, capsule, pills, aerosol, spray, powder inhalation and collunarium),new technology and new dosage forms(sustained-release and controlled-release, targeted and pulse-automatic regulated drug delivery system, transdermal drug delivery system and new intellectual drug)of treating diabetes, also discussed bioequivalence. In concluding, presentlythe medicines with reducing blood sugar showed some side effects after administration of long term. Therefore, development of safe and effective traditional Chinese medicine preparation which was combined with the theory of components compatibility and pharmaceutics, pharmacology and pharmaceutical chemistry may bring new hopes for curing diabetes.关键词：diabetes;medicines of reducing blood sugar;insulin;new dosage forms
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发布时间：2024-01-04 - 摘要：Objective: to summarize the studies on the chemical constituents of Prunella vulgaris. Method : collect all the literatures on the chemical constituents of P. vulgaris, then classify the compounds by their chemical structures and summarize the characteristics of different types. Result : Triterpene and their glucosides, nonsteroidal, flavone, coumarin are the main structure types of the compounds in Prunella vulgaris. Conclusion : The paper will lay a foundation for deepening the chemical study on Prunella vulgaris and improving the quality standards of P. vulgaris and its compound preparations.关键词：Prunella vulgaris;chemical constituents;Triterpene glucosides
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发布时间：2024-01-04 - 摘要：Objective :To review and analyze the research papers of 20(S)-protopanaxadiol pharmacological activity. Method :References in CNKI,Wan Fang VIP,Springer, Pubmed,Ovid and other databases were accessed for 20(S)-protopanaxadiol, an active compound of troditional Chinese medicine.Some thirty papers in the past 15 years home and abroad were summarized statistically for its pharmacological activity by popularity. Result :20(S)-protopanaxadiol has anti-cancer,anti-depressant actions. It also shows actions of activating chloride ion channel, inhibiting the depolarization of activated sodium Channel, and inhibiting the growth of human embryonic kidney HEK-293 cells and Helicobacter pylori and many other pharmacological activity. Conclusion : The 20(S)-protopanaxadiol's pharmacological activities are comprehensively summarized,which may give a reference for the medical researchers to carry out the 20(S)-protopanaxadiol pharmacological research in the future. For new drug development, studies on pharmacological mechanisms and toxicity should be carried out in the futnre.关键词：20(S)-protopanaxadiol;pharmacological activity;cancer;depressant
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发布时间：2024-01-04 - 摘要：Based on professor Zhang’s treatment of functional dyspepsia and their case studies of the disease etiology, pathogenesis, differential treatment and their views, summed up the views of its etiology and pathogenesis,the Spleen and Stomach deficiency as the basis of the incidence of the disease, Liver qi stagnation as its conditions, Function dyspepsia disease conditions originated in the qi stagnation, Blood stasis, damp, phlegm as a pathological product of functional dyspepsia, Starting from the etiology and pathogenesis, she explained the essence of the clinical syndrome,she made qi spleen, liver qi stagnation, phlegm stasis for the treatment, Professor Zhang also attached importance to physical and mental recuperation, she thought that the physical and mental recuperation in the treatment of this disease is also important,she concluded the law Herbal prescription,In particular the clinical treatment of functional dyspepsia with the characteristics of medication side, also she looked forwarded to provided a reference for functional dyspepsia in clinical.关键词：functional dyspepsia;increase spleen qi;dredge stagnation of liver qi;ease blood stasis and dispel phlegm;pay attention on both physical and mental;Zhang Zhaolan.
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发布时间：2024-01-04 - 摘要：Objective : To evaluate the therapeutic effect of promoting blood circulation to remove blood stasis on idiopathic pulmonary hemosiderosis in the period of recurrence. Method : Fifteen cases with idiopathic pulmonary hemosiderosis were in accordance with the diagnostic and therapeutic standard of traditional Chinese medicine, and the self-calibrated method was applied to observe the effect of this therapy. The total therapy lasts four weeks including the previous hormone treatment followed by that of traditional Chinese medicine, and the results of the efficacy were regarded as significant improvement, improvement and no effect. Result : The four-week treatment showed that five cases were improved significantly, eight improved, two with no effect, and the overall efficiency was 86.7%. Conclusion : The present study demonstrated that the therapeutic effect of promoting blood circulation to remove blood stasis on idiopathic pulmonary hemosiderosis in the period of recurrence was confirmed and needed the further investigation.关键词：idiopathic pulmonary hemosiderosis;pulmonary fibrosis;haemostasis;method of promoting blood circulation to remove blood stasis
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